B-Cell Lymphomas

Common Name(s)

B-Cell Lymphomas

Lymphoma is the most common blood cancer. Lymphocytes are a type of white blood cell that are part of our body’s immune system and help our body fight infections. Lymphoma occurs when these lymphocytes grow and multiply uncontrollably. The body has two main types of lymphocytes, B-lymphocytes (B-cells) and T-lymphocytes (T-cells). B-cell lymphoma occurs when the B-cells in particular grow into lymphomas. The cancerous lymphocyte cells can then travel to various parts of the body including the lymph nodes, blood, spleen, bone marrow and other organs. There are many different types of B-cell lymphomas and the most common type is called diffuse large b-cell lymphoma (DLBCL) which is aggressive (fast-growing) and requires immediate treatment. There are other forms that are slow-growing and respond well to treatment and can go into remission for many years. Genetic factors as well as environmental factors, weak immune system (immunodeficiency due to an organ transplant or HIV/AIDS), drug and chemical exposures, viruses and other unknown factors are thought to play a role in the development of lymphoma.

Symptoms are variable but can include: swollen lymph glands, fevers, night sweats, fatigue, unexplained weight loss, pain or abdominal bloating, chest pain, cough, difficulty breathing. Diagnosis may include physical exam of the lymph nodes, spleen and liver, blood tests, x-rays, scans, and finally a biopsy from lymph tissue. The treatment and prognosis or outlook depends upon the specific type of B-cell lymphoma and other factors present but often includes radiation, chemotherapy and medications. Speak with your physician for the most current treatment options. Support groups are also a great resource for support and information and can help connect you to other individuals with B-cell lymphoma.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "B-Cell Lymphomas" for support, advocacy or research.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "B-Cell Lymphomas" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "B-Cell Lymphomas" returned 520 free, full-text research articles on human participants. First 3 results:

TOX expression in cutaneous B-cell lymphomas.
 

Author(s): Anne M R Schrader, Patty M Jansen, Rein Willemze

Journal: Arch. Dermatol. Res.. 2016 Aug;308(6):423-7.

 

Thymocyte selection-associated high-mobility group box (TOX) is aberrantly expressed in cutaneous T-cell lymphomas. In a recent study, TOX expression was noted unexpectedly in the follicle center (germinal center) B-cells of reactive lymph nodes and tonsils, used as external controls. ...

Last Updated: 12 Jul 2016

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Mutational status of EZH2 and CD79B hot spots in mature B-cell non-Hodgkin's lymphomas: novel CD79B variations have been revealed.
 

Author(s): G O Cetin, I C Baris, V Caner, B Sarikepe, N Sen Turk, E Tepeli, S Hacioglu, I Sari, G Bagci, A Keskin

Journal: Eur Rev Med Pharmacol Sci. 2016 Mar;20(5):830-6.

 

We aimed to determine the hot spot mutational frequencies of Enhancer of Zeste homolog 2 (EZH2) and cluster of differentiation 79B (CD79B) genes in a cohort of mature B-cell non-Hodgkin's lymphomas.

Last Updated: 25 Mar 2016

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C-MYC and BCL2 translocation frequency in diffuse large B-cell lymphomas: A study of 97 patients.
 

Author(s): Bahar Akkaya, Ozan Salim, Hampar Akkaya, Mualla Ozcan, Orhan Kemal Yucel, Ramazan Erdem, Utku Iltar, Levent Undar

Journal: Indian J Pathol Microbiol. ;59(1):41-6.

 

Diffuse large B-cell lymphoma (DLBCL) is an aggressive non-Hodgkin lymphoma with marked biologic heterogeneity. MYC and BCL2 rearrangements have been reported in a proportion of DLBCLs, where they may be associated with an adverse clinical outcome. The aim of this study was to determine ...

Last Updated: 10 Mar 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "B-Cell Lymphomas" returned 41 free, full-text review articles on human participants. First 3 results:

Cutaneous primary B-cell lymphomas: from diagnosis to treatment.
 

Author(s): Margarida Lima

Journal: An Bras Dermatol. ;90(5):687-706.

 

Primary cutaneous B-cell lymphomas are a heterogeneous group of mature B-cells neoplasms with tropism for the skin, whose biology and clinical course differ significantly from the equivalent nodal lymphomas. The most indolent forms comprise the primary cutaneous marginal zone and ...

Last Updated: 12 Nov 2015

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Mutation of chromatin modifiers; an emerging hallmark of germinal center B-cell lymphomas.
 

Author(s): M A Lunning, M R Green

Journal:

 

Subtypes of non-Hodgkin's lymphomas align with different stages of B-cell development. Germinal center B-cell (GCB)-like diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL) and Burkitt's lymphoma (BL) each share molecular similarities with normal GCB cells. Recent next-generation ...

Last Updated: 17 Oct 2015

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The many faces of small B cell lymphomas with plasmacytic differentiation and the contribution of MYD88 testing.
 

Author(s): Steven H Swerdlow, Isinsu Kuzu, Ahmet Dogan, Stephan Dirnhofer, John K C Chan, Birgitta Sander, German Ott, Luc Xerri, Leticia Quintanilla-Martinez, Elias Campo

Journal: Virchows Arch.. 2016 Mar;468(3):259-75.

 

Plasmacytic differentiation may occur in almost all small B cell lymphomas (SBLs), although it varies from being uniformly present (as in lymphoplasmacytic lymphoma (LPL)) to very uncommon (as in mantle cell lymphomas (MCLs)). The discovery of MYD88 L265P mutations in the vast majority ...

Last Updated: 29 Mar 2016

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Bruton's Tyrosine Kinase (BTK) Inhibition in B-cell Lymphomas
 

Status: Recruiting

Condition Summary: B-cell Lymphoma

 

Last Updated: 8 Mar 2017

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A Study Evaluating CPI-1205 in Patients With B-Cell Lymphomas
 

Status: Recruiting

Condition Summary: B-Cell Lymphoma

 

Last Updated: 22 Nov 2016

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Last Updated: 16 Oct 2014

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