Stiff person syndrome

Common Name(s)

Stiff person syndrome

Stiff person syndrome is a rare neurological disorder with features of an autoimmune disease. It affects twice as many women as men. It is frequently associated with other autoimmune diseases such as diabetes, thyroiditis, vitiligo, and pernicious anemia .  Symptoms may include muscle stiffness in the trunk and limbs, heightened sensitivity to noise and touch, and emotional distress which can set off muscle spasms and cause falls. Treatment may involve high-dose diazepam, anti-convulsants, or intravenous immunoglobulin.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Stiff person syndrome" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Stiff person syndrome" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Stiff person syndrome" returned 32 free, full-text research articles on human participants. First 3 results:

Anti-GAD negative stiff person syndrome with a favorable response to intravenous methylprednisolone: an experience over evidence.
 

Author(s): Bhawna Sharma, Kadam Nagpal, Swayam Prakash, Pankaj Gupta

Journal: Neurol India. ;62(1):76-7.

 

Last Updated: 10 Mar 2014

Go To URL
Paraneoplastic stiff person syndrome associated with colon cancer misdiagnosed as idiopathic Parkinson's disease worsened after capecitabine therapy.
 

Author(s): Sasa Badzek, Vladimir Miletic, Juraj Prejac, Irma Gorsic, Hilda Golem, Ervina Bilic, Domina Kekez, Niksa Librenjak, Stjepko Plestina

Journal:

 

To refresh clinical diagnostic dilemmas in patients presenting with symptoms resembling to those of parkinsonism, to report rare association of colon cancer and paraneoplastic stiff person syndrome (SPS), and to draw attention on the possible correlation of capecitabine therapy with ...

Last Updated: 15 Nov 2013

Go To URL
Anti-GAD positive stiff-person syndrome and cerebellar ataxia: two treatable conditions that clinicians should be aware of.
 

Author(s): Henrique Ballalai Ferraz

Journal: Arq Neuropsiquiatr. 2012 Sep;70(9):655-6.

 

Last Updated: 19 Sep 2012

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Stiff person syndrome" returned 3 free, full-text review articles on human participants. First 3 results:

Autoimmune stiff person syndrome and related myelopathies: understanding of electrophysiological and immunological processes.
 

Author(s): Goran Rakocevic, Mary Kay Floeter

Journal: Muscle Nerve. 2012 May;45(5):623-34.

 

Stiff person syndrome (SPS) is a disabling autoimmune central nervous system disorder characterized by progressive muscle rigidity and gait impairment with superimposed painful spasms that involve axial and limb musculature, triggered by heightened sensitivity to external stimuli. ...

Last Updated: 13 Apr 2012

Go To URL

Last Updated: 29 Oct 2010

Go To URL
Stiff-person syndrome associated with cerebellar ataxia and high glutamic acid decarboxylase antibody titer.
 

Author(s): S Kono, H Miyajima, M Sugimoto, Y Suzuki, Y Takahashi, A Hishida

Journal: Intern. Med.. 2001 Sep;40(9):968-71.

 

Glutamic acid decarboxylase (GAD) is the main target of humoral autoimmunity in patients with insulin-dependent diabetes mellitus (IDDM) and stiff-person syndrome. We reviewed the case of a 46-year-old woman who had cerebellar ataxia before getting stiff-person syndrome and IDDM with ...

Last Updated: 2 Oct 2001

Go To URL
 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Last Updated: 6 Feb 2014

Go to URL