Synovial sarcoma

Common Name(s)

Synovial sarcoma

Synovial sarcoma is rare and aggressive soft tissue sarcoma that appears as deep, painless, slowly growing masses. Most frequently the tumor affects the legs, especially the knees, and the arms. Less frequently, this disease develops in the trunk, head and neck region, or the abdomen. Although synovial sarcoma does not have a clearly defined cause, genetic factors are believed to influence the development of this disease. Cells in these tumors are usually characterized by the presence of a translocation involving chromosomes X and 18. This translocation is specific to synovial sarcoma and is often used to diagnose this cancer. Although this condition generally affects adults, about 30% of reported cases occur in children and adolescents.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Synovial sarcoma" for support, advocacy or research.

Cancer Hope Network

To provide one-on-one support to people undergoing treatment for cancer and to their families. We provide this support by training individuals who have recovered from cancer and matching them with cancer patients currently undergoing a similar experience. Through this matching process, we strive to instill hope and to make a difference in their fight against cancer.

Last Updated: 29 Jul 2015

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Sarcoma Alliance

The Sarcoma Alliance strives to improve the lives of people affected by sarcoma through accurate diagnosis, improved access to care, guidance, education and support.

Last Updated: 20 Feb 2013

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Synovial sarcoma" for support, advocacy or research.

Cancer Hope Network

To provide one-on-one support to people undergoing treatment for cancer and to their families. We provide this support by training individuals who have recovered from cancer and matching them with cancer patients currently undergoing a similar experience. Through this matching process, we strive to instill hope and to make a difference in their fight against cancer.

http://www.CancerHopeNetwork.org

Last Updated: 29 Jul 2015

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Sarcoma Alliance

The Sarcoma Alliance strives to improve the lives of people affected by sarcoma through accurate diagnosis, improved access to care, guidance, education and support.

http://sarcomaalliance.org

Last Updated: 20 Feb 2013

View Details

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Synovial sarcoma" returned 218 free, full-text research articles on human participants. First 3 results:

[Results of treatment of synovial sarcoma of the limbs].
 

Author(s): Loubet Unyendje Lukulunga, Abdou Kadri Moussa, Mustapha Mahfoud, Ahmed El Bardouni, Farid Ismail, Mohammed Kharmaz, Mohamed Saleh Berrada, Moradh El Yaacoubi

Journal:

 

Last Updated: 9 Jan 2015

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Vorinostat synergizes with ridaforolimus and abrogates the ridaforolimus-induced activation of AKT in synovial sarcoma cells.
 

Author(s): Sherif S Morgan, Lee D Cranmer

Journal:

 

Curative treatments for patients with metastatic synovial sarcoma (SS) do not exist, and such patients have a poor prognosis. We explored combinations of molecularly-targeted and cytotoxic agents to identify synergistic treatment combinations in SS cells.

Last Updated: 27 Nov 2014

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Primary pulmonary synovial sarcoma requiring differentiation from pulmonary metastasis of tibial adamantinoma: a case report.
 

Author(s): Toshiharu Shirai, Shinji Tsuchida, Ryu Terauchi, Naoki Mizoshiri, Eiichi Konishi, Yasuhiko Tomita, Junichi Shimada, Hiroyoshi Fujiwara, Toshikazu Kubo

Journal:

 

Primary pulmonary synovial sarcoma (PPSS) is rare. We describe a case of PPSS complicated by tibial adamantinoma that required differentiation from lung metastasis.

Last Updated: 25 Oct 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Synovial sarcoma" returned 26 free, full-text review articles on human participants. First 3 results:

A patient with primary pericardial synovial sarcoma who presented with cardiac tamponade: a case report and review of the literature.
 

Author(s): Michishige Ohzeki, Shu-ichi Fujita, Hirota Miyazaki, Hideaki Morita, Sachiko Kanki, Hideki Ozawa, Takahiro Katsumata, Yoshitaka Kurisu, Motomu Tsuji, Jun Tanigawa, Koichi Sohmiya, Masaaki Hoshiga, Nobukazu Ishizaka

Journal: Intern. Med.. 2014 ;53(6):595-601.

 

A 36-year-old man presented with near-syncope. He was found to have massive pericardial effusion with a giant pericardial tumorous lesion. The pericardial effusion exhibited a bloody nature; however, neither malignant cells nor infectious organisms were detected. (18)F-fluorodeoxyglucose-positron ...

Last Updated: 17 Mar 2014

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Pericardial synovial sarcoma: case report and literature review.
 

Author(s): Sabrina Godoy Bezerra, Andrea Araújo Brandão, Denilson Campos Albuquerque, Rochelle Coppo Militão, Marcelo Souza Hadlich, Clerio Francisco Azevedo

Journal: Arq. Bras. Cardiol.. 2013 Dec;101(6):e103-6.

 

Last Updated: 13 Feb 2014

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The SYT-SSX fusion protein and histological epithelial differentiation in synovial sarcoma: relationship with extracellular matrix remodeling.
 

Author(s): Tsuyoshi Saito

Journal:

 

Synovial sarcoma (SS) tumor cells, which have the chromosomal translocation t(X;18)(p11.2;q11.2), have an inherently greater propensity for epithelial differentiation than other mesenchymal tumors, especially spindle cell sarcomas. This is caused by de-repression of the transcription ...

Last Updated: 14 Nov 2013

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Whole Lung IMRT in Children and Adults With Synovial Sarcoma and Lung Metastases
 

Status: Recruiting

Condition Summary: Synovial Sarcoma; Single or Multiple Lung Metastases

 

Last Updated: 28 Apr 2015

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Last Updated: 1 Apr 2015

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NY-ESO-1 Specific T Cells After Cyclophosphamide in Treating Patients With Advanced Synovial Sarcoma or Myxoid/Round Cell Liposarcoma
 

Status: Recruiting

Condition Summary: Adult Synovial Sarcoma; Myxoid/Round Cell Liposarcoma; Recurrent Adult Soft Tissue Sarcoma; Stage III Adult Soft Tissue Sarcoma; Stage IV Adult Soft Tissue Sarcoma

 

Last Updated: 1 Apr 2015

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