Baroreflex failure

Common Name(s)

Baroreflex failure

Baroreflex failure is a rare condition in which individuals experience blood pressure changes including periods of severely high blood pressure (hypertension) during times of stress alternating with normal or low blood pressure (hypotension) at rest. Symptoms for baroreflex failure may include headaches, excessive sweating, heart rate that is unchanged by medications, extremely high blood pressure and heart rate with stress and low blood pressure at rest. In many cases, the cause of baroreflex failure is unknown. However, it can be caused when there is damage to the nerves in the neck that should sense blood pressure. Causes can include damage from surgery to this region, after radiation cancer treatment involving the neck, or certain types of strokes. Unfortunately, baroreflex failure is hard to diagnose as it mirrors other more common disorders. In order to properly diagnose the condition, physicians monitor one’s heart rate and blood pressure during daily activities and other specific testing options. Upon diagnosis, treatment is the use of medications used to manage blood pressure, stress, and heart rate. If you have experienced any of these causes or suspect that you might have baroreflex failure, contact your physician. If you have been diagnosed with baroreflex failure, talk with your doctor and specialists about the most current treatment options.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Baroreflex failure" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Baroreflex failure" returned 41 free, full-text research articles on human participants. First 3 results:

Dialysate temperature adjustment as an effective treatment for baroreflex failure syndrome in hemodialysis patient.
 

Author(s): Natsumi Tanabe, Koki Takane, Keitaro Yokoyama, Yudo Tanno, Izumi Yamamoto, Ichiro Ohkido, Takashi Yokoo

Journal:

 

Baroreflex failure syndrome is a rare disorder which causes labile blood pressure, headache, flushing, diaphoresis and emotional lability. It is caused by history of trauma or radiotherapy in the cervical legion, bilateral carotid-body tumor or resection of glossopharyngeal nerve. ...

Last Updated: 23 Sep 2014

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Chronic baroreflex activation effects on sympathetic nerve traffic, baroreflex function, and cardiac haemodynamics in heart failure: a proof-of-concept study.
 

Author(s): Edoardo Gronda, Gino Seravalle, Gianmaria Brambilla, Giuseppe Costantino, Andrea Casini, Ali Alsheraei, Eric G Lovett, Giuseppe Mancia, Guido Grassi

Journal: Eur. J. Heart Fail.. 2014 Sep;16(9):977-83.

 

Heart failure (HF) pathophysiology is believed to be mediated by autonomic dysfunction, including chronic sympathoexcitation and diminished baroreflex sensitivity, which correlate with mortality risk. Baroreflex activation therapy (BAT) is a device-based treatment providing chronic ...

Last Updated: 4 Sep 2014

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Baroreflex failure, sympathetic storm, and cerebral vasospasm in fibulin-4 cutis laxa.
 

Author(s): Thilinie Rajapakse, Aleksandra Mineyko, Caroline Chee, Suresh Subramaniam, Frank Dicke, Francois P Bernier, Adam Kirton

Journal: Pediatrics. 2014 May;133(5):e1396-400.

 

Sudden, severe, and life-threatening, the crises associated with baroreflex failure are diagnostically challenging, particularly in children, a population in which it has rarely been described. The baroreflex failure syndrome results from impaired afferent baroreceptive input and ...

Last Updated: 3 Oct 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Baroreflex failure" returned 4 free, full-text review articles on human participants. First 3 results:

Baroreflex activation for the treatment of heart failure.
 

Author(s): Hani N Sabbah

Journal: Curr Cardiol Rep. 2012 Jun;14(3):326-33.

 

Autonomic dysregulation is a feature of heart failure (HF) characterized by sustained increase of sympathetic drive and by withdrawal of parasympathetic activity. Both maladaptations are independent predictors of poor long-term outcome in patients with HF. Considerable evidence exists ...

Last Updated: 9 May 2012

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Baroreflex failure: a neglected type of secondary hypertension.
 

Author(s): H J L M Timmers, W Wieling, J M Karemaker, J W M Lenders

Journal: Neth J Med. 2004 May;62(5):151-5.

 

The arterial baroreflex buffers abrupt transients of blood pressure and prevents pressure from rising or falling excessively. In experimental animals, baroreceptor denervation results in temporary or permanent increases in blood pressure level and variability, depending on the extent ...

Last Updated: 15 Sep 2004

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Four faces of baroreflex failure: hypertensive crisis, volatile hypertension, orthostatic tachycardia, and malignant vagotonia.
 

Author(s): Terry Ketch, Italo Biaggioni, RoseMarie Robertson, David Robertson

Journal: Circulation. 2002 May;105(21):2518-23.

 

The baroreflex normally serves to buffer blood pressure against excessive rise or fall. Baroreflex failure occurs when afferent baroreceptive nerves or their central connections become impaired. In baroreflex failure, there is loss of buffering ability, and wide excursions of pressure ...

Last Updated: 29 May 2002

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Effect of Bi-ventricular Pacing on Autonomous Nervous System
 

Status: Not yet recruiting

Condition Summary: Congestive Heart Failure

 

Last Updated: 5 Oct 2010

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