Vascular malformations

Common Name(s)

Vascular malformations

Vascular malformations are a type of congenital lesion (a growth present at birth) made up of arteries, veins, capillaries and/or lymphatic vessels. About 3% of children are born with vascular malformations. These malformations are not tumors and are therefore not cancerous. Most of the lesions only cause cosmetic issues, but some can cause difficulties depending on where it forms. Unlike hemangiomas, vascular malformations are present at birth (though it may take a few weeks to even a few years to be noticeable) and grow throughout a person’s lifetime. There are several different types depending on the type of blood vessel involved. Two common types of vascular malformations are salmon patches and port wine stains.

Symptoms vary based on the location of the lesion and the affected type of blood or lymph vessel. Some growths may affect vision or breathing. The causes of most of the lesions are not well understood. Vascular malformations are believed to have a genetic cause and display autosomal dominant inheritance, meaning you only need to inherit one changed gene to cause the condition (genes come in pairs one from each parent). Most of the involved genes are not known at this time, and the change usually happens by chance (sporadic). However, affected individuals will still have a 50% chance of passing it to their children. Locations and sizes of lesions can vary greatly within a family.

In order to diagnose vascular malformations, your doctor will perform a physical exam. Other tests may include imaging tests, including MRIs, CT scans, and ultrasounds. Treatment options may include surgery, laser therapy or injection of medicine into the vessel to make it less visible; however, treatment may not always be necessary. Talk to your doctor(s) about the most current treatment options. Genetic counselors and support groups are also good sources of information and can help connect you with others affected by vascular malformations.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Vascular malformations" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Vascular malformations" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Vascular malformations" returned 101 free, full-text research articles on human participants. First 3 results:

Time-resolved contrast-enhanced MR angiography of spinal vascular malformations.
 

Author(s): M Amarouche, J L Hart, A Siddiqui, T Hampton, D C Walsh

Journal: AJNR Am J Neuroradiol. 2015 Feb;36(2):417-22.

 

The diagnosis of spinal vascular malformations may be challenging on conventional MR imaging because neither the location of the signal abnormality in the spinal cord nor the level of the abnormal flow voids correlates with the level of the fistula. We conducted a retrospective evaluation ...

Last Updated: 12 Feb 2015

Go To URL
Disorganized vascular structures in sporadic venous malformations: a possible correlation with balancing effect between Tie2 and TGF-β.
 

Author(s): Gang Chen, Jian-Gang Ren, Wei Zhang, Yan-Fang Sun, Feng-Qin Wang, Rui-Fang Li, Jian Zhang, Yi-Fang Zhao

Journal:

 

Venous malformations (VMs) are among the most common slow-flow vascular malformations characterized by irregular venous channels, luminal thrombi, and phleboliths. To systematically manifest the disorganized vascular structures in sporadic VMs, we initially evaluated histopathological ...

Last Updated: 26 Jun 2014

Go To URL
Advanced technologies applied to physiopathological analysis of central nervous system aneurysms and vascular malformations.
 

Author(s): M Edjlali, P Roca, J-C Gentric, D Trystram, C Rodriguez-Régent, F Nataf, F Chrétien, O Wieben, P Turski, J-F Meder, O Naggara, C Oppenheim

Journal: Diagn Interv Imaging. 2014 Dec;95(12):1187-93.

 

While depiction and definition of morphological and architectural characteristics of CNS vascular disorders remains the first step of an MR analysis, emerging imaging techniques offer new functional information that might help to characterize rupture risk of CNS vascular disorders. ...

Last Updated: 9 Dec 2014

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Vascular malformations" returned 24 free, full-text review articles on human participants. First 3 results:

Peripheral limb vascular malformations: an update of appropriate imaging and treatment options of a challenging condition.
 

Author(s): H Madani, J Farrant, N Chhaya, I Anwar, H Marmery, A Platts, B Holloway

Journal: Br J Radiol. 2015 Mar;88(1047):20140406.

 

Peripheral vascular malformations encompass a wide spectrum of lesions that can present as an incidental finding or produce potentially life- or limb-threatening complications. They can have intra-articular and intraosseous extensions that will result in more diverse symptomology ...

Last Updated: 20 Feb 2015

Go To URL
Epidemiology, diagnostics and treatment of vascular tumours and malformations.
 

Author(s): Piotr Wójcicki, Karolina Wójcicka

Journal: Adv Clin Exp Med. ;23(3):475-84.

 

Vascular tumours and vascular malformations are common vasculose anomalies characteristic for dissimilar clinical course, specific biological as well as immune cytological and histological properties. Vascular lesions classification system and their detailed division into groups and ...

Last Updated: 1 Jul 2014

Go To URL
Arteriovenous malformations and other vascular malformation syndromes.
 

Author(s): Kevin J Whitehead, Matthew C P Smith, Dean Y Li

Journal:

 

Vascular malformations are a disruption of the normal vascular pattern in which it is expected that a capillary network of microscopic vessels lies interposed between high-pressure arteries that deliver blood and thin-walled veins that collect low-pressure blood for return to the ...

Last Updated: 4 Feb 2013

Go To URL
 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

the Efficiency of Thalidomide for Recurrent Small Intestinal Bleeding Due to Gastrointestinal Vascular Malformation
 

Status: Not yet recruiting

Condition Summary: Gastrointestinal Vascular Malformation

 

Last Updated: 14 Mar 2016

Go to URL
the Efficiency of Endoscopic Treatment for Recurrent Small Intestinal Bleeding Due to Gastrointestinal Vascular Malformation
 

Status: Not yet recruiting

Condition Summary: Gastrointestinal Vascular Malformation

 

Last Updated: 19 Apr 2016

Go to URL
suPERficial Slow-flow Vascular malFORMations Treated With sirolimUS
 

Status: Recruiting

Condition Summary: Vascular Malformation

 

Last Updated: 25 Feb 2016

Go to URL