Transplantation

Common Name(s)

Transplantation

Transplantation is the process of moving an object from one place to another. Organ transplantation refers to the surgical transferring of a donor organ into a person in need, the recipient. Organ transplantation is often used to replace a damaged, dysfunctional, or missing organ usually due to illness or injury. End-stage organ failure is the most common reason for organ transplantation and some conditions that may lead to such a procedure include: cardiomyopathy (heart), cirrhosis of the liver, chronic obstructive pulmonary disease (lungs), diabetes, and cystic fibrosis among many others.

Donor transplant organs may come from living or deceased individuals and must be carefully matched to their recipient to reduce the chance of rejection. Transplant rejection occurs when a person's body reacts to the new organ tissue as if it were a foreign invader such as an infectious bacteria or virus. Using tissue from a close relative or someone closely matching the individual in need may lessen the chance of transplant rejection. Certain medications may also help repress the immune system while the body adjusts to the new organ or tissue.

Organs that have been successfully transplanted many times include the kidneys, liver, heart, lungs, pancreas, intestine, and thymus. Tissues such as bones, tendons, cornea, skin, heart valves, nerves, and veins have also been successfully transplanted. Other organs and tissues have been transplanted, but are less common and often less successful. Your doctor or specialist can help guide you through the process should you or a loved one be in need of an organ transplant. Support groups are also a great resource for support and information.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Transplantation" for support, advocacy or research.

Association of Gastrointestinal Motility Disorders, Inc. (AGMD)

AGMD is a nonprofit international organization which serves as an integral educational resource concerning digestive motility diseases and disorders. It also functions as an important information base for members of the medical and scientific communities. In addition, it provides a forum for patients suffering from digestive motility diseases and disorders as well as their families and members of the medical community.

Last Updated: 28 Feb 2015

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Transplantation" for support, advocacy or research.

Association of Gastrointestinal Motility Disorders, Inc. (AGMD)

AGMD is a nonprofit international organization which serves as an integral educational resource concerning digestive motility diseases and disorders. It also functions as an important information base for members of the medical and scientific communities. In addition, it provides a forum for patients suffering from digestive motility diseases and disorders as well as their families and members of the medical community.

http://www.agmd-gimotility.org

Last Updated: 28 Feb 2015

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Transplantation" returned 21986 free, full-text research articles on human participants. First 3 results:

Risk Factors for Mortality in Asian Children Admitted to the Paediatric Intensive Care Unit after Haematopoietic Stem Cell Transplantation.
 

Author(s): Haripriya Santhanam, Jacqueline Sm Ong, Liang Shen, Poh Lin Tan, Pei Lin Koh

Journal: Ann. Acad. Med. Singap.. 2017 Feb;46(2):44-49.

 

This study aimed to investigate the risk factors associated with mortality in haematopoietic stem cell transplant (HSCT) patients admitted to our paediatric intensive care unit (PICU) over an 8-year period.

Last Updated: 6 Mar 2017

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Living Donor Liver Transplantation for Combined Hepatocellular Carcinoma and Cholangiocarcinoma: Experience of a Single Center.
 

Author(s): Cheng-Chih Chang, Ying-Ju Chen, Tzu-Hao Huang, Chun-Han Chen, Fang-Ying Kuo, Hock-Liew Eng, Chee-Chien Yong, Yueh-Wei Liu, Ting-Lung Lin, Wei-Feng Li, Yu-Hung Lin, Chih-Che Lin, Chih-Chi Wang, Chao-Long Chen

Journal:

 

BACKGROUND Because the outcome of liver transplantation for cholangiocarcinoma is often poor, cholangiocarcinoma is a contraindication for liver transplantation in most centers. Combined hepatocellular carcinoma and cholangiocarcinoma is a rare type of primary hepatic malignancy containing ...

Last Updated: 28 Feb 2017

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Syndrome of Inappropriate Antidiuretic Hormone Secretion Following Liver Transplantation.
 

Author(s): Kosei Takagi, Takahito Yagi, Susumu Shinoura, Yuzo Umeda, Ryuichi Yoshida, Daisuke Nobuoka, Nobuyuki Watanabe, Takashi Kuise, Tomokazu Fuji, Hiroyuki Araki, Toshiyoshi Fujiwara

Journal: Acta Med. Okayama. 2017 Feb;71(1):85-89.

 

Syndrome of inappropriate antidiuretic hormone secretion (SIADH) is an extremely rare cause of hyponatremia post-liver transplantation. A 15-year-old Japanese girl with recurrent cholangitis after Kasai surgery for biliary atresia underwent successful living donor liver transplantation. ...

Last Updated: 26 Feb 2017

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Transplantation" returned 3200 free, full-text review articles on human participants. First 3 results:

Endothelial Cells in Antibody-Mediated Rejection of Kidney Transplantation: Pathogenesis Mechanisms and Therapeutic Implications.
 

Author(s): Shuo Wang, Chao Zhang, Jina Wang, Cheng Yang, Ming Xu, Ruiming Rong, Tongyu Zhu, Dong Zhu

Journal: J Immunol Res. 2017 ;2017():8746303.

 

Antibody-mediated rejection (AMR) has been identified as a main obstacle for stable immune tolerance and long survival of kidney allografts. In spite of new insights into the underlying mechanisms of AMR, accurate diagnosis and efficient treatment are still challenges in clinical ...

Last Updated: 3 Mar 2017

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The Role of Humoral Alloreactivity in Liver Transplantation: Lessons Learned and New Perspectives.
 

Author(s): Elaine Y Cheng

Journal: J Immunol Res. 2017 ;2017():3234906.

 

More than ten years after the initial description of the humoral theory of transplantation by Dr. Paul I. Terasaki, the significance of humoral alloimmunity in liver transplantation has yet to be clearly defined. The liver allograft has an inherent tolerogenic capacity which confers ...

Last Updated: 6 Feb 2017

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From Humoral Theory to Performant Risk Stratification in Kidney Transplantation.
 

Author(s): C Lefaucheur, D Viglietti, M Mangiola, A Loupy, A Zeevi

Journal: J Immunol Res. 2017 ;2017():5201098.

 

The purpose of the present review is to describe how we improve the model for risk stratification of transplant outcomes in kidney transplantation by incorporating the novel insights of donor-specific anti-HLA antibody (DSA) characteristics. The detection of anti-HLA DSA is widely ...

Last Updated: 30 Jan 2017

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Last Updated: 7 Nov 2015

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Safety Study of Multipotent Progenitor Cells for Immunomodulation Therapy After Liver Transplantation
 

Status: Recruiting

Condition Summary: Liver Transplantation

 

Last Updated: 27 Sep 2016

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Hepatitis E Virus Infection in Pediatric Transplantation, a Prevalence Study
 

Status: Recruiting

Condition Summary: Transplantation

 

Last Updated: 22 Jun 2016

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