Transplantation

Common Name(s)

Transplantation

Transplantation is the process of moving an object from one place to another. Organ transplantation refers to the surgical transferring of a donor organ into a person in need, the recipient. Organ transplantation is often used to replace a damaged, dysfunctional, or missing organ usually due to illness or injury. End-stage organ failure is the most common reason for organ transplantation and some conditions that may lead to such a procedure include: cardiomyopathy (heart), cirrhosis of the liver, chronic obstructive pulmonary disease (lungs), diabetes, and cystic fibrosis among many others.

Donor transplant organs may come from living or deceased individuals and must be carefully matched to their recipient to reduce the chance of rejection. Transplant rejection occurs when a person's body reacts to the new organ tissue as if it were a foreign invader such as an infectious bacteria or virus. Using tissue from a close relative or someone closely matching the individual in need may lessen the chance of transplant rejection. Certain medications may also help repress the immune system while the body adjusts to the new organ or tissue.

Organs that have been successfully transplanted many times include the kidneys, liver, heart, lungs, pancreas, intestine, and thymus. Tissues such as bones, tendons, cornea, skin, heart valves, nerves, and veins have also been successfully transplanted. Other organs and tissues have been transplanted, but are less common and often less successful. Your doctor or specialist can help guide you through the process should you or a loved one be in need of an organ transplant. Support groups are also a great resource for support and information.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Transplantation" for support, advocacy or research.

Association of Gastrointestinal Motility Disorders, Inc. (AGMD)

AGMD is a nonprofit international organization which serves as an integral educational resource concerning digestive motility diseases and disorders. It also functions as an important information base for members of the medical and scientific communities. In addition, it provides a forum for patients suffering from digestive motility diseases and disorders as well as their families and members of the medical community.

Last Updated: 28 Feb 2015

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Transplantation" for support, advocacy or research.

Association of Gastrointestinal Motility Disorders, Inc. (AGMD)

AGMD is a nonprofit international organization which serves as an integral educational resource concerning digestive motility diseases and disorders. It also functions as an important information base for members of the medical and scientific communities. In addition, it provides a forum for patients suffering from digestive motility diseases and disorders as well as their families and members of the medical community.

http://www.agmd-gimotility.org

Last Updated: 28 Feb 2015

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Transplantation" returned 16789 free, full-text research articles on human participants. First 3 results:

One-unit versus two-unit cord-blood transplantation.
 

Author(s): John E Wagner, Mary Eapen, Joanne Kurtzberg

Journal: N. Engl. J. Med.. 2015 Jan;372(3):288.

 

Last Updated: 15 Jan 2015

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Eligibility for renal transplantation: a Moroccan interregional survey.
 

Author(s): Nadia Kabbali, Souad Mikou, Ghita El Bardai, Adil Najdi, Meriem Ezziani, Fatima Zahra Batta, Nada Tazi El Pardiya, Chadia El Fadil, Aniss El Hassani, Mohamed Arrayhani, Tarik Sqalli Houssaini

Journal: Saudi J Kidney Dis Transpl. 2015 Jan;26(1):153-60.

 

In the treatment of end-stage renal disease, kidney transplantation (KT) is the best and most cost-effective alternative with regard to both prognosis and quality of life. To identify the proportion and the characteristics of kidney transplant candidates who can be considered eligible, ...

Last Updated: 12 Jan 2015

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More on shift of HIV tropism in stem-cell transplantation with CCR5 delta32/delta32 mutation.
 

Author(s): Jens Verheyen, Stefan Esser, Lambros Kordelas

Journal: N. Engl. J. Med.. 2014 Dec;371(25):2438.

 

Last Updated: 18 Dec 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Transplantation" returned 2406 free, full-text review articles on human participants. First 3 results:

Effect of sirolimus on malignancy and survival after kidney transplantation: systematic review and meta-analysis of individual patient data.
 

Author(s): Greg A Knoll, Madzouka B Kokolo, Ranjeeta Mallick, Andrew Beck, Chieny D Buenaventura, Robin Ducharme, Rashad Barsoum, Corrado Bernasconi, Tom D Blydt-Hansen, Henrik Ekberg, Claudia R Felipe, John Firth, Lorenzo Gallon, Marielle Gelens, Denis Glotz, Jan Gossmann, Markus Guba, Ahmed Ali Morsy, Rebekka Salgo, Earnst H Scheuermann, Helio Tedesco-Silva, Stefan Vitko, Christopher Watson, Dean A Fergusson

Journal:

 

To examine risk of malignancy and death in patients with kidney transplant who receive the immunosuppressive drug sirolimus.

Last Updated: 25 Nov 2014

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[Challenges of the modern antibody diagnostics in kidney transplantation].
 

Author(s): Dániel Wettstein, Dorottya Szentiványi

Journal: Orv Hetil. 2014 Nov;155(46):1820-30.

 

Overcoming antibody mediated rejection is of increasing interest in the field of transplantation immunology. The recipient's antibodies against the graft human leukocyte antigens are responsible for antibody mediated graft injury. Introduction of the solid phase immunoassay technology ...

Last Updated: 10 Nov 2014

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[Effects of dipeptidyl peptidase-4 on the hematopoiesis and transplantation].
 

Author(s): De-guan Li, Ai-min Meng

Journal: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2014 Oct;36(5):538-41.

 

Dipeptidyl peptidase-4 (DPP-4) is a protease that cleaves the peptides with alanine, praline, or other selective amino acids at the N-terminal penultimate position. The substrates of DPP-4 include many chemokines, colony-stimulating factors, and interleukins. Recent research has shown ...

Last Updated: 1 Nov 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

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Clinical Trial Information This information is provided by ClinicalTrials.gov

The Collection and Storage of Umbilical Cord Blood for Transplantation
 

Status: Recruiting

Condition Summary: Cord Blood Stem Cell Transplantation; Cord Blood Transplantation; Hematopoietic Stem Cell Transplantation

 

Last Updated: 9 Mar 2015

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Pharmacogenetic Trial of Tacrolimus After Pediatric Transplantation
 

Status: Recruiting

Condition Summary: Heart Transplantation; Liver Transplantation; Kidney Transplantation

 

Last Updated: 21 Aug 2014

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Fludarabine-IV Busulfan ± Clofarabine and Allogeneic Hematopoietic Stem Cell Transplantation for Acute Myeloid Leukemia (AML) and Myelodysplastic Syndrome (MDS)
 

Status: Recruiting

Condition Summary: Disorder Related to Bone Marrow Transplantation; Leukemia; Transplantation Infection

 

Last Updated: 24 Oct 2014

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