Transplantation

Common Name(s)

Transplantation

Transplantation is the process of moving an object from one place to another. Organ transplantation refers to the surgical transferring of a donor organ into a person in need, the recipient. Organ transplantation is often used to replace a damaged, dysfunctional, or missing organ usually due to illness or injury. End-stage organ failure is the most common reason for organ transplantation and some conditions that may lead to such a procedure include: cardiomyopathy (heart), cirrhosis of the liver, chronic obstructive pulmonary disease (lungs), diabetes, and cystic fibrosis among many others.

Donor transplant organs may come from living or deceased individuals and must be carefully matched to their recipient to reduce the chance of rejection. Transplant rejection occurs when a person's body reacts to the new organ tissue as if it were a foreign invader such as an infectious bacteria or virus. Using tissue from a close relative or someone closely matching the individual in need may lessen the chance of transplant rejection. Certain medications may also help repress the immune system while the body adjusts to the new organ or tissue.

Organs that have been successfully transplanted many times include the kidneys, liver, heart, lungs, pancreas, intestine, and thymus. Tissues such as bones, tendons, cornea, skin, heart valves, nerves, and veins have also been successfully transplanted. Other organs and tissues have been transplanted, but are less common and often less successful. Your doctor or specialist can help guide you through the process should you or a loved one be in need of an organ transplant. Support groups are also a great resource for support and information.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Transplantation" for support, advocacy or research.

Association of Gastrointestinal Motility Disorders, Inc. (AGMD)

AGMD is a nonprofit international organization which serves as an integral educational resource concerning digestive motility diseases and disorders. It also functions as an important information base for members of the medical and scientific communities. In addition, it provides a forum for patients suffering from digestive motility diseases and disorders as well as their families and members of the medical community.

Last Updated: 28 Feb 2015

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Transplantation" for support, advocacy or research.

Association of Gastrointestinal Motility Disorders, Inc. (AGMD)

AGMD is a nonprofit international organization which serves as an integral educational resource concerning digestive motility diseases and disorders. It also functions as an important information base for members of the medical and scientific communities. In addition, it provides a forum for patients suffering from digestive motility diseases and disorders as well as their families and members of the medical community.

http://www.agmd-gimotility.org

Last Updated: 28 Feb 2015

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Transplantation" returned 17613 free, full-text research articles on human participants. First 3 results:

Effect of allogeneic umbilical cord mesenchymal stem cell transplantation in a rat model of hepatic cirrhosis.
 

Author(s): Lihua Yang, Yun Wang, Xiaohua Wang, Yanqing Liu

Journal: J Tradit Chin Med. 2015 Feb;35(1):63-8.

 

To determine the effects of human umbilical cord mesenchymal stem cell (UCMSC) transplantation, alone or in combination with tanshinone IIA (Tan IIA) on hepatic cirrhosis in rats.

Last Updated: 6 Apr 2015

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Time interval to recurrence as a predictor of overall survival in salvage liver transplantation for patients with hepatocellular carcinoma associated with hepatitis B virus.
 

Author(s): Zhenhua Hu, Jie Zhou, Zhiwei Li, Jie Xiang, Ze Qian, Jian Wu, Min Zhang, Shusen Zheng

Journal: Surgery. 2015 Feb;157(2):239-48.

 

Salvage liver transplantation (SLT) has been proposed for recurrent hepatocellular carcinoma (HCC) after hepatectomy; however, it is unclear how the time interval to tumor recurrence from previous hepatectomy affects prognosis.

Last Updated: 24 Jan 2015

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One-unit versus two-unit cord-blood transplantation.
 

Author(s): John E Wagner, Mary Eapen, Joanne Kurtzberg

Journal: N. Engl. J. Med.. 2015 Jan;372(3):288.

 

Last Updated: 15 Jan 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Transplantation" returned 2560 free, full-text review articles on human participants. First 3 results:

Effect of sirolimus on malignancy and survival after kidney transplantation: systematic review and meta-analysis of individual patient data.
 

Author(s): Greg A Knoll, Madzouka B Kokolo, Ranjeeta Mallick, Andrew Beck, Chieny D Buenaventura, Robin Ducharme, Rashad Barsoum, Corrado Bernasconi, Tom D Blydt-Hansen, Henrik Ekberg, Claudia R Felipe, John Firth, Lorenzo Gallon, Marielle Gelens, Denis Glotz, Jan Gossmann, Markus Guba, Ahmed Ali Morsy, Rebekka Salgo, Earnst H Scheuermann, Helio Tedesco-Silva, Stefan Vitko, Christopher Watson, Dean A Fergusson

Journal:

 

To examine risk of malignancy and death in patients with kidney transplant who receive the immunosuppressive drug sirolimus.

Last Updated: 25 Nov 2014

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Significance of CD20 expression by lymphoproliferative lesions developing after liver transplantation: post-transplant lymphoproliferative disorders international survey.
 

Author(s): Hossein Khedmat, Mohammad Ebrahim Ghamar-Chehreh, Mohsen Amini

Journal: Saudi J Kidney Dis Transpl. 2014 Nov;25(6):1293-300.

 

Last Updated: 14 Nov 2014

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Burkitt's lymphoma developing post liver transplantation: posttransplant lymphoproliferative disorders international survey.
 

Author(s): Hossein Khedmat, Mohammad Ebrahim Ghamar-Chehreh, Mohsen Amini, Saeed Taheri

Journal: Saudi J Kidney Dis Transpl. 2014 Nov;25(6):1290-2.

 

Last Updated: 14 Nov 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

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Clinical Trial Information This information is provided by ClinicalTrials.gov

The Collection and Storage of Umbilical Cord Blood for Transplantation
 

Status: Recruiting

Condition Summary: Cord Blood Stem Cell Transplantation; Cord Blood Transplantation; Hematopoietic Stem Cell Transplantation

 

Last Updated: 9 Mar 2015

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Pharmacogenetic Trial of Tacrolimus After Pediatric Transplantation
 

Status: Recruiting

Condition Summary: Heart Transplantation; Liver Transplantation; Kidney Transplantation

 

Last Updated: 21 Aug 2014

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Fludarabine-IV Busulfan ± Clofarabine and Allogeneic Hematopoietic Stem Cell Transplantation for Acute Myeloid Leukemia (AML) and Myelodysplastic Syndrome (MDS)
 

Status: Recruiting

Condition Summary: Disorder Related to Bone Marrow Transplantation; Leukemia; Transplantation Infection

 

Last Updated: 24 Oct 2014

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