Stevens-Johnson syndrome

Common Name(s)

Stevens-Johnson syndrome, Stevens Johnson Syndrome

Stevens-Johnson Syndrome (SJS), also called erythema multiforme major, is a limited form of toxic epidermal necrolysis. This disorder affects the skin, mucous membranes and eyes. Stevens-Johnson syndrome occurs twice as often in men as women, and most cases appear in children and young adults under 30, although it can develop in people at any age.  It is an emergency medical condition that usually requires hospitalization. Treatment focuses on eliminating the underlying cause, controlling symptoms and minimizing complications.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Stevens-Johnson syndrome" for support, advocacy or research.

Stevens Johnson Syndrome Foundation

The SJS Foundation was founded to be a resource to SJS victims and their families. Our mission is provide support services, and compile and distribute valuable information about SJS to the public and medical professionals regarding treatments and therapies that prove beneficial to SJS sufferers. We work to promote public awareness about the signs of SJS so that a quick diagnosis can be made and the offending drug stopped as soon as possible.

Last Updated: 28 Apr 2014

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Stevens-Johnson syndrome" for support, advocacy or research.

Stevens Johnson Syndrome Foundation

The SJS Foundation was founded to be a resource to SJS victims and their families. Our mission is provide support services, and compile and distribute valuable information about SJS to the public and medical professionals regarding treatments and therapies that prove beneficial to SJS sufferers. We work to promote public awareness about the signs of SJS so that a quick diagnosis can be made and the offending drug stopped as soon as possible.

http://www.sjsupport.org

Last Updated: 28 Apr 2014

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Stevens-Johnson syndrome" returned 127 free, full-text research articles on human participants. First 3 results:

Evaluation of conjunctival bacterial flora in patients with Stevens-Johnson Syndrome.
 

Author(s): Luciana Frizon, Marília Cavalcante Araújo, Larissa Andrade, Maria Cecília Zorat Yu, Tais Hitomi Wakamatsu, Ana Luisa Höfling-Lima, José Álvaro Pereira Gomes

Journal: Clinics (Sao Paulo). 2014 Mar;69(3):168-72.

 

To determine the conjunctival bacterial flora present in patients with Stevens-Johnson syndrome.

Last Updated: 14 Mar 2014

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Pancytopenia as an early indicator for Stevens-Johnson syndrome complicated with hemophagocytic lymphohistiocytosis: a case report.
 

Author(s): Zhi-Dan Fan, Xiao-Qing Qian, Hai-Guo Yu

Journal:

 

Stevens-Johnson syndrome (SJS) is a severe skin and mucosal bullous disease. When complicated with Hemophagocytic lymphohistiocytosis (HLH), the condition is especially life-threatening.

Last Updated: 14 Feb 2014

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Association between the HLA-B*15:02 allele and carbamazepine-induced Stevens-Johnson syndrome/toxic epidermal necrolysis in Han individuals of northeastern China.
 

Author(s): Xiao-Jing He, Ling-Yan Jian, Xiao-Lin He, Yan Wu, Yuan-Yuan Xu, Xiao-Jie Sun, Li-Yan Miao, Li-Mei Zhao

Journal: Pharmacol Rep. 2013 ;65(5):1256-62.

 

This study examined the significant association between carbamazepine (CBZ)-induced Stevens-Johnson Syndrome (SJS)/toxic epidermal necrolysis (TEN) and HLA-B*15:02 in epilepsy patients of Han ethnicity living in northeastern China.

Last Updated: 8 Jan 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Stevens-Johnson syndrome" returned 14 free, full-text review articles on human participants. First 3 results:

A systematic review of the drug-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in Indian population.
 

Author(s): Tejas K Patel, Manish J Barvaliya, Dineshchandra Sharma, Chandrabhanu Tripathi

Journal: Indian J Dermatol Venereol Leprol. ;79(3):389-98.

 

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare severe cutaneous drug reactions. No large scale epidemiological data are available for this disorder in India.

Last Updated: 26 Apr 2013

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[Stevens-Johnson syndrome and toxic epidermal necrolysis].
 

Author(s): Ana Oliveira, Madalena Sanches, Manuela Selores

Journal: Acta Med Port. 2011 Dec;24 Suppl 4():995-1002.

 

Stevens-Johnson syndrome and toxic epidermal necrolysis are potentially life-threatening adverse cutaneous drug reactions. Clinically, it manifests as a rash, often morbilliform, or atypical target lesions that evolve to epidermal detachment. There is mucosal involvement in almost ...

Last Updated: 6 Aug 2012

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Association of HLA-B*5801 allele and allopurinol-induced Stevens Johnson syndrome and toxic epidermal necrolysis: a systematic review and meta-analysis.
 

Author(s): Ratchadaporn Somkrua, Elizabeth E Eickman, Surasak Saokaew, Manupat Lohitnavy, Nathorn Chaiyakunapruk

Journal:

 

Despite some studies suggesting a possible association between human leukocyte antigen, HLA-B*5801 and allopurinol induced Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN), the evidence of association and its magnitude remain inconclusive. This study aims to systematically ...

Last Updated: 10 Oct 2011

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Last Updated: 18 Dec 2012

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Topical Infliximab in Autoimmune Eyes With Keratoprosthesis
 

Status: Not yet recruiting

Condition Summary: Stevens-Johnson Syndrome; Toxic Epidermal Necrolysis (Lyell) Syndrome; Mucous Membrane Pemphigoid

 

Last Updated: 27 Apr 2014

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Study to Evaluate the Use of Palifermin to Treat Toxic Epidermal Necrolysis
 

Status: Recruiting

Condition Summary: Toxic Epidermal Necrolysis; Stevens-Johnson Syndrome

 

Last Updated: 13 Jan 2014

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