Takayasu arteritis

Common Name(s)

Takayasu arteritis, Takayasu's arteritis, TAK, Pulseless disease, Aortic arch syndrome

Takayasu’s arteritis is a rare form of blood vessel inflammation (vasculitis) that typically affects the large artery that carries blood from your heart to the rest of your body (the aorta), as well as the artery that carries blood from the heart to the lungs (pulmonary artery). Signs and symptoms of Takayasu’s arteritis often occur in two stages. The first stage (systemic stage) may include symptoms such general fatigue, fever, headache, fast and unintentional weight loss, joint pain and sore muscles. The second stage (occlusive stage) develops when inflammation causes the affected arteries to narrow. This narrowing can cause a decrease in blood flow along with a decrease in the amount of oxygen and nutrients that can reach tissues and organs. Symptoms of the second stage can include dizziness, visual problems, shortness of breath, chest or abdominal pain, weakness, change in limb color, fainting, stroke, seizure, or high blood pressure. Symptoms depend on which arteries are inflamed.

The exact cause of Takayasu’s arteritis is not known. The inflamed arteries are believed to be caused by an autoimmune disease, which means the body’s immune cells attack the tissue in the arteries, mistaking it for something foreign (from outside the body). To diagnose the condition, a doctor will collect a medical history, conduct a physical exam, perform blood tests and collect images of the heart, chest and arteries. In some cases, Takayasu’s arteritis can be managed by medication. However, if it becomes severe enough, surgery may be necessary. If you are diagnosed with Takayasu’s arteritis, talk with your doctor to discuss the right treatment plan for you.

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Condition Specific Organizations

Following organizations serve the condition "Takayasu arteritis" for support, advocacy or research.

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Takayasu arteritis" returned 186 free, full-text research articles on human participants. First 3 results:

Takayasu arteritis associated with severe renovascular hypertension.
 

Author(s): Mohamed Hassani

Journal: Saudi J Kidney Dis Transpl. 2016 Mar;27(2):402-6.

 

Takayasu arteritis (TA) is an inflammatory process frequently associated with stenosis and obliteration of the aorta and its primary branches. We report a 16-year-old girl in whom TA manifested mainly with a sudden decrease in visual acuity and severe arterial hypertension in both ...

Last Updated: 21 Mar 2016

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Vessel Wall Inflammation of Takayasu Arteritis Detected by Contrast-Enhanced Magnetic Resonance Imaging: Association with Disease Distribution and Activity.
 

Author(s): Yoko Kato, Masahiro Terashima, Hirokazu Ohigashi, Daisuke Tezuka, Takashi Ashikaga, Kenzo Hirao, Mitsuaki Isobe

Journal:

 

The assessment of the distribution and activity of vessel wall inflammation is clinically important in patients with Takayasu arteritis. Magnetic resonance imaging (MRI) is a useful tool, but the clinical utility of late gadolinium enhancement (LGE) in Takayasu arteritis has yet to ...

Last Updated: 1 Jan 2016

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Takayasu Arteritis With Antiphosphatidylserine/Prothrombin Antibody-Positive Antiphospholipid Syndrome: Case Report and Literature Review.
 

Author(s): Shoichi Fukui, Shogo Hirota, Naoki Iwamoto, Hiroki Karata, Atsushi Kawakami

Journal: Medicine (Baltimore). 2015 Dec;94(51):e2345.

 

A relationship between Takayasu arteritis (TA) and positive antiphospholipid antibody states has been pointed out, but patients with TA complicated with antiphospholipid antibody syndrome (APS) are rare. Here we report the case of a 17-year-old Japanese man diagnosed with TA based ...

Last Updated: 25 Dec 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Takayasu arteritis" returned 14 free, full-text review articles on human participants. First 3 results:

Aortic rupture during aortoplasty in Takayasu arteritis--a rare complication: case report and review of literature.
 

Author(s): Vimal Mehta, Bhagya Narayan Pandit, Jamal Yusuf, Saibal Mukhopadhyay, Jagdeep Yadav, Vijay Trehan, Sanjay Tyagi

Journal: Indian Heart J. ;66(3):350-4.

 

Balloon angioplasty of the stenosed aorta is usually a relatively simple, yet potentially a catastrophic procedure. Aortic rupture during aortoplasty, though uncommon, carries a high mortality. We report case of a 39-year-old female with aortoarteritis with multiple arterial stenoses ...

Last Updated: 30 Jun 2014

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Management of Takayasu arteritis: a systematic review.
 

Author(s): Gokhan Keser, Haner Direskeneli, Kenan Aksu

Journal: Rheumatology (Oxford). 2014 May;53(5):793-801.

 

Assessment of the pattern and extent of arterial involvement and measurement of current disease activity are essential for the management of Takayasu arteritis (TA). Since there is no completed, placebo-controlled, randomized clinical trial, the level of evidence for management of ...

Last Updated: 17 Apr 2014

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Takayasu arteritis in a 4-year-old girl: case report and brief overview of the pediatric literature.
 

Author(s): Ebru Aypar, Ash Celebi-Tayfur, Melike Keser, Dursun Odabaş, Fatih Ozaltin, Yahya Paksoy, Seza Ozen

Journal: Turk. J. Pediatr.. ;54(5):536-9.

 

Takayasu arteritis (TA) is a large vessel vasculitis that involves the aorta, its major branches and pulmonary arteries. Diagnosis of TA during childhood remains challenging due to the non-specific symptoms. We report a four-year-old girl presenting with fever, fatigue, weight loss, ...

Last Updated: 22 Feb 2013

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Efficacy and Tolerance of Tocilizumab In Takayasu Arteritis
 

Status: Not yet recruiting

Condition Summary: TAKAYASU ARTERITIS

 

Last Updated: 27 Mar 2014

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Determining Disease Activity Biomarkers in Individuals With Takayasu's Arteritis
 

Status: Recruiting

Condition Summary: Takayasu's Arteritis

 

Last Updated: 10 May 2016

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Clinical Study of Anti-tumor Necrosis Factor Therapy in Patients With Takayasu Arteritis
 

Status: Recruiting

Condition Summary: Takayasu's Arteritis

 

Last Updated: 26 May 2015

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