Typhoid fever

Common Name(s)

Typhoid fever

Typhoid fever, caused by the bacteria Salmonella Typhi, is a life-threatening illness that causes diarrhea and a rash. Infection can be prevented and treated with antibiotics. Common in the developing world, this illness is spread by consuming contaminated food or drink, especially in areas of the world where water is likely to be contaminated by sewage or where hand-washing is not as frequent. Once infected, the body shows symptoms of fevers as high as 103 to 104 F, stomach pains, headache, feelings of weakness, or loss of appetite. Fluids and electrolytes should be consumed to replace nutrients lost from severe diarrhea along with antibiotic treatment. A vaccine is recommended to those traveling to developing areas.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Typhoid fever" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Typhoid fever" returned 414 free, full-text research articles on human participants. First 3 results:

Epidemiology, clinical manifestations, and molecular typing of salmonella typhi isolated from patients with typhoid fever in Lebanon.
 

Author(s): Souha S Kanj, Zeina A Kanafani, Marwa Shehab, Nisreen Sidani, Tania Baban, Kedak Baltajian, Ghenwa K Dakdouki, Mohamad Zaatari, George F Araj, Rima Hanna Wakim, Ghassan Dbaibo, Ghassan M Matar

Journal: J Epidemiol Glob Health. 2015 Jun;5(2):159-65.

 

The objective of this study was to examine the epidemiology and the clinical manifestations of typhoid fever as well as the susceptibility and strain relatedness of Salmonella typhi isolates in Lebanon from 2006 to 2007. A total of 120 patients with typhoid fever were initially identified ...

Last Updated: 29 Apr 2015

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Expression and function of S100A8/A9 (calprotectin) in human typhoid fever and the murine Salmonella model.
 

Author(s): Hanna K De Jong, Ahmed Achouiti, Gavin C K W Koh, Christopher M Parry, Stephen Baker, Mohammed Abul Faiz, Jaap T van Dissel, Albert M Vollaard, Ester M M van Leeuwen, Joris J T H Roelofs, Alex F de Vos, Johannes Roth, Tom van der Poll, Thomas Vogl, Willem Joost Wiersinga

Journal:

 

Typhoid fever, caused by the Gram-negative bacterium Salmonella enterica serovar Typhi, is a major cause of community-acquired bacteremia and death worldwide. S100A8 (MRP8) and S100A9 (MRP14) form bioactive antimicrobial heterodimers (calprotectin) that can activate Toll-like receptor ...

Last Updated: 11 Apr 2015

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Typhoid fever in young children in Bangladesh: clinical findings, antibiotic susceptibility pattern and immune responses.
 

Author(s): Farhana Khanam, Md Abu Sayeed, Feroza Kaneez Choudhury, Alaullah Sheikh, Dilruba Ahmed, Doli Goswami, Md Lokman Hossain, Abdullah Brooks, Stephen B Calderwood, Richelle C Charles, Alejandro Cravioto, Edward T Ryan, Firdausi Qadri

Journal:

 

Children bear a large burden of typhoid fever caused by Salmonella enterica serotype Typhi (S. Typhi) in endemic areas. However, immune responses and clinical findings in children are not well defined. Here, we describe clinical and immunological characteristics of young children ...

Last Updated: 8 Apr 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Typhoid fever" returned 31 free, full-text review articles on human participants. First 3 results:

Typhoid fever: misuse of Widal test in Libya.
 

Author(s): Abdulaziz Zorgani, Hisham Ziglam

Journal:

 

The worldwide gold standard of diagnosing of enteric fever depends on the isolation of Salmonella enterica serovar Typhi from a patient's bone marrow and/or blood culture. In Libya clinicians are heavily dependent on the Widal test for diagnosis of enteric fever which has been used ...

Last Updated: 11 Jun 2014

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Typhoid fever as a triggering factor in acute and intractable bronchial asthma attack.
 

Author(s): Wardhana, Eko E Surachmanto, E A Datau

Journal: Acta Med Indones. 2013 Oct;45(4):312-20.

 

Typhoid fever is an enteric infection caused by Salmonella typhi. In Indonesia, typhoid fever is endemic with high incidence of the disease. In daily practice we frequently have patients with bronchial asthma, and it is becoming worse when these patients get typhoid fever. After oral ...

Last Updated: 22 Jan 2014

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A systematic review and meta-analysis of the performance of two point of care typhoid fever tests, Tubex TF and Typhidot, in endemic countries.
 

Author(s): Kamala Thriemer, Benedikt Ley, Joris Menten, Jan Jacobs, Jef van den Ende

Journal:

 

In the absence of well-equipped laboratory infrastructure in many developing countries the accurate diagnosis of typhoid fever is challenging. Rapid diagnostic tests (RDT) with good performance indicators would be helpful to improve clinical management of suspected cases. We performed ...

Last Updated: 20 Dec 2013

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Typhoid Fever: Combined vs. Single Antibiotic Therapy
 

Status: Recruiting

Condition Summary: Typhoid Fever

 

Last Updated: 26 Aug 2014

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Vaccines Against Salmonella Typhi
 

Status: Recruiting

Condition Summary: Typhoid Fever; Enteric Fever

 

Last Updated: 6 Nov 2015

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Investigating Enteric Fever - Salmonella Typhi and Paratyphi Challenge Study
 

Status: Recruiting

Condition Summary: Typhoid Fever; Paratyphoid Fever

 

Last Updated: 6 Nov 2015

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