Synovial sarcoma

Common Name(s)

Synovial sarcoma

Synovial sarcoma is rare and aggressive soft tissue sarcoma that appears as deep, painless, slowly growing masses. Most frequently the tumor affects the legs, especially the knees, and the arms. Less frequently, this disease develops in the trunk, head and neck region, or the abdomen. Although synovial sarcoma does not have a clearly defined cause, genetic factors are believed to influence the development of this disease. Cells in these tumors are usually characterized by the presence of a translocation involving chromosomes X and 18. This translocation is specific to synovial sarcoma and is often used to diagnose this cancer. Although this condition generally affects adults, about 30% of reported cases occur in children and adolescents.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Synovial sarcoma" for support, advocacy or research.

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Sarcoma Alliance

The Sarcoma Alliance strives to improve the lives of people affected by sarcoma through accurate diagnosis, improved access to care, guidance, education and support.

Last Updated: 20 Feb 2013

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Synovial sarcoma" for support, advocacy or research.

Logo
Sarcoma Alliance

The Sarcoma Alliance strives to improve the lives of people affected by sarcoma through accurate diagnosis, improved access to care, guidance, education and support.

http://sarcomaalliance.org

Last Updated: 20 Feb 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Synovial sarcoma" returned 197 free, full-text research articles on human participants. First 3 results:

Prognostic significance of bcl-2, c-myc, survivin and tumor grade in synovial sarcoma.
 

Author(s): Derya Demır, Banu Yaman, Yavuz Anacak, Burçin Keçecı, Gülşen Kandıloğlu, Taner Akalin

Journal: Turk Patoloji Derg. 2014 ;30(1):55-65.

 

We aimed to determine the prognostic value of bcl-2, c-myc and survivin in synovial sarcoma cases and to evaluate the relationship between the conventional morphological findings with prognosis.

Last Updated: 22 Jan 2014

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Dumb-bell shaped poorly differentiated pelvic synovial sarcoma with molecular confirmation: a rare presentation of an uncommon disease entity.
 

Author(s): Roumina Hasan, Sandeep Kumar, Lakshmi Rao

Journal: Indian J Pathol Microbiol. ;56(4):396-8.

 

Pelvic localization of synovial sarcoma is a rare phenomenon and to the best of our knowledge its presentation as a large "dumb-bell"-shaped abdomino-pelvic mass showing extension to the thigh has never been reported in the literature. We report a case of a young adult presenting ...

Last Updated: 20 Jan 2014

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Synovial sarcoma of the neck masquerading as a malignant second branchial cleft cyst.
 

Author(s): Yao-Shu Teng, Zhi-Hong Lin, Yong Li, Xiao-Lin Cao, Feng-Chun Lin, Jing-Jing Xiang

Journal:

 

Synovial sarcoma is an uncommon, aggressive malignant tumor of the soft tissues primarily involving the extremities of young adults. Head and neck synovial sarcoma is rare, and its diagnosis and therapy are still challenging.We report a case of a young patient with synovial sarcoma, ...

Last Updated: 17 Oct 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Synovial sarcoma" returned 22 free, full-text review articles on human participants. First 3 results:

The SYT-SSX fusion protein and histological epithelial differentiation in synovial sarcoma: relationship with extracellular matrix remodeling.
 

Author(s): Tsuyoshi Saito

Journal:

 

Synovial sarcoma (SS) tumor cells, which have the chromosomal translocation t(X;18)(p11.2;q11.2), have an inherently greater propensity for epithelial differentiation than other mesenchymal tumors, especially spindle cell sarcomas. This is caused by de-repression of the transcription ...

Last Updated: 14 Nov 2013

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Synovial sarcoma presenting with huge mediastinal mass: a case report and review of literature.
 

Author(s): Samer Salah, Akram Al-Ibraheem, Amal Daboor, Maysa Al-Hussaini

Journal:

 

Synovial sarcoma presenting in the mediastinum is exceedingly rare. Furthermore, data addressing optimal therapy is limited. Herein we present a case where an attempt to downsize the tumor to a resectable state with chemotherapy was employed.

Last Updated: 5 Jul 2013

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Primary monophasic synovial sarcoma of the tonsil: immunohistochemical and molecular study of a case and review of the literature.
 

Author(s): Danny Soria-Céspedes, Aldo Iván Galván-Linares, Cuauhtemoc Oros-Ovalle, Francisco Gaitan-Gaona, Carlos Ortiz-Hidalgo

Journal: Head Neck Pathol. 2013 Dec;7(4):400-3.

 

Synovial sarcoma (SS) arises primarily in the lower extremities with a predilection for sites in proximity to large joints, such as the knee. It rarely occurs in the head and neck region, and the tonsil is an unusual site for the tumor, with only eight previously published cases in ...

Last Updated: 1 Nov 2013

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Last Updated: 4 Dec 2013

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Whole Lung IMRT in Children and Adults With Synovial Sarcoma and Lung Metastases
 

Status: Recruiting

Condition Summary: Synovial Sarcoma; Single or Multiple Lung Metastases

 

Last Updated: 2 Jul 2014

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NY-ESO-1 Specific T Cells After Cyclophosphamide in Treating Patients With Advanced Synovial Sarcoma or Myxoid/Round Cell Liposarcoma
 

Status: Recruiting

Condition Summary: Adult Liposarcoma; Adult Synovial Sarcoma; Recurrent Adult Soft Tissue Sarcoma; Stage III Adult Soft Tissue Sarcoma; Stage IV Adult Soft Tissue Sarcoma

 

Last Updated: 28 Jul 2014

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