Still's disease adult onset

Common Name(s)

Still's disease adult onset

Adult-onset Still's disease is an inflammatory condition characterized by high fevers, rash, sore throat, and joint pain. As it progresses, adult-onset Still's disease may lead to chronic arthritis and other complications.  Still's disease was named after an English doctor named George Still, who described the condition in children in 1896. Still's disease which occurs in children (those under the age of 16) is now known as systemic onset juvenile rheumatoid arthritis (JRA). In 1971, the term "adult Still's disease" was used to describe adults who had a condition similar to systemic onset JRA.  The cause of adult-onset Still's disease is unknown. No risk factors for the disease have been identified. There's no cure for adult-onset Still's disease; however, treatment may offer symptom relief and help prevent complications.

 

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Still's disease adult onset" for support, advocacy or research.

Autoinflammatory Alliance

The Autoinflammatory Alliance is a 501 (c)(3) non-profit public charity dedicated to promoting awareness, proper diagnosis and treatment, and improved care for people with autoinflammatory diseases. We started in 2006 under the name, The NOMID Alliance with the same basic goal: to help patients with CAPS and other autoinflammatory diseases. We have a IRS approval as tax-exempt under both names.

Last Updated: 24 Jul 2015

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International Foundation for Autoimmune Arthritis

We are committed to eliminating the adversity caused by autoimmune arthritis by uniting resources that will raise global awareness, providing wellness education and support, and conducting patient-centered research that will improve the quality of life for those affected by these diseases.

Last Updated: 18 Sep 2014

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International Still's Disease Foundation, Inc.

The purpose and Mission Statement of the International Still's Disease Foundation is to: * Provide support to those who live with Still’s Disease. * Encourage and facilitate communication between people living with, and those impacted by, Still’s Disease. * Provide up-to-date information on Still’s Disease research, treatments and related studies to those with the disease, their families, friends, and health care workers. * Increase general awareness of Still’s to the public.

Last Updated: 8 May 2014

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Still's disease adult onset" for support, advocacy or research.

Autoinflammatory Alliance

The Autoinflammatory Alliance is a 501 (c)(3) non-profit public charity dedicated to promoting awareness, proper diagnosis and treatment, and improved care for people with autoinflammatory diseases. We started in 2006 under the name, The NOMID Alliance with the same basic goal: to help patients with CAPS and other autoinflammatory diseases. We have a IRS approval as tax-exempt under both names.

http://www.autoinflammatory.org

Last Updated: 24 Jul 2015

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International Foundation for Autoimmune Arthritis

We are committed to eliminating the adversity caused by autoimmune arthritis by uniting resources that will raise global awareness, providing wellness education and support, and conducting patient-centered research that will improve the quality of life for those affected by these diseases.

http://www.ifautoimmunearthritis.org

Last Updated: 18 Sep 2014

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International Still's Disease Foundation, Inc.

The purpose and Mission Statement of the International Still's Disease Foundation is to: * Provide support to those who live with Still’s Disease. * Encourage and facilitate communication between people living with, and those impacted by, Still’s Disease. * Provide up-to-date information on Still’s Disease research, treatments and related studies to those with the disease, their families, friends, and health care workers. * Increase general awareness of Still’s to the public.

http://www.stillsdisease.org

Last Updated: 8 May 2014

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General Support Organizations

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General Resources

Still's Disease Video Series

This four part video series can be viewed on our website without being downloaded. It is a free informational series presented by Dr. John J. Cush, on the History, Manifestations, Diagnosis and Management of Still's disease.

Updated 8 Feb 2014

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Still's Disease Free Informational Brochure

Free informational brochure about Adult-onset Still's disease, it's symptoms, medications and helpful information. Will be mailed via USPS to all addresses Internationally.

Updated 8 Feb 2014

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Healthier Ever After (injection tips book & program)

This child-friendly book is for patients and their families to learn how to manage their injectable medications, and has a program to help children to discuss and make a plan of care, and goals with rewards to chart on a reusable white board page.

Updated 6 May 2015

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Still's disease adult onset" returned 133 free, full-text research articles on human participants. First 3 results:

Efficacy of Anakinra in Refractory Adult-Onset Still's Disease: Multicenter Study of 41 Patients and Literature Review.
 

