Tetanus

Common Name(s)

Tetanus, Lockjaw

Tetanus, also called "lockjaw", is a disease caused by a bacterial infection from Clostridium tetani which can be found in dirt, dust, or animal feces. Infection occurs from contact with the bacteria through open skin wounds. The bacteria affects muscular activity, and can cause spasms, stiffness, and other discomfort. There is a tetanus vaccine available and a booster shot that you can receive if you have a deep or dirty wound. Treatment given usually includes wound care, antibiotics, and bedrest.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Tetanus" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Tetanus" returned 951 free, full-text research articles on human participants. First 3 results:

Notes from the Field: Tetanus Cases After Voluntary Medical Male Circumcision for HIV Prevention--Eastern and Southern Africa, 2012-2015.
 

Author(s): Jonathan M Grund, Carlos Toledo, Stephanie M Davis, Renee Ridzon, Edna Moturi, Heather Scobie, Boubker Naouri, Jason B Reed, Emmanuel Njeuhmeli, Anne G Thomas, Francis Ndwiga Benson, Martin W Sirengo, Leon Ngeruka Muyenzi, Gissenge J I Lija, John H Rogers, Salli Mwanasalli, Elijah Odoyo-June, Nafuna Wamai, Geoffrey Kabuye, James Exnobert Zulu, Jane Ruth Aceng, Naomi Bock

Journal:

 

Voluntary medical male circumcision (VMMC) decreases the risk for female-to-male HIV transmission by approximately 60%, and the President's Emergency Plan for AIDS Relief (PEPFAR) is supporting the scale-up of VMMC for adolescent and adult males in countries with high prevalence of ...

Last Updated: 22 Jan 2016

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Altered Memory T-Cell Responses to Bacillus Calmette-Guerin and Tetanus Toxoid Vaccination and Altered Cytokine Responses to Polyclonal Stimulation in HIV-Exposed Uninfected Kenyan Infants.
 

Author(s): Miguel A Garcia-Knight, Eunice Nduati, Amin S Hassan, Faith Gambo, Dennis Odera, Timothy J Etyang, Nassim J Hajj, James Alexander Berkley, Britta C Urban, Sarah L Rowland-Jones

Journal:

 

Implementation of successful prevention of mother-to-child transmission of HIV strategies has resulted in an increased population of HIV-exposed uninfected (HEU) infants. HEU infants have higher rates of morbidity and mortality than HIV-unexposed (HU) infants. Numerous factors may ...

Last Updated: 17 Nov 2015

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Profile and outcome of patients with post-neonatal tetanus in a tertiary centre in south west Nigeria: any remarkable reduction in the scourge?
 

Author(s): Barakat Adeola Animasahun, Olusegun Henry Gbelee, Aminat Titilayo Ogunlana, Olisamedua Fidelis Njokanma, Olumuyiwa Odusanya

Journal:

 

The incidence of tetanus has remained unacceptably high in developing countries. We aimed to describe the profile and outcome of children with tetanus admitted at the Lagos State University Teaching Hospital (LASUTH), Ikeja.

Last Updated: 3 Nov 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Tetanus" returned 32 free, full-text review articles on human participants. First 3 results:

Pharmacological management of tetanus: an evidence-based review.
 

Author(s): Chaturaka Rodrigo, Deepika Fernando, Senaka Rajapakse

Journal:

 

Tetanus is becoming rarer in both industrialized and developing nations due to an effective vaccination program. In 2010, the World Health Organization estimated there was a 93% reduction in newborns dying from tetanus worldwide, compared to the situation in the late 1980s. Due to ...

Last Updated: 21 Jul 2014

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Prognostic factors for mortality in neonatal tetanus: a systematic review and meta-analysis.
 

Author(s): Jonathan A Lambo, Emmanuel A Anokye

Journal: Int. J. Infect. Dis.. 2013 Dec;17(12):e1100-10.

 

To determine prognostic factors for mortality in neonates with tetanus and to assess the associations between prognostic factors and neonatal tetanus (NT) mortality.

Last Updated: 2 Dec 2013

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Combined hexavalent diphtheria-tetanus-acellular pertussis-hepatitis B-inactivated poliovirus-Haemophilus influenzae type B vaccine; Infanrix™ hexa: twelve years of experience in Italy.
 

Author(s): Vincenzo Baldo, Paolo Bonanni, Marcela Castro, Giovanni Gabutti, Elisabetta Franco, Federico Marchetti, Rosa Prato, Francesco Vitale

Journal: Hum Vaccin Immunother. 2014 ;10(1):129-37.

 

Infant vaccination using 2-dose priming at 3 and 5 mo of age with a booster at 11-12 mo of age was pioneered in Italy. The 3-5-11 schedule is now used in a growing number of European countries. Infanrix™ hexa (DTPa-HBV-IPV/Hib, GlaxoSmithKline Vaccines) was first licensed for use ...

Last Updated: 16 May 2014

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Study of Tetanus Toxoid, Reduced Diphtheria Toxoid, and Acellular Pertussis Vaccine Adsorbed in Healthy Subjects
 

Status: Recruiting

Condition Summary: Tetanus; Diphtheria; Pertussis; Whooping Cough

 

Last Updated: 6 Jun 2016

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Vaccine -diphthEria -tetaNus -Acellular pertUssis-inactivated polioviruS
 

Status: Recruiting

Condition Summary: Diphtheria; Tetanus; Pertussis; Poliomyelitis

 

Last Updated: 14 Jun 2016

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Safety and Immunogenicity Study of Tetanus, Diphtheria and Acellular Pertussis (Tdap) Vaccine
 

Status: Not yet recruiting

Condition Summary: Tetanus; Diphtheria; Whooping Cough

 

Last Updated: 22 Jun 2016

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