Tetanus

Common Name(s)

Tetanus, Lockjaw

Tetanus, also called "lockjaw", is a disease caused by a bacterial infection from Clostridium tetani which can be found in dirt, dust, or animal feces. Infection occurs from contact with the bacteria through open skin wounds. The bacteria affects muscular activity, and can cause spasms, stiffness, and other discomfort. There is a tetanus vaccine available and a booster shot that you can receive if you have a deep or dirty wound. Treatment given usually includes wound care, antibiotics, and bedrest.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Tetanus" for support, advocacy or research.

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Tetanus" returned 993 free, full-text research articles on human participants. First 3 results:

Prevention of Pertussis, Tetanus, and Diphtheria with Vaccines in the United States: Recommendations of the Advisory Committee on Immunization Practices (ACIP).
 

Author(s): Jennifer L Liang, Tejpratap Tiwari, Pedro Moro, Nancy E Messonnier, Arthur Reingold, Mark Sawyer, Thomas A Clark

Journal:

 

This report compiles and summarizes all recommendations from CDC's Advisory Committee on Immunization Practices (ACIP) regarding prevention and control of tetanus, diphtheria, and pertussis in the United States. As a comprehensive summary of previously published recommendations, this ...

Last Updated: 31 Dec 1969

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Immunogenicity and safety of the quadrivalent meningococcal ACWY-tetanus toxoid conjugate vaccine (MenACWY-TT) in splenectomized or hyposplenic children and adolescents: Results of a phase III, open, non-randomized study.
 

Author(s): Nicola P Klein, Tomas Habanec, Pavel Kosina, Nirmish R Shah, Devayani Kolhe, Jacqueline M Miller, Marjan Hezareh, Marie Van der Wielen

Journal: Vaccine. 2018 04;36(17):2356-2363.

 

Individuals with functional or anatomic asplenia are at high risk for meningococcal disease. We evaluated the immunogenicity and safety of 1 and 2 doses of the quadrivalent meningococcal serogroups A, C, W, Y tetanus toxoid-conjugate vaccine (MenACWY-TT) in this high-risk population.

Last Updated: 31 Dec 1969

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A phase III, open-label, randomised multicentre study to evaluate the immunogenicity and safety of a booster dose of two different reduced antigen diphtheria-tetanus-acellular pertussis-polio vaccines, when co-administered with measles-mumps-rubella vaccine in 3 and 4-year-old healthy children in the UK.
 

Author(s): Robin Marlow, Sherine Kuriyakose, Narcisa Mesaros, Htay Htay Han, Richard Tomlinson, Saul N Faust, Matthew D Snape, Andrew J Pollard, Adam Finn

Journal: Vaccine. 2018 04;36(17):2300-2306.

 

To evaluate the immunogenicity and safety of a reduced antigen diphtheria-tetanus-acellular pertussis-inactivated poliovirus (dTap-IPV) vaccine (Boostrix-IPV, GSK) as a pre-school booster in 3-4 year old children as compared to dTap-IPV (Repevax, Sanofi Pasteur), when co-administered ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Tetanus" returned 41 free, full-text review articles on human participants. First 3 results:

Immunization of preterm infants with GSK's hexavalent combined diphtheria-tetanus-acellular pertussis-hepatitis B-inactivated poliovirus-Haemophilus influenzae type b conjugate vaccine: A review of safety and immunogenicity.
 

Author(s): Felix Omeñaca, Liliana Vázquez, Pilar Garcia-Corbeira, Narcisa Mesaros, Linda Hanssens, Jan Dolhain, Ivonne Puente Gómez, Johannes Liese, Markus Knuf

Journal: Vaccine. 2018 02;36(7):986-996.

 

Infants with history of prematurity (<37 weeks gestation) and low birth weight (LBW, <2500 g) are at high risk of infection due to functional immaturity of normal physical and immunological defense mechanisms. Despite current recommendations that infants with history of prematurity/LBW ...

Last Updated: 31 Dec 1969

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Strategies to increase immunization coverage of tetanus vaccine among women in Sub Saharan Africa: a systematic review.
 

Author(s): Marius Zambou Vouking, Carine Nouboudem Tadenfok, Jean Marie Edengue Ekani

Journal:

 

World Health Organization (WHO) estimated in 2013 that 49,000 deaths all over the world were caused by neonatal tetanus. Only as recently as the year 2000, neonatal tetanus was a public health problem in 59 countries, but since then it has been eliminated in 36 of the countries concerned. ...

Last Updated: 31 Dec 1969

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Progress towards achieving and maintaining maternal and neonatal tetanus elimination in the African region.
 

Author(s): Alison Delano Ridpath, Heather Melissa Scobie, Messeret Eshetu Shibeshi, Ahmadu Yakubu, Flint Zulu, Azhar Abid Raza, Balcha Masresha, Rania Tohme

Journal:

 

Despite the availability of effective tetanus prevention strategies, as of 2016, Maternal and Neonatal Tetanus Elimination (MNTE) has not yet been achieved in 18 countries globally. In this paper, we review the status of MNTE in the World Health Organization African Region (AFR),and ...

Last Updated: 31 Dec 1969

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Intrathecal Tetanus Immunoglobulin to Treat Tetanus
 

Status: Recruiting

Condition Summary: Tetanus

 

Last Updated: 8 Apr 2018

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Heterologous Effect of Diptheria, Tetanus, Acellular Pertussis Vaccination on Influenza Challenge in the Elderly
 

Status: Recruiting

Condition Summary: Heterologous Effects of Vaccines

 

Last Updated: 25 Jul 2017

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