Ulcerative colitis

Common Name(s)

Ulcerative colitis

Ulcerative colitis (UC) is a type of inflammatory bowel disease that affects the large intestine (colon) and rectum. The inner lining of the rectum and colon become red and swollen (inflamed). The condition also causes small sores (ulcers) to form inside the colon and rectum. UC is a long lasting condition, but affected individuals usually have periods with symptoms (flare ups) and periods without symptoms (remission). Symptoms include stomach pains, cramping, rectal bleeds, diarrhea or pain when passing stool. The cause of this condition is unknown, but some experts believe it is caused by an overreaction by the body’s immune system (autoimmune condition). Genetic and environmental factors are also involved. UC typically affects individuals between 15 and 30 years of age and, in the United States, 20% of UC cases occur under the age of 20 years.

Your doctor may suspect UC after ruling out other causes for your symptoms. To confirm the diagnosis, they may order blood tests to look for low blood count (anemia), x-rays and CT scans to image your colon, examine the inside of your colon using a camera (colonoscopy) or examine a stool sample. Although there is no cure, there are various treatment options to help manage the symptoms of this condition. Medications may be prescribed to reduce the inflammation or decrease the response from your immune system. Nutritional supplements may also help. If severe enough, surgery may be needed to remove part of your colon. If you have been diagnosed with UC, talk with your doctor to decide which treatment option is best for you. Support groups are also good resources for support and information.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Ulcerative colitis" for support, advocacy or research.

Association of Gastrointestinal Motility Disorders, Inc. (AGMD)

AGMD is a nonprofit international organization which serves as an integral educational resource concerning digestive motility diseases and disorders. It also functions as an important information base for members of the medical and scientific communities. In addition, it provides a forum for patients suffering from digestive motility diseases and disorders as well as their families and members of the medical community.

Last Updated: 28 Feb 2015

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Crohn's & Colitis Foundation of America, Inc.

CCFA's mission is to cure Crohn's disease and ulcerative colitis and to improve the quality of life of children and adults affected by these diseases.

Last Updated: 8 Apr 2014

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Digestive Disease National Coalition

The Digestive Disease National Coalition (DDNC) has provided national leadership on behalf of patient organizations, professional societies, and industry interested in the full spectrum of digestive disorders.

Last Updated: 29 Apr 2014

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Ulcerative colitis" for support, advocacy or research.

Association of Gastrointestinal Motility Disorders, Inc. (AGMD)

AGMD is a nonprofit international organization which serves as an integral educational resource concerning digestive motility diseases and disorders. It also functions as an important information base for members of the medical and scientific communities. In addition, it provides a forum for patients suffering from digestive motility diseases and disorders as well as their families and members of the medical community.

http://www.agmd-gimotility.org

Last Updated: 28 Feb 2015

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Crohn's & Colitis Foundation of America, Inc.

CCFA's mission is to cure Crohn's disease and ulcerative colitis and to improve the quality of life of children and adults affected by these diseases.

http://www.ccfa.org

Last Updated: 8 Apr 2014

View Details
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Digestive Disease National Coalition

The Digestive Disease National Coalition (DDNC) has provided national leadership on behalf of patient organizations, professional societies, and industry interested in the full spectrum of digestive disorders.

http://ddnc.org/

Last Updated: 29 Apr 2014

View Details

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Ulcerative colitis" returned 2015 free, full-text research articles on human participants. First 3 results:

Ileal pouch morphology and microbiology in ulcerative colitis patients.
 

Author(s): Dorota Pawełka, Wiktor Bednarz, Zbigniew Krawczyk, Marta Rzeszutko, Robert Olewiński, Piotr Czopnik

Journal: Adv Clin Exp Med. ;24(2):267-74.

 

Ideal pouch created during restorative proctocolectomy is a new gastrointestinal organ--"neorectum". Although it is made from the ileum, it takes over function of the removed rectum. This new function results in significant morphological changes in pouch's mucous membrane, which becomes ...

