Uterine sarcoma

Common Name(s)

Uterine sarcoma

Uterine sarcoma is a type of cancer that affects the uterine muscle and the surrounding tissue. The uterus is a female organ in the lower abdomen where the development of a fetus occurs. The lower end of the uterus, called the cervix, leads to the vagina. The upper end is known as the body or corpus of the uterus and is made of three layers. Cancers form when a mutation in DNA causes certain cells to grow out of control, sometimes forming a lump or a tumor. Some of these cancerous cells can break off and spread to other parts of the body where they will continue to grow. This process is known as metastasis. Factors that increase the risk for uterine sarcoma are exposure to pelvic radiation, being of African American race, and having an abnormal copy of the Rb gene.

Endometrial stromal sarcomas are a type of uterine sarcoma that start in the connective tissue of the endometrium, the inner layer of the body of the uterus. These cancers grow slowly. Undifferentiated sarcomas are another type that are fast growing and more aggressive. Uterine leiomyosarcomas are another type that begin in the muscle layer of the body of the uterus known as the myometrium. Symptoms of uterine sarcoma are vaginal bleeding or spotting, pelvic pain, a feeling of pelvic heaviness, and abnormal vaginal discharge. However, these may also be symptoms of other, non-cancerous conditions.

Diagnosis of uterine sarcoma is made through a combination of a pelvic exam, taking a biopsy or tissue sample, and imaging techniques such as an ultrasound, PET, and MRI. Treatment for uterine sarcoma can include surgery, chemotherapy, radiation therapy, and hormone therapy. If you have been diagnosed with uterine sarcoma, talk to your doctor or a gynecologic oncologist about the most current treatment options. Support groups are available for more information and to connect you to other women with uterine sarcoma.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Uterine sarcoma" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Uterine sarcoma" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Uterine sarcoma" returned 53 free, full-text research articles on human participants. First 3 results:

Uterine malignant mixed Müllerian tumor camouflaging as pelvic sarcoma.
 

Author(s): Vidya Monappa, Ranjini Kudva, Roumina Hasan

Journal: J Cancer Res Ther. ;11(4):997-9.

 

Malignant mixed Müllerian tumors (MMMTs) of the uterus are rare, aggressive tumors that present at an advanced stage and are associated with poor prognosis. They arise as a result of divergent carcinomatous and mesenchymal differentiation of tumor stem cells. Rarely one of the components ...

Last Updated: 17 Feb 2016

Go To URL
A Retrospective Analysis of the Impact of Myomectomy on Survival in Uterine Sarcoma.
 

Author(s): Zhenzhen Gao, Li'an Li, Yuanguang Meng

Journal:

 

Laparoscopic myomectomy is a minimally invasive, conservative surgical approach commonly used for the treatment of uterine fibroids. However, there is a lack of effective means to distinguish the nature of uterine tumors prior to surgery. The impact of fibroid morcellation during ...

Last Updated: 2 Feb 2016

Go To URL
CD146 as an adverse prognostic factor in uterine sarcoma.
 

Author(s): Yun Zhou, He Huang, Lin-Jing Yuan, Ying Xiong, Xin Huang, Jia-Xin Lin, Min Zheng

Journal:

 

Uterine sarcoma is an aggressive malignancy with a poor prognosis. This study aimed to determine the expression of CD146, P53, and Ki-67 in uterine sarcoma and to evaluate their prognostic significance.

Last Updated: 21 Aug 2015

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Uterine sarcoma" returned 7 free, full-text review articles on human participants. First 3 results:

Primary alveolar soft part sarcoma of uterine corpus: a case report with immunohistochemical, ultrastructural study and review of literature.
 

Author(s): Giovanna Giordano, Tiziana D'Adda, Elena Varotti, Giuseppe Crovini, Enrico Maria Silini

Journal:

 

Alveolar soft part sarcoma (ASPS) is a rare mesenchymal malignancy. ASPS usually occurs most commonly in the deep soft tissues of the thigh and buttock or the head and neck regions. ASPS that originate from the uterine corpus are even more rare, with only 10 previous cases reported ...

Last Updated: 3 Feb 2016

Go To URL
Primary alveolar soft part sarcoma of the uterine cervix: a case report and literature review.
 

Author(s): Min Feng, Wei Jiang, Yanmei He, Lei Li

Journal:

 

Alveolar soft part sarcoma (ASPS) is a tumor of unknown histogenesis, composed of large, epithelioid cells with eosinophilic cytoplasm, having an alveolar pattern. Primary ASPS of uterine cervix is very rare. In this report, we present a 21-aged-old female with primary ASPS in the ...

Last Updated: 31 Dec 2014

Go To URL
Non-puerperal uterine inversion caused by malignant mixed mullerian sarcoma.
 

Author(s): Reeti Mehra, Sujata Siwatch, Sunita Arora, Reetu Kundu

Journal:

 

Non puerperal uterine inversions resulting from mixed mullerian uterine sarcoma are rare. We present a case of a postmenopausal woman with a large mixed mullerian tumour presenting as a huge abdominopelvic mass. It required a challenging surgical procedure to remove the tumour which ...

Last Updated: 16 Dec 2013

Go To URL
 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

IRCI Gynae Sarcomas, High Grade Uterine Sarcoma
 

Status: Recruiting

Condition Summary: Uterine Sarcoma

 

Last Updated: 11 Oct 2016

Go to URL

Last Updated: 26 Oct 2016

Go to URL
Gemcitabine Hydrochloride, Docetaxel, and Radiation Therapy in Treating Patients With Uterine Sarcoma That Has Been Removed By Surgery
 

Status: Recruiting

Condition Summary: Stage IA Uterine Sarcoma; Stage IB Uterine Sarcoma; Stage IC Uterine Sarcoma; Stage IIA Uterine Sarcoma; Stage IIB Uterine Sarcoma; Stage IIIA Uterine Sarcoma; Stage IIIB Uterine Sarcoma; Stage IIIC Uterine Sarcoma; Stage IVA Uterine Sarcoma; Stage IVB Uterine Sarcoma; Uterine Corpus Leiomyosarcoma

 

Last Updated: 16 Jan 2015

Go to URL