Stargardt disease

Common Name(s)

Stargardt disease, Stargardt Macular Dystrophies

Stargardt disease is a genetic eye disorder that causes progressive vision loss. This disorder affects the macula, an area of the retina responsible for sharp central vision (needed for detailed tasks such as reading, driving, and recognizing faces). Individuals with the condition have abnormal accumulation of a fatty yellow pigment (lipofuscin) in the cells underlying the macula, which causes central vision loss. People with Stargardt disease also have problems with night vision and some people may have problems with color vision. The signs and symptoms of Stargardt disease typically appear in late childhood to early adulthood and worsen over time. It is usually caused by mutations in the ABCA4 gene and inherited in an autosomal recessive manner, but it can also be caused by mutations in the ELOVL4 gene and inherited in an autosomal dominant manner.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Stargardt disease" for support, advocacy or research.

Logo
Foundation Fighting Blindness

The urgent mission of the Foundation Fighting Blindness is to drive the research that will provide preventions, treatments, and cures for people affected by retinitis pigmentosa, macular degeneration, Usher syndrome and the entire spectrum of retinal degenerative diseases.

Last Updated: 3 Nov 2012

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Stargardt disease" for support, advocacy or research.

Logo
Foundation Fighting Blindness

The urgent mission of the Foundation Fighting Blindness is to drive the research that will provide preventions, treatments, and cures for people affected by retinitis pigmentosa, macular degeneration, Usher syndrome and the entire spectrum of retinal degenerative diseases.

https://www.fightblindness.org

Last Updated: 3 Nov 2012

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Stargardt disease" returned 56 free, full-text research articles on human participants. First 3 results:

Clinical and molecular characteristics of childhood-onset Stargardt disease.
 

Author(s): Kaoru Fujinami, Jana Zernant, Ravinder K Chana, Genevieve A Wright, Kazushige Tsunoda, Yoko Ozawa, Kazuo Tsubota, Anthony G Robson, Graham E Holder, Rando Allikmets, Michel Michaelides, Anthony T Moore

Journal: Ophthalmology. 2015 Feb;122(2):326-34.

 

To describe the clinical and molecular characteristics of patients with childhood-onset Stargardt disease (STGD).

Last Updated: 27 Jan 2015

Go To URL
The external limiting membrane in early-onset Stargardt disease.
 

Author(s): Winston Lee, Kalev Nõupuu, Maris Oll, Tobias Duncker, Tomas Burke, Jana Zernant, Srilaxmi Bearelly, Stephen H Tsang, Janet R Sparrow, Rando Allikmets

Journal:

 

To describe pathologic changes of the external limiting membrane (ELM) in young patients with early-onset Stargardt (STGD1) disease.

Last Updated: 3 Oct 2014

Go To URL
Molecular diagnosis of putative Stargardt disease by capture next generation sequencing.
 

Author(s): Xiao Zhang, Xianglian Ge, Wei Shi, Ping Huang, Qingjie Min, Minghan Li, Xinping Yu, Yaming Wu, Guangyu Zhao, Yi Tong, Zi-Bing Jin, Jia Qu, Feng Gu

Journal:

 

Stargardt Disease (STGD) is the commonest genetic form of juvenile or early adult onset macular degeneration, which is a genetically heterogeneous disease. Molecular diagnosis of STGD remains a challenge in a significant proportion of cases. To address this, seven patients from five ...

Last Updated: 25 Apr 2014

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Stargardt disease" returned 1 free, full-text review articles on human participants. First 3 results:

Frequency of ABCA4 mutations in 278 Spanish controls: an insight into the prevalence of autosomal recessive Stargardt disease.
 

Author(s): R Riveiro-Alvarez, J Aguirre-Lamban, M Angel Lopez-Martinez, M Jose Trujillo-Tiebas, D Cantalapiedra, E Vallespin, A Avila-Fernandez, C Ramos, C Ayuso

Journal: Br J Ophthalmol. 2009 Oct;93(10):1359-64.

 

To determine the carrier frequency of ABCA4 mutations in order to achieve an insight into the prevalence of autosomal recessive Stargardt disease (arSTGD) in the Spanish population.

Last Updated: 25 Sep 2009

Go To URL
 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Tolerability and Effects of ALK-001 on Stargardt Disease
 

Status: Not yet recruiting

Condition Summary: Stargardt Disease; Stargardt Macular Degeneration; Stargardt Macular Dystrophy; Autosomal Recessive Stargardt Disease 1 (ABCA4-related)

 

Last Updated: 27 Mar 2015

Go to URL
Novel Quantification Methods for Fluorescence to Detect Progression in Stargardt Disease
 

Status: Recruiting

Condition Summary: Stargardt Disease

 

Last Updated: 19 Sep 2012

Go to URL

Last Updated: 1 Apr 2015

Go to URL