Tetanus

Common Name(s)

Tetanus, Lockjaw

Tetanus, also called "lockjaw", is a disease caused by a bacterial infection from Clostridium tetani which can be found in dirt, dust, or animal feces. Infection occurs from contact with the bacteria through open skin wounds. The bacteria affects muscular activity, and can cause spasms, stiffness, and other discomfort. There is a tetanus vaccine available and a booster shot that you can receive if you have a deep or dirty wound. Treatment given usually includes wound care, antibiotics, and bedrest.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Tetanus" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Tetanus" returned 999 free, full-text research articles on human participants. First 3 results:

Barriers to Receipt of Prenatal Tetanus Toxoid, Reduced Diphtheria Toxoid, and Acellular Pertussis Vaccine Among Mothers of Infants Aged <4 Months with Pertussis - California, 2016.
 

Author(s): Sarah New, Kathleen Winter, Rebeca Boyte, Kathleen Harriman, Anya Gutman, Amber Christiansen, Sarah Royce

Journal:

 

Vaccination with tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis (Tdap) vaccine is recommended for all pregnant women to protect infants who are too young for vaccination from severe pertussis-related outcomes (1-3). However, Tdap vaccine coverage among pregnant ...

Last Updated: 31 Dec 1969

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Immunogenicity and safety of the quadrivalent meningococcal vaccine MenACWY-TT co-administered with a combined diphtheria-tetanus-acellular pertussis vaccine versus their separate administration in adolescents and young adults: A phase III, randomized study.
 

Author(s): Luis Rivera, Tino F Schwarz, Kyung-Hyo Kim, Yun-Kyung Kim, Ulrich Behre, Sung-Ho Cha, Dae Sun Jo, Jacob Lee, Jin-Soo Lee, Brigitte Cheuvart, Archana Jastorff, Marie Van der Wielen

Journal: Vaccine. 2018 07;36(31):4750-4758.

 

This study evaluated the immunogenicity and safety of quadrivalent meningococcal conjugate vaccine using tetanus (T) toxoid as carrier protein (MenACWY-TT) co-administered with combined diphtheria-tetanus-acellular pertussis vaccine (Tdap) versus their separate administration in adolescents ...

Last Updated: 31 Dec 1969

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Prevention of Pertussis, Tetanus, and Diphtheria with Vaccines in the United States: Recommendations of the Advisory Committee on Immunization Practices (ACIP).
 

Author(s): Jennifer L Liang, Tejpratap Tiwari, Pedro Moro, Nancy E Messonnier, Arthur Reingold, Mark Sawyer, Thomas A Clark

Journal:

 

This report compiles and summarizes all recommendations from CDC's Advisory Committee on Immunization Practices (ACIP) regarding prevention and control of tetanus, diphtheria, and pertussis in the United States. As a comprehensive summary of previously published recommendations, this ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Tetanus" returned 42 free, full-text review articles on human participants. First 3 results:

A rare case of type 1 leprosy reactions following tetanus infection in a borderline tuberculoid leprosy patient and a literature review.
 

Author(s): Chao Shi, Zhi-Chun Jing, De-Gang Yang, Jian-Yu Zhu

Journal:

 

Type 1 leprosy reaction, also known as "reversal reaction", is related to cellular immune responses to Mycobacterium leprae antigens. The risk factors that trigger type 1 leprosy reactions are poorly understood. Leprosy with concurrent tetanus is rare, and there are no publicly available ...

Last Updated: 31 Dec 1969

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Immunization of preterm infants with GSK's hexavalent combined diphtheria-tetanus-acellular pertussis-hepatitis B-inactivated poliovirus-Haemophilus influenzae type b conjugate vaccine: A review of safety and immunogenicity.
 

Author(s): Felix Omeñaca, Liliana Vázquez, Pilar Garcia-Corbeira, Narcisa Mesaros, Linda Hanssens, Jan Dolhain, Ivonne Puente Gómez, Johannes Liese, Markus Knuf

Journal: Vaccine. 2018 02;36(7):986-996.

 

Infants with history of prematurity (<37 weeks gestation) and low birth weight (LBW, <2500 g) are at high risk of infection due to functional immaturity of normal physical and immunological defense mechanisms. Despite current recommendations that infants with history of prematurity/LBW ...

Last Updated: 31 Dec 1969

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Strategies to increase immunization coverage of tetanus vaccine among women in Sub Saharan Africa: a systematic review.
 

Author(s): Marius Zambou Vouking, Carine Nouboudem Tadenfok, Jean Marie Edengue Ekani

Journal:

 

World Health Organization (WHO) estimated in 2013 that 49,000 deaths all over the world were caused by neonatal tetanus. Only as recently as the year 2000, neonatal tetanus was a public health problem in 59 countries, but since then it has been eliminated in 36 of the countries concerned. ...

Last Updated: 31 Dec 1969

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Intrathecal Tetanus Immunoglobulin to Treat Tetanus
 

Status: Recruiting

Condition Summary: Tetanus

 

Last Updated: 8 Apr 2018

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Heterologous Effect of Diptheria, Tetanus, Acellular Pertussis Vaccination on Influenza Challenge in the Elderly
 

Status: Recruiting

Condition Summary: Heterologous Effects of Vaccines

 

Last Updated: 25 Jul 2017

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