Ulcerative colitis

Common Name(s)

Ulcerative colitis

Ulcerative colitis (UC) is a type of inflammatory bowel disease that affects the large intestine (colon) and rectum. The inner lining of the rectum and colon become red and swollen (inflamed). The condition also causes small sores (ulcers) to form inside the colon and rectum. UC is a long lasting condition, but affected individuals usually have periods with symptoms (flare ups) and periods without symptoms (remission). Symptoms include stomach pains, cramping, rectal bleeds, diarrhea or pain when passing stool. The cause of this condition is unknown, but some experts believe it is caused by an overreaction by the body’s immune system (autoimmune condition). Genetic and environmental factors are also involved. UC typically affects individuals between 15 and 30 years of age and, in the United States, 20% of UC cases occur under the age of 20 years.

Your doctor may suspect UC after ruling out other causes for your symptoms. To confirm the diagnosis, they may order blood tests to look for low blood count (anemia), x-rays and CT scans to image your colon, examine the inside of your colon using a camera (colonoscopy) or examine a stool sample. Although there is no cure, there are various treatment options to help manage the symptoms of this condition. Medications may be prescribed to reduce the inflammation or decrease the response from your immune system. Nutritional supplements may also help. If severe enough, surgery may be needed to remove part of your colon. If you have been diagnosed with UC, talk with your doctor to decide which treatment option is best for you. Support groups are also good resources for support and information.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Ulcerative colitis" for support, advocacy or research.

Association of Gastrointestinal Motility Disorders, Inc. (AGMD)

AGMD is a nonprofit international organization which serves as an integral educational resource concerning digestive motility diseases and disorders. It also functions as an important information base for members of the medical and scientific communities. In addition, it provides a forum for patients suffering from digestive motility diseases and disorders as well as their families and members of the medical community.

Last Updated: 28 Feb 2015

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Crohn's & Colitis Foundation of America, Inc.

CCFA's mission is to cure Crohn's disease and ulcerative colitis and to improve the quality of life of children and adults affected by these diseases.

Last Updated: 8 Apr 2014

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Digestive Disease National Coalition

The Digestive Disease National Coalition (DDNC) has provided national leadership on behalf of patient organizations, professional societies, and industry interested in the full spectrum of digestive disorders.

Last Updated: 29 Apr 2014

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Ulcerative colitis" for support, advocacy or research.

Association of Gastrointestinal Motility Disorders, Inc. (AGMD)

AGMD is a nonprofit international organization which serves as an integral educational resource concerning digestive motility diseases and disorders. It also functions as an important information base for members of the medical and scientific communities. In addition, it provides a forum for patients suffering from digestive motility diseases and disorders as well as their families and members of the medical community.

http://www.agmd-gimotility.org

Last Updated: 28 Feb 2015

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Crohn's & Colitis Foundation of America, Inc.

CCFA's mission is to cure Crohn's disease and ulcerative colitis and to improve the quality of life of children and adults affected by these diseases.

http://www.ccfa.org

Last Updated: 8 Apr 2014

View Details
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Digestive Disease National Coalition

The Digestive Disease National Coalition (DDNC) has provided national leadership on behalf of patient organizations, professional societies, and industry interested in the full spectrum of digestive disorders.

http://ddnc.org/

Last Updated: 29 Apr 2014

View Details

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Ulcerative colitis" returned 2463 free, full-text research articles on human participants. First 3 results:

Patients with longstanding ulcerative colitis in remission do not have more irritable bowel syndrome-like symptoms than controls.
 

Author(s): D Lundgren, J Rutegård, V Eklöf, R Palmqvist, P Karling

Journal:

 

Irritable bowel syndrome (IBS) is more common in patients with ulcerative colitis (UC) than expected. The prevalence of IBS in patients with UC with longstanding disease is not known. We investigated the prevalence of IBS-like symptoms in patients with UC in remission and longstanding ...

Last Updated: 24 Nov 2016

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Regulatory effects of glycyrrhizae radix extract on DSS-induced ulcerative colitis.
 

Author(s): Yong-Deok Jeon, Keuk-Soo Bang, Min-Kyoung Shin, Jong-Hyun Lee, Young-Nam Chang, Jong-Sik Jin

Journal:

 

Glycyrrhizae Radix (GR) is a Korean traditional herb medicine that is widely-used in clinical health care. The clinical functions of GR include relief of toxicity, anti-cancer, regulating blood cholesterol and anti-inflammation. This study investigated the role of GR on ulcerative ...

Last Updated: 16 Nov 2016

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A Rare Case of Colonic Leiomyosarcoma in Association with Ulcerative Colitis.
 

Author(s): Daisuke Akutsu, Yuji Mizokami, Hideo Suzuki, Masahiko Terasaki, Toshiaki Narasaka, Tsuyoshi Kaneko, Hirofumi Matsui, Tsuyoshi Enomoto, Taiki Sato, Ichinosuke Hyodo

Journal: Intern. Med.. ;55(19):2799-2803.

 

Ulcerative colitis (UC) is known to be associated with an increased risk of colorectal cancer. However, the occurrence of non-epithelial malignancies is uncommon. An elevated lesion in the descending colon was found in a 51-year-old woman with a 30-year history of UC. Despite tumor ...

Last Updated: 11 Oct 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Ulcerative colitis" returned 241 free, full-text review articles on human participants. First 3 results:

Concomitant herpes simplex virus colitis and hepatitis in a man with ulcerative colitis: Case report and review of the literature.
 

Author(s): Varun K Phadke, Rachel J Friedman-Moraco, Brian C Quigley, Alton B Farris, J P Norvell

Journal: Medicine (Baltimore). 2016 Oct;95(42):e5082.

 

Herpesvirus infections often complicate the clinical course of patients with inflammatory bowel disease; however, invasive disease due to herpes simplex virus is distinctly uncommon.

Last Updated: 19 Oct 2016

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Fecal Microbiota Transplantation as a Novel Therapy for Ulcerative Colitis: A Systematic Review and Meta-Analysis.
 

Author(s): Dali Sun, Weiming Li, Shumin Li, Yunyun Cen, Qingwen Xu, Yijun Li, Yanbo Sun, Yuxing Qi, Yueying Lin, Ting Yang, Pengyuan Xu, Qiping Lu

Journal: Medicine (Baltimore). 2016 Jun;95(23):e3765.

 

Variation in clinical evidence has prevented the adoption of fecal microbiota transplantation (FMT) in patients with ulcerative colitis (UC). We aimed to conduct a systematic review and meta-analysis to determine the efficacy and safety of FMT in UC.A systematic literature search ...

Last Updated: 10 Jun 2016

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Onset of ulcerative colitis after thyrotoxicosis: a case report and review of the literature.
 

Author(s): L Laterza, A C Piscaglia, S Lecce, A Gasbarrini, M L Stefanelli

Journal: Eur Rev Med Pharmacol Sci. 2016 ;20(4):685-8.

 

Ulcerative colitis is a chronic disease that could be triggered by acute stressful events, such as gastrointestinal infections or emotional stress.

Last Updated: 9 Mar 2016

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Last Updated: 12 Jan 2017

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Optimising Infliximab Induction Therapy for Acute Severe Ulcerative Colitis
 

Status: Recruiting

Condition Summary: Ulcerative Colitis

 

Last Updated: 2 Jul 2016

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Efficacy of Treatment With Berberine to Maintain Remission in Ulcerative Colitis
 

Status: Not yet recruiting

Condition Summary: Ulcerative Colitis

 

Last Updated: 10 Nov 2016

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