Synovial sarcoma

Common Name(s)

Synovial sarcoma

Synovial sarcoma is rare and aggressive soft tissue sarcoma that appears as deep, painless, slowly growing masses. Most frequently the tumor affects the legs, especially the knees, and the arms. Less frequently, this disease develops in the trunk, head and neck region, or the abdomen. Although synovial sarcoma does not have a clearly defined cause, genetic factors are believed to influence the development of this disease. Cells in these tumors are usually characterized by the presence of a translocation involving chromosomes X and 18. This translocation is specific to synovial sarcoma and is often used to diagnose this cancer. Although this condition generally affects adults, about 30% of reported cases occur in children and adolescents.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Synovial sarcoma" for support, advocacy or research.

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Sarcoma Alliance

The Sarcoma Alliance strives to improve the lives of people affected by sarcoma through accurate diagnosis, improved access to care, guidance, education and support.

Last Updated: 20 Feb 2013

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Synovial sarcoma" for support, advocacy or research.

Logo
Sarcoma Alliance

The Sarcoma Alliance strives to improve the lives of people affected by sarcoma through accurate diagnosis, improved access to care, guidance, education and support.

http://sarcomaalliance.org

Last Updated: 20 Feb 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Synovial sarcoma" returned 208 free, full-text research articles on human participants. First 3 results:

Poorly differentiated synovial sarcoma in the wrist--case report.
 

Author(s): Daniela Cristina Caetano Maia, Carla Kellen da Silva Menezes, Thales Costa Bastos, Luiz Carlos de Lima Ferreira, Fabio Francesconi

Journal: An Bras Dermatol. ;89(5):816-8.

 

Synovial sarcomas are rare malignant tumors affecting mainly young adults, presenting as a slow growth mass located in deep soft tissues of extremities, near the joints. In this report a 34-year-old male patient, presented an ulcerovegetative lesion on the right wrist which was completely ...

Last Updated: 4 Sep 2014

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Primary synovial sarcoma of the prostate metastatic to the liver and lung: a case report.
 

Author(s): Qi Zhang, Huiju Wang, Ligang Ren, Xiaolong Qi, Feng Liu, Dahong Zhang

Journal:

 

Primary synovial sarcoma of the prostate is an uncommon malignant tumor. There are few cases reported in the English medical literature to date. Here, we present a case of 22-year-old man with primary synovial sarcoma of the prostate metastatic to the liver and lung. To our knowledge, ...

Last Updated: 9 Jul 2014

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Clinical and pathological features of patients with resected synovial sarcoma: a multicenter retrospective analysis of the Anatolian Society of Medical Oncology.
 

Author(s): Yetisyigit Tarkan, Arpaci Erkan, Erdogan Seber Selcuk, Kucukoner Mehmet, Kos F Tugba, Uysal Sonmez Ozlem, Alici Suleyman, Akman Tulay, Aktas Bilge, Yildiz Ramazan, Gunaydin Yusuf, Inanc Mevlude, Demirci Umut, Oztop Ilhan, Isikdogan Abdurrahman, Sevinc Alper, Uncu Dogan, Alkis Necati, Oksuzoglu Berna, Durnali Ayse Gok, Yilmaz Ugur, Gumus Mahmut

Journal: J Cancer Res Ther. ;10(1):73-8.

 

Synovial sarcoma (SS) is a rare disease and compared with other soft-tissue sarcomas has a relatively high mortality rate. The optimal management of this disease and prognostic factors associated with patient outcome remains controversial.

Last Updated: 25 Apr 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Synovial sarcoma" returned 24 free, full-text review articles on human participants. First 3 results:

Pericardial synovial sarcoma: case report and literature review.
 

Author(s): Sabrina Godoy Bezerra, Andrea Araújo Brandão, Denilson Campos Albuquerque, Rochelle Coppo Militão, Marcelo Souza Hadlich, Clerio Francisco Azevedo

Journal: Arq. Bras. Cardiol.. 2013 Dec;101(6):e103-6.

 

Last Updated: 13 Feb 2014

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The SYT-SSX fusion protein and histological epithelial differentiation in synovial sarcoma: relationship with extracellular matrix remodeling.
 

Author(s): Tsuyoshi Saito

Journal:

 

Synovial sarcoma (SS) tumor cells, which have the chromosomal translocation t(X;18)(p11.2;q11.2), have an inherently greater propensity for epithelial differentiation than other mesenchymal tumors, especially spindle cell sarcomas. This is caused by de-repression of the transcription ...

Last Updated: 14 Nov 2013

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Synovial sarcoma of the spine: a case involving paraspinal muscle with extensive calcification and the surgical consideration in treatment.
 

Author(s): Junhyung Kim, Sun-Ho Lee, Yoon-La Choi, Go Eun Bae, Eun-Sang Kim, Whan Eoh

Journal: Eur Spine J. 2014 Jan;23(1):27-31.

 

Synovial sarcoma is a rare malignant tumor of the spine. This tumor may present as a painless mass of the spine or slowly enlarge, causing pain or neurologic deficits. As it is difficult to differentiate this lesion from other soft tissue tumors, synovial sarcoma requires histologic ...

Last Updated: 4 Mar 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Whole Lung IMRT in Children and Adults With Synovial Sarcoma and Lung Metastases
 

Status: Recruiting

Condition Summary: Synovial Sarcoma; Single or Multiple Lung Metastases

 

Last Updated: 21 Oct 2014

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Last Updated: 1 Apr 2015

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NY-ESO-1 Specific T Cells After Cyclophosphamide in Treating Patients With Advanced Synovial Sarcoma or Myxoid/Round Cell Liposarcoma
 

Status: Recruiting

Condition Summary: Adult Synovial Sarcoma; Myxoid/Round Cell Liposarcoma; Recurrent Adult Soft Tissue Sarcoma; Stage III Adult Soft Tissue Sarcoma; Stage IV Adult Soft Tissue Sarcoma

 

Last Updated: 1 Apr 2015

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