Uveal melanoma

Common Name(s)

Uveal melanoma

Description for this condition is not yet available.
 

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Condition Specific Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Uveal melanoma" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Uveal melanoma" returned 432 free, full-text research articles on human participants. First 3 results:

Integrative Analysis Identifies Four Molecular and Clinical Subsets in Uveal Melanoma.
 

Author(s): A Gordon Robertson, Juliann Shih, Christina Yau, Ewan A Gibb, Junna Oba, Karen L Mungall, Julian M Hess, Vladislav Uzunangelov, Vonn Walter, Ludmila Danilova, Tara M Lichtenberg, Melanie Kucherlapati, Patrick K Kimes, Ming Tang, Alexander Penson, Ozgun Babur, Rehan Akbani, Christopher A Bristow, Katherine A Hoadley, Lisa Iype, Matthew T Chang, , Andrew D Cherniack, Christopher Benz, Gordon B Mills, Roel G W Verhaak, Klaus G Griewank, Ina Felau, Jean C Zenklusen, Jeffrey E Gershenwald, Lynn Schoenfield, Alexander J Lazar, Mohamed H Abdel-Rahman, Sergio Roman-Roman, Marc-Henri Stern, Colleen M Cebulla, Michelle D Williams, Martine J Jager, Sarah E Coupland, Bita Esmaeli, Cyriac Kandoth, Scott E Woodman

Journal: Cancer Cell. 2017 Aug;32(2):204-220.e15.

 

Comprehensive multiplatform analysis of 80 uveal melanomas (UM) identifies four molecularly distinct, clinically relevant subtypes: two associated with poor-prognosis monosomy 3 (M3) and two with better-prognosis disomy 3 (D3). We show that BAP1 loss follows M3 occurrence and correlates ...

Last Updated: 15 Aug 2017

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Systematic genomic and translational efficiency studies of uveal melanoma.
 

Author(s): Chelsea Place Johnson, Ivana K Kim, Bita Esmaeli, Ali Amin-Mansour, Daniel J Treacy, Scott L Carter, Eran Hodis, Nikhil Wagle, Sara Seepo, Xiaoxing Yu, Anne Marie Lane, Evangelos S Gragoudas, Francisca Vazquez, Elizabeth Nickerson, Kristian Cibulskis, Aaron McKenna, Stacey B Gabriel, Gad Getz, Eliezer M Van Allen, Peter A C 't Hoen, Levi A Garraway, Scott E Woodman

Journal:

 

To further our understanding of the somatic genetic basis of uveal melanoma, we sequenced the protein-coding regions of 52 primary tumors and 3 liver metastases together with paired normal DNA. Known recurrent mutations were identified in GNAQ, GNA11, BAP1, EIF1AX, and SF3B1. The ...

Last Updated: 8 Jun 2017

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PRAME as a Potential Target for Immunotherapy in Metastatic Uveal Melanoma.
 

Author(s): Gülçin Gezgin, Sietse J Luk, Jinfeng Cao, Mehmet Dogrusöz, Dirk M van der Steen, Renate S Hagedoorn, Daniëlle Krijgsman, Pieter A van der Velden, Matthew G Field, Gregorius P M Luyten, Karoly Szuhai, J William Harbour, Ekaterina S Jordanova, Mirjam H M Heemskerk, Martine J Jager

Journal: JAMA Ophthalmol. 2017 Jun;135(6):541-549.

 

Uveal melanoma (UM) is an intraocular primary malignant neoplasm that often gives rise to metastatic disease for which there are no effective therapies. A substantial proportion of UMs express the cancer-testis antigen PRAME (preferentially expressed antigen in melanoma), which can ...

Last Updated: 27 Apr 2017

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Uveal melanoma" returned 44 free, full-text review articles on human participants. First 3 results:

Uveal Melanoma Treatment and Prognostication.
 

Author(s): Mehmet Dogrusöz, Martine J Jager, Bertil Damato

Journal: Asia Pac J Ophthalmol (Phila). ;6(2):186-196.

 

Approximately 90% of uveal melanoma develop in the choroid, with the remainder arising in the ciliary body or the iris. The treatment of uveal melanoma is aimed at conserving the eye and useful vision, and, if possible, preventing metastatic disease. Enucleation is now reserved for ...

Last Updated: 11 Apr 2017

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Uveal Melanoma: Identifying Immunological and Chemotherapeutic Targets to Treat Metastases.
 

Author(s): Martine J Jager, Mehmet Dogrusöz, Scott E Woodman

Journal: Asia Pac J Ophthalmol (Phila). ;6(2):179-185.

 

Uveal melanoma is an intraocular malignancy that, depending on its size and genetic make-up, may lead to metastases in up to 50% of cases. Currently, no therapy has been proven to improve survival. However, new therapies exploiting immune responses against metastases are being developed. ...

Last Updated: 11 Apr 2017

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Uveal Melanoma Cell Lines: Where do they come from? (An American Ophthalmological Society Thesis).
 

Author(s): Martine J Jager, J Antonio Bermudez Magner, Bruce R Ksander, Sander R Dubovy

Journal: Trans Am Ophthalmol Soc. 2016 Aug;114():T5.

 

To determine whether some of the most often used uveal melanoma cell lines resemble their original tumor.

Last Updated: 26 Dec 2016

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Vorinostat in Patients With Class 2 High Risk Uveal Melanoma
 

Status: Not yet recruiting

Condition Summary: Uveal Melanoma

 

Last Updated: 31 Aug 2017

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Last Updated: 27 Sep 2011

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Dendritic Cells Plus Autologous Tumor RNA in Uveal Melanoma
 

Status: Recruiting

Condition Summary: Uveal Melanoma

 

Last Updated: 4 May 2017

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