Vitiligo

Common Name(s)

Vitiligo

Vitiligo is a pigmentation disorder in which melanocytes (the cells that make pigment) in the skin are destroyed. As a result, white patches appear on the skin in different parts of the body, and sometimes also on both the mucous membranes and the retina. The average age of onset is in the mid-20s.  It is generally considered to be an autoimmune disorder, and about 20-25 percent of people with vitiligo also have at least one other autoimmune disorder. In the absence of other conditions, vitiligo does not affect general health; however, concerns about appearance and ethnic identity are significant issues for many affected individuals. The exact cause of vitiligo is not known, but there are several different theories. There is strong evidence that people with vitiligo inherit a group of genes that make them susceptible to depigmentation. The main goal of treating vitiligo is to improve appearance; current treatment options include medication, surgery, and adjunctive therapies (used along with surgical or medical treatments).
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Vitiligo" for support, advocacy or research.

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American Vitiligo Research Foundation

American Vitiligo Research Foundation Inc. (AVRF) provides public awareness about vitiligo through dedicated work, education and counseling. We seek to make a difference worldwide to those afflicted by the disease, focusing on children and their families. We embrace diversity and encourage acceptance. The AVRF encourages higher ethical standards in research, and therefore supports finding a cure through alternatives to animal testing.

Last Updated: 14 Jan 2013

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Vitiligo Research Foundation (VR Foundation)

Firmly committed to curing Vitiligo, the VR Foundation is a disease-specific non-profit organization funding and fast-tracking medical research globally. Our mission is to accelerate the end of suffering for millions of people who suffer from vitiligo through research, support and education.

Last Updated: 21 Aug 2014

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Vitiligo Support International Inc.

Vitiligo Support International Inc. (VSI) is a patient driven 501 (c) (3) nonprofit organization, committed to supporting those affected by vitiligo, raising awareness, promoting research, and discussing effective treatments until a cure is found.

Last Updated: 30 Nov 2012

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Vitiligo" for support, advocacy or research.

Logo
American Vitiligo Research Foundation

American Vitiligo Research Foundation Inc. (AVRF) provides public awareness about vitiligo through dedicated work, education and counseling. We seek to make a difference worldwide to those afflicted by the disease, focusing on children and their families. We embrace diversity and encourage acceptance. The AVRF encourages higher ethical standards in research, and therefore supports finding a cure through alternatives to animal testing.

http://www.avrf.org/

Last Updated: 14 Jan 2013

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Vitiligo Research Foundation (VR Foundation)

Firmly committed to curing Vitiligo, the VR Foundation is a disease-specific non-profit organization funding and fast-tracking medical research globally. Our mission is to accelerate the end of suffering for millions of people who suffer from vitiligo through research, support and education.

http://vrfoundation.org

Last Updated: 21 Aug 2014

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Vitiligo Support International Inc.

Vitiligo Support International Inc. (VSI) is a patient driven 501 (c) (3) nonprofit organization, committed to supporting those affected by vitiligo, raising awareness, promoting research, and discussing effective treatments until a cure is found.

https://www.vitiligosupport.org/front_page.cfm

Last Updated: 30 Nov 2012

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General Resources

Vitiligo Biobank

The Vitiligo BioBank is a non-profit, independent collection of biological samples and detailed associated data, designed to facilitate medical research into vitiligo, a devastating skin disease that is much neglected. Here at the Vitiligo Biob

Updated 18 Apr 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Vitiligo" returned 461 free, full-text research articles on human participants. First 3 results:

A study of the association of glutathione S-transferase M1/T1 polymorphisms with susceptibility to vitiligo in Egyptian patients.
 

Author(s): Dalia Gamal Aly, Samar Abdallah Salem, Khalda Sayed Amr, Mahmoud Fawzy Abd El-Hamid

Journal: An Bras Dermatol. ;93(1):54-58.

 

The association of glutathione S-transferases M1/T1 (GSTM1/T1) null polymorphisms with vitiligo was proposed in several studies including two Egyptian studies with contradictory results.

Last Updated: 31 Dec 1969

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Optimizing suction blister epidermal graft technique in the surgical treatment of vitiligo.
 

Author(s): Gerson Dellatorre, Wagner Bertolini, Caio Cesar Silva de Castro

Journal: An Bras Dermatol. ;92(6):888-890.

 

Surgical management of vitiligo is considered an excellent terapeutic option for recalcitrant cases, provided the disease is stable and there is absence of Koebner phenomenom. Among surgical modalities, Suction Blister Epidermal Graft is a low cost and effective option (65 to 100% ...

Last Updated: 31 Dec 1969

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Prepubertal and postpubertal vitiligo: a multivariate comparative study in 375 patients.
 

Author(s): Huma Khurrum, Khalid M AlGhamdi

Journal: An Bras Dermatol. ;92(6):811-815.

 

The onset of vitiligo during childhood is common. Limited data exist that compare the clinical associations of prepubertal and postpubertal vitiligo in Arabs.

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Vitiligo" returned 53 free, full-text review articles on human participants. First 3 results:

Upregulation of Melanogenesis and Tyrosinase Activity: Potential Agents for Vitiligo.
 

Author(s): Chao Niu, Haji A Aisa

Journal:

 

Melanin, the compound primarily responsible in humans for hair, eye and skin pigmentation, is produced by melanocytes through a complicated process called melanogenesis that is catalyzed by tyrosinase and other tyrosinase-related proteins. The abnormal loss of melanin causes dermatological ...

Last Updated: 31 Dec 1969

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Phototherapy for Vitiligo: A Systematic Review and Meta-analysis.
 

Author(s): Jung Min Bae, Han Mi Jung, Bo Young Hong, Joo Hee Lee, Won Joon Choi, Ji Hae Lee, Gyong Moon Kim

Journal: JAMA Dermatol. 2017 Jul;153(7):666-674.

 

References to the expected treatment response to phototherapy would be helpful in the management of vitiligo because phototherapy requires long treatment durations over several months.

Last Updated: 31 Dec 1969

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Vitiligo Pathogenesis and Emerging Treatments.
 

Author(s): Mehdi Rashighi, John E Harris

Journal: Dermatol Clin. 2017 Apr;35(2):257-265.

 

The pathogenesis of vitiligo involves interplay between intrinsic and extrinsic melanocyte defects, innate immune inflammation, and T-cell-mediated melanocyte destruction. The goal of treatment is to not only halt disease progression but also promote repigmentation through melanocyte ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Last Updated: 8 Jun 2017

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Last Updated: 10 Nov 2016

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A Study of INCB018424 Phosphate Cream in Subjects With Vitiligo
 

Status: Recruiting

Condition Summary: Vitiligo

 

Last Updated: 4 Jan 2018

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