Synovial sarcoma

Common Name(s)

Synovial sarcoma

Synovial sarcoma is rare and aggressive soft tissue sarcoma that appears as deep, painless, slowly growing masses. Most frequently the tumor affects the legs, especially the knees, and the arms. Less frequently, this disease develops in the trunk, head and neck region, or the abdomen. Although synovial sarcoma does not have a clearly defined cause, genetic factors are believed to influence the development of this disease. Cells in these tumors are usually characterized by the presence of a translocation involving chromosomes X and 18. This translocation is specific to synovial sarcoma and is often used to diagnose this cancer. Although this condition generally affects adults, about 30% of reported cases occur in children and adolescents.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Synovial sarcoma" for support, advocacy or research.

Cancer Hope Network

To provide one-on-one support to people undergoing treatment for cancer and to their families. We provide this support by training individuals who have recovered from cancer and matching them with cancer patients currently undergoing a similar experience. Through this matching process, we strive to instill hope and to make a difference in their fight against cancer.

Last Updated: 29 Jul 2015

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Sarcoma Alliance

The Sarcoma Alliance strives to improve the lives of people affected by sarcoma through accurate diagnosis, improved access to care, guidance, education and support.

Last Updated: 20 Feb 2013

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Synovial sarcoma" for support, advocacy or research.

Cancer Hope Network

To provide one-on-one support to people undergoing treatment for cancer and to their families. We provide this support by training individuals who have recovered from cancer and matching them with cancer patients currently undergoing a similar experience. Through this matching process, we strive to instill hope and to make a difference in their fight against cancer.

http://www.CancerHopeNetwork.org

Last Updated: 29 Jul 2015

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Sarcoma Alliance

The Sarcoma Alliance strives to improve the lives of people affected by sarcoma through accurate diagnosis, improved access to care, guidance, education and support.

http://sarcomaalliance.org

Last Updated: 20 Feb 2013

View Details

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Synovial sarcoma" returned 301 free, full-text research articles on human participants. First 3 results:

Primary synovial sarcoma of the kidney.
 

Author(s): Shwetank Mishra, Nipun Awasthi, S P Hazra, M K Bera

Journal: Saudi J Kidney Dis Transpl. 2015 Sep;26(5):996-9.

 

Primary synovial sarcoma (SS) of the kidney is a very rare disease as well as a diagnostic dilemma. Here, we present a case of a 60-year-old male clinically diagnosed as renal cell carcinoma. The radical nephrectomy specimen showed a well-circumscribed renal mass of approximately ...

Last Updated: 10 Sep 2015

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Primary Pulmonary Synovial Sarcoma in a Tertiary Referral Center: Clinical Characteristics, CT, and 18F-FDG PET Findings, With Pathologic Correlations.
 

Author(s): Gun Ha Kim, Mi Young Kim, Hyun Jung Koo, Joon Seon Song, Chang-Min Choi

Journal: Medicine (Baltimore). 2015 Aug;94(34):e1392.

 

The purpose of this study was to describe the patient characteristics, computed tomography (CT) and F-fluorodeoxyglucose positron emission tomography (FDG PET) findings, and clinical outcomes of primary pulmonary synovial sarcoma (PPSS), together with their pathologic correlations. ...

Last Updated: 28 Aug 2015

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Intravascular synovial sarcoma of the pulmonary artery with massive pleural effusion: report of a case with a favorable response to Ifosfamide chemotherapy and palliative radiation therapy.
 

Author(s): Toshiya Maekura, Shigeki Shimizu, Tomoya Kawaguchi, Masahiro Morimoto, Tomohisa Okuma, Hideo Matsui, Shinji Atagi

Journal: Intern. Med.. 2015 ;54(9):1095-8.

 

Synovial sarcoma (SS) commonly arises in the para-articular soft tissue; however, very few cases of intravascular SS have so far been reported. We herein describe a case of pulmonary artery SS with massive pleural effusion. A biopsy of the pleural lesions showed uniform short spindle ...

Last Updated: 7 May 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Synovial sarcoma" returned 30 free, full-text review articles on human participants. First 3 results:

Intestinal Intussusception by Monophasic Synovial Sarcoma: Case Report and Literature Review.
 

Author(s): F Sista, A Della Penna, V Abruzzese, S Leardi, G Amicucci

Journal: Chirurgia (Bucur). ;110(4):391-5.

 

Synovial sarcomas are rare malignant tumors of soft tissues, arising mainly from periarticular structures. Gastrointestinal localizations are unusual presentation of these rare sarcomas.

Last Updated: 26 Aug 2015

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Synovial sarcoma of the abdominal wall: Imaging findings and review of the literature.
 

Author(s): Robbert J de Haas, Johannes J Bonenkamp, Uta E Flucke, Jacky W J de Rooy

Journal:

 

Synovial sarcoma is the fourth most common type of soft-tissue sarcoma (following undifferentiated pleomorphic sarcoma, liposarcoma, and rhabdomyosarcoma), and should be considered a high-grade neoplasm with a high number of local recurrences and late metastases. Synovial sarcoma ...

Last Updated: 30 Apr 2015

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Synovial sarcoma: recent discoveries as a roadmap to new avenues for therapy.
 

Author(s): Torsten O Nielsen, Neal M Poulin, Marc Ladanyi

Journal: Cancer Discov. 2015 Feb;5(2):124-34.

 

Oncogenesis in synovial sarcoma is driven by the chromosomal translocation t(X,18; p11,q11), which generates an in-frame fusion of the SWI/SNF subunit SS18 to the C-terminal repression domains of SSX1 or SSX2. Proteomic studies have identified an integral role of SS18-SSX in the SWI/SNF ...

Last Updated: 6 Feb 2015

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Whole Lung IMRT in Children and Adults With Synovial Sarcoma and Lung Metastases
 

Status: Recruiting

Condition Summary: Synovial Sarcoma; Single or Multiple Lung Metastases

 

Last Updated: 11 Jan 2016

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Last Updated: 8 Dec 2015

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A Phase 1 Study of the EZH2 Inhibitor Tazemetostat in Pediatric Subjects With Relapsed or Refractory INI1-Negative Tumors or Synovial Sarcoma
 

Status: Recruiting

Condition Summary: Rhabdoid Tumors; INI1-negative Tumors; Synovial Sarcoma; Malignant Rhabdoid Tumor of Ovary

 

Last Updated: 28 Jan 2016

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