Vitiligo

Common Name(s)

Vitiligo

Vitiligo is a pigmentation disorder in which melanocytes (the cells that make pigment) in the skin are destroyed. As a result, white patches appear on the skin in different parts of the body, and sometimes also on both the mucous membranes and the retina. The average age of onset is in the mid-20s.  It is generally considered to be an autoimmune disorder, and about 20-25 percent of people with vitiligo also have at least one other autoimmune disorder. In the absence of other conditions, vitiligo does not affect general health; however, concerns about appearance and ethnic identity are significant issues for many affected individuals. The exact cause of vitiligo is not known, but there are several different theories. There is strong evidence that people with vitiligo inherit a group of genes that make them susceptible to depigmentation. The main goal of treating vitiligo is to improve appearance; current treatment options include medication, surgery, and adjunctive therapies (used along with surgical or medical treatments).
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Vitiligo" for support, advocacy or research.

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American Vitiligo Research Foundation

American Vitiligo Research Foundation Inc. (AVRF) provides public awareness about vitiligo through dedicated work, education and counseling. We seek to make a difference worldwide to those afflicted by the disease, focusing on children and their families. We embrace diversity and encourage acceptance. The AVRF encourages higher ethical standards in research, and therefore supports finding a cure through alternatives to animal testing.

Last Updated: 14 Jan 2013

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Vitiligo Research Foundation (VR Foundation)

Firmly committed to curing Vitiligo, the VR Foundation is a disease-specific non-profit organization funding and fast-tracking medical research globally. Our mission is to accelerate the end of suffering for millions of people who suffer from vitiligo through research, support and education.

Last Updated: 21 Aug 2014

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Vitiligo Support International Inc.

Vitiligo Support International Inc. (VSI) is a patient driven 501 (c) (3) nonprofit organization, committed to supporting those affected by vitiligo, raising awareness, promoting research, and discussing effective treatments until a cure is found.

Last Updated: 30 Nov 2012

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Vitiligo" for support, advocacy or research.

Logo
American Vitiligo Research Foundation

American Vitiligo Research Foundation Inc. (AVRF) provides public awareness about vitiligo through dedicated work, education and counseling. We seek to make a difference worldwide to those afflicted by the disease, focusing on children and their families. We embrace diversity and encourage acceptance. The AVRF encourages higher ethical standards in research, and therefore supports finding a cure through alternatives to animal testing.

http://www.avrf.org/

Last Updated: 14 Jan 2013

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Vitiligo Research Foundation (VR Foundation)

Firmly committed to curing Vitiligo, the VR Foundation is a disease-specific non-profit organization funding and fast-tracking medical research globally. Our mission is to accelerate the end of suffering for millions of people who suffer from vitiligo through research, support and education.

http://vrfoundation.org

Last Updated: 21 Aug 2014

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Vitiligo Support International Inc.

Vitiligo Support International Inc. (VSI) is a patient driven 501 (c) (3) nonprofit organization, committed to supporting those affected by vitiligo, raising awareness, promoting research, and discussing effective treatments until a cure is found.

https://www.vitiligosupport.org/front_page.cfm

Last Updated: 30 Nov 2012

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General Resources

Vitiligo Biobank

The Vitiligo BioBank is a non-profit, independent collection of biological samples and detailed associated data, designed to facilitate medical research into vitiligo, a devastating skin disease that is much neglected. Here at the Vitiligo Biob

Updated 18 Apr 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Vitiligo" returned 485 free, full-text research articles on human participants. First 3 results:

A case series pilot study on the combination of 5-aminolevulinic acid and photodynamic therapy (ALA-PDT) for treatment of vitiligo.
 

Author(s): YunJie Zhang, Hui Lin, XiaoJuan Guo, XianBiao Zou

Journal: An Bras Dermatol. ;93(4):539-545.

 

To study the effective therapeutic concentration, drug application duration, irradiation duration and irradiation dosage of 5-aminolevulinic acid photodynamic therapy (ALA-PDT) for treating vitiligo and observe its clinical efficacy.

Last Updated: 31 Dec 1969

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Decreased choroidal thickness in vitiligo patients.
 

Author(s): Serkan Demirkan, Zafer Onaran, Güzin Samav, Fatma Özkal, Erhan Yumuşak, Özgür Gündüz, Ayşe Karabulut

Journal:

 

Vitiligo is a disease characterized by depigmented macules and patches that occur as a result of the loss of functional melanocytes from the affected skin through a mechanism which has not been elucidated yet. Destruction of pigment cells in vitiligo may not remain limited to the ...

Last Updated: 31 Dec 1969

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Macrophage migration inhibitory factor as an incriminating agent in vitiligo.
 

Author(s): Azza Gaber Antar Farag, Mostafa Ahmed Hammam, Mona SalahEldeen Habib, Nada Farag Elnaidany, Mona Eaid Kamh

Journal: An Bras Dermatol. 2018 Mar;93(2):191-196.

 

Vitiligo is an autoimmune skin disorder in which the loss of melanocytes is mainly attributed to defective autoimmune mechanisms and, lately, there has been more emphasis on autoinflammatory mediators. Among these is the macrophage migration inhibitory factor, which is involved in ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Vitiligo" returned 60 free, full-text review articles on human participants. First 3 results:

Vitamin D receptor gene polymorphism, serum 25-hydroxyvitamin D levels, and risk of vitiligo: A meta-analysis.
 

Author(s): Jing-Zhan Zhang, Man Wang, Yuan Ding, Feng Gao, Yan-Yan Feng, Buwajieer Yakeya, Peng Wang, Xiu-Juan Wu, Feng-Xia Hu, Jun Xian, Xiao-Jing Kang

Journal: Medicine (Baltimore). 2018 Jul;97(29):e11506.

 

To explore the relationship among the vitamin D receptor (VDR) gene polymorphisms, serum 25-hydroxyvitamin D levels, and vitiligo.

Last Updated: 31 Dec 1969

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Clinical and Molecular Aspects of Vitiligo Treatments.
 

Author(s): Anuradha Bishnoi, Davinder Parsad

Journal:

 

Vitiligo is an asymptomatic but cosmetically disfiguring disorder that results in the formation of depigmented patches on skin and/or mucosae. Vitiligo can be segmental or non-segmental depending upon the morphology of the clinical involvement. It can also be classified as progressing ...

Last Updated: 31 Dec 1969

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Involvement of Different Genes Expressions during Immunological and Inflammatory Responses in Vitiligo.
 

Author(s): Chandra Kant Sharma, Monika Sharma, Kanika Prasad

Journal: Crit. Rev. Eukaryot. Gene Expr.. 2017 ;27(3):277-287.

 

Vitiligo is a condition of the skin distinguished by hypo-pigmentation. Etiology of this disorder is unknown, and several theories and mechanisms have been hypothesized. The inflammatory response in vitiligo is thought to be mediated by polymorphism in genes such as FOXP3, ACE, APE, ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Microneedling and Latanoprost in Acrofacial Vitiligo
 

Status: Not yet recruiting

Condition Summary: Vitiligo

 

Last Updated: 26 Aug 2018

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Last Updated: 12 Sep 2018

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Last Updated: 10 Nov 2016

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