Uveal melanoma

Common Name(s)

Uveal melanoma

Description for this condition is not yet available.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Uveal melanoma" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Uveal melanoma" returned 436 free, full-text research articles on human participants. First 3 results:

Integrative Analysis Identifies Four Molecular and Clinical Subsets in Uveal Melanoma.
 

Author(s): A Gordon Robertson, Juliann Shih, Christina Yau, Ewan A Gibb, Junna Oba, Karen L Mungall, Julian M Hess, Vladislav Uzunangelov, Vonn Walter, Ludmila Danilova, Tara M Lichtenberg, Melanie Kucherlapati, Patrick K Kimes, Ming Tang, Alexander Penson, Ozgun Babur, Rehan Akbani, Christopher A Bristow, Katherine A Hoadley, Lisa Iype, Matthew T Chang, , Andrew D Cherniack, Christopher Benz, Gordon B Mills, Roel G W Verhaak, Klaus G Griewank, Ina Felau, Jean C Zenklusen, Jeffrey E Gershenwald, Lynn Schoenfield, Alexander J Lazar, Mohamed H Abdel-Rahman, Sergio Roman-Roman, Marc-Henri Stern, Colleen M Cebulla, Michelle D Williams, Martine J Jager, Sarah E Coupland, Bita Esmaeli, Cyriac Kandoth, Scott E Woodman

Journal: Cancer Cell. 2017 Aug;32(2):204-220.e15.

 

Comprehensive multiplatform analysis of 80 uveal melanomas (UM) identifies four molecularly distinct, clinically relevant subtypes: two associated with poor-prognosis monosomy 3 (M3) and two with better-prognosis disomy 3 (D3). We show that BAP1 loss follows M3 occurrence and correlates ...

Last Updated: 15 Aug 2017

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Systematic genomic and translational efficiency studies of uveal melanoma.
 

Author(s): Chelsea Place Johnson, Ivana K Kim, Bita Esmaeli, Ali Amin-Mansour, Daniel J Treacy, Scott L Carter, Eran Hodis, Nikhil Wagle, Sara Seepo, Xiaoxing Yu, Anne Marie Lane, Evangelos S Gragoudas, Francisca Vazquez, Elizabeth Nickerson, Kristian Cibulskis, Aaron McKenna, Stacey B Gabriel, Gad Getz, Eliezer M Van Allen, Peter A C 't Hoen, Levi A Garraway, Scott E Woodman

Journal:

 

To further our understanding of the somatic genetic basis of uveal melanoma, we sequenced the protein-coding regions of 52 primary tumors and 3 liver metastases together with paired normal DNA. Known recurrent mutations were identified in GNAQ, GNA11, BAP1, EIF1AX, and SF3B1. The ...

Last Updated: 8 Jun 2017

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Evaluation of nicotinamide as an anti-inflammatory and anti-angiogenic agent in uveal melanoma cell lines.
 

Author(s): Evangelina Esposito, Sultan Aldrees, Christina Mastromonaco, Pablo Zoroquiain, Natalia Vila, Patrick T Logan, Shriya Hari, Miguel N Burnier

Journal: Arq Bras Oftalmol. ;80(2):74-77.

 

To investigate the effect of nicotinamide on the secretion of pro-an giogenic and pro-inflammatory cytokines in uveal melanoma cell lines.

Last Updated: 7 Jun 2017

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Uveal melanoma" returned 45 free, full-text review articles on human participants. First 3 results:

Focus on cutaneous and uveal melanoma specificities.
 

Author(s): Charlotte Pandiani, Guillaume E Béranger, Justine Leclerc, Robert Ballotti, Corine Bertolotto

Journal: Genes Dev.. 2017 Apr;31(8):724-743.

 

Cutaneous melanoma (CM) and uveal melanoma (UM) derive from cutaneous and uveal melanocytes that share the same embryonic origin and display the same cellular function. However, the etiopathogenesis and biological behaviors of these melanomas are very different. CM and UM display ...

Last Updated: 17 May 2017

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Uveal Melanoma Treatment and Prognostication.
 

Author(s): Mehmet Dogrusöz, Martine J Jager, Bertil Damato

Journal: Asia Pac J Ophthalmol (Phila). ;6(2):186-196.

 

Approximately 90% of uveal melanoma develop in the choroid, with the remainder arising in the ciliary body or the iris. The treatment of uveal melanoma is aimed at conserving the eye and useful vision, and, if possible, preventing metastatic disease. Enucleation is now reserved for ...

Last Updated: 11 Apr 2017

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Uveal Melanoma: Identifying Immunological and Chemotherapeutic Targets to Treat Metastases.
 

Author(s): Martine J Jager, Mehmet Dogrusöz, Scott E Woodman

Journal: Asia Pac J Ophthalmol (Phila). ;6(2):179-185.

 

Uveal melanoma is an intraocular malignancy that, depending on its size and genetic make-up, may lead to metastases in up to 50% of cases. Currently, no therapy has been proven to improve survival. However, new therapies exploiting immune responses against metastases are being developed. ...

Last Updated: 11 Apr 2017

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Vorinostat in Patients With Class 2 High Risk Uveal Melanoma
 

Status: Not yet recruiting

Condition Summary: Uveal Melanoma

 

Last Updated: 3 Oct 2017

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Last Updated: 27 Sep 2011

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Dendritic Cells Plus Autologous Tumor RNA in Uveal Melanoma
 

Status: Recruiting

Condition Summary: Uveal Melanoma

 

Last Updated: 4 May 2017

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