Twin twin transfusion syndrome

Common Name(s)

Twin twin transfusion syndrome, Twin to Twin Transfusion Syndrome (TTTS)

Twin-to-twin transfusion syndrome is a rare condition that occurs when blood moves from one identical twin (the Òdonor twinÓ) to the other (the Òrecipient twinÓ) while in the womb. The donor twin may be born smaller, with paleness, anemia, and dehydration. The recipient twin may be born larger, with redness, too much blood, and increased blood pressure, resulting in an increased risk for heart failure. Treatment may require repeated amniocentesis during pregnancy. Fetal laser surgery may be done to interrupt the flow of blood from one twin to the other. After birth, treatment depends on the infant's specific symptoms. The donor twin may need a blood transfusion to treat anemia. The recipient twin may need to have the volume of body fluid reduced. This may involve an exchange transfusion. Medications may be given to treat heart failure in the recipient twin.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Twin twin transfusion syndrome" for support, advocacy or research.

Sidelines National Support Network

Sidelines provides support, education, advocacy and resources to women and their families experiencing a complicated high-risk pregnancy or premature birth.

Last Updated: 4 Apr 2013

View Details
The Twin to Twin Transfusion Syndrome Foundation

The first and only nonproft organization in the world solely dedicated to providing immediate and lifesaving educational, emotional and financial support to families, medical professionals, and other caregivers before, during, and after a diagnosis of twin to twin transfusion syndrome. Dedicated to saving the babies, improving their future health and care, providing NICU, special needs and bereavement support, furthering medical research, and keeping families together the way twins are meant to be.

Last Updated: 12 Jan 2013

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Twin twin transfusion syndrome" for support, advocacy or research.

Sidelines National Support Network

Sidelines provides support, education, advocacy and resources to women and their families experiencing a complicated high-risk pregnancy or premature birth.

http://www.sidelines.org

Last Updated: 4 Apr 2013

View Details
The Twin to Twin Transfusion Syndrome Foundation

The first and only nonproft organization in the world solely dedicated to providing immediate and lifesaving educational, emotional and financial support to families, medical professionals, and other caregivers before, during, and after a diagnosis of twin to twin transfusion syndrome. Dedicated to saving the babies, improving their future health and care, providing NICU, special needs and bereavement support, furthering medical research, and keeping families together the way twins are meant to be.

http://www.tttsfoundation.org

Last Updated: 12 Jan 2013

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Twin twin transfusion syndrome" returned 139 free, full-text research articles on human participants. First 3 results:

[Clinical analysis of twin-twin transfusion syndrome complicated by cardiac abnormalities in preterm infants].
 

Author(s): Hong-Ling Wei, Zai-Ling Li

Journal: Zhongguo Dang Dai Er Ke Za Zhi. 2014 May;16(5):473-7.

 

To investigate the complications of twin-twin transfusion syndrome (TTTS) in preterm infants and to analyze the clinical conditions and prognosis of cardiac abnormalities in TTTS recipients.

Last Updated: 26 May 2014

Go To URL
Limb arteriovenous malformation identified after radiofrequency ablation for selective termination in twin-to-twin transfusion syndrome.
 

Author(s): A Rebarber, C Dolin, N S Fox, A S Roman

Journal: Ultrasound Obstet Gynecol. 2013 Nov;42(5):605-6.

 

Last Updated: 29 Oct 2013

Go To URL
N-terminal pro-brain natriuretic peptide levels in monochorionic diamniotic twins with twin-to-twin transfusion syndrome treated by fetoscopic laser photocoagulation.
 

Author(s): Kazumichi Fujioka, Hitomi Sakai, Satoshi Tanaka, Sota Iwatani, Keiko Wada, Masami Mizobuchi, Seiji Yoshimoto, Hideto Nakao

Journal:

 

Twin-to-twin transfusion syndrome (TTTS) affects 15% of monochorionic diamniotic (MD) twin pregnancies, and is associated with adverse perinatal outcome. Recently, fetoscopic laser photocoagulation (FLP) has been widely accepted as the most definitive therapy to treat TTTS. N-terminal ...

Last Updated: 12 Jun 2013

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Twin twin transfusion syndrome" returned 9 free, full-text review articles on human participants. First 3 results:

Cerebral injury and neurodevelopmental impairment after amnioreduction versus laser surgery in twin-twin transfusion syndrome: a systematic review and meta-analysis.
 

Author(s): Jeanine M M van Klink, Hendrik M Koopman, Erik W van Zwet, Dick Oepkes, Frans J Walther, Enrico Lopriore

Journal: Fetal. Diagn. Ther.. 2013 ;33(2):81-9.

 

To estimate the odds of severe cerebral injury and long-term neurodevelopmental impairment in monochorionic twins treated with amnioreduction versus laser surgery for twin-twin transfusion syndrome.

Last Updated: 14 Mar 2013

Go To URL
Recurrent twin-twin transfusion syndrome after selective fetoscopic laser photocoagulation: a systematic review of the literature.
 

Author(s): C A Walsh, F M McAuliffe

Journal: Ultrasound Obstet Gynecol. 2012 Nov;40(5):506-12.

 

Selective fetoscopic laser photocoagulation (SFLP) is now the treatment of choice for twin-twin transfusion syndrome (TTTS). The incidence of recurrent TTTS following SFLP has been inconsistently reported across different studies. We performed a systematic review of TTTS recurrence following SFLP.

Last Updated: 21 Nov 2012

Go To URL
[Management of twin twin transfusion syndrome].
 

Author(s): J Stirnemann

Journal: J Gynecol Obstet Biol Reprod (Paris). 2009 Dec;38(8 Suppl):S76-84.

 

The diagnosis of twin twin transfusion syndrome is an emergency and is generally easily done by ultrasound. Once the diagnosis is established patients should be referred rapidly for counselling and treatment within a network that can offer fetoscopic laser surgery as first-line treatment. ...

Last Updated: 9 Feb 2010

Go To URL
 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Sequential vs. Standard Laser Treatment of Twin-twin Transfusion Syndrome
 

Status: Recruiting

Condition Summary: Twin Twin Transfusion Syndrome

 

Last Updated: 22 Apr 2014

Go to URL

Last Updated: 22 Sep 2014

Go to URL