Ventricular septal defects

Common Name(s)

Ventricular septal defects

Ventricular septal defect (VSD) is a heart condition present at birth (congenital) in which there is a hole in the wall (septum) that separates the ventricles (bottom two chambers of the heart). The septum separates oxygenated blood from deoxygenated blood. Normally, the holes in the septum close before the baby is born, but VSD is a common heart birth defect, affecting about 1 in 500 babies. There are several types of VSDs depending on where the hole in the septum is located. If the hole is very small, it may not alter how hard the heart has to work, and affected individuals may not have symptoms. Sometimes a VSD is not diagnosed until childhood or even adulthood.

Often, symptoms are present as soon as a few days after birth and may include poor eating, fast breathing, breathlessness, and getting tired easily. Ventricular septal defects often occur in families (hereditary) or occur with other genetic conditions, such as Down syndrome. Medical researchers believe most VSDs are caused by a combination of genetic and environmental factors.

Doctors may hear a swishing sound in the heartbeat (a murmur) when listening with a stethoscope. Tests used to confirm a VSD may include a chest X-ray, electrocardiogram (EKG) (tests the electrical impulses), echocardiogram (used sound waves to create a picture), or cardiac MRI.

Treatment depends on location of the defect and the size as well as severity of symptoms. Many small VSDs close on their own. Surgical repair is the most common treatment but sometimes medication may be used temporarily to increase heart function. If your baby or child has been diagnosed with a VSD, talk to their pediatric cardiologist (a heart doctor for children) about the most current treatment options. Support organizations and genetic counselors are also a good source of information and can help connect you with others affected by VSDs.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Ventricular septal defects" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Ventricular septal defects" returned 139 free, full-text research articles on human participants. First 3 results:

Percutaneous closure of perimembranous ventricular septal defects associated with septal aneurysm in adults.
 

Author(s): Oktay Ergene, Nihan Kahya Eren, Cem Nazlı, Hamza Duygu, Uğur Kocabaş

Journal: Turk Kardiyol Dern Ars. 2015 Dec;43(8):699-704.

 

Percutaneous closure of perimembranous ventricular septal defects (pmVSD) has become an accepted alternative to surgical closure in selected cases. However, closure of pmVSDs associated with septal aneurysm is more challenging. We report our experience of device closure of pmVSDs ...

Last Updated: 31 Dec 2015

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Minimally invasive perventricular device closure of doubly committed sub-arterial ventricular septal defects: single center long-term follow-up results.
 

Author(s): Shu Zhang, Da Zhu, Qi An, Hong Tang, Dajiang Li, Ke Lin

Journal:

 

To evaluate the long-term safety and efficacy of using perventricular device closure in treating selected patient with doubly committed sub-arterial ventricular septal defect (VSD) METHODS: During July 2007 and April 2011, 86 patients with doubly committed subarterial VSD who met ...

Last Updated: 16 Sep 2015

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Characterization of SMAD3 Gene Variants for Possible Roles in Ventricular Septal Defects and Other Congenital Heart Diseases.
 

Author(s): Fei-Feng Li, Jing Zhou, Dan-Dan Zhao, Peng Yan, Xia Li, Ying Han, Xian-Shu Li, Gui-Yu Wang, Kai-Jiang Yu, Shu-Lin Liu

Journal:

 

Nodal/TGF signaling pathway has an important effect at early stages of differentiation of human embryonic stem cells in directing them to develop into different embryonic lineages. SMAD3 is a key intracellular messenger regulating factor in the Nodal/TGF signaling pathway, playing ...

Last Updated: 26 Jun 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Ventricular septal defects" returned 7 free, full-text review articles on human participants. First 3 results:

Insights gained from three-dimensional imaging modalities for closure of ventricular septal defects.
 

Author(s): Marietta Charakida, Kuberan Pushparajah, David Anderson, John M Simpson

Journal: Circ Cardiovasc Imaging. 2014 Nov;7(6):954-61.

 

Last Updated: 21 Nov 2014

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Paravalvular leaks and ventricular septal defects: endovascular approaches to treatment.
 

Author(s): Chad Kliger

Journal: Tex Heart Inst J. 2013 ;40(5):591-4.

 

Last Updated: 6 Jan 2014

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Surgical repair of postinfarction ventricular septal defects-2013 update.
 

Author(s): Susumu Isoda, Motohiko Osako, Tamizo Kimura, Kenji Nishimura, Nozomu Yamanaka, Shingo Nakamura, Tadaaki Maehara

Journal: Ann Thorac Cardiovasc Surg. 2013 ;19(2):95-102.

 

Treatment for postinfarction ventricular septal defect has been improving for several decades. Aggressive resection of the infarcted myocardium (infarctectomy and closure technique) and preserving infarcted myocardium (infarct exclusion technique) have been technically modified. Recent ...

Last Updated: 22 Apr 2013

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Minimally Invasive Transthoracic Device Closure in Perimembranous Ventricular Septal Defect
 

Status: Recruiting

Condition Summary: Perimembranous Ventricular Septal Defect

 

Last Updated: 30 Dec 2015

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Aortic Regurgitation After Surgical Repair of Outlet-Type Ventricular Septal Defect
 

Status: Recruiting

Condition Summary: Heart Septal Defects, Ventricular; Aortic Valve Insufficiency

 

Last Updated: 12 Sep 2005

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Study of Energy Expenditure in Infants With Ventricular Septal Defects
 

Status: Recruiting

Condition Summary: Heart Septal Defects, Ventricular

 

Last Updated: 23 Jun 2005

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