Uveal melanoma

Common Name(s)

Uveal melanoma

Description for this condition is not yet available.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Uveal melanoma" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Uveal melanoma" returned 378 free, full-text research articles on human participants. First 3 results:

MiR-144 Inhibits Uveal Melanoma Cell Proliferation and Invasion by Regulating c-Met Expression.
 

Author(s): Lei Sun, Guangqing Bian, ZhaoJun Meng, Guangfu Dang, DeJing Shi, Shuyong Mi

Journal:

 

MicroRNAs (miRNAs) are a group endogenous small non-coding RNAs that inhibit protein translation through binding to specific target mRNAs. Recent studies have demonstrated that miRNAs are implicated in the development of cancer. However, the role of miR-144 in uveal melanoma metastasis ...

Last Updated: 12 May 2015

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Development and external validation of a prognostic nomogram for metastatic uveal melanoma.
 

Author(s): Sara Valpione, Justin C Moser, Raffaele Parrozzani, Marco Bazzi, Aaron S Mansfield, Simone Mocellin, Jacopo Pigozzo, Edoardo Midena, Svetomir N Markovic, Camillo Aliberti, Luca G Campana, Vanna Chiarion-Sileni

Journal:

 

Approximately 50% of patients with uveal melanoma (UM) will develop metastatic disease, usually involving the liver. The outcome of metastatic UM (mUM) is generally poor and no standard therapy has been established. Additionally, clinicians lack a validated prognostic tool to evaluate ...

Last Updated: 18 Mar 2015

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Digital PCR validates 8q dosage as prognostic tool in uveal melanoma.
 

Author(s): Mieke Versluis, Mark J de Lange, Sake I van Pelt, Claudia A L Ruivenkamp, Wilma G M Kroes, Jinfeng Cao, Martine J Jager, Gre P M Luyten, Pieter A van der Velden

Journal:

 

Uveal melanoma (UM) development and progression is correlated with specific molecular changes. Recurrent mutations in GNAQ and GNA11 initiate UM development while tumour progression is correlated with monosomy of chromosome 3 and gain of chromosome 8q. Hence, molecular analysis of ...

Last Updated: 13 Mar 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Uveal melanoma" returned 24 free, full-text review articles on human participants. First 3 results:

Uveal Melanoma UK National Guidelines.
 

Author(s): P Nathan, V Cohen, S Coupland, K Curtis, B Damato, J Evans, S Fenwick, L Kirkpatrick, O Li, E Marshall, K McGuirk, C Ottensmeier, N Pearce, S Salvi, B Stedman, P Szlosarek, N Turnbull,

Journal: Eur. J. Cancer. 2015 Nov;51(16):2404-12.

 

The United Kingdom (UK) uveal melanoma guideline development group used an evidence based systematic approach (Scottish Intercollegiate Guidelines Network (SIGN)) to make recommendations in key areas of uncertainty in the field including: the use and effectiveness of new technologies ...

Last Updated: 14 Oct 2015

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MicroRNA dysregulation in uveal melanoma: a new player enters the game.
 

Author(s): Zheng Li, Xin Yu, Jianxiong Shen, Yang Jiang

Journal: Oncotarget. 2015 Mar;6(7):4562-8.

 

Uveal melanoma is the second most common form of melanoma and a predominant intraocular malignant tumor in adults. The development of uveal melanoma is a multistep process involving genetic and epigenetic alteration of proto-oncogenes and tumor-suppressor genes. Recent discoveries ...

Last Updated: 27 Mar 2015

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Characterization, treatment, and outcome of uveal melanoma in the first two years of life.
 

Author(s): Yacoub A Yousef, Mais Alkilany

Journal: Hematol Oncol Stem Cell Ther. 2015 Mar;8(1):1-5.

 

Features and characteristics of uveal melanoma are well described in adults, but little is known about the presentation of uveal melanoma in infancy.

Last Updated: 14 Apr 2015

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Pembrolizumab in Treating Patients With Advanced Uveal Melanoma
 

Status: Recruiting

Condition Summary: Stage IIIA Uveal Melanoma; Stage IIIB Uveal Melanoma; Stage IIIC Uveal Melanoma; Stage IV Uveal Melanoma

 

Last Updated: 24 Aug 2015

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Glembatumumab Vedotin in Treating Patients With Metastatic or Locally Recurrent Uveal Melanoma
 

Status: Recruiting

Condition Summary: Recurrent Uveal Melanoma; Stage IV Uveal Melanoma

 

Last Updated: 11 Feb 2016

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A Phase I Study of LXS196 in Patients With Metastatic Uveal Melanoma
 

Status: Not yet recruiting

Condition Summary: Uveal Melanoma

 

Last Updated: 23 Dec 2015

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