Still's disease adult onset

Common Name(s)

Still's disease adult onset

Adult-onset Still's disease is an inflammatory condition characterized by high fevers, rash, sore throat, and joint pain. As it progresses, adult-onset Still's disease may lead to chronic arthritis and other complications.  Still's disease was named after an English doctor named George Still, who described the condition in children in 1896. Still's disease which occurs in children (those under the age of 16) is now known as systemic onset juvenile rheumatoid arthritis (JRA). In 1971, the term "adult Still's disease" was used to describe adults who had a condition similar to systemic onset JRA.  The cause of adult-onset Still's disease is unknown. No risk factors for the disease have been identified. There's no cure for adult-onset Still's disease; however, treatment may offer symptom relief and help prevent complications.

 

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Still's disease adult onset" for support, advocacy or research.

Autoinflammatory Alliance

The Autoinflammatory Alliance is a 501 (c)(3) non-profit public charity dedicated to promoting awareness, proper diagnosis and treatment, and improved care for people with autoinflammatory diseases. We started in 2006 under the name, The NOMID Alliance with the same basic goal: to help patients with CAPS and other autoinflammatory diseases. We have a IRS approval as tax-exempt under both names.

Last Updated: 24 Jul 2015

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International Foundation for Autoimmune Arthritis

We are committed to eliminating the adversity caused by autoimmune arthritis by uniting resources that will raise global awareness, providing wellness education and support, and conducting patient-centered research that will improve the quality of life for those affected by these diseases.

Last Updated: 18 Sep 2014

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International Still's Disease Foundation, Inc.

The purpose and Mission Statement of the International Still's Disease Foundation is to: * Provide support to those who live with Still’s Disease. * Encourage and facilitate communication between people living with, and those impacted by, Still’s Disease. * Provide up-to-date information on Still’s Disease research, treatments and related studies to those with the disease, their families, friends, and health care workers. * Increase general awareness of Still’s to the public.

Last Updated: 8 May 2014

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Still's disease adult onset" for support, advocacy or research.

Autoinflammatory Alliance

The Autoinflammatory Alliance is a 501 (c)(3) non-profit public charity dedicated to promoting awareness, proper diagnosis and treatment, and improved care for people with autoinflammatory diseases. We started in 2006 under the name, The NOMID Alliance with the same basic goal: to help patients with CAPS and other autoinflammatory diseases. We have a IRS approval as tax-exempt under both names.

http://www.autoinflammatory.org

Last Updated: 24 Jul 2015

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International Foundation for Autoimmune Arthritis

We are committed to eliminating the adversity caused by autoimmune arthritis by uniting resources that will raise global awareness, providing wellness education and support, and conducting patient-centered research that will improve the quality of life for those affected by these diseases.

http://www.ifautoimmunearthritis.org

Last Updated: 18 Sep 2014

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International Still's Disease Foundation, Inc.

The purpose and Mission Statement of the International Still's Disease Foundation is to: * Provide support to those who live with Still’s Disease. * Encourage and facilitate communication between people living with, and those impacted by, Still’s Disease. * Provide up-to-date information on Still’s Disease research, treatments and related studies to those with the disease, their families, friends, and health care workers. * Increase general awareness of Still’s to the public.

http://www.stillsdisease.org

Last Updated: 8 May 2014

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General Support Organizations

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General Resources

Still's Disease Video Series

This four part video series can be viewed on our website without being downloaded. It is a free informational series presented by Dr. John J. Cush, on the History, Manifestations, Diagnosis and Management of Still's disease.

Updated 8 Feb 2014

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Still's Disease Free Informational Brochure

Free informational brochure about Adult-onset Still's disease, it's symptoms, medications and helpful information. Will be mailed via USPS to all addresses Internationally.

Updated 8 Feb 2014

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Healthier Ever After (injection tips book & program)

This child-friendly book is for patients and their families to learn how to manage their injectable medications, and has a program to help children to discuss and make a plan of care, and goals with rewards to chart on a reusable white board page.

Updated 6 May 2015

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Still's disease adult onset" returned 163 free, full-text research articles on human participants. First 3 results:

Macrophage Activation Syndrome Associated With Adult Onset Still's Disease.
 

