Ulcerative colitis

Common Name(s)

Ulcerative colitis

Ulcerative colitis (UC) is a type of inflammatory bowel disease that affects the large intestine (colon) and rectum. The inner lining of the rectum and colon become red and swollen (inflamed). The condition also causes small sores (ulcers) to form inside the colon and rectum. UC is a long lasting condition, but affected individuals usually have periods with symptoms (flare ups) and periods without symptoms (remission). Symptoms include stomach pains, cramping, rectal bleeds, diarrhea or pain when passing stool. The cause of this condition is unknown, but some experts believe it is caused by an overreaction by the body’s immune system (autoimmune condition). Genetic and environmental factors are also involved. UC typically affects individuals between 15 and 30 years of age and, in the United States, 20% of UC cases occur under the age of 20 years.

Your doctor may suspect UC after ruling out other causes for your symptoms. To confirm the diagnosis, they may order blood tests to look for low blood count (anemia), x-rays and CT scans to image your colon, examine the inside of your colon using a camera (colonoscopy) or examine a stool sample. Although there is no cure, there are various treatment options to help manage the symptoms of this condition. Medications may be prescribed to reduce the inflammation or decrease the response from your immune system. Nutritional supplements may also help. If severe enough, surgery may be needed to remove part of your colon. If you have been diagnosed with UC, talk with your doctor to decide which treatment option is best for you. Support groups are also good resources for support and information.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Ulcerative colitis" for support, advocacy or research.

Association of Gastrointestinal Motility Disorders, Inc. (AGMD)

AGMD is a nonprofit international organization which serves as an integral educational resource concerning digestive motility diseases and disorders. It also functions as an important information base for members of the medical and scientific communities. In addition, it provides a forum for patients suffering from digestive motility diseases and disorders as well as their families and members of the medical community.

Last Updated: 28 Feb 2015

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Crohn's & Colitis Foundation of America, Inc.

CCFA's mission is to cure Crohn's disease and ulcerative colitis and to improve the quality of life of children and adults affected by these diseases.

Last Updated: 8 Apr 2014

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Digestive Disease National Coalition

The Digestive Disease National Coalition (DDNC) has provided national leadership on behalf of patient organizations, professional societies, and industry interested in the full spectrum of digestive disorders.

Last Updated: 29 Apr 2014

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Ulcerative colitis" for support, advocacy or research.

Association of Gastrointestinal Motility Disorders, Inc. (AGMD)

AGMD is a nonprofit international organization which serves as an integral educational resource concerning digestive motility diseases and disorders. It also functions as an important information base for members of the medical and scientific communities. In addition, it provides a forum for patients suffering from digestive motility diseases and disorders as well as their families and members of the medical community.

http://www.agmd-gimotility.org

Last Updated: 28 Feb 2015

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Crohn's & Colitis Foundation of America, Inc.

CCFA's mission is to cure Crohn's disease and ulcerative colitis and to improve the quality of life of children and adults affected by these diseases.

http://www.ccfa.org

Last Updated: 8 Apr 2014

View Details
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Digestive Disease National Coalition

The Digestive Disease National Coalition (DDNC) has provided national leadership on behalf of patient organizations, professional societies, and industry interested in the full spectrum of digestive disorders.

http://ddnc.org/

Last Updated: 29 Apr 2014

View Details

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Ulcerative colitis" returned 2638 free, full-text research articles on human participants. First 3 results:

Disseminated Nocardiosis Associated with Treatment with Infliximab in a Patient with Ulcerative Colitis.
 

Author(s): Orlando Garner, Ana Ramirez-Berlioz, Alfredo Iardino, Satish Mocherla, Kalpana Bhairavarasu

Journal:

 

BACKGROUND Opportunistic infections may occur when patients with inflammatory bowel disease (IBD) are treated with tumor necrosis factor (TNF)-alpha inhibitors. With the increasing use of new immunosuppressant drugs, the incidence of opportunistic or atypical infections is also increasing, ...

Last Updated: 31 Dec 1969

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Profound loss of neprilysin accompanied by decreased levels of neuropeptides and increased CRP in ulcerative colitis.
 

Author(s): Zeynep Gök Sargın, Nuray Erin, Gokhan Tazegul, Gülsüm Özlem Elpek, Bülent Yıldırım

Journal:

 

Neprilysin (NEP, CD10) acts to limit excessive inflammation partly by hydrolyzing neuropeptides. Although deletion of NEP exacerbates intestinal inflammation in animal models, its role in ulcerative colitis (UC) is not well explored. Herein, we aimed to demonstrate changes in NEP ...

Last Updated: 31 Dec 1969

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Challenges in the diagnosis of ulcerative colitis with concomitant bacterial infections and chronic infectious colitis.
 

Author(s): Wei-Chen Lin, Chen-Wang Chang, Ming-Jen Chen, Cheng-Hsin Chu, Shou-Chuan Shih, Tzu-Chi Hsu, Horng-Yang Wang

Journal:

 

Ulcerative colitis (UC) is a chronic inflammation of the large bowel characterized by diarrhea and a negative stool culture. However, several enteropathogens have been implicated as causative agents in UC. The differentiation between chronic infectious colitis (IC) and UC with concurrent ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Ulcerative colitis" returned 272 free, full-text review articles on human participants. First 3 results:

Beverage consumption and risk of ulcerative colitis: Systematic review and meta-analysis of epidemiological studies.
 

Author(s): Jia-Yan Nie, Qiu Zhao

Journal: Medicine (Baltimore). 2017 Dec;96(49):e9070.

 

Epidemiological studies have provided controversial evidence between beverage consumption and the risk of ulcerative colitis (UC). This study aimed to determine the role of beverage consumption in the development of UC. A systematic search was conducted in public databases to identify ...

Last Updated: 31 Dec 1969

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Ulcerative colitis with acute pleurisy: A case report and review of the literature.
 

Author(s): Shuming Lu, Lihua Wang, Weisheng Zhang, Zhuqing Zhang, Lina Liu, Yingde Wang, Hua Meng

Journal: Medicine (Baltimore). 2017 Jul;96(30):e7630.

 

Inflammatory bowel diseases (IBD), including ulcerative colitis (UC) and Crohn's disease, are associated with a large number of extraintestinal manifestations. Pulmonary manifestations are infrequently seen in patients with IBD. Moreover, serositis including pleural and pericardial ...

Last Updated: 31 Dec 1969

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Golimumab for the treatment of ulcerative colitis.
 

Author(s): Mathurin Flamant, Stephane Paul, Xavier Roblin

Journal: Expert Opin Biol Ther. 2017 Jul;17(7):879-886.

 

Tumor necrosis factor antagonists have revolutionized the therapeutic management of inflammatory bowel disease. Infliximab and adalimumab were the first biological agents used to induce and maintain remission in ulcerative colitis. More recently, a third tumor necrosis factor antagonist, ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Faecal Bacteriotherapy for Ulcerative Colitis
 

Status: Recruiting

Condition Summary: Ulcerative Colitis

 

Last Updated: 31 Mar 2017

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