T cell immunodeficiency primary

Common Name(s)

T cell immunodeficiency primary

Description for this condition is not yet available.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "T cell immunodeficiency primary" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "T cell immunodeficiency primary" returned 45 free, full-text research articles on human participants. First 3 results:

T-cell activation discriminates subclasses of symptomatic primary humoral immunodeficiency diseases in adults.
 

Author(s): Marie-Quitterie Picat, Rodolphe Thiébaut, François Lifermann, Xavier Delbrel, Daniel Adoue, Linda Wittkop, Anne-Laure Fauchais, Patrick Rispal, Jean-François Moreau, Jean-François Viallard

Journal:

 

Symptomatic Primary Humoral Immunodeficiency Diseases (PHID) constitute a highly heterogeneous group of diseases characterized by a shared hypogammaglobulinemia, resulting in increased risk of recurrent or severe infections. Associations have been described with a variety of immunological ...

Last Updated: 25 Mar 2014

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The impact of viral evolution and frequency of variant epitopes on primary and memory human immunodeficiency virus type 1-specific CD8⁺ T cell responses.
 

Author(s): Nada M Melhem, Kellie N Smith, Xiao-Li Huang, Bonnie A Colleton, Weimin Jiang, Robbie B Mailliard, James I Mullins, Charles R Rinaldo

Journal: Virology. 2014 Feb;450-451():34-48.

 

It is unclear if HIV-1 variants lose the ability to prime naïve CD8(+) cytotoxic T lymphocytes (CTL) during progressive, untreated infection. We conducted a comprehensive longitudinal analysis of viral evolution and its impact on primary and memory CD8(+) T cell responses pre-seroconversion ...

Last Updated: 7 Feb 2014

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MST1 mutations in autosomal recessive primary immunodeficiency characterized by defective naive T-cell survival.
 

Author(s): Nadine T Nehme, Jana Pachlopnik Schmid, Franck Debeurme, Isabelle André-Schmutz, Annick Lim, Patrick Nitschke, Frédéric Rieux-Laucat, Patrick Lutz, Capucine Picard, Nizar Mahlaoui, Alain Fischer, Geneviève de Saint Basile

Journal: Blood. 2012 Apr;119(15):3458-68.

 

The molecular mechanisms that underlie T-cell quiescence are poorly understood. In the present study, we report a primary immunodeficiency phenotype associated with MST1 deficiency and primarily characterized by a progressive loss of naive T cells. The in vivo consequences include ...

Last Updated: 13 Apr 2012

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "T cell immunodeficiency primary" returned 2 free, full-text review articles on human participants. First 3 results:

Loss of MAGT1 abrogates the Mg2+ flux required for T cell signaling and leads to a novel human primary immunodeficiency.
 

Author(s): Feng-Yen Li, Michael J Lenardo, Benjamin Chaigne-Delalande

Journal: Magnes Res. 2011 Sep;24(3):S109-14.

 

Although Mg(2+) has a well-recognized role as an essential cofactor for all ATP-binding enzymes, its role as a signaling ion, like Ca(2+), has been controversial. A requirement for Mg(2+)for optimal T lymphocyte stimulation was demonstrated more than 30 years ago, but the mechanism ...

Last Updated: 19 Oct 2011

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Breakdown of T cell tolerance and autoimmunity in primary immunodeficiency--lessons learned from monogenic disorders in mice and men.
 

Author(s): Lisa S Westerberg, Christoph Klein, Scott B Snapper

Journal: Curr. Opin. Immunol.. 2008 Dec;20(6):646-54.

 

A key feature of the immune system is the capacity to monitor and control infections from non-self pathogens while maintaining tolerance to self-antigens. Primary immunodeficiencies (PID) are characterized by an increased susceptibility to infections, often associated with aberrant ...

Last Updated: 28 Nov 2008

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Safety Study of Gene Modified Donor T Cell Infusion After Stem Cell Transplant for Non-Malignant Diseases
 

Status: Recruiting

Condition Summary: Primary Immune Deficiency Disorders; Hemophagocytic Lymphohistiocytosis; Inherited Bone Marrow Failure Syndrome; Hemoglobinopathies; Metabolic Disorders

 

Last Updated: 10 Feb 2015

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Multivirus-specific Cytotoxic T Lymphocytes (mCTL)
 

Status: Recruiting

Condition Summary: Refractory Viral Infections

 

Last Updated: 27 Jul 2015

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Screening Protocol for Genetic Diseases of Lymphocyte Homeostasis and Programmed Cell Death
 

Status: Recruiting

Condition Summary: Primary Immune Deficiency

 

Last Updated: 19 May 2015

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