Still's disease adult onset

Common Name(s)

Still's disease adult onset

Adult-onset Still's disease is an inflammatory condition characterized by high fevers, rash, sore throat, and joint pain. As it progresses, adult-onset Still's disease may lead to chronic arthritis and other complications.  Still's disease was named after an English doctor named George Still, who described the condition in children in 1896. Still's disease which occurs in children (those under the age of 16) is now known as systemic onset juvenile rheumatoid arthritis (JRA). In 1971, the term "adult Still's disease" was used to describe adults who had a condition similar to systemic onset JRA.  The cause of adult-onset Still's disease is unknown. No risk factors for the disease have been identified. There's no cure for adult-onset Still's disease; however, treatment may offer symptom relief and help prevent complications.

 

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Still's disease adult onset" for support, advocacy or research.

Autoinflammatory Alliance

The Autoinflammatory Alliance is a 501 (c)(3) non-profit public charity dedicated to promoting awareness, proper diagnosis and treatment, and improved care for people with autoinflammatory diseases. We started in 2006 under the name, The NOMID Alliance with the same basic goal: to help patients with CAPS and other autoinflammatory diseases. We have a IRS approval as tax-exempt under both names.

Last Updated: 24 Jul 2015

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International Foundation for Autoimmune Arthritis

We are committed to eliminating the adversity caused by autoimmune arthritis by uniting resources that will raise global awareness, providing wellness education and support, and conducting patient-centered research that will improve the quality of life for those affected by these diseases.

Last Updated: 18 Sep 2014

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International Still's Disease Foundation, Inc.

The purpose and Mission Statement of the International Still's Disease Foundation is to: * Provide support to those who live with Still’s Disease. * Encourage and facilitate communication between people living with, and those impacted by, Still’s Disease. * Provide up-to-date information on Still’s Disease research, treatments and related studies to those with the disease, their families, friends, and health care workers. * Increase general awareness of Still’s to the public.

Last Updated: 8 May 2014

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Still's disease adult onset" for support, advocacy or research.

Autoinflammatory Alliance

The Autoinflammatory Alliance is a 501 (c)(3) non-profit public charity dedicated to promoting awareness, proper diagnosis and treatment, and improved care for people with autoinflammatory diseases. We started in 2006 under the name, The NOMID Alliance with the same basic goal: to help patients with CAPS and other autoinflammatory diseases. We have a IRS approval as tax-exempt under both names.

http://www.autoinflammatory.org

Last Updated: 24 Jul 2015

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International Foundation for Autoimmune Arthritis

We are committed to eliminating the adversity caused by autoimmune arthritis by uniting resources that will raise global awareness, providing wellness education and support, and conducting patient-centered research that will improve the quality of life for those affected by these diseases.

http://www.ifautoimmunearthritis.org

Last Updated: 18 Sep 2014

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International Still's Disease Foundation, Inc.

The purpose and Mission Statement of the International Still's Disease Foundation is to: * Provide support to those who live with Still’s Disease. * Encourage and facilitate communication between people living with, and those impacted by, Still’s Disease. * Provide up-to-date information on Still’s Disease research, treatments and related studies to those with the disease, their families, friends, and health care workers. * Increase general awareness of Still’s to the public.

http://www.stillsdisease.org

Last Updated: 8 May 2014

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General Support Organizations

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General Resources

Still's Disease Video Series

This four part video series can be viewed on our website without being downloaded. It is a free informational series presented by Dr. John J. Cush, on the History, Manifestations, Diagnosis and Management of Still's disease.

Updated 8 Feb 2014

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Still's Disease Free Informational Brochure

Free informational brochure about Adult-onset Still's disease, it's symptoms, medications and helpful information. Will be mailed via USPS to all addresses Internationally.

Updated 8 Feb 2014

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Healthier Ever After (injection tips book & program)

This child-friendly book is for patients and their families to learn how to manage their injectable medications, and has a program to help children to discuss and make a plan of care, and goals with rewards to chart on a reusable white board page.

Updated 6 May 2015

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Still's disease adult onset" returned 155 free, full-text research articles on human participants. First 3 results:

A case of adult onset Still's disease with mutations of the MEFV gene who is partially responsive to colchicine.
 

