Twin twin transfusion syndrome

Common Name(s)

Twin twin transfusion syndrome, Twin to Twin Transfusion Syndrome (TTTS)

Twin-to-twin transfusion syndrome is a rare condition that occurs when blood moves from one identical twin (the Òdonor twinÓ) to the other (the Òrecipient twinÓ) while in the womb. The donor twin may be born smaller, with paleness, anemia, and dehydration. The recipient twin may be born larger, with redness, too much blood, and increased blood pressure, resulting in an increased risk for heart failure. Treatment may require repeated amniocentesis during pregnancy. Fetal laser surgery may be done to interrupt the flow of blood from one twin to the other. After birth, treatment depends on the infant's specific symptoms. The donor twin may need a blood transfusion to treat anemia. The recipient twin may need to have the volume of body fluid reduced. This may involve an exchange transfusion. Medications may be given to treat heart failure in the recipient twin.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Twin twin transfusion syndrome" for support, advocacy or research.

Sidelines National Support Network

Sidelines provides support, education, advocacy and resources to women and their families experiencing a complicated high-risk pregnancy or premature birth.

Last Updated: 4 Apr 2013

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The Twin to Twin Transfusion Syndrome Foundation

The first and only nonproft organization in the world solely dedicated to providing immediate and lifesaving educational, emotional and financial support to families, medical professionals, and other caregivers before, during, and after a diagnosis of twin to twin transfusion syndrome. Dedicated to saving the babies, improving their future health and care, providing NICU, special needs and bereavement support, furthering medical research, and keeping families together the way twins are meant to be.

Last Updated: 12 Jan 2013

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Twin twin transfusion syndrome" for support, advocacy or research.

Sidelines National Support Network

Sidelines provides support, education, advocacy and resources to women and their families experiencing a complicated high-risk pregnancy or premature birth.

http://www.sidelines.org

Last Updated: 4 Apr 2013

View Details
The Twin to Twin Transfusion Syndrome Foundation

The first and only nonproft organization in the world solely dedicated to providing immediate and lifesaving educational, emotional and financial support to families, medical professionals, and other caregivers before, during, and after a diagnosis of twin to twin transfusion syndrome. Dedicated to saving the babies, improving their future health and care, providing NICU, special needs and bereavement support, furthering medical research, and keeping families together the way twins are meant to be.

http://www.tttsfoundation.org

Last Updated: 12 Jan 2013

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Twin twin transfusion syndrome" returned 169 free, full-text research articles on human participants. First 3 results:

Twin-twin transfusion syndrome: neurodevelopment of infants treated with laser surgery.
 

Author(s): Denise Campos, Amabile V Arias, Thatiane M Campos-Zanelli, Daniela S Souza, Orlando G Dos Santos Neto, Cleisson Fabio A Peralta, Marilisa M Guerreiro

Journal: Arq Neuropsiquiatr. 2016 Apr;74(4):307-13.

 

To assess the neurodevelopmental functions of survivors of twin-twin transfusion syndrome (TTTS) treated by fetoscopic laser coagulation (FLC), during the first year of life, comparing them to a control group; and to verify the influence of specific variables on neurodevelopment.

Last Updated: 21 Apr 2016

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Impact of Monochorionicity and Twin to Twin Transfusion Syndrome on Prenatal Attachment, Post Traumatic Stress Disorder, Anxiety and Depressive Symptoms.
 

Author(s): Berengere Beauquier-Maccotta, Gihad E Chalouhi, Anne-Laure Picquet, Aude Carrier, Laurence Bussières, Bernard Golse, Yves Ville

Journal:

 

Monochronioric (MC) twin pregnancies are considered as high-risk pregnancies with potential complications requiring in-utero interventions. We aimed to assess prenatal attachment, anxiety, post-traumatic stress disorder (PTSD) and depressive symptoms in MC pregnancies complicated ...

Last Updated: 12 Jan 2016

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Change of maternal thyroid function in twin-twin transfusion syndrome.
 

Author(s): Masachi Hanaoka, Naoko Arata, Haruhiko Sago

Journal: Endocr. J.. 2015 ;62(10):949-52.

 

Human chorionic gonadotropin (hCG) has weak thyroid-stimulating activity because of its homology with thyroid stimulating hormone (TSH). In twin-twin transfusion syndrome (TTTS), which is a severe complication of monochorionic twin pregnancies, a close association between maternal ...

Last Updated: 2 Nov 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Twin twin transfusion syndrome" returned 11 free, full-text review articles on human participants. First 3 results:

Twenty-Five Years of Fetoscopic Laser Coagulation in Twin-Twin Transfusion Syndrome: A Systematic Review.
 

Author(s): Joost Akkermans, Suzanne H P Peeters, Frans J Klumper, Enrico Lopriore, Johanna M Middeldorp, Dick Oepkes

Journal: Fetal. Diagn. Ther.. 2015 ;38(4):241-53.

 

The aim of this study was to assess the perinatal outcome of pregnancies with twin-twin transfusion syndrome (TTTS) treated with laser therapy over the past 25 years, and in relation to different techniques used in this time period.

Last Updated: 17 Dec 2015

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Comparison of Solomon technique with selective laser ablation for twin-twin transfusion syndrome: a systematic review.
 

Author(s): R K Dhillon, S C Hillman, R Pounds, R K Morris, M D Kilby

Journal: Ultrasound Obstet Gynecol. 2015 Nov;46(5):526-33.

 

To compare the Solomon and selective techniques for fetoscopic laser ablation (FLA) for the treatment of twin-twin transfusion syndrome (TTTS) in monochorionic-diamniotic twin pregnancies.

Last Updated: 3 Nov 2015

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Cerebral injury and neurodevelopmental impairment after amnioreduction versus laser surgery in twin-twin transfusion syndrome: a systematic review and meta-analysis.
 

Author(s): Jeanine M M van Klink, Hendrik M Koopman, Erik W van Zwet, Dick Oepkes, Frans J Walther, Enrico Lopriore

Journal: Fetal. Diagn. Ther.. 2013 ;33(2):81-9.

 

To estimate the odds of severe cerebral injury and long-term neurodevelopmental impairment in monochorionic twins treated with amnioreduction versus laser surgery for twin-twin transfusion syndrome.

Last Updated: 14 Mar 2013

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Sequential vs. Standard Laser Treatment of Twin-twin Transfusion Syndrome
 

Status: Recruiting

Condition Summary: Twin Twin Transfusion Syndrome

 

Last Updated: 26 Oct 2016

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Last Updated: 6 Jul 2016

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The Trial of Pessary After Laser for TTTS
 

Status: Recruiting

Condition Summary: Premature Birth

 

Last Updated: 1 Sep 2015

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