Still's disease adult onset

Common Name(s)

Still's disease adult onset

Adult-onset Still's disease is an inflammatory condition characterized by high fevers, rash, sore throat, and joint pain. As it progresses, adult-onset Still's disease may lead to chronic arthritis and other complications.  Still's disease was named after an English doctor named George Still, who described the condition in children in 1896. Still's disease which occurs in children (those under the age of 16) is now known as systemic onset juvenile rheumatoid arthritis (JRA). In 1971, the term "adult Still's disease" was used to describe adults who had a condition similar to systemic onset JRA.  The cause of adult-onset Still's disease is unknown. No risk factors for the disease have been identified. There's no cure for adult-onset Still's disease; however, treatment may offer symptom relief and help prevent complications.

 

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Still's disease adult onset" for support, advocacy or research.

Autoinflammatory Alliance

The Autoinflammatory Alliance is a 501 (c)(3) non-profit public charity dedicated to promoting awareness, proper diagnosis and treatment, and improved care for people with autoinflammatory diseases. We started in 2006 under the name, The NOMID Alliance with the same basic goal: to help patients with CAPS and other autoinflammatory diseases. We have a IRS approval as tax-exempt under both names.

Last Updated: 7 May 2015

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International Foundation for Autoimmune Arthritis

We are committed to eliminating the adversity caused by autoimmune arthritis by uniting resources that will raise global awareness, providing wellness education and support, and conducting patient-centered research that will improve the quality of life for those affected by these diseases.

Last Updated: 18 Sep 2014

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International Still's Disease Foundation, Inc.

The purpose and Mission Statement of the International Still's Disease Foundation is to: * Provide support to those who live with Still’s Disease. * Encourage and facilitate communication between people living with, and those impacted by, Still’s Disease. * Provide up-to-date information on Still’s Disease research, treatments and related studies to those with the disease, their families, friends, and health care workers. * Increase general awareness of Still’s to the public.

Last Updated: 8 May 2014

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Still's disease adult onset" for support, advocacy or research.

Autoinflammatory Alliance

The Autoinflammatory Alliance is a 501 (c)(3) non-profit public charity dedicated to promoting awareness, proper diagnosis and treatment, and improved care for people with autoinflammatory diseases. We started in 2006 under the name, The NOMID Alliance with the same basic goal: to help patients with CAPS and other autoinflammatory diseases. We have a IRS approval as tax-exempt under both names.

http://www.autoinflammatory.org

Last Updated: 7 May 2015

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International Foundation for Autoimmune Arthritis

We are committed to eliminating the adversity caused by autoimmune arthritis by uniting resources that will raise global awareness, providing wellness education and support, and conducting patient-centered research that will improve the quality of life for those affected by these diseases.

http://www.ifautoimmunearthritis.org

Last Updated: 18 Sep 2014

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International Still's Disease Foundation, Inc.

The purpose and Mission Statement of the International Still's Disease Foundation is to: * Provide support to those who live with Still’s Disease. * Encourage and facilitate communication between people living with, and those impacted by, Still’s Disease. * Provide up-to-date information on Still’s Disease research, treatments and related studies to those with the disease, their families, friends, and health care workers. * Increase general awareness of Still’s to the public.

http://www.stillsdisease.org

Last Updated: 8 May 2014

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General Support Organizations

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General Resources

Still's Disease Video Series

This four part video series can be viewed on our website without being downloaded. It is a free informational series presented by Dr. John J. Cush, on the History, Manifestations, Diagnosis and Management of Still's disease.

Updated 8 Feb 2014

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Still's Disease Free Informational Brochure

Free informational brochure about Adult-onset Still's disease, it's symptoms, medications and helpful information. Will be mailed via USPS to all addresses Internationally.

Updated 8 Feb 2014

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Healthier Ever After (injection tips book & program)

This child-friendly book is for patients and their families to learn how to manage their injectable medications, and has a program to help children to discuss and make a plan of care, and goals with rewards to chart on a reusable white board page.

Updated 6 May 2015

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Still's disease adult onset" returned 114 free, full-text research articles on human participants. First 3 results:

Hemophagocytic syndrome and inflammatory myopathy with abundant macrophages in a patient with adult-onset Still's disease.
 

