Transplantation

Common Name(s)

Transplantation

Transplantation is the process of moving an object from one place to another. Organ transplantation refers to the surgical transferring of a donor organ into a person in need, the recipient. Organ transplantation is often used to replace a damaged, dysfunctional, or missing organ usually due to illness or injury. End-stage organ failure is the most common reason for organ transplantation and some conditions that may lead to such a procedure include: cardiomyopathy (heart), cirrhosis of the liver, chronic obstructive pulmonary disease (lungs), diabetes, and cystic fibrosis among many others.

Donor transplant organs may come from living or deceased individuals and must be carefully matched to their recipient to reduce the chance of rejection. Transplant rejection occurs when a person's body reacts to the new organ tissue as if it were a foreign invader such as an infectious bacteria or virus. Using tissue from a close relative or someone closely matching the individual in need may lessen the chance of transplant rejection. Certain medications may also help repress the immune system while the body adjusts to the new organ or tissue.

Organs that have been successfully transplanted many times include the kidneys, liver, heart, lungs, pancreas, intestine, and thymus. Tissues such as bones, tendons, cornea, skin, heart valves, nerves, and veins have also been successfully transplanted. Other organs and tissues have been transplanted, but are less common and often less successful. Your doctor or specialist can help guide you through the process should you or a loved one be in need of an organ transplant. Support groups are also a great resource for support and information.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Transplantation" for support, advocacy or research.

Association of Gastrointestinal Motility Disorders, Inc. (AGMD)

AGMD is a nonprofit international organization which serves as an integral educational resource concerning digestive motility diseases and disorders. It also functions as an important information base for members of the medical and scientific communities. In addition, it provides a forum for patients suffering from digestive motility diseases and disorders as well as their families and members of the medical community.

Last Updated: 28 Feb 2015

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Transplantation" for support, advocacy or research.

Association of Gastrointestinal Motility Disorders, Inc. (AGMD)

AGMD is a nonprofit international organization which serves as an integral educational resource concerning digestive motility diseases and disorders. It also functions as an important information base for members of the medical and scientific communities. In addition, it provides a forum for patients suffering from digestive motility diseases and disorders as well as their families and members of the medical community.

http://www.agmd-gimotility.org

Last Updated: 28 Feb 2015

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Transplantation" returned 18525 free, full-text research articles on human participants. First 3 results:

Human Herpes Virus-6 Following Pediatric Allogeneic Hematopoietic Stem Cell Transplantation.
 

Author(s): Yael Shachor-Meyouhas, Alla Fesenko, Zipi Kra-Oz, Irina Zaidman, Moran Szwarcwort-Cohen, Einat Shafran, Imad Kassis

Journal: Isr. Med. Assoc. J.. 2015 May;17(5):302-5.

 

Human herpes virus-6 (HHV-6) reactivation after hematopoietic stem cell transplantation (HSCT) is well known and has been linked with several clinical manifestations. The significance of HHV-6 viremia and related complications in this setting is still unclear.

Last Updated: 2 Jul 2015

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Liver transplantation reverses hypergammaglobulinemia in patients with chronic hepatic failure.
 

Author(s): Diana Lebherz-Eichinger, Remy Schwarzer, Michael C Motal, Daniel A Klaus, Andreas Mangold, Hendrik J Ankersmit, Gabriela A Berlakovich, Claus G Krenn, Georg A Roth

Journal:

 

Sparse data are available about the effect of therapy methods on antibody levels in patients with liver failure. The aim of this study was to determine serum immunoglobulin concentrations in patients with chronic hepatic failure (CHF), acute- (ALF), or acute-on-chronic liver failure ...

Last Updated: 25 Jun 2015

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Electrical storm in an adolescent with arrhythmogenic right ventricle cardiomyopathy treated with cardiac transplantation.
 

Author(s): Hayrettin Hakan Aykan, Mustafa Gülgün, İlker Ertuğrul, Tevfik Karagöz

Journal: Anatol J Cardiol. 2015 Jun;15(6):513.

 

Last Updated: 9 Jun 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Transplantation" returned 2756 free, full-text review articles on human participants. First 3 results:

Stem cell transplantation as rescue therapy for refractory Crohn's disease: a sytematic review.
 

Author(s): Asma Labidi, Meriem Serghini, Nadia Ben Mustapha, Monia Fekih, Jalel Boubaker, Azza Filali

Journal: Tunis Med. 2014 Nov;92(11):655-9.

 

Crohn's disease is a chronic relapsing- remitting affection. It has a strong immunologic component which represent the target of standard therapies including immunosppressants and biological therapies. However, many patients remain refracory or intolerant to these therapies.

Last Updated: 14 Apr 2015

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[Heart transplantation: preoperative evaluation, perioperative management, postoperative follow-up].
 

Author(s): Tahir Yağdı, Sanem Nalbantgil, Mustafa Özbaran

Journal: Turk Kardiyol Dern Ars. 2015 Jan;43(1):95-108.

 

Heart transplantation has, over the years, become the best treatment choice for patients with end-stage heart failure. The increase in longer waiting times among patients awaiting transplantation is due to scarcity of suitable donor organs. Major improvements in recipient and donor ...

Last Updated: 6 Feb 2015

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Simultaneous pancreas and kidney transplantation: current trends and future directions.
 

Author(s): Robert R Redfield, Joseph R Scalea, Jon S Odorico

Journal: Curr Opin Organ Transplant. 2015 Feb;20(1):94-102.

 

Important trends are being observed in pancreas transplantation in the USA. We will describe recent trends in simultaneous pancreas kidney (SPK) transplantation related to immunosuppression, treatment of rejection, and transplantation for patients of advanced age and C-peptide positive diabetes.

Last Updated: 8 Jan 2015

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

The Collection and Storage of Umbilical Cord Blood for Transplantation
 

Status: Recruiting

Condition Summary: Cord Blood Stem Cell Transplantation; Cord Blood Transplantation; Hematopoietic Stem Cell Transplantation

 

Last Updated: 13 Aug 2015

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Pharmacogenetic Trial of Tacrolimus After Pediatric Transplantation
 

Status: Recruiting

Condition Summary: Heart Transplantation; Liver Transplantation; Kidney Transplantation

 

Last Updated: 20 May 2015

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Fludarabine-IV Busulfan ± Clofarabine and Allogeneic Hematopoietic Stem Cell Transplantation for Acute Myeloid Leukemia (AML) and Myelodysplastic Syndrome (MDS)
 

Status: Recruiting

Condition Summary: Disorder Related to Bone Marrow Transplantation; Leukemia; Transplantation Infection

 

Last Updated: 27 Apr 2015

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