Stevens-Johnson syndrome

Common Name(s)

Stevens-Johnson syndrome, Stevens Johnson Syndrome

Stevens-Johnson Syndrome (SJS), also called erythema multiforme major, is a limited form of toxic epidermal necrolysis. This disorder affects the skin, mucous membranes and eyes. Stevens-Johnson syndrome occurs twice as often in men as women, and most cases appear in children and young adults under 30, although it can develop in people at any age.  It is an emergency medical condition that usually requires hospitalization. Treatment focuses on eliminating the underlying cause, controlling symptoms and minimizing complications.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Stevens-Johnson syndrome" for support, advocacy or research.

Stevens Johnson Syndrome Foundation

The SJS Foundation was founded to be a resource to SJS victims and their families. Our mission is provide support services, and compile and distribute valuable information about SJS to the public and medical professionals regarding treatments and therapies that prove beneficial to SJS sufferers. We work to promote public awareness about the signs of SJS so that a quick diagnosis can be made and the offending drug stopped as soon as possible.

Last Updated: 28 Apr 2014

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Stevens-Johnson syndrome" for support, advocacy or research.

Stevens Johnson Syndrome Foundation

The SJS Foundation was founded to be a resource to SJS victims and their families. Our mission is provide support services, and compile and distribute valuable information about SJS to the public and medical professionals regarding treatments and therapies that prove beneficial to SJS sufferers. We work to promote public awareness about the signs of SJS so that a quick diagnosis can be made and the offending drug stopped as soon as possible.

http://www.sjsupport.org

Last Updated: 28 Apr 2014

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Stevens-Johnson syndrome" returned 138 free, full-text research articles on human participants. First 3 results:

Ocular manifestation, complications and aetiological factors in Stevens-Johnson syndrome/toxic epidermal necrolysis.
 

Author(s): Shaukat Ali Chhipa, Sadia Masood, Yasir Salarzai, Qazi Assad Khan, Khabir Ahmad, Sara Sajid

Journal: J Pak Med Assoc. 2015 Jan;65(1):62-4.

 

To describe the ocular manifestations of Stevens-Johnson Syndrome/Toxic Epidermal Necrosis among inpatients at a tertiary care hospital.

Last Updated: 2 Apr 2015

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Bronchiolitis obliterans associated with Stevens-Johnson syndrome: a case report.
 

Author(s): Hyungchul Park, Young Bo Ko, Hyouk-Soo Kwon, Chae-Man Lim

Journal: Yonsei Med. J.. 2015 Mar;56(2):578-81.

 

We report a case of bronchiolitis obliterans associated with Stevens-Johnson syndrome. A 59-year-old man presented with respiratory distress that gradually worsened over 3 months. He had been diagnosed with Stevens-Johnson syndrome 3 months before admission. He had no history of previous ...

Last Updated: 16 Feb 2015

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Beneficial therapeutic effects of hemoperfusion in the treatment of severe Stevens-Johnson syndrome/toxic epidermal necrolysis: preliminary results.
 

Author(s): Y-M Wang, Y-H Tao, T Feng, H Li

Journal: Eur Rev Med Pharmacol Sci. 2014 ;18(23):3696-701.

 

Most of Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe drug eruptions. There is currently no established treatment due to a lack of controlled/blinded studies. High-dose glucocorticoids and intravenous immunoglobulins (IVIG) therapy have been widely ...

Last Updated: 23 Dec 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Stevens-Johnson syndrome" returned 14 free, full-text review articles on human participants. First 3 results:

A systematic review of the drug-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in Indian population.
 

Author(s): Tejas K Patel, Manish J Barvaliya, Dineshchandra Sharma, Chandrabhanu Tripathi

Journal: Indian J Dermatol Venereol Leprol. ;79(3):389-98.

 

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare severe cutaneous drug reactions. No large scale epidemiological data are available for this disorder in India.

Last Updated: 26 Apr 2013

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[Stevens-Johnson syndrome and toxic epidermal necrolysis].
 

Author(s): Ana Oliveira, Madalena Sanches, Manuela Selores

Journal: Acta Med Port. 2011 Dec;24 Suppl 4():995-1002.

 

Stevens-Johnson syndrome and toxic epidermal necrolysis are potentially life-threatening adverse cutaneous drug reactions. Clinically, it manifests as a rash, often morbilliform, or atypical target lesions that evolve to epidermal detachment. There is mucosal involvement in almost ...

Last Updated: 6 Aug 2012

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[Stevens-Johnson syndrome and toxic epidermal necrolysis in children].
 

Author(s): Norberto Sotelo-Cruz

Journal: Gac Med Mex. ;148(3):265-75.

 

The Stevens-Johnson syndrome (SJS) and the toxic epidermal necrolysis (TEN) are clinical conditions manifesting as adverse cutaneous reaction to drugs in majority of cases, constituting the same clinical spectrum, differing only in the severity of epidermolysis; both conditions are ...

Last Updated: 23 Jul 2012

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Last Updated: 18 Dec 2012

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Study to Evaluate the Use of Palifermin to Treat Toxic Epidermal Necrolysis
 

Status: Recruiting

Condition Summary: Toxic Epidermal Necrolysis; Stevens-Johnson Syndrome

 

Last Updated: 13 Jan 2014

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Clinical Trial on the Effect of Autologous Oral Mucosal Epithelial Sheet Transplantation
 

Status: Available

Condition Summary: Limbal Stem Cell Deficiency; Stevens-johnson Syndrome; Ocular Cicatricial Pemphigoid; Chemical Burn

 

Last Updated: 20 May 2015

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