Vogt-Koyanagi-Harada syndrome

Common Name(s)

Vogt-Koyanagi-Harada syndrome

Vogt-Koyanagi-Harada syndrome (VKH disease) is a condition that involves chronic inflammation of melanocytes, which are specialized cells that produce a pigment called melanin. Melanin is the substance that gives skin, hair, and eyes their color. Melanin is also found in the retina, where it plays a role in normal vision. People with VKH disease usually develop vision and hearing disturbances first, followed by signs of skin problems. The most common symptoms include headaches, panuveitis, vitiligo, hair loss (alopecia), and inner ear disturbances. Neurological symptoms may also occur. The exact cause of VKH disease is not well understood, but research suggests it is an autoimmune disease. It is more common in people with darker skin pigmentation including Asian, Middle Eastern, Hispanic, and Native American populations.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Vogt-Koyanagi-Harada syndrome" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Vogt-Koyanagi-Harada syndrome" returned 58 free, full-text research articles on human participants. First 3 results:

Association of a NOS3 gene polymorphism with Behçet's disease but not with Vogt-Koyanagi-Harada syndrome in Han Chinese.
 

Author(s): Yan Zhou, Hongsong Yu, Shengping Hou, Jing Fang, Jieying Qin, Gangxiang Yuan, Aize Kijlstra, Peizeng Yang

Journal:

 

Previous studies have identified that nitric oxide synthase (NOS) genes are associated with several immune-mediated diseases. This study aimed to investigate whether NOS2 and NOS3 gene polymorphisms are associated with Behçet's disease (BD) and Vogt-Koyanagi-Harada (VKH) syndrome ...

Last Updated: 26 Apr 2016

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CFI-rs7356506 polymorphisms associated with Vogt-Koyanagi-Harada syndrome.
 

Author(s): Ma-Li Dai, Xiu-Feng Huang, Qing-Feng Wang, Wei-Jun Cai, Zi-Bing Jin, Yuqin Wang

Journal:

 

Complement factor I (CFI) plays an important role in complement activation pathways and is known to affect the development of uveitis. The present study was performed to investigate the existence of an association between CFI genetic polymorphisms and Vogt-Koyanagi-Harada (VKH) syndrome.

Last Updated: 22 Feb 2016

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[Sudden hearing loss revealing Vogt-Koyanagi-Harada syndrome].
 

Author(s): Madiha Mahfoudhi, Khaled Khamassi

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Last Updated: 5 Feb 2016

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Reviews from the PubMed Database

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The terms "Vogt-Koyanagi-Harada syndrome" returned 0 free, full-text review articles on human participants.

 
 
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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

There are currently no open clinical trials for this condition.