Tetanus

Common Name(s)

Tetanus, Lockjaw

Tetanus, also called "lockjaw", is a disease caused by a bacterial infection from Clostridium tetani which can be found in dirt, dust, or animal feces. Infection occurs from contact with the bacteria through open skin wounds. The bacteria affects muscular activity, and can cause spasms, stiffness, and other discomfort. There is a tetanus vaccine available and a booster shot that you can receive if you have a deep or dirty wound. Treatment given usually includes wound care, antibiotics, and bedrest.

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Condition Specific Organizations

Following organizations serve the condition "Tetanus" for support, advocacy or research.

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Tetanus" returned 908 free, full-text research articles on human participants. First 3 results:

Coverage with Tetanus, Diphtheria, and Acellular Pertussis Vaccine and Influenza Vaccine Among Pregnant Women - Minnesota, March 2013-December 2014.
 

Author(s): Alexandra Barber, Miriam Halstead Muscoplat, Anna Fedorowicz

Journal:

 

Pertussis and influenza infections can result in severe disease in infants. The diphtheria, tetanus, acellular pertussis (DTaP) vaccine is recommended for infants beginning at age 2 months, and influenza vaccine is recommended for infants aged ≥6 months. Vaccination of pregnant ...

Last Updated: 19 Jan 2017

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Does vaccination ensure protection? Assessing diphtheria and tetanus antibody levels in a population of healthy children: A cross-sectional study.
 

Author(s): Ewelina Gowin, Jacek Wysocki, Ewelina Kałużna, Bogna Świątek-Kościelna, Joanna Wysocka-Leszczyńska, Michał Michalak, Danuta Januszkiewicz-Lewandowska

Journal: Medicine (Baltimore). 2016 Dec;95(49):e5571.

 

Vaccination effectiveness is proven when the disease does not develop after a patient is exposed to the pathogen. In the case of rare diseases, vaccination effectiveness is assessed by monitoring specific antibody levels in the population. Such recurrent analyses allow the evaluation ...

Last Updated: 8 Dec 2016

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Tetanus in the Elderly: The Management of Intensive Care and Prolonged Hospitalization.
 

Author(s): Hiroki Isono, Taiju Miyagami, Kohta Katayama, Momoko Isono, Ryuichi Hasegawa, Harumi Gomi, Hiroyuki Kobayashi

Journal: Intern. Med.. ;55(22):3399-3402.

 

Tetanus is a potentially fatal infection. Approximately 100 cases are reported in Japan each year; however, little is known about its clinical course and outcomes in the current era of treatment. We herein report three cases of tetanus in elderly patients who survived after mechanical ...

Last Updated: 17 Nov 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Tetanus" returned 33 free, full-text review articles on human participants. First 3 results:

Eradication of tetanus.
 

Author(s): C L Thwaites, H T Loan

Journal: Br. Med. Bull.. 2015 ;116():69-77.

 

The causative agent of tetanus, Clostridium tetani is widespread in the environment throughout the world and cannot be eradicated. To reduce the number of cases of tetanus efforts are focussed on prevention using vaccination and post-exposure wound care.

Last Updated: 15 Dec 2015

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On the translocation of botulinum and tetanus neurotoxins across the membrane of acidic intracellular compartments.
 

Author(s): Marco Pirazzini, Domenico Azarnia Tehran, Oneda Leka, Giulia Zanetti, Ornella Rossetto, Cesare Montecucco

Journal: Biochim. Biophys. Acta. 2016 Mar;1858(3):467-74.

 

Tetanus and botulinum neurotoxins are produced by anaerobic bacteria of the genus Clostridium and are the most poisonous toxins known, with 50% mouse lethal dose comprised within the range of 0.1-few nanograms per Kg, depending on the individual toxin. Botulinum neurotoxins are similarly ...

Last Updated: 3 Feb 2016

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Pharmacological management of tetanus: an evidence-based review.
 

Author(s): Chaturaka Rodrigo, Deepika Fernando, Senaka Rajapakse

Journal:

 

Tetanus is becoming rarer in both industrialized and developing nations due to an effective vaccination program. In 2010, the World Health Organization estimated there was a 93% reduction in newborns dying from tetanus worldwide, compared to the situation in the late 1980s. Due to ...

Last Updated: 21 Jul 2014

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Vaccine -diphthEria -tetaNus -Acellular pertUssis-inactivated polioviruS
 

Status: Recruiting

Condition Summary: Diphtheria; Tetanus; Pertussis; Poliomyelitis

 

Last Updated: 3 Feb 2017

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Last Updated: 21 Mar 2017

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Immunogenicity and Safety Study of GlaxoSmithKline (GSK) Biologicals' Boostrix™ Vaccine in Pregnant Women
 

Status: Recruiting

Condition Summary: Diphtheria-Tetanus-acellular Pertussis Vaccines

 

Last Updated: 21 Mar 2017

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