Thrombasthenia

Common Name(s)

Thrombasthenia

Description for this condition is not yet available.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Thrombasthenia" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Thrombasthenia" returned 144 free, full-text research articles on human participants. First 3 results:

The international, prospective Glanzmann Thrombasthenia Registry: treatment modalities and outcomes of non-surgical bleeding episodes in patients with Glanzmann thrombasthenia.
 

Author(s): Giovanni Di Minno, Rainer B Zotz, Roseline d'Oiron, Niels Bindslev, Matteo Nicola Dario Di Minno, Man-Chiu Poon,

Journal: Haematologica. 2015 Aug;100(8):1031-7.

 

Standard treatment for Glanzmann thrombasthenia is platelet transfusion. Recombinant activated factor VII has been shown to be successful in patients with Glanzmann thrombasthenia with platelet antibodies or who are refractory to platelet transfusions. The Glanzmann Thrombasthenia ...

Last Updated: 28 Aug 2015

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The international, prospective Glanzmann Thrombasthenia Registry: treatment and outcomes in surgical intervention.
 

Author(s): Man-Chiu Poon, Roseline d'Oiron, Rainer B Zotz, Niels Bindslev, Matteo Nicola Dario Di Minno, Giovanni Di Minno,

Journal: Haematologica. 2015 Aug;100(8):1038-44.

 

Standard treatment for Glanzmann thrombasthenia, a severe inherited bleeding disorder, is platelet transfusion. Recombinant factor VIIa is reported to be effective in Glanzmann thrombasthenia with platelet antibodies and/or refractoriness to platelet transfusions. We aimed to evaluate ...

Last Updated: 28 Aug 2015

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αIIbβ3 variants defined by next-generation sequencing: predicting variants likely to cause Glanzmann thrombasthenia.
 

Author(s): Lorena Buitrago, Augusto Rendon, Yupu Liang, Ilenia Simeoni, Ana Negri, , Marta Filizola, Willem H Ouwehand, Barry S Coller

Journal: Proc. Natl. Acad. Sci. U.S.A.. 2015 Apr;112(15):E1898-907.

 

Next-generation sequencing is transforming our understanding of human genetic variation but assessing the functional impact of novel variants presents challenges. We analyzed missense variants in the integrin αIIbβ3 receptor subunit genes ITGA2B and ITGB3 identified by whole-exome ...

Last Updated: 15 Apr 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Thrombasthenia" returned 11 free, full-text review articles on human participants. First 3 results:

Glanzmann thrombasthenia: state of the art and future directions.
 

Author(s): Alan T Nurden, Xavier Pillois, David A Wilcox

Journal: Semin. Thromb. Hemost.. 2013 Sep;39(6):642-55.

 

Glanzmann thrombasthenia (GT) is the principal inherited disease of platelets and the most commonly encountered disorder of an integrin. GT is characterized by spontaneous mucocutaneous bleeding and an exaggerated response to trauma caused by platelets that fail to aggregate when ...

Last Updated: 28 Aug 2013

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Glanzmann thrombasthenia: a review of ITGA2B and ITGB3 defects with emphasis on variants, phenotypic variability, and mouse models.
 

Author(s): Alan T Nurden, Mathieu Fiore, Paquita Nurden, Xavier Pillois

Journal: Blood. 2011 Dec;118(23):5996-6005.

 

Characterized by mucocutaneous bleeding arising from a lack of platelet aggregation to physiologic stimuli, Glanzmann thrombasthenia (GT) is the archetype-inherited disorder of platelets. Transmitted by autosomal recessive inheritance, platelets in GT have quantitative or qualitative ...

Last Updated: 2 Dec 2011

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[Glanzmann's thrombasthenia and pregnancy: report of a case and literature review].
 

Author(s): Myriam Rachad, Hikmat Chaara, Fatim zahra Fdili, Sofia Jayi, Hakimat Bouguern, Moulay Abdelilah Melhouf

Journal: Pan Afr Med J. 2011 ;10():61.

 

Last Updated: 2 Mar 2012

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Abatacept Reduced Intensity for Non-Malignant Diseases
 

Status: Recruiting

Condition Summary: Hurler Syndrome; Fanconi Anemia; Glanzmann Thrombasthenia; Wiskott-Aldrich Syndrome; Chronic Granulomatous Disease; Severe Congenital Neutropenia; Leukocyte Adhesion Deficiency; Shwachman Diamond Syndrome; Diamond Blackfan Anemia; Dyskeratosis Congenita; Chediak Higashi Syndrome; Severe Aplastic Anemia; Thalassemia; Hemophagocytic Lymphohistiocytosis

 

Last Updated: 11 Apr 2016

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Last Updated: 16 Feb 2016

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