Takayasu arteritis

Common Name(s)

Takayasu arteritis, Takayasu's arteritis, TAK, Pulseless disease, Aortic arch syndrome

Takayasu’s arteritis is a rare form of blood vessel inflammation (vasculitis) that typically affects the large artery that carries blood from your heart to the rest of your body (the aorta), as well as the artery that carries blood from the heart to the lungs (pulmonary artery). Signs and symptoms of Takayasu’s arteritis often occur in two stages. The first stage (systemic stage) may include symptoms such general fatigue, fever, headache, fast and unintentional weight loss, joint pain and sore muscles. The second stage (occlusive stage) develops when inflammation causes the affected arteries to narrow. This narrowing can cause a decrease in blood flow along with a decrease in the amount of oxygen and nutrients that can reach tissues and organs. Symptoms of the second stage can include dizziness, visual problems, shortness of breath, chest or abdominal pain, weakness, change in limb color, fainting, stroke, seizure, or high blood pressure. Symptoms depend on which arteries are inflamed.

The exact cause of Takayasu’s arteritis is not known. The inflamed arteries are believed to be caused by an autoimmune disease, which means the body’s immune cells attack the tissue in the arteries, mistaking it for something foreign (from outside the body). To diagnose the condition, a doctor will collect a medical history, conduct a physical exam, perform blood tests and collect images of the heart, chest and arteries. In some cases, Takayasu’s arteritis can be managed by medication. However, if it becomes severe enough, surgery may be necessary. If you are diagnosed with Takayasu’s arteritis, talk with your doctor to discuss the right treatment plan for you.

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Condition Specific Organizations

Following organizations serve the condition "Takayasu arteritis" for support, advocacy or research.

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Takayasu arteritis" returned 140 free, full-text research articles on human participants. First 3 results:

Successful treatment of a huge thrombus with thrombolytic therapy in a patient with normal left ventricle function and Takayasu arteritis.
 

Author(s): Taner Şeker, Ahmet Oytun Baykan, Abdurrezzak Börekçi, Mustafa Gür, Murat Çaylı

Journal: Turk Kardiyol Dern Ars. 2014 Dec;42(8):763-6.

 

We report a case of thrombus treated with thrombolytic therapy in a patient with normal cardiac functions and Takayasu arteritis. A 27-year-old man with a history of Takayasu arteritis was admitted to our out-patient clinic with a complaint of both right and left foot pain and weakness. ...

Last Updated: 27 Jan 2015

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[Aseptic necrosis of the femoral head in a patient with Takayasu arteritis].
 

Author(s): Hanen Loukil, Faten Frikha, Mouna Snoussi, Raida Ben Salah, Zouhir Bahloul

Journal:

 

Last Updated: 24 Nov 2014

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[Susceptibility HLA alleles and amino acids to Takayasu arteritis].
 

Author(s): Chikashi Terao, Hajime Yoshifuji, Tsuneyo Mimori, Fumihiko Matsuda

Journal: Nihon Rinsho Meneki Gakkai Kaishi. 2014 ;37(3):166-70.

 

Takayasu arteritis (TAK) is a systemic vasculitis affecting aorta and its large branches which were firstly reported from Japan. TAK develops mainly in young females and the number of patients with TAK in Japan is estimated about 6,000 to 10,000. This low prevalence has made genetic ...

Last Updated: 30 Jun 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Takayasu arteritis" returned 12 free, full-text review articles on human participants. First 3 results:

Takayasu arteritis in a 4-year-old girl: case report and brief overview of the pediatric literature.
 

Author(s): Ebru Aypar, Ash Celebi-Tayfur, Melike Keser, Dursun Odabaş, Fatih Ozaltin, Yahya Paksoy, Seza Ozen

Journal: Turk. J. Pediatr.. ;54(5):536-9.

 

Takayasu arteritis (TA) is a large vessel vasculitis that involves the aorta, its major branches and pulmonary arteries. Diagnosis of TA during childhood remains challenging due to the non-specific symptoms. We report a four-year-old girl presenting with fever, fatigue, weight loss, ...

Last Updated: 22 Feb 2013

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Takayasu arteritis as a cause of arterial hypertension. Case report and literature review.
 

Author(s): Elżbieta Sadurska, Renata Jawniak, Marek Majewski, Elżbieta Czekajska-Chehab

Journal: Eur. J. Pediatr.. 2012 May;171(5):863-9.

 

We report a 16-year-old girl in whom Takayasu arteritis (TA) was manifested mainly by severe arterial hypertension on her right arm, which was detected during a routine examination at school. Her systolic blood pressure on the right arm was significantly higher than that on the left ...

Last Updated: 1 Jun 2012

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Takayasu arteritis with intracranial involvement mimicking epilepsy: case report and review of the literature.
 

Author(s): Zahit Bolaman, Irfan Yavasoglu, Gurhan Kadikoylu, Mustafa Unubol, Kutsi Koseoglu, Ali Akyol

Journal: Intern. Med.. 2011 ;50(12):1345-8.

 

The symptoms of Takayasu arteritis (TA) are related to end organ ischemia. Here we present a patient with convulsions and intracranial involvement. A 15-year-old young woman was admitted with the complaint of convulsions since one and a half months previously. Her physical examination ...

Last Updated: 15 Jun 2011

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Efficacy and Tolerance of Tocilizumab In Takayasu Arteritis
 

Status: Not yet recruiting

Condition Summary: TAKAYASU ARTERITIS

 

Last Updated: 27 Mar 2014

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Determining Disease Activity Biomarkers in Individuals With Takayasu's Arteritis
 

Status: Recruiting

Condition Summary: Takayasu's Arteritis

 

Last Updated: 13 Feb 2015

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Clinical Study of Anti-tumor Necrosis Factor Therapy in Patients With Takayasu Arteritis
 

Status: Recruiting

Condition Summary: Takayasu's Arteritis

 

Last Updated: 26 May 2015

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