Author(s): Madeeha Gulzar, Ali Sabir, Muhammad Afzal Hamdani, Asma Saadia

Journal: J Ayub Med Coll Abbottabad. ;30(2):289-292.

 

Macrophage activation syndrome (MAS) is a potentially lethal complication of chronic rheumatological conditions like ankylosing spondylitis, rheumatoid arthritis, and adult-onset Still's disease (AOSD). It is a multisystem inflammatory syndrome caused by immense cytokine release from ...

Last Updated: 31 Dec 1969

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Adding colchicine to immunosuppressive treatments; a potential option for biologics-refractory adult-onset Still's disease.
 

Author(s): Tomoyuki Asano, Makiko Yashiro Furuya, Shuzo Sato, Hiroko Kobayashi, Hiroshi Watanabe, Eiji Suzuki, Kiyoshi Migita

Journal:

 

Adult-onset Still's disease (AOSD) is a rare inflammatory disorder characterized by the classical triad of daily spiking fever, arthritis, and typical salmon-colored rash. Resistance to first-line corticosteroids and second-line disease modified anti-rheumatic-drugs defines refractory ...

Last Updated: 31 Dec 1969

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A case of adult onset Still's disease with mutations of the MEFV gene who is partially responsive to colchicine.
 

Author(s): Liang-Jun Ou-Yang, Kuo-Tung Tang

Journal: Medicine (Baltimore). 2018 Apr;97(15):e0333.

 

Familial Mediterranean fever (FMF) and adult onset Still's disease (AOSD) have overlapping features, and are categorized as being on the spectrum of autoinflammatory diseases (AIDs). FMF is more prevalent in the Mediterranean region but rarely, described in the Chinese population.

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Still's disease adult onset" returned 15 free, full-text review articles on human participants. First 3 results:

Adult onset Still's disease-The evidence that anti-interleukin-1 treatment is effective and well-tolerated (a comprehensive literature review).
 

Author(s): Guido Junge, June Mason, Eugen Feist

Journal: Semin. Arthritis Rheum.. 2017 10;47(2):295-302.

 

The literature contains many reports of the use of commercially available anti-IL-1 agents (anakinra/Kineret, canakinumab/Ilaris, or rilonacept/Arcalyst) in treatment-resistant adult-onset Still's disease (AOSD). These have been widely summarized in many review articles, but a full ...

Last Updated: 31 Dec 1969

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Adult-Onset Still's Disease: Still a Serious Health Problem (a Case Report and Literature Review).
 

Author(s): Mojgan Agha-Abbaslou, Ana Maria Bensaci, Oluchi Dike, Mark C Poznansky, Arooj Hyat

Journal:

 

BACKGROUND Adult-onset Still's Disease (AOSD) is a rare systemic inflammatory disease accompanied by a triad of spiking fever, maculopapular exanthema, and arthralgia. To date, there is no definite laboratory or imaging test available for diagnosing AOSD, and the diagnosis is one ...

Last Updated: 31 Dec 1969

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Adult Onset Still's Disease With Different Antibodies: A Case Report and Review of Literature.
 

Author(s): Maryam Mobini, Roya Ghasemian, Fatemeh Zameni

Journal: Acta Med Iran. 2016 Oct;54(10):683-685.

 

 Adult-onset Still's disease (AOSD) is a rare systemic inflammatory disorder of unknown etiology. There is not currently any specific serological markers for AOSD , and  diagnosis still relying on the exclusion of other likely diagnoses. Yamaguchi's criteria are used as a diagnostic ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Multi-center Registration Study of Adult Onset Still's Disease in Chinese Population
 

Status: Not yet recruiting

Condition Summary: Adult Onset Still Disease

 

Last Updated: 29 Aug 2018

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Natural History, Genetics, and Pathophysiology of Systemic Juvenile Idiopathic Arthritis, Adult-Onset Still's Disease, and Related Conditions
 

Status: Recruiting

Condition Summary: Still's Disease, Adult-Onset; Systemic Inflammation; Autoinflammatory Syndromes; Arthritis

 

Last Updated: 2 Aug 2018

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A Study to Evaluate Efficacy and Safety of Anakinra in the Treatment of Still's Disease (SJIA and AOSD)
 

Status: Recruiting

Condition Summary: Still's Disease, Adult-Onset; Still's Disease, Juvenile-Onset

 

Last Updated: 1 Oct 2018

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