Synovial sarcoma

Common Name(s)

Synovial sarcoma

Synovial sarcoma is rare and aggressive soft tissue sarcoma that appears as deep, painless, slowly growing masses. Most frequently the tumor affects the legs, especially the knees, and the arms. Less frequently, this disease develops in the trunk, head and neck region, or the abdomen. Although synovial sarcoma does not have a clearly defined cause, genetic factors are believed to influence the development of this disease. Cells in these tumors are usually characterized by the presence of a translocation involving chromosomes X and 18. This translocation is specific to synovial sarcoma and is often used to diagnose this cancer. Although this condition generally affects adults, about 30% of reported cases occur in children and adolescents.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Synovial sarcoma" for support, advocacy or research.

Logo
Ben's Friends

Our mission is to ensure that everyone in the world with a rare disease has a safe place to go and connect with others like them.

Last Updated: 11 Jul 2016

View Details
Cancer Hope Network

To provide one-on-one support to people undergoing treatment for cancer and to their families. We provide this support by training individuals who have recovered from cancer and matching them with cancer patients currently undergoing a similar experience. Through this matching process, we strive to instill hope and to make a difference in their fight against cancer.

Last Updated: 29 Jul 2015

View Details
Logo
Sarcoma Alliance

The Sarcoma Alliance strives to improve the lives of people affected by sarcoma through accurate diagnosis, improved access to care, guidance, education and support.

Last Updated: 20 Feb 2013

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Synovial sarcoma" for support, advocacy or research.

Logo
Ben's Friends

Our mission is to ensure that everyone in the world with a rare disease has a safe place to go and connect with others like them.

http://www.bensfriends.org

Last Updated: 11 Jul 2016

View Details
Cancer Hope Network

To provide one-on-one support to people undergoing treatment for cancer and to their families. We provide this support by training individuals who have recovered from cancer and matching them with cancer patients currently undergoing a similar experience. Through this matching process, we strive to instill hope and to make a difference in their fight against cancer.

http://www.CancerHopeNetwork.org

Last Updated: 29 Jul 2015

View Details
Logo
Sarcoma Alliance

The Sarcoma Alliance strives to improve the lives of people affected by sarcoma through accurate diagnosis, improved access to care, guidance, education and support.

http://sarcomaalliance.org

Last Updated: 20 Feb 2013

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Synovial sarcoma" returned 295 free, full-text research articles on human participants. First 3 results:

Synovial Sarcoma Complicating Total Knee Arthroplasty.
 

Author(s): Olga D Savvidou, George D Chloros, Panagiotis Koutsouradis, Panayiotis D Megaloikonomos, Eva Skarpidi, Panayiotis J Papagelopoulos

Journal: Clin Orthop Surg. 2017 Dec;9(4):547-552.

 

Synovial sarcoma is a relatively common periarticular soft tissue malignancy, occurring mostly in the extremities of younger patients. Occasionally, diversity in its clinical features may lead to misdiagnosis and inappropriate management. The authors report herein a unique case of ...

Last Updated: 31 Dec 1969

Go To URL
Transforming growth factor-β1 signaling promotes epithelial-mesenchymal transition-like phenomena, cell motility, and cell invasion in synovial sarcoma cells.
 

Author(s): Yan Qi, Ning Wang, Yonglai He, Jun Zhang, Hong Zou, Wenjie Zhang, Wenyi Gu, Yalan Huang, Xiaojuan Lian, Jianming Hu, Jin Zhao, Xiaobin Cui, Lijuan Pang, Feng Li

Journal:

 

The epithelial-to-mesenchymal transition (EMT) and the reverse process (the mesenchymal-to-epithelial transition [MET]) have been shown to be associated with tumor cell invasion and metastasis in different carcinomas. The EMT and MET have recently been shown to play a key role in ...

Last Updated: 31 Dec 1969

Go To URL
[Primary pharynx synovial sarcoma: a case report].
 

Author(s): Cui Qingying, Zhang Youmei, Fu Shuai, Zhang Changbin, Li Ming

Journal: Hua Xi Kou Qiang Yi Xue Za Zhi. 2017 Apr;35(2):221-222.

 

A case of primary pharynx synovial sarcoma was reported in this paper. A 15-year-old male patient experienced painless pharyngeal swelling that gradually proliferated for 1 month. Special examination showed an 8 cm × 4 cm × 3 cm tumor located in the left pharynx and the supratonsillar ...

Last Updated: 31 Dec 1969

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Synovial sarcoma" returned 33 free, full-text review articles on human participants. First 3 results:

[Initial manifestation and atypical site for metastatic synovial sarcoma in an immunocompetent adult patient: about a case and literature review].
 

Author(s): Amina Atmane, Sanaa Hammi, Asmâa Regragui, Mohammed Raoufi, Karima Marc, Mouna Soualhi, Rachida Zahraoui, Jouda Benamor, Jamal Eddine Bourkadi

Journal:

 

Synovial sarcoma (SS) is a rare tumor. It is characterized by various sites of occurrence but rarely involves the chest. The tumor may be wrongly diagnosed as benign due to its slow growth. Less than 10% of patients present with metastatic cancer. Endobronchial metastases are exceptional. ...

Last Updated: 31 Dec 1969

Go To URL
A primary gastric synovial sarcoma: A case report and literature review.
 

Author(s): In Tae So, Kwang Bum Cho, Ju Yup Lee, Sang Jin Kim, Hye In Jung, Jong Hwan Choi, Yoo Jin Lee, Hyun Jik Lee, Kyung Sik Park, Seung Wan Ryu, Yu Na Kang

Journal: Medicine (Baltimore). 2017 Dec;96(49):e8904.

 

When a gastric spindle cell tumor is observed, the possibility of synovial carcinoma, besides common mesenchymal tumor, should also be considered.

Last Updated: 31 Dec 1969

Go To URL
Current status of engineered T-cell therapy for synovial sarcoma.
 

Author(s): Matthew Dallos, William D Tap, Sandra P D'Angelo

Journal: Immunotherapy. 2016 09;8(9):1073-80.

 

Synovial sarcoma is a rare soft tissue sarcoma characterized by a t(X;18) translocation, which results in a SYT-SSX gene fusion. In the metastatic setting, chemotherapy has limited, durable efficacy prompting the necessity for new therapeutic modalities. One emerging new strategy ...

Last Updated: 31 Dec 1969

Go To URL
 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Last Updated: 6 Apr 2018

Go to URL

Last Updated: 10 Apr 2018

Go to URL
DHEA in Synovial Sarcoma Patients
 

Status: Recruiting

Condition Summary: Synovial Sarcoma; Sarcoma, Synovial

 

Last Updated: 31 Aug 2017

Go to URL