Author(s): Liang-Jun Ou-Yang, Kuo-Tung Tang

Journal: Medicine (Baltimore). 2018 Apr;97(15):e0333.

 

Familial Mediterranean fever (FMF) and adult onset Still's disease (AOSD) have overlapping features, and are categorized as being on the spectrum of autoinflammatory diseases (AIDs). FMF is more prevalent in the Mediterranean region but rarely, described in the Chinese population.

Last Updated: 31 Dec 1969

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Purulent constrictive pericarditis caused by Salmonella enteritidis in a patient with adult-onset Still's disease: A case report.
 

Author(s): Chia-Cheng Kuo, Wen-Liang Yu, Chen-Hui Lee, Nan-Chun Wu

Journal: Medicine (Baltimore). 2017 Dec;96(50):e8949.

 

Purulent pericarditis is a rare and usually fatal disease. Immunodeficiency state and preexisting pericardial effusion can predispose patients to infections. However, we are not aware of similar cases in patients with adult-onset Still's disease (AOSD). In addition, it is seldom caused ...

Last Updated: 31 Dec 1969

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Acute appendicitis complicated with necrotizing fasciitis in a patient with adult-onset Still's disease: A case report.
 

Author(s): Zheng-Hao Huang, Yu-Chen Chiu, Li-Lu Ho, Hsiu-Lung Fan, Chun-Chi Lu

Journal: Medicine (Baltimore). 2018 Feb;97(5):e9794.

 

Adult-onset Still disease (AOSD) is a rare systemic inflammatory disease of unknown etiology characterized by evanescent salmon-pink rash, spiking fever, arthralgia/ arthritis, and lymphadenopathy. AOSD sometimes was fatal when it is complicated by macrophage activation syndrome (MAS) ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Still's disease adult onset" returned 14 free, full-text review articles on human participants. First 3 results:

Adult-Onset Still's Disease: Still a Serious Health Problem (a Case Report and Literature Review).
 

Author(s): Mojgan Agha-Abbaslou, Ana Maria Bensaci, Oluchi Dike, Mark C Poznansky, Arooj Hyat

Journal:

 

BACKGROUND Adult-onset Still's Disease (AOSD) is a rare systemic inflammatory disease accompanied by a triad of spiking fever, maculopapular exanthema, and arthralgia. To date, there is no definite laboratory or imaging test available for diagnosing AOSD, and the diagnosis is one ...

Last Updated: 31 Dec 1969

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Adult Onset Still's Disease With Different Antibodies: A Case Report and Review of Literature.
 

Author(s): Maryam Mobini, Roya Ghasemian, Fatemeh Zameni

Journal: Acta Med Iran. 2016 Oct;54(10):683-685.

 

 Adult-onset Still's disease (AOSD) is a rare systemic inflammatory disorder of unknown etiology. There is not currently any specific serological markers for AOSD , and  diagnosis still relying on the exclusion of other likely diagnoses. Yamaguchi's criteria are used as a diagnostic ...

Last Updated: 31 Dec 1969

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[Pathophysiology, subtypes, and treatments of adult-onset Still's disease: An update].
 

Author(s): M Gerfaud-Valentin, P Sève, A Hot, C Broussolle, Y Jamilloux

Journal: Rev Med Interne. 2015 May;36(5):319-27.

 

Adult-onset Still's disease is a rare and difficult to diagnose multisystemic disorder considered as a multigenic autoinflammatory syndrome. Its immunopathogenesis seems to be at the crossroads between inflammasomopathies and hemophagocytic lymphohistiocytosis, the most severe manifestation ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Canakinumab for Treatment of Adult Onset Still's Disease
 

Status: Recruiting

Condition Summary: Adult-Onset Still´s Disease

 

Last Updated: 19 Dec 2017

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Admission of Adult-onset Still Disease Patients in the ICU
 

Status: Recruiting

Condition Summary: Adult-Onset Still Disease; Critically Ill

 

Last Updated: 1 Feb 2018

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A Study to Evaluate Efficacy and Safety of Anakinra in the Treatment of Still's Disease (SJIA and AOSD)
 

Status: Recruiting

Condition Summary: Still's Disease, Adult-Onset; Still's Disease, Juvenile-Onset

 

Last Updated: 5 Oct 2017

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