Stevens-Johnson syndrome

Common Name(s)

Stevens-Johnson syndrome, Stevens Johnson Syndrome

Stevens-Johnson Syndrome (SJS), also called erythema multiforme major, is a limited form of toxic epidermal necrolysis. This disorder affects the skin, mucous membranes and eyes. Stevens-Johnson syndrome occurs twice as often in men as women, and most cases appear in children and young adults under 30, although it can develop in people at any age.  It is an emergency medical condition that usually requires hospitalization. Treatment focuses on eliminating the underlying cause, controlling symptoms and minimizing complications.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Stevens-Johnson syndrome" for support, advocacy or research.

Stevens Johnson Syndrome Foundation

The SJS Foundation was founded to be a resource to SJS victims and their families. Our mission is provide support services, and compile and distribute valuable information about SJS to the public and medical professionals regarding treatments and therapies that prove beneficial to SJS sufferers. We work to promote public awareness about the signs of SJS so that a quick diagnosis can be made and the offending drug stopped as soon as possible.

Last Updated: 28 Apr 2014

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Stevens-Johnson syndrome" for support, advocacy or research.

Stevens Johnson Syndrome Foundation

The SJS Foundation was founded to be a resource to SJS victims and their families. Our mission is provide support services, and compile and distribute valuable information about SJS to the public and medical professionals regarding treatments and therapies that prove beneficial to SJS sufferers. We work to promote public awareness about the signs of SJS so that a quick diagnosis can be made and the offending drug stopped as soon as possible.

http://www.sjsupport.org

Last Updated: 28 Apr 2014

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Stevens-Johnson syndrome" returned 182 free, full-text research articles on human participants. First 3 results:

Stevens Johnson syndrome-Toxic Epidermal Necrolysis Overlap induced by sulfasalazine treatment: a case report.
 

Author(s): Nada Zizi, Abdelhafid Elmrahi, Siham Dikhaye, Nadia Fihmi, Zayneb Alami

Journal: Tunis Med. 2015 Jul;93(7):413-5.

 

Stevens Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are life-threatening and severe adverse cutaneous drug reactions characterized by epidermal detachment presenting as blisters and areas of denuded skin. SJS, SJS-TEN overlap and TEN differ only by their extent of skin detachment.

Last Updated: 13 Jan 2016

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[Bronchiolitis obliterans associated with Stevens-Johnson syndrome].
 

Author(s): Mariano Fielli, Adrián Ceccato, Alejandra González, Marcelo Villaverde

Journal: Medicina (B Aires). 2015 ;75(6):413-5.

 

Stevens-Johnson syndrome is a severe disease which is characterized by fever and mucocutaneous lesions. It has also been described as a small airway compromise in the form of bronchiolitis obliterans. We report a 22-year-old male patient with Stevens-Johnson syndrome due to antibiotic ...

Last Updated: 28 Dec 2015

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Lingual botryomycoma in the aftermath of Stevens-Johnson syndrome.
 

Author(s): Houyam Moundib, Fouzia Hali

Journal:

 

Last Updated: 25 Sep 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Stevens-Johnson syndrome" returned 17 free, full-text review articles on human participants. First 3 results:

[News in severe clinical adverse drug reactions: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN)].
 

Author(s): Sylvia Aide Martínez-Cabriales, Minerva Gómez-Flores, Jorge Ocampo-Candiani

Journal: Gac Med Mex. ;151(6):777-87.

 

Stevens-Johnson syndrome and toxic epidermal necrolysis are life-threatening conditions associated with significant morbidity and mortality. They are considered to be part of a spectrum of cutaneous drug reactions, differing only by their extent of skin detachment due to keratinocyte ...

Last Updated: 20 Nov 2015

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Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN): could retinoids play a causative role?
 

Author(s): Anthony R Mawson, Ike Eriator, Sridhar Karre

Journal:

 

Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) are overlapping manifestations on a spectrum of acute drug-induced conditions associated with severe blistering, skin peeling, and multi-organ damage. TEN is an eruption resembling severe scalding, with ≥30% skin ...

Last Updated: 12 Jan 2015

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A systematic review of the drug-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in Indian population.
 

Author(s): Tejas K Patel, Manish J Barvaliya, Dineshchandra Sharma, Chandrabhanu Tripathi

Journal: Indian J Dermatol Venereol Leprol. ;79(3):389-98.

 

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare severe cutaneous drug reactions. No large scale epidemiological data are available for this disorder in India.

Last Updated: 26 Apr 2013

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Severe Cutaneous Adverse Reactions in Thailand
 

Status: Recruiting

Condition Summary: Steven-Johnson Syndrome; Toxic Epidermal Necrolysis; Drug Reaction With Eosinophilia and Systemic Symptoms; Acute Generalized Exanthematous Pustulosis; Generalized Bullous Fixed Drug Eruption

 

Last Updated: 29 Oct 2015

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Study to Evaluate the Use of Palifermin to Treat Toxic Epidermal Necrolysis
 

Status: Recruiting

Condition Summary: Toxic Epidermal Necrolysis; Stevens-Johnson Syndrome

 

Last Updated: 13 Jan 2014

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Clinical Trial on the Effect of Autologous Oral Mucosal Epithelial Sheet Transplantation
 

Status: Available

Condition Summary: Limbal Stem Cell Deficiency; Stevens-johnson Syndrome; Ocular Cicatricial Pemphigoid; Chemical Burn

 

Last Updated: 18 Apr 2016

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