Vogt-Koyanagi-Harada syndrome

Common Name(s)

Vogt-Koyanagi-Harada syndrome

Vogt-Koyanagi-Harada syndrome is a condition that involves chronic inflammation of melanocytes, which are specialized cells that produce a pigment called melanin.  Melanin is the substance that gives skin, hair, and eyes their color.  Melanin is also found in the retina, where it plays a role in normal vision.  Individuals with Vogt-Koyanagi-Harada syndrome usually develop vision and hearing disturbances first, followed by signs of skin problems.  Research suggests this condition is an autoimmune disease.  Vogt-Koyanagi-Harada syndrome is more common in individuals with darker skin pigmentation including Asian, Middle Eastern, Hispanic, and Native American populations.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Vogt-Koyanagi-Harada syndrome" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Vogt-Koyanagi-Harada syndrome" returned 49 free, full-text research articles on human participants. First 3 results:

A functional variant of PTPN22 confers risk for Vogt-Koyanagi-Harada syndrome but not for ankylosing spondylitis.
 

Author(s): Qi Zhang, Jian Qi, Shengping Hou, Liping Du, Hongsong Yu, Qingfeng Cao, Yan Zhou, Dan Liao, Aize Kijlstra, Peizeng Yang

Journal:

 

Protein tyrosine phosphatase non-receptor 22 (PTPN22) is a key negative regulator of T lymphocytes and has emerged as an important candidate susceptibility factor for a number of immune-related diseases. This study aimed to examine the predisposition of PTPN22 SNPs to Vogt-Koyanagi-Harada ...

Last Updated: 12 May 2014

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Association of a TNIP1 polymorphism with Vogt-Koyanagi-Harada syndrome but not with ocular Behcet's disease in Han Chinese.
 

Author(s): Yanyun Shi, Yading Jia, Shengping Hou, Jing Fang, Yan Zhou, Aize Kijlstra, Peizeng Yang

Journal:

 

The aim of the study was to investigate the association of TNFα-induced protein 3 interacting with protein 1 (TNIP1) gene polymorphisms with Vogt-Koyanagi-Harada (VKH) syndrome and Behcet's disease (BD) in a Han Chinese population.

Last Updated: 5 May 2014

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TRAF5 and TRAF3IP2 gene polymorphisms are associated with Behçet's disease and Vogt-Koyanagi-Harada syndrome: a case-control study.
 

Author(s): Qin Xiang, Lu Chen, Shengping Hou, Jing Fang, Yan Zhou, Lin Bai, Yunjia Liu, Aize Kijlstra, Peizeng Yang

Journal:

 

TRAF5 and TRAF3IP2 have been reported to be associated with several autoimmune diseases. Behçet's disease (BD) and Vogt-Koyanagi-Harada (VKH) syndrome are two autoimmune uveitis entities whereby both genetic and environmental factors are thought to be involved.

Last Updated: 13 Jan 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Vogt-Koyanagi-Harada syndrome" returned 0 free, full-text review articles on human participants.

 
 
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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

There are currently no open clinical trials for this condition.