Transplantation

Common Name(s)

Transplantation

Transplantation is the process of moving an object from one place to another. Organ transplantation refers to the surgical transferring of a donor organ into a person in need, the recipient. Organ transplantation is often used to replace a damaged, dysfunctional, or missing organ usually due to illness or injury. End-stage organ failure is the most common reason for organ transplantation and some conditions that may lead to such a procedure include: cardiomyopathy (heart), cirrhosis of the liver, chronic obstructive pulmonary disease (lungs), diabetes, and cystic fibrosis among many others.

Donor transplant organs may come from living or deceased individuals and must be carefully matched to their recipient to reduce the chance of rejection. Transplant rejection occurs when a person's body reacts to the new organ tissue as if it were a foreign invader such as an infectious bacteria or virus. Using tissue from a close relative or someone closely matching the individual in need may lessen the chance of transplant rejection. Certain medications may also help repress the immune system while the body adjusts to the new organ or tissue.

Organs that have been successfully transplanted many times include the kidneys, liver, heart, lungs, pancreas, intestine, and thymus. Tissues such as bones, tendons, cornea, skin, heart valves, nerves, and veins have also been successfully transplanted. Other organs and tissues have been transplanted, but are less common and often less successful. Your doctor or specialist can help guide you through the process should you or a loved one be in need of an organ transplant. Support groups are also a great resource for support and information.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Transplantation" for support, advocacy or research.

Association of Gastrointestinal Motility Disorders, Inc. (AGMD)

AGMD is a nonprofit international organization which serves as an integral educational resource concerning digestive motility diseases and disorders. It also functions as an important information base for members of the medical and scientific communities. In addition, it provides a forum for patients suffering from digestive motility diseases and disorders as well as their families and members of the medical community.

Last Updated: 28 Feb 2015

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Transplantation" for support, advocacy or research.

Association of Gastrointestinal Motility Disorders, Inc. (AGMD)

AGMD is a nonprofit international organization which serves as an integral educational resource concerning digestive motility diseases and disorders. It also functions as an important information base for members of the medical and scientific communities. In addition, it provides a forum for patients suffering from digestive motility diseases and disorders as well as their families and members of the medical community.

http://www.agmd-gimotility.org

Last Updated: 28 Feb 2015

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Transplantation" returned 21798 free, full-text research articles on human participants. First 3 results:

Prognostic Mutations in Myelodysplastic Syndrome after Stem-Cell Transplantation.
 

Author(s): R Coleman Lindsley, Wael Saber, Brenton G Mar, Robert Redd, Tao Wang, Michael D Haagenson, Peter V Grauman, Zhen-Huan Hu, Stephen R Spellman, Stephanie J Lee, Michael R Verneris, Katharine Hsu, Katharina Fleischhauer, Corey Cutler, Joseph H Antin, Donna Neuberg, Benjamin L Ebert

Journal: N. Engl. J. Med.. 2017 02;376(6):536-547.

 

Background Genetic mutations drive the pathogenesis of the myelodysplastic syndrome (MDS) and are closely associated with clinical phenotype. Therefore, genetic mutations may predict clinical outcomes after allogeneic hematopoietic stem-cell transplantation. Methods We performed targeted ...

Last Updated: 8 Feb 2017

Go To URL
Safety and Efficacy of Small Bowel Examination by Capsule Endoscopy for Patients before Liver Transplantation.
 

Author(s): Kawano Seiji, Takaki Akinobu, Iwamuro Masaya, Yasunaka Tetsuya, Kono Yoshiyasu, Miura Kou, Inokuchi Toshihiro, Kawahara Yoshiro, Umeda Yuzo, Yagi Takahito, Okada Hiroyuki

Journal: Biomed Res Int. 2017 ;2017():8193821.

 

Background and Aims. Gastrointestinal surveillance is a requirement prior to liver transplantation (LT), but small intestine examination is not generally undertaken. The aim of the present study was to evaluate the safety and efficacy of capsule endoscopy (CE) for patients with end-stage ...

Last Updated: 7 Feb 2017

Go To URL
Adult to adult right lobe living donor liver transplantation: does biological relationship matter?
 

Author(s): Wei Zhang, Yifei Tan, Shu Shen, Li Jiang, Lunan Yan, Jiayin Yang, Bo Li, Tianfu Wen, Yong Zeng, WenTao Wang, Mingqing Xu

Journal: Medicine (Baltimore). 2017 Jan;96(4):e4139.

 

The influence of the biological relationship between the donor and the recipient is rarely discussed in living donor liver transplantation (LDLT), although it is believed to be an important risk factor in other types of organ transplantations. A total of 272 consecutive patients undergoing ...

Last Updated: 25 Jan 2017

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Transplantation" returned 3171 free, full-text review articles on human participants. First 3 results:

De novo thyroid cancer following solid organ transplantation-A 25-year experience at a high-volume institution with a review of the literature.
 

Author(s): Wouter P Kluijfhout, Frederick T Drake, Jesse D Pasternak, Toni Beninato, Elliot J Mitmaker, Jessica E Gosnell, Wen T Shen, Insoo Suh, Chris E Freise, Quan-Yang Duh

Journal: J Surg Oncol. 2017 Feb;115(2):105-108.

 

We investigated the rate, stage, and prognosis of thyroid cancer in patients after solid-organ transplantations, and compared this to the general population.

Last Updated: 5 Jan 2017

Go To URL
Bortezomib followed by autologous stem cell transplantation in a patient with rheumatoid arthritis: A case report and review of the literature.
 

Author(s): Junru Liu, Juan Li, Meilan Chen, Lifen Kuang

Journal: Medicine (Baltimore). 2016 Dec;95(52):e5760.

 

Despite the introduction of varied disease-modifying antirheumatic drugs and biological agents, a substantial proportion of patients remain untreatable. We report a 56-year-old Chinese female patient with a case of refractory rheumatoid arthritis (RA) complicated with multiple myeloma ...

Last Updated: 29 Dec 2016

Go To URL
Maximizing kidneys for transplantation using machine perfusion: from the past to the future: A comprehensive systematic review and meta-analysis.
 

Author(s): Ahmer M Hameed, Henry C Pleass, Germaine Wong, Wayne J Hawthorne

Journal: Medicine (Baltimore). 2016 Oct;95(40):e5083.

 

The two main options for renal allograft preservation are static cold storage (CS) and machine perfusion (MP). There has been considerably increased interest in MP preservation of kidneys, however conflicting evidence regarding its efficacy and associated costs have impacted its scale ...

Last Updated: 17 Oct 2016

Go To URL
 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Last Updated: 7 Nov 2015

Go to URL
Fecal Microbiota Transplantation After HSCT
 

Status: Recruiting

Condition Summary: Bone Marrow Transplantation

 

Last Updated: 3 Oct 2016

Go to URL
Safety Study of Multipotent Progenitor Cells for Immunomodulation Therapy After Liver Transplantation
 

Status: Recruiting

Condition Summary: Liver Transplantation

 

Last Updated: 27 Sep 2016

Go to URL