Author(s): Francisco Ortiz-Sanjuán, Ricardo Blanco, Leyre Riancho-Zarrabeitia, Santos Castañeda, Alejandro Olivé, Anne Riveros, María L Velloso-Feijoo, Javier Narváez, Inmaculada Jiménez-Moleón, Olga Maiz-Alonso, Carmen Ordóñez, José A Bernal, María V Hernández, Walter A Sifuentes-Giraldo, Catalina Gómez-Arango, Eva Galíndez-Agirregoikoa, Juan Blanco-Madrigal, Vera Ortiz-Santamaria, Jordi del Blanco-Barnusell, Juan R De Dios, Mireia Moreno, Jordi Fiter, Marina de los Riscos, Patricia Carreira, María J Rodriguez-Valls, M Carmen González-Vela, Vanesa Calvo-Río, Javier Loricera, Natalia Palmou-Fontana, Trinitario Pina, Javier Llorca, Miguel A González-Gay

Journal: Medicine (Baltimore). 2015 Sep;94(39):e1554.

 

Adult-onset Still's disease (AOSD) is often refractory to standard therapy. Anakinra (ANK), an interleukin-1 receptor antagonist, has demonstrated efficacy in single cases and small series of AOSD. We assessed the efficacy of ANK in a series of AOSD patients. Multicenter retrospective ...

Last Updated: 2 Oct 2015

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The potential role of advanced glycation end products (AGEs) and soluble receptors for AGEs (sRAGE) in the pathogenesis of adult-onset still's disease.
 

Author(s): Der-Yuan Chen, Yi-Ming Chen, Chi-Chen Lin, Chia-Wei Hsieh, Yen-Ching Wu, Wei-Ting Hung, Hsin-Hua Chen, Joung-Liang Lan

Journal:

 

Accumulating evidence has demonstrated a pathogenic role of advanced glycation end products (AGEs) and receptors for AGEs (RAGE) in inflammation. Soluble RAGE (sRAGE), with the same ligands-binding capacity as full-length RAGE, acts as a "decoy" receptor. However, there has been scanty ...

Last Updated: 19 May 2015

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Adult-onset Still's disease with disseminated intravascular coagulation and hemophagocytic syndrome: a case report.
 

Author(s): Tetsuhiko Mimura, Masanori Shimodaira, Minoru Kibata, Akihiro Tsukadaira, Kumiko Shirahata

Journal:

 

Adult-onset Still's disease is a rare inflammatory condition of unknown origin characterized by high spiking fever, arthralgia, arthritis, myalgia, salmon-colored evanescent rash, and hepatosplenomegaly. The diagnosis of adult-onset Still's disease requires the exclusion of other ...

Last Updated: 5 Jan 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Still's disease adult onset" returned 14 free, full-text review articles on human participants. First 3 results:

[Pathophysiology, subtypes, and treatments of adult-onset Still's disease: An update].
 

Author(s): M Gerfaud-Valentin, P Sève, A Hot, C Broussolle, Y Jamilloux

Journal: Rev Med Interne. 2015 May;36(5):319-27.

 

Adult-onset Still's disease is a rare and difficult to diagnose multisystemic disorder considered as a multigenic autoinflammatory syndrome. Its immunopathogenesis seems to be at the crossroads between inflammasomopathies and hemophagocytic lymphohistiocytosis, the most severe manifestation ...

Last Updated: 30 Apr 2015

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Adult-onset Still's disease.
 

Author(s): Mathieu Gerfaud-Valentin, Yvan Jamilloux, Jean Iwaz, Pascal Sève

Journal: Autoimmun Rev. 2014 Jul;13(7):708-22.

 

First described in 1971, adult-onset Still's disease (AOSD) is a rare multisystemic disorder considered as a complex (multigenic) autoinflammatory syndrome. A genetic background would confer susceptibility to the development of autoinflammatory reactions to environmental triggers. ...

Last Updated: 21 Apr 2014

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Adult onset Still's disease as a paraneoplastic syndrome--a case report and review of the literature.
 

Author(s): Sedat Yilmaz, Ahmet Karakas, Muhammet Cinar, Omer Coskun, Ismail Simsek, Hakan Erdem, Can Polat Eyigun, Salih Pay

Journal: Bull Hosp Jt Dis (2013). 2013 ;71(2):156-60.

 

Adult onset Still's disease (AOSD) is a systemic inflammatory disease with unknown etiology and characterized by evanescent salmon pink rash, sore throat, liver dysfunction, lymphadenopathy, hepatosplenomegaly, arthritis, and leukocytosis. It is a diagnosis of exclusion; however, ...

Last Updated: 16 Sep 2013

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Canakinumab for Treatment of Adult Onset Still's Disease
 

Status: Recruiting

Condition Summary: Adult-Onset Still´s Disease

 

Last Updated: 27 Jul 2015

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Efficacy and Safety of Tocilizumab in Adult's Still Disease
 

Status: Not yet recruiting

Condition Summary: Adult's Still Disease

 

Last Updated: 26 Oct 2009

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Therapeutic Use of Tadekinig Alfa in Adult-onset Still's Disease
 

Status: Recruiting

Condition Summary: Still's Disease, Adult-Onset

 

Last Updated: 22 Dec 2015

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