Vogt-Koyanagi-Harada syndrome

Common Name(s)

Vogt-Koyanagi-Harada syndrome

Vogt-Koyanagi-Harada syndrome (VKH disease) is a condition that involves chronic inflammation of melanocytes, which are specialized cells that produce a pigment called melanin. Melanin is the substance that gives skin, hair, and eyes their color. Melanin is also found in the retina, where it plays a role in normal vision. People with VKH disease usually develop vision and hearing disturbances first, followed by signs of skin problems. The most common symptoms include headaches, panuveitis, vitiligo, hair loss (alopecia), and inner ear disturbances. Neurological symptoms may also occur. The exact cause of VKH disease is not well understood, but research suggests it is an autoimmune disease. It is more common in people with darker skin pigmentation including Asian, Middle Eastern, Hispanic, and Native American populations.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Vogt-Koyanagi-Harada syndrome" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Vogt-Koyanagi-Harada syndrome" returned 54 free, full-text research articles on human participants. First 3 results:

Copy number variations and gene polymorphisms of complement components in ocular Behcet's disease and Vogt-Koyanagi-Harada syndrome.
 

Author(s): Dengfeng Xu, Shengping Hou, Jun Zhang, Yanni Jiang, Aize Kijlstra, Peizeng Yang

Journal:

 

Complement is involved in many immune-mediated diseases. However, the association of its copy number variations (CNVs) and polymorphisms with Behcet's disease (BD) and Vogt-Koyanagi-Harada syndrome (VKH) is unknown. We examined copy number and mRNA expression by real-time PCR. Cytokine ...

Last Updated: 13 Aug 2015

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Interleukin-10 gene polymorphisms are associated with Behcet's disease but not with Vogt-Koyanagi-Harada syndrome in the Chinese Han population.
 

Author(s): Jianmin Hu, Shengping Hou, Xueping Zhu, Jing Fang, Yan Zhou, Yunjia Liu, Lin Bai, Aize Kijlstra, Peizeng Yang

Journal:

 

This study aimed to investigate the association of interleukin (IL)-10 gene polymorphisms with Behcet's disease (BD) and Vogt-Koyanagi-Harada (VKH) syndrome in the Chinese Han population.

Last Updated: 27 May 2015

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Copy number variants and genetic polymorphisms in TBX21, GATA3, Rorc, Foxp3 and susceptibility to Behcet's disease and Vogt-Koyanagi-Harada syndrome.
 

Author(s): Dan Liao, Shengping Hou, Jun Zhang, Jing Fang, Yunjia Liu, Lin Bai, Qingfeng Cao, Aize Kijlstra, Peizeng Yang

Journal:

 

This study aimed to investigate the role of genetic variants including single nucleotide polymorphisms (SNPs) and copy number variants (CNVs) of TBX21, GATA3, Rorc and Foxp3 genes in Behcet's disease (BD) and Vogt-Koyanagi-Harada (VKH) syndrome in a Chinese Han population. Genotyping ...

Last Updated: 15 Apr 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Vogt-Koyanagi-Harada syndrome" returned 0 free, full-text review articles on human participants.

 
 
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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

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