Tetanus

Common Name(s)

Tetanus

Tetanus, also called "lockjaw", is a disease caused by a bacterial infection from Clostridium tetani which can be found in dirt, dust, or animal feces. Infection occurs from contact with the bacteria through open skin wounds. The bacteria affects muscular activity, and can cause spasms, stiffness, and other discomfort. There is a tetanus vaccine available and a booster shot that you can receive if you have a deep or dirty wound. Treatment given usually includes wound care, antibiotics, and bedrest.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Tetanus" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Tetanus" returned 750 free, full-text research articles on human participants. First 3 results:

Vaccination with tetanus, diphtheria, and acellular pertussis vaccine of pregnant women enrolled in Medicaid--Michigan, 2011-2013.
 

Author(s): Michelle Housey, Fan Zhang, Corinne Miller, Sarah Lyon-Callo, Jevon McFadden, Erika Garcia, Rachel Potter,

Journal: MMWR Morb. Mortal. Wkly. Rep.. 2014 Sep;63(38):839-42.

 

In October 2011, the Advisory Committee on Immunization Practices (ACIP) first recommended the routine administration of a tetanus, diphtheria, and acellular pertussis vaccine (Tdap) during pregnancy as a strategy to protect infants from pertussis (also known as whooping cough). This ...

Last Updated: 26 Sep 2014

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Tetanus in Poland in 2012.
 

Author(s): Andrzej Zieliński

Journal: Przegl Epidemiol. 2014 ;68(2):271-3, 373-4.

 

Despite of the small number of cases reported in Poland tetanus is a permanent risk to unvaccinated people. The severity of the disease is associated with high case fatality, especially among people in older age groups.

Last Updated: 19 Aug 2014

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The majority of human memory B cells recognizing RhD and tetanus resides in IgM+ B cells.
 

Author(s): Luciana Della Valle, Serge E Dohmen, Onno J H M Verhagen, Magdalena A Berkowska, Gestur Vidarsson, C Ellen van der Schoot

Journal: J. Immunol.. 2014 Aug;193(3):1071-9.

 

B cell memory to T cell-dependent (TD) Ags are considered to largely reside in class-switched CD27(+) cells. However, we previously observed that anti-RhD (D) Igs cloned from two donors, hyperimmunized with D(+) erythrocytes, were predominantly of the IgM isotype. We therefore analyzed ...

Last Updated: 22 Jul 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Tetanus" returned 28 free, full-text review articles on human participants. First 3 results:

Prognostic factors for mortality in neonatal tetanus: a systematic review and meta-analysis.
 

Author(s): Jonathan A Lambo, Emmanuel A Anokye

Journal: Int. J. Infect. Dis.. 2013 Dec;17(12):e1100-10.

 

To determine prognostic factors for mortality in neonates with tetanus and to assess the associations between prognostic factors and neonatal tetanus (NT) mortality.

Last Updated: 2 Dec 2013

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Interventions to reduce neonatal mortality from neonatal tetanus in low and middle income countries--a systematic review.
 

Author(s): Adeel Ahmed Khan, Aysha Zahidie, Fauziah Rabbani

Journal:

 

In 1988, WHO estimated around 787,000 newborns deaths due to neonatal tetanus. Despite few success stories majority of the Low and Middle Income Countries (LMICs) are still struggling to reduce neonatal mortality due to neonatal tetanus. We conducted a systematic review to understand ...

Last Updated: 29 Apr 2013

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Tetanus: pathophysiology, treatment, and the possibility of using botulinum toxin against tetanus-induced rigidity and spasms.
 

Author(s): Bjørnar Hassel

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Tetanus toxin, the product of Clostridium tetani, is the cause of tetanus symptoms. Tetanus toxin is taken up into terminals of lower motor neurons and transported axonally to the spinal cord and/or brainstem. Here the toxin moves trans-synaptically into inhibitory nerve terminals, ...

Last Updated: 9 Jan 2013

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Post Marketing Surveillance for ADACEL™ in South Korea
 

Status: Recruiting

Condition Summary: Diphtheria; Tetanus; Pertussis

 

Last Updated: 23 Jul 2014

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Regulatory Post-Marketing Surveillance Study for TETRAXIM™
 

Status: Recruiting

Condition Summary: Diphtheria; Tetanus; Pertussis; Poliomyelitis

 

Last Updated: 20 Aug 2014

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Post-marketing Surveillance to Assess the Safety of Infanrix-IPV Vaccine Among Infants and Children in Korea
 

Status: Recruiting

Condition Summary: Acellular Pertussis; Diphtheria; Tetanus; Poliomyelitis

 

Last Updated: 6 Nov 2014

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