Tardive dyskinesia

Common Name(s)

Tardive dyskinesia, Oral facial dyskinesia

Tardive dyskinesia is a debilitating motor disorder manifest as hyperkinetic, involuntary, repetitive movements predominantly of the orofacial region. It is a complication of treatment with so-called typical antipsychotic or neuroleptic agents, such as chlorpromazine or haloperidol, and is estimated to occur in 20 to 30% of chronic schizophrenics on long-term treatment ({3:Thelma et al., 2008}).
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Tardive dyskinesia" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Tardive dyskinesia" returned 101 free, full-text research articles on human participants. First 3 results:

Gray matter abnormalities in schizophrenia patients with tardive dyskinesia: a magnetic resonance imaging voxel-based morphometry study.
 

Author(s): Cheng-Ta Li, Kun-Hsien Chou, Tung-Ping Su, Chu-Chung Huang, Mu-Hong Chen, Ya-Mei Bai, Ching-Po Lin

Journal:

 

The pathophysiological mechanism of TD remains unknown. All previous studies, using the region-of-interest method, focused on basal ganglion areas, were with inconsistent results. This whole-brain voxel-based morphometry (VBM) study investigate the grey matter abnormality of TD and ...

Last Updated: 22 Aug 2013

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Conservative approach to tardive dyskinesia-induced neck and upper back pain.
 

Author(s): Jeremy W Reifsnyder, Melicien A Tettambel

Journal: J Am Osteopath Assoc. 2013 Aug;113(8):636-9.

 

The management of schizophrenia typically involves the use of antipsychotics (neuroleptics). Use of such medications, however, can result in tardive dyskinesia, or the involuntary contracture of muscles, and associated symptomatic somatic dysfunction. The authors present a case of ...

Last Updated: 6 Aug 2013

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Tardive dyskinesia in schizophrenia.
 

Author(s): Peter F Liddle

Journal: Br J Psychiatry. 2013 Jul;203(1):6-7.

 

Sarró et al report grey matter deficits associated with tardive dyskinesia in schizophrenia. Much evidence suggests that the intrinsic pathophysiology of schizophrenia contributes to predisposition to tardive dyskinesia. The possibility that antipsychotics might play a causal role ...

Last Updated: 2 Jul 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Tardive dyskinesia" returned 11 free, full-text review articles on human participants. First 3 results:

New and emerging treatments for symptomatic tardive dyskinesia.
 

Author(s): Abdul Qayyum Rana, Zishan M Chaudry, Pierre J Blanchet

Journal:

 

The aim of this review is to assess new, emerging, and experimental treatment options for tardive dyskinesia (TD). The methods to obtain relevant studies for review included a MEDLINE search and a review of studies in English, along with checking reference lists of articles. The leading ...

Last Updated: 15 Nov 2013

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Globus pallidus interna deep brain stimulation for tardive dyskinesia: case report and review of the literature.
 

Author(s): Meredith A Spindler, Nicholas B Galifianakis, Jayne R Wilkinson, John E Duda

Journal: Parkinsonism Relat. Disord.. 2013 Feb;19(2):141-7.

 

Tardive dyskinesia (TD) can be a disabling condition and is frequently refractory to medical therapy. Over the past decade there have been many reports of TD patients experiencing significant benefit with deep brain stimulation (DBS) of the globus pallidus interna (GPi). The growing ...

Last Updated: 12 Feb 2013

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Relevance of animal models to human tardive dyskinesia.
 

Author(s): Pierre J Blanchet, Marie-Thérèse Parent, Pierre H Rompré, Daniel Lévesque

Journal:

 

Tardive dyskinesia remains an elusive and significant clinical entity that can possibly be understood via experimentation with animal models. We conducted a literature review on tardive dyskinesia modeling. Subchronic antipsychotic drug exposure is a standard approach to model tardive ...

Last Updated: 30 Apr 2012

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Efficacy of Docosahexaenoic Acid on Tardive Dyskinesia
 

Status: Recruiting

Condition Summary: Tardive Dyskinesia

 

Last Updated: 21 Feb 2008

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D-Serine Treatment For Tardive Dyskinesia
 

Status: Recruiting

Condition Summary: Schizophrenia and Schizoaffective Disorder; Tardive Dyskinesia

 

Last Updated: 19 Aug 2014

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Reducing Involuntary Movements in Tardive Dyskinesia
 

Status: Not yet recruiting

Condition Summary: Tardive Dyskinesia

 

Last Updated: 22 Jul 2014

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