Typhoid fever

Common Name(s)

Typhoid fever

Typhoid fever, caused by the bacteria Salmonella Typhi, is a life-threatening illness that causes diarrhea and a rash. Infection can be prevented and treated with antibiotics. Common in the developing world, this illness is spread by consuming contaminated food or drink, especially in areas of the world where water is likely to be contaminated by sewage or where hand-washing is not as frequent. Once infected, the body shows symptoms of fevers as high as 103 to 104 F, stomach pains, headache, feelings of weakness, or loss of appetite. Fluids and electrolytes should be consumed to replace nutrients lost from severe diarrhea along with antibiotic treatment. A vaccine is recommended to those traveling to developing areas.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Typhoid fever" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Typhoid fever" returned 337 free, full-text research articles on human participants. First 3 results:

Cellular and cytokine responses to Salmonella enterica serotype Typhi proteins in patients with typhoid fever in Bangladesh.
 

Author(s): Saruar Bhuiyan, Abu Sayeed, Farhana Khanam, Daniel T Leung, Taufiqur Rahman Bhuiyan, Alaullah Sheikh, Umme Salma, Regina C LaRocque, Jason B Harris, Marcin Pacek, Stephen B Calderwood, Joshua LaBaer, Edward T Ryan, Firdausi Qadri, Richelle C Charles

Journal: Am. J. Trop. Med. Hyg.. 2014 Jun;90(6):1024-30.

 

We assessed interferon-gamma (IFN-γ) responses via enzyme-linked immunosorbent spot (ELISPOT) to a number of S. Typhi antigens in samples from humans with S. Typhi bacteremia and typhoid fever in Bangladesh. Compared with responses in healthy endemic zone controls, there were significantly ...

Last Updated: 6 Jun 2014

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Typhoid Fever in nineteenth-century Colombia: between medical geography and bacteriology.
 

Author(s): Mónica García

Journal: Med Hist. 2014 Jan;58(1):27-45.

 

This paper analyses how the Colombian medical elites made sense of typhoid fever before and during the inception of bacteriological ideas and practices in the second half of the nineteenth century. Assuming that the identity of typhoid fever has to be understood within the broader ...

Last Updated: 16 Dec 2013

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Evaluation of the diagnostic accuracy of a typhoid IgM flow assay for the diagnosis of typhoid fever in Cambodian children using a Bayesian latent class model assuming an imperfect gold standard.
 

Author(s): Catrin E Moore, Wirichada Pan-Ngum, Lalith P M Wijedoru, Soeng Sona, Tran Vu Thieu Nga, Pham Thanh Duy, Phat Voong Vinh, Kheng Chheng, Varun Kumar, Kate Emary, Michael Carter, Lisa White, Stephen Baker, Nicholas P J Day, Christopher M Parry

Journal: Am. J. Trop. Med. Hyg.. 2014 Jan;90(1):114-20.

 

Rapid diagnostic tests are needed for typhoid fever (TF) diagnosis in febrile children in endemic areas. Five hundred children admitted to the hospital in Cambodia between 2009 and 2010 with documented fever (≥ 38°C) were investigated using blood cultures (BCs), Salmonella Typhi/Paratyphi ...

Last Updated: 9 Jan 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Typhoid fever" returned 24 free, full-text review articles on human participants. First 3 results:

Vaccination for typhoid fever in sub-Saharan Africa.
 

Author(s): Rachel B Slayton, Kashmira A Date, Eric D Mintz

Journal: Hum Vaccin Immunother. 2013 Apr;9(4):903-6.

 

Emerging data on the epidemiologic, clinical and microbiologic aspects of typhoid fever in sub-Saharan Africa call for new strategies and new resources to bring the regional epidemic under control. Areas with endemic disease at rates approaching those in south Asia have been identified; ...

Last Updated: 4 Oct 2013

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Typhoid fever & vaccine development: a partially answered question.
 

Author(s): Sandhya A Marathe, Amit Lahiri, Vidya Devi Negi, Dipshikha Chakravortty

Journal: Indian J. Med. Res.. 2012 ;135():161-9.

 

Typhoid fever is a systemic disease caused by the human specific Gram-negative pathogen Salmonella enterica serovar Typhi (S. Typhi). The extra-intestinal infections caused by Salmonella are very fatal. The incidence of typhoid fever remains very high in impoverished areas and the ...

Last Updated: 26 Mar 2012

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Typhoid fever: "you can't hit what you can't see".
 

Author(s): Tamding Wangdi, Sebastian E Winter, Andreas J Bäumler

Journal: Gut Microbes. ;3(2):88-92.

 

The host restricts dissemination of invasive enteric pathogens, such as non-typhoidal Salmonella serovars, by mounting acute inflammatory responses characterized by the recruitment of neutrophils. However, some enteric pathogens, such as Salmonella enterica serovar Typhi (S. typhi), ...

Last Updated: 31 May 2012

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Typhoid Fever: Combined vs. Single Antibiotic Therapy
 

Status: Recruiting

Condition Summary: Typhoid Fever

 

Last Updated: 26 Aug 2014

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Investigating Enteric Fever - Salmonella Typhi and Paratyphi Challenge Study
 

Status: Not yet recruiting

Condition Summary: Typhoid Fever; Paratyphoid Fever

 

Last Updated: 14 Jul 2014

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Understanding Paratyphoid Infection
 

Status: Recruiting

Condition Summary: Enteric Fever Caused by Salmonella Enterica Serovar Paratyphi A

 

Last Updated: 14 Jul 2014

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