Transplantation

Common Name(s)

Transplantation

Transplantation is the process of moving an object from one place to another. Organ transplantation refers to the surgical transferring of a donor organ into a person in need, the recipient. Organ transplantation is often used to replace a damaged, dysfunctional, or missing organ usually due to illness or injury. End-stage organ failure is the most common reason for organ transplantation and some conditions that may lead to such a procedure include: cardiomyopathy (heart), cirrhosis of the liver, chronic obstructive pulmonary disease (lungs), diabetes, and cystic fibrosis among many others.

Donor transplant organs may come from living or deceased individuals and must be carefully matched to their recipient to reduce the chance of rejection. Transplant rejection occurs when a person's body reacts to the new organ tissue as if it were a foreign invader such as an infectious bacteria or virus. Using tissue from a close relative or someone closely matching the individual in need may lessen the chance of transplant rejection. Certain medications may also help repress the immune system while the body adjusts to the new organ or tissue.

Organs that have been successfully transplanted many times include the kidneys, liver, heart, lungs, pancreas, intestine, and thymus. Tissues such as bones, tendons, cornea, skin, heart valves, nerves, and veins have also been successfully transplanted. Other organs and tissues have been transplanted, but are less common and often less successful. Your doctor or specialist can help guide you through the process should you or a loved one be in need of an organ transplant. Support groups are also a great resource for support and information.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Transplantation" for support, advocacy or research.

Association of Gastrointestinal Motility Disorders, Inc. (AGMD)

AGMD is a nonprofit international organization which serves as an integral educational resource concerning digestive motility diseases and disorders. It also functions as an important information base for members of the medical and scientific communities. In addition, it provides a forum for patients suffering from digestive motility diseases and disorders as well as their families and members of the medical community.

Last Updated: 28 Feb 2015

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Transplantation" for support, advocacy or research.

Association of Gastrointestinal Motility Disorders, Inc. (AGMD)

AGMD is a nonprofit international organization which serves as an integral educational resource concerning digestive motility diseases and disorders. It also functions as an important information base for members of the medical and scientific communities. In addition, it provides a forum for patients suffering from digestive motility diseases and disorders as well as their families and members of the medical community.

http://www.agmd-gimotility.org

Last Updated: 28 Feb 2015

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Transplantation" returned 22600 free, full-text research articles on human participants. First 3 results:

Cord-Blood Transplantation in Patients with Minimal Residual Disease.
 

Author(s): Filippo Milano, Ted Gooley, Brent Wood, Ann Woolfrey, Mary E Flowers, Kristine Doney, Robert Witherspoon, Marco Mielcarek, Joachim H Deeg, Mohamed Sorror, Ann Dahlberg, Brenda M Sandmaier, Rachel Salit, Effie Petersdorf, Frederick R Appelbaum, Colleen Delaney

Journal: N. Engl. J. Med.. 2016 Sep;375(10):944-53.

 

The majority of patients in need of a hematopoietic-cell transplant do not have a matched related donor. Data are needed to inform the choice among various alternative donor-cell sources.

Last Updated: 8 Sep 2016

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Portal Steal Syndrome After Full-Size Deceased Donor Liver Transplantation.
 

Author(s): Anahita Dua, Lisa McElroy, Abby Wochinski, Johnny C Hong, David C Cronin

Journal: WMJ. 2016 Jun;115(3):147-50.

 

Successful liver transplantation typically results in an immediate decrease in intrahepatic resistance accompanied by an initial increased hepatopedal portal flow. Within a short period of time, the portal hypertension resolves and the variceal shunts involute. However, in situations ...

Last Updated: 22 Jul 2016

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Ipilimumab for Patients with Relapse after Allogeneic Transplantation.
 

Author(s): Matthew S Davids, Haesook T Kim, Pavan Bachireddy, Caitlin Costello, Rebecca Liguori, Alexandra Savell, Alexander P Lukez, David Avigan, Yi-Bin Chen, Peter McSweeney, Nicole R LeBoeuf, Michael S Rooney, Michaela Bowden, Chensheng W Zhou, Scott R Granter, Jason L Hornick, Scott J Rodig, Masahiro Hirakawa, Mariano Severgnini, F Stephen Hodi, Catherine J Wu, Vincent T Ho, Corey Cutler, John Koreth, Edwin P Alyea, Joseph H Antin, Philippe Armand, Howard Streicher, Edward D Ball, Jerome Ritz, Asad Bashey, Robert J Soiffer,

Journal: N. Engl. J. Med.. 2016 Jul;375(2):143-53.

 

Loss of donor-mediated immune antitumor activity after allogeneic hematopoietic stem-cell transplantation (HSCT) permits relapse of hematologic cancers. We hypothesized that immune checkpoint blockade established by targeting cytotoxic T-lymphocyte-associated protein 4 with ipilimumab ...

Last Updated: 14 Jul 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Transplantation" returned 3313 free, full-text review articles on human participants. First 3 results:

Allogeneic Transplantation for Chronic Lymphocytic Leukemia in the Age of Novel Treatment Strategies.
 

Author(s): Mark-Alexander Schwarzbich, Fabienne McClanahan, John Gribben

Journal: Oncology (Williston Park, N.Y.). 2016 Jun;30(6):526-33, 540.

 

Hematopoietic stem cell transplantation (HSCT) is the only established potentially curative treatment option for chronic lymphocytic leukemia (CLL) to date. However, this approach is associated with high toxicity and significant treatment-related morbidity and mortality; thus, it ...

Last Updated: 17 Jun 2016

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How do we choose the best donor for T-cell-replete, HLA-haploidentical transplantation?
 

Author(s): Ying-Jun Chang, Leo Luznik, Ephraim J Fuchs, Xiao-Jun Huang

Journal:

 

In haploidentical stem cell transplantations (haplo-SCT), nearly all patients have more than one donor. A key issue in the haplo-SCT setting is the search for the best donor, because donor selection can significantly impact the incidences of acute and chronic graft-versus-host disease, ...

Last Updated: 13 Apr 2016

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Calcineurin Inhibitors Associated Posterior Reversible Encephalopathy Syndrome in Solid Organ Transplantation: Report of 2 Cases and Literature Review.
 

Author(s): Turun Song, Zhengsheng Rao, Qiling Tan, Yang Qiu, Jinpeng Liu, Zhongli Huang, Xianding Wang, Tao Lin

Journal: Medicine (Baltimore). 2016 Apr;95(14):e3173.

 

Posterior reversible encephalopathy syndrome (PRES) is a rare neurologic side effect of calcineurin inhibitors (CNIs) with poorly understood clinical features.We report cases of 2 patients with PRES developing after kidney transplantation and summarize PRES clinical features through ...

Last Updated: 9 Apr 2016

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Last Updated: 7 Nov 2015

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Pediatric Heart Transplantation: Transitioning to Adult Care
 

Status: Recruiting

Condition Summary: Heart Transplantation

 

Last Updated: 4 Aug 2015

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Fecal Microbiota Transplantation After HSCT
 

Status: Recruiting

Condition Summary: Bone Marrow Transplantation

 

Last Updated: 3 Oct 2016

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