Ulcerative colitis

Common Name(s)

Ulcerative colitis

Ulcerative colitis (UC) is a type of inflammatory bowel disease that affects the large intestine (colon) and rectum. The inner lining of the rectum and colon become red and swollen (inflamed). The condition also causes small sores (ulcers) to form inside the colon and rectum. UC is a long lasting condition, but affected individuals usually have periods with symptoms (flare ups) and periods without symptoms (remission). Symptoms include stomach pains, cramping, rectal bleeds, diarrhea or pain when passing stool. The cause of this condition is unknown, but some experts believe it is caused by an overreaction by the body’s immune system (autoimmune condition). Genetic and environmental factors are also involved. UC typically affects individuals between 15 and 30 years of age and, in the United States, 20% of UC cases occur under the age of 20 years.

Your doctor may suspect UC after ruling out other causes for your symptoms. To confirm the diagnosis, they may order blood tests to look for low blood count (anemia), x-rays and CT scans to image your colon, examine the inside of your colon using a camera (colonoscopy) or examine a stool sample. Although there is no cure, there are various treatment options to help manage the symptoms of this condition. Medications may be prescribed to reduce the inflammation or decrease the response from your immune system. Nutritional supplements may also help. If severe enough, surgery may be needed to remove part of your colon. If you have been diagnosed with UC, talk with your doctor to decide which treatment option is best for you. Support groups are also good resources for support and information.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Ulcerative colitis" for support, advocacy or research.

Association of Gastrointestinal Motility Disorders, Inc. (AGMD)

AGMD is a nonprofit international organization which serves as an integral educational resource concerning digestive motility diseases and disorders. It also functions as an important information base for members of the medical and scientific communities. In addition, it provides a forum for patients suffering from digestive motility diseases and disorders as well as their families and members of the medical community.

Last Updated: 28 Feb 2015

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Crohn's & Colitis Foundation of America, Inc.

CCFA's mission is to cure Crohn's disease and ulcerative colitis and to improve the quality of life of children and adults affected by these diseases.

Last Updated: 8 Apr 2014

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Digestive Disease National Coalition

The Digestive Disease National Coalition (DDNC) has provided national leadership on behalf of patient organizations, professional societies, and industry interested in the full spectrum of digestive disorders.

Last Updated: 29 Apr 2014

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Ulcerative colitis" for support, advocacy or research.

Association of Gastrointestinal Motility Disorders, Inc. (AGMD)

AGMD is a nonprofit international organization which serves as an integral educational resource concerning digestive motility diseases and disorders. It also functions as an important information base for members of the medical and scientific communities. In addition, it provides a forum for patients suffering from digestive motility diseases and disorders as well as their families and members of the medical community.

http://www.agmd-gimotility.org

Last Updated: 28 Feb 2015

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Crohn's & Colitis Foundation of America, Inc.

CCFA's mission is to cure Crohn's disease and ulcerative colitis and to improve the quality of life of children and adults affected by these diseases.

http://www.ccfa.org

Last Updated: 8 Apr 2014

View Details
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Digestive Disease National Coalition

The Digestive Disease National Coalition (DDNC) has provided national leadership on behalf of patient organizations, professional societies, and industry interested in the full spectrum of digestive disorders.

http://ddnc.org/

Last Updated: 29 Apr 2014

View Details

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Ulcerative colitis" returned 2412 free, full-text research articles on human participants. First 3 results:

Genome-wide rare copy number variation screening in ulcerative colitis identifies potential susceptibility loci.
 

Author(s): Hamid Reza Saadati, Michael Wittig, Ingo Helbig, Robert Häsler, Carl A Anderson, Christopher G Mathew, Limas Kupcinskas, Miles Parkes, Tom Hemming Karlsen, Philip Rosenstiel, Stefan Schreiber, Andre Franke

Journal:

 

Ulcerative colitis (UC), a complex polygenic disorder, is one of the main subphenotypes of inflammatory bowel disease. A comprehensive dissection of the genetic etiology of UC needs to assess the contribution of rare genetic variants including copy number variations (CNVs) to disease ...

Last Updated: 2 Apr 2016

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Effect of a Medicinal Agaricus blazei Murill-Based Mushroom Extract, AndoSan™, on Symptoms, Fatigue and Quality of Life in Patients with Ulcerative Colitis in a Randomized Single-Blinded Placebo Controlled Study.
 

Author(s): Stig Palm Therkelsen, Geir Hetland, Torstein Lyberg, Idar Lygren, Egil Johnson

Journal:

 

Ingestion of AndoSan™, based on the mushroom Agaricus blazei Murill, has previously been shown to exhibit anti-inflammatory effects because of reduction of pro-inflammatory cytokines in healthy individuals and patients with ulcerative colitis. In this randomized single-blinded placebo ...

Last Updated: 3 Mar 2016

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Dose Escalation and Healthcare Resource Use among Ulcerative Colitis Patients Treated with Adalimumab in English Hospitals: An Analysis of Real-World Data.
 

Author(s): Christopher M Black, Eric Yu, Eilish McCann, Sumesh Kachroo

Journal:

 

To describe the real-world use of adalimumab for maintenance treatment of ulcerative colitis (UC) and associated healthcare costs in English hospitals.

Last Updated: 27 Feb 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Ulcerative colitis" returned 222 free, full-text review articles on human participants. First 3 results:

Treatment and prevention of pouchitis after ileal pouch-anal anastomosis for chronic ulcerative colitis.
 

Author(s): Siddharth Singh, Andrea M Stroud, Stefan D Holubar, William J Sandborn, Darrell S Pardi

Journal:

 

Pouchitis occurs in approximately 50% of patients following ileal pouch-anal anastomosis (IPAA) for chronic ulcerative colitis.

Last Updated: 1 Dec 2015

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Budesonide Multi-matrix for the Treatment of Patients with Ulcerative Colitis.
 

Author(s): Gary R Lichtenstein

Journal: Dig. Dis. Sci.. 2016 Feb;61(2):358-70.

 

Ulcerative colitis (UC) is a chronic idiopathic inflammatory disorder in which patients cycle between active disease and remission. Budesonide multi-matrix (MMX) is an oral second-generation corticosteroid designed to deliver active drug throughout the colon. In pharmacokinetic studies, ...

Last Updated: 28 Jan 2016

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The impact of Clostridum difficile on surgical rate among ulcerative colitis patients: A systemic review and meta-analysis.
 

Author(s): Jiang-Chen Peng, Jun Shen, Qi Zhu, Zhi-Hua Ran

Journal: Saudi J Gastroenterol. ;21(4):208-12.

 

There is growing recognition of the impact of Clostridum difficile infection (CDI) on patients with inflammatory bowel disease. Clostridium difficile infection causes greater morbidity and mortality. This study aimed to evaluate the impact of C. difficile on surgical risk among ulcerative ...

Last Updated: 3 Aug 2015

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

TD-1473 for Active Ulcerative Colitis (UC)
 

Status: Recruiting

Condition Summary: Ulcerative Colitis, Active Moderate; Ulcerative Colitis, Active Severe

 

Last Updated: 18 Aug 2016

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Evaluation of Safety, Efficacy, Pharmacokinetic and Pharmacodynamic of Bertilimumab in Patients With Active Moderate to Severe Ulcerative Colitis
 

Status: Recruiting

Condition Summary: Ulcerative Colitis, Active Moderate; Ulcerative Colitis, Active Severe

 

Last Updated: 12 Feb 2016

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Melatonin & Ulcerative Colitis
 

Status: Recruiting

Condition Summary: Ulcerative Colitis

 

Last Updated: 22 Dec 2009

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