Tetanus

Common Name(s)

Tetanus, Lockjaw

Tetanus, also called "lockjaw", is a disease caused by a bacterial infection from Clostridium tetani which can be found in dirt, dust, or animal feces. Infection occurs from contact with the bacteria through open skin wounds. The bacteria affects muscular activity, and can cause spasms, stiffness, and other discomfort. There is a tetanus vaccine available and a booster shot that you can receive if you have a deep or dirty wound. Treatment given usually includes wound care, antibiotics, and bedrest.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Tetanus" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Tetanus" returned 920 free, full-text research articles on human participants. First 3 results:

[A rare complication of generalized tetanus: pulmonary embolism].
 

Author(s): Kais Regaieg, Mabrouk Bahloul, Rahma Gargouri, Abir Bouattour, Hèdi Chelly, Mounir Bouaziz

Journal:

 

Tetanus is a disease characterized by spastic paralysis and spasms. It is a serious pathology that requires treatment in the ICU. Mortality rate is primarily due to neurodegenerative and infectious complications. Thromboembolic complications are rare. To the best of our knowledge, ...

Last Updated: 15 Mar 2017

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[Tetanus associated with medical treatments: about a case].
 

Author(s): Savadogo Mamoudou

Journal:

 

Tetanus prophylaxis in routine wound management is a major strategy for tetanus prevention in health care settings. Failed wound management interventions leave patient dangerously exposed to this disease. We report the case of a patient with tetanus occurred after medical treatment ...

Last Updated: 15 Mar 2017

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The Introduction of Diphtheria-Tetanus-Pertussis and Oral Polio Vaccine Among Young Infants in an Urban African Community: A Natural Experiment.
 

Author(s): Søren Wengel Mogensen, Andreas Andersen, Amabelia Rodrigues, Christine S Benn, Peter Aaby

Journal: EBioMedicine. 2017 Mar;17():192-198.

 

We examined the introduction of diphtheria-tetanus-pertussis (DTP) and oral polio vaccine (OPV) in an urban community in Guinea-Bissau in the early 1980s.

Last Updated: 11 Feb 2017

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Tetanus" returned 33 free, full-text review articles on human participants. First 3 results:

Eradication of tetanus.
 

Author(s): C L Thwaites, H T Loan

Journal: Br. Med. Bull.. 2015 ;116():69-77.

 

The causative agent of tetanus, Clostridium tetani is widespread in the environment throughout the world and cannot be eradicated. To reduce the number of cases of tetanus efforts are focussed on prevention using vaccination and post-exposure wound care.

Last Updated: 15 Dec 2015

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On the translocation of botulinum and tetanus neurotoxins across the membrane of acidic intracellular compartments.
 

Author(s): Marco Pirazzini, Domenico Azarnia Tehran, Oneda Leka, Giulia Zanetti, Ornella Rossetto, Cesare Montecucco

Journal: Biochim. Biophys. Acta. 2016 Mar;1858(3):467-74.

 

Tetanus and botulinum neurotoxins are produced by anaerobic bacteria of the genus Clostridium and are the most poisonous toxins known, with 50% mouse lethal dose comprised within the range of 0.1-few nanograms per Kg, depending on the individual toxin. Botulinum neurotoxins are similarly ...

Last Updated: 3 Feb 2016

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Pharmacological management of tetanus: an evidence-based review.
 

Author(s): Chaturaka Rodrigo, Deepika Fernando, Senaka Rajapakse

Journal:

 

Tetanus is becoming rarer in both industrialized and developing nations due to an effective vaccination program. In 2010, the World Health Organization estimated there was a 93% reduction in newborns dying from tetanus worldwide, compared to the situation in the late 1980s. Due to ...

Last Updated: 21 Jul 2014

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Vaccine -diphthEria -tetaNus -Acellular pertUssis-inactivated polioviruS
 

Status: Recruiting

Condition Summary: Diphtheria; Tetanus; Pertussis; Poliomyelitis

 

Last Updated: 3 Feb 2017

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Last Updated: 20 Apr 2017

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Immunogenicity and Safety Study of GlaxoSmithKline (GSK) Biologicals' Boostrix™ Vaccine in Pregnant Women
 

Status: Recruiting

Condition Summary: Diphtheria-Tetanus-acellular Pertussis Vaccines

 

Last Updated: 27 Apr 2017

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