Author(s): Masataka Umeda, Tomoki Origuchi, Keita Fujikawa, Tomohiro Koga, Akinari Mizokami, Yoshikazu Nakashima, Takahisa Suzuki, Akitomo Okada, Shin-ya Kawashiri, Kunihiro Ichinose, Mami Tamai, Satoshi Yamasaki, Hideki Nakamura, Atsushi Kawakami, Katsumi Eguchi

Journal: Intern. Med.. 2014 ;53(20):2385-9.

 

We herein describe a 71-year-old woman with adult-onset Still's disease (AOSD) who developed fever, myalgia, and pancytopenia. The bone marrow aspiration and muscle biopsy revealed hemophagocytic syndrome (HPS) and inflammatory myopathy with abundant macrophages (IMAM). Immunostained ...

Last Updated: 16 Oct 2014

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A rare case of diffuse pulmonary nodules in a patient with adult-onset Still's disease.
 

Author(s): Haiyu Qi, Chenghong Yin, Hongli Xiao, Ting Duan

Journal: Intern. Med.. 2014 ;53(16):1869-72.

 

Adult-onset Still's disease (AOSD) is a multisystemic inflammatory disorder, but pulmonary involvement is rare. We herein describe the case of a woman diagnosed with AOSD; treatment resolved her symptoms, but nine days later she was admitted with pyrexia and a productive cough. A ...

Last Updated: 18 Aug 2014

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Possible macrophage activation syndrome following initiation of adalimumab in a patient with adult-onset Still's disease.
 

Author(s): Leila Souabni, Leila Dridi, Kawther Ben Abdelghani, Selma Kassab, Selma Chekili, Ahmed Laater, Leith Zakraoui

Journal:

 

Macrophage activation syndrome (MAS) has been rarely reported in the course of adult-onset Still's disease (AOSD) and in the majority of cases, it was triggered by an infection. Here, we report, to our knowledge, the first case of MAS occurring after adalimumab treatment initiation ...

Last Updated: 14 Jul 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Still's disease adult onset" returned 11 free, full-text review articles on human participants. First 3 results:

Adult-onset Still's disease.
 

Author(s): Mathieu Gerfaud-Valentin, Yvan Jamilloux, Jean Iwaz, Pascal Sève

Journal: Autoimmun Rev. 2014 Jul;13(7):708-22.

 

First described in 1971, adult-onset Still's disease (AOSD) is a rare multisystemic disorder considered as a complex (multigenic) autoinflammatory syndrome. A genetic background would confer susceptibility to the development of autoinflammatory reactions to environmental triggers. ...

Last Updated: 21 Apr 2014

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Adult onset Still's disease as a paraneoplastic syndrome--a case report and review of the literature.
 

Author(s): Sedat Yilmaz, Ahmet Karakas, Muhammet Cinar, Omer Coskun, Ismail Simsek, Hakan Erdem, Can Polat Eyigun, Salih Pay

Journal: Bull Hosp Jt Dis (2013). 2013 ;71(2):156-60.

 

Adult onset Still's disease (AOSD) is a systemic inflammatory disease with unknown etiology and characterized by evanescent salmon pink rash, sore throat, liver dysfunction, lymphadenopathy, hepatosplenomegaly, arthritis, and leukocytosis. It is a diagnosis of exclusion; however, ...

Last Updated: 16 Sep 2013

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Adult-onset Still's disease complicated by autoimmune hepatitis: successful treatment with infliximab.
 

Author(s): Kenji Fujii, Ryo Rokutanda, Yasuhiro Osugi, Yoshinobu Koyama, Toshiyuki Ota

Journal: Intern. Med.. 2012 ;51(9):1125-8.

 

A 17-year-old woman was previously diagnosed with autoimmune hepatitis (AIH) by liver biopsy. Adult-onset Still's disease (AOSD) was subsequently diagnosed on the basis of high fever, arthralgia, erythema, leukocytosis (>80% granulocytes), cervical lymph node swelling, splenomegaly, ...

Last Updated: 11 May 2012

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Canakinumab for Treatment of Adult Onset Still's Disease
 

Status: Recruiting

Condition Summary: Adult-Onset Still´s Disease

 

Last Updated: 29 Jul 2014

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Efficacy and Safety of Tocilizumab in Adult's Still Disease
 

Status: Not yet recruiting

Condition Summary: Adult's Still Disease

 

Last Updated: 26 Oct 2009

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Therapeutic Use of Tadekinig Alfa in in Adult-onset Still's Disease
 

Status: Recruiting

Condition Summary: Still's Disease, Adult-Onset

 

Last Updated: 20 Mar 2015

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