Thalassemia

Common Name(s)

Thalassemia

Thalassemia is an inherited blood disorder that occurs when the body does not make enough or makes an abnormal form of hemoglobin, an important component of red blood cells. With a lack of hemoglobin, the red blood cells are unable to function properly, meaning that there is not enough oxygen delivered to cells in the body, causing people to feel tired, weak, or short of breath (anemia). Severe anemia can lead to damage to the organs and death. There are two main types of thalassemia: alpha thalassemia and beta thalassemia. Both alpha and beta include two forms: thalassemia major and thalassemia minor. Thalassemia occurs most commonly in persons from Southeast Asia, the Mediterranean, and in those of African descent. The most severe form of alpha thalassemia major causes stillbirth. Children who are born with thalassemia major, also known as Cooley’s anemia, are normal at birth but develop severe anemia during the first year of life, and can also develop other symptoms including bone deformities in the face, fatigue, growth failure, shortness of breath, and yellow skin.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Thalassemia" for support, advocacy or research.

Cochrane Collaboration

The Cochrane Collaboration is an international network of healthcare professionals, researchers and consumers preparing, maintaining, and disseminating high quality systematic reviews of randomised control trials. This review group focuses on genetic disorders such as cystic fibrosis (CF), haemoglobinopathies, coagulopathies and inborn errors of metabolism.

Last Updated: 12 May 2015

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Cooleys Anemia Foundation, Inc.

Advancing the treatment and cure for this genetic blood disease. Enhancing the quality of life of patients. Educating the medical profession, thalassemia trait carriers and the public about thalassemia.

Last Updated: 1 Jun 2015

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werathah

To provide support and health education to patients and their families with genetic and congenital disorders

Last Updated: 1 May 2013

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Thalassemia" for support, advocacy or research.

Cochrane Collaboration

The Cochrane Collaboration is an international network of healthcare professionals, researchers and consumers preparing, maintaining, and disseminating high quality systematic reviews of randomised control trials. This review group focuses on genetic disorders such as cystic fibrosis (CF), haemoglobinopathies, coagulopathies and inborn errors of metabolism.

http://cfgd.cochrane.org

Last Updated: 12 May 2015

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Cooleys Anemia Foundation, Inc.

Advancing the treatment and cure for this genetic blood disease. Enhancing the quality of life of patients. Educating the medical profession, thalassemia trait carriers and the public about thalassemia.

http://cooleysanemia.org

Last Updated: 1 Jun 2015

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werathah

To provide support and health education to patients and their families with genetic and congenital disorders

http://www.werathah.com

Last Updated: 1 May 2013

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Thalassemia" returned 1455 free, full-text research articles on human participants. First 3 results:

The long-term efficacy and tolerability of oral deferasirox for patients with transfusion-dependent β-thalassemia in Taiwan.
 

Author(s): Hsiu-Hao Chang, Meng-Yao Lu, Steven Shinn-Forng Peng, Yung-Li Yang, Dong-Tsamn Lin, Shiann-Tarng Jou, Kai-Hsin Lin

Journal: Ann. Hematol.. 2015 Dec;94(12):1945-52.

 

Deferasirox is a novel once-daily, oral iron chelator. The aim of this study was to evaluate the long-term efficacy and tolerability of deferasirox in Taiwanese patients with transfusion-dependent β-thalassemia who have been treated with deferasirox for 7 years. Taiwanese patients ...

Last Updated: 14 Oct 2015

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Burden of Hemoglobinopathies (Thalassemia, Sickle Cell Disorders and G6PD Deficiency) in Iran, 1990-2010: findings from the Global Burden of Disease Study 2010.
 

Author(s): Nazila Rezaei, Shohreh Naderimagham, Anoosheh Ghasemian, Sahar Saeedi Moghaddam, Kimia Gohari, Saeid Zareiy, Sahar Sobhani, Mitra Modirian, Farzad Kompani

Journal: Arch Iran Med. 2015 Aug;18(8):502-7.

 

Hemoglobinopathies are known as the most common genetic disorders in Iran. The paper aims to provide global estimates of deaths and disability adjusted life years (DALYs) due to hemoglobinopathies in Iran by sex and age during 1990 to 2010 and describe the challenges due to limitations ...

Last Updated: 12 Aug 2015

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Coexistence of Malaria and Thalassemia in Malaria Endemic Areas of Thailand.
 

Author(s): Jiraporn Kuesap, W Chaijaroenkul, K Rungsihirunrat, K Pongjantharasatien, Kesara Na-Bangchang

Journal: Korean J. Parasitol.. 2015 Jun;53(3):265-70.

 

Hemoglobinopathy and malaria are commonly found worldwide particularly in malaria endemic areas. Thalassemia, the alteration of globin chain synthesis, has been reported to confer resistance against malaria. The prevalence of thalassemia was investigated in 101 malaria patients with ...

Last Updated: 16 Jul 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Thalassemia" returned 71 free, full-text review articles on human participants. First 3 results:

α-Globin as a molecular target in the treatment of β-thalassemia.
 

Author(s): Sachith Mettananda, Richard J Gibbons, Douglas R Higgs

Journal: Blood. 2015 Jun;125(24):3694-701.

 

The thalassemias, together with sickle cell anemia and its variants, are the world's most common form of inherited anemia, and in economically undeveloped countries, they still account for tens of thousands of premature deaths every year. In developed countries, treatment of thalassemia ...

Last Updated: 13 Jun 2015

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Endocrine and bone complications in β-thalassemia intermedia: current understanding and treatment.
 

Author(s): Adlette Inati, MohammadHassan A Noureldine, Anthony Mansour, Hussein A Abbas

Journal: Biomed Res Int. 2015 ;2015():813098.

 

Thalassemia intermedia (TI), also known as nontransfusion dependent thalassemia (NTDT), is a type of thalassemia where affected patients do not require lifelong regular transfusions for survival but may require occasional or even frequent transfusions in certain clinical settings ...

Last Updated: 2 Apr 2015

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Sonographic markers of fetal α-thalassemia major.
 

Author(s): Xinyan Li, Qichang Zhou, Ming Zhang, Xiaoxian Tian, Yili Zhao

Journal: J Ultrasound Med. 2015 Feb;34(2):197-206.

 

α-Thalassemia prevails in Southeast Asia, where α-thalassemia major is a lethal type. Sonography is a helpful and cost-effective screening tool for detecting α-thalassemia major fetuses. The cardiothoracic ratio, placental thickness, and middle cerebral artery peak systolic velocity ...

Last Updated: 23 Jan 2015

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Reproductive Capacity and Iron Burden in Thalassemia
 

Status: Recruiting

Condition Summary: THALASSEMIA MAJOR

 

Last Updated: 24 Nov 2015

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Detection of β Thalassemia Carriers by Red Cell Parameters Obtained From the H2 Automatic Counter
 

Status: Recruiting

Condition Summary: Thalassemia; Iron Deficiency

 

Last Updated: 30 Aug 2015

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