Last Updated: 1 May 2015

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Tracheobronchitis with dyspnea in a patient with ulcerative colitis.
 

Author(s): Masaya Hiyoshi, Kazushige Kawai, Mihoko Shibuya, Tsuyoshi Ozawa, Junko Kishikawa, Takako Nirei, Toshiaki Tanaka, Junichiro Tanaka, Tomomichi Kiyomatsu, Tomohiro Tada, Takamitsu Kanazawa, Shinsuke Kazama, Hirofumi Shoda, Shuji Sumitomo, Kanae Kubo, Hironori Yamaguchi, Soichiro Ishihara, Eiji Sunami, Joji Kitayama, Kazuhiko Yamamoto, Toshiaki Watanabe

Journal: Intern. Med.. 2015 ;54(7):749-53.

 

We herein report the case of a 42-year-old man with a one-year history of ulcerative colitis who presented with exacerbated bloody diarrhea, a productive cough and increasing breathing difficulties. Colonoscopy revealed typical deep ulcers in the rectosigmoid colon and atypical multiple ...

Last Updated: 2 Apr 2015

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Acute pancreatitis secondary to long-term 5- aminosalicylic acid therapy in a patient with ulcerative colitis: a case-report.
 

Author(s): Asma Ouakaa-Kchaou, Dalila Gargouri, Asma Kochlef, Norsaf Bibani, Héla Elloumi, Dorra Trad, Jamel Kharrat

Journal: Tunis Med. 2014 Jun;92(6):423.

 

Last Updated: 6 Mar 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Ulcerative colitis" returned 200 free, full-text review articles on human participants. First 3 results:

Inflammatory bowel disease in Hispanic communities: a concerted South American approach could identify the aetiology of Crohn's disease and ulcerative colitis.
 

Author(s): Affifa Farrukh, John Francis Mayberry

Journal: Arq Gastroenterol. ;51(4):271-5.

 

Despite intensive research we remain ignorant of the cause of both Crohn's disease and ulcerative colitis. The dramatic rise in incidence, particularly of Crohn's disease, points towards environmental factors as playing a significant role. A major purpose of this review is to stimulate ...

Last Updated: 16 Jan 2015

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Ulcerative colitis-associated colorectal cancer.
 

Author(s): Masakazu Yashiro

Journal: World J. Gastroenterol.. 2014 Nov;20(44):16389-97.

 

The association between ulcerative colitis (UC) and colorectal cancer (CRC) has been acknowledged. One of the most serious and life threatening consequences of UC is the development of CRC (UC-CRC). UC-CRC patients are younger, more frequently have multiple cancerous lesions, and ...

Last Updated: 3 Dec 2014

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Interleukin-17 SNPs and serum levels increase ulcerative colitis risk: a meta-analysis.
 

Author(s): Juan Li, Hao Tian, Hui-Jun Jiang, Bin Han

Journal: World J. Gastroenterol.. 2014 Nov;20(42):15899-909.

 

To investigate the associations of interleukin-17 (IL-17) genetic polymorphisms and serum levels with ulcerative colitis (UC) risk.

Last Updated: 17 Nov 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Evaluation of Safety, Efficacy, Pharmacokinetic and Pharmacodynamic of Bertilimumab in Patients With Active Moderate to Severe Ulcerative Colitis
 

Status: Recruiting

Condition Summary: Ulcerative Colitis, Active Moderate; Ulcerative Colitis, Active Severe

 

Last Updated: 3 Aug 2015

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Melatonin & Ulcerative Colitis
 

Status: Recruiting

Condition Summary: Ulcerative Colitis

 

Last Updated: 22 Dec 2009

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Epidemiology of Ulcerative Colitis and Crohn's Disease in Non Jewish Israel Population
 

Status: Recruiting

Condition Summary: Ulcerative Colitis; Crohn's Disease

 

Last Updated: 2 Dec 2012

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