Tetanus

Common Name(s)

Tetanus, Lockjaw

Tetanus, also called "lockjaw", is a disease caused by a bacterial infection from Clostridium tetani which can be found in dirt, dust, or animal feces. Infection occurs from contact with the bacteria through open skin wounds. The bacteria affects muscular activity, and can cause spasms, stiffness, and other discomfort. There is a tetanus vaccine available and a booster shot that you can receive if you have a deep or dirty wound. Treatment given usually includes wound care, antibiotics, and bedrest.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Tetanus" for support, advocacy or research.

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Tetanus" returned 931 free, full-text research articles on human participants. First 3 results:

Paediatric otogenic tetanus: an evidence of poor immunization in Nigeria.
 

Author(s): Segun Ayodeji Ogunkeyede, Adekunle Daniel, Omowonuola Ogundoyin

Journal:

 

Suppurative otitis media is a common childhood infection that predisposes to otogenic tetanus. Tetanus is a vaccine preventable disease that is associated with high cost of care and mortality. This study highlights reasons for otogenic tetanus in Nigerian children and way of reducing ...

Last Updated: 4 Jul 2017

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Assessment of safety and efficacy against Bordetella pertussis of a new tetanus-reduced dose diphtheria-acellular pertussis vaccine in a murine model.
 

Author(s): Hyo Jin Kwon, Seung Beom Han, Bo Ram Kim, Kyu Ri Kang, Dong Ho Huh, Gi Sub Choi, Dong Ho Ahn, Jin Han Kang

Journal:

 

Tetanus-reduced dose diphtheria-acellular pertussis (Tdap) vaccination during adolescence was introduced in response to the resurgence of pertussis in various countries. A new Tdap vaccine was manufactured in Korea as a countermeasure against a predicted Tdap vaccine shortage. This ...

Last Updated: 5 Apr 2017

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Tetanus" returned 35 free, full-text review articles on human participants. First 3 results:

Prevention of Tetanus Outbreak Following Natural Disaster in Indonesia: Lessons Learned from Previous Disasters.
 

Author(s): Dyshelly Nurkartika Pascapurnama, Aya Murakami, Haorile Chagan-Yasutan, Toshio Hattori, Hiroyuki Sasaki, Shinichi Egawa

Journal: Tohoku J. Exp. Med.. 2016 ;238(3):219-27.

 

In Indonesia, the Aceh earthquake and tsunami in 2004 killed 127,000 people and caused half a million injuries, while the Yogyakarta earthquake in 2006 caused 5,700 deaths and 37,000 injuries. Because disaster-affected areas are vulnerable to epidemic-prone diseases and tetanus is ...

Last Updated: 10 Mar 2016

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Eradication of tetanus.
 

Author(s): C L Thwaites, H T Loan

Journal: Br. Med. Bull.. 2015 ;116():69-77.

 

The causative agent of tetanus, Clostridium tetani is widespread in the environment throughout the world and cannot be eradicated. To reduce the number of cases of tetanus efforts are focussed on prevention using vaccination and post-exposure wound care.

Last Updated: 15 Dec 2015

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On the translocation of botulinum and tetanus neurotoxins across the membrane of acidic intracellular compartments.
 

Author(s): Marco Pirazzini, Domenico Azarnia Tehran, Oneda Leka, Giulia Zanetti, Ornella Rossetto, Cesare Montecucco

Journal: Biochim. Biophys. Acta. 2016 Mar;1858(3):467-74.

 

Tetanus and botulinum neurotoxins are produced by anaerobic bacteria of the genus Clostridium and are the most poisonous toxins known, with 50% mouse lethal dose comprised within the range of 0.1-few nanograms per Kg, depending on the individual toxin. Botulinum neurotoxins are similarly ...

Last Updated: 3 Feb 2016

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Vaccine -diphthEria -tetaNus -Acellular pertUssis-inactivated polioviruS
 

Status: Recruiting

Condition Summary: Diphtheria; Tetanus; Pertussis; Poliomyelitis

 

Last Updated: 3 Feb 2017

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Last Updated: 24 Jul 2017

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