Spotted fever

Common Name(s)

Spotted fever

Spotted fever is an infectious disease caused by certain types of Rickettsial bacteria. The bacteria are transmitted though tick bites. There are four types of spotted fever: Mediterranean spotted fever, Rocky Mountain spotted fever, Queensland tick typhus, and Helvetica spotted fever. Spotted fevers are difficult to diagnose at first. Common initial symptoms include fever, muscle pains, headache, nausea and vomiting. Later symptoms includes a spotted rash, joint pain, pains in the abdomen or stomach area and forgetfullness. Diagnosis is made usually by the combination of fever, skin rash and known tick bite. Blood tests may also be performed. Most types of spotted fever are mild to moderate illnesses. However if left untreated they can become potentially serious and even fatal, especially in older people and in people whose immune system (the body's defense system against disease and infection) is weak. The most serious type of the spotted fever is the Rocky Mountain spotted fever, and many people affected with Rocky Mountain spotted fever require hospitalization. Antibiotics are used to treat spotted fevers, and if the infection becomes more serious, other symptoms are treated as needed. If you or a family member has been bitten by a tick and develops a fever and skin rash, it is important to go to your doctor.

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Condition Specific Organizations

Following organizations serve the condition "Spotted fever" for support, advocacy or research.

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Spotted fever" returned 218 free, full-text research articles on human participants. First 3 results:

Complete genomic DNA sequence of the East Asian spotted fever disease agent Rickettsia japonica.
 

Author(s): Minenosuke Matsutani, Motohiko Ogawa, Naohisa Takaoka, Nozomu Hanaoka, Hidehiro Toh, Atsushi Yamashita, Kenshiro Oshima, Hideki Hirakawa, Satoru Kuhara, Harumi Suzuki, Masahira Hattori, Toshio Kishimoto, Shuji Ando, Yoshinao Azuma, Mutsunori Shirai

Journal:

 

Rickettsia japonica is an obligate intracellular alphaproteobacteria that causes tick-borne Japanese spotted fever, which has spread throughout East Asia. We determined the complete genomic DNA sequence of R. japonica type strain YH (VR-1363), which consists of 1,283,087 base pairs ...

Last Updated: 16 Sep 2013

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Mediterranean spotted fever in southeastern Romania.
 

Author(s): Daniela Pitigoi, Ioana D Olaru, Daniela Badescu, Alexandru Rafila, Victoria Arama, Adriana Hristea

Journal: Biomed Res Int. 2013 ;2013():395806.

 

Although cases of Mediterranean spotted fever (MSF) have been reported for decades in southeastern Romania, there are few published data. We retrospectively studied 339 patients, diagnosed with MSF at the National Institute of Infectious Diseases "Prof. Dr. Matei Bals" between 2000 ...

Last Updated: 11 Sep 2013

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Changes of Bcl-2, Bax and Caspase-3 expression in the dermal microvascular endothelial cells and the epidermal layers of the eschar (tache noire) in patients with Mediterranean spotted fever.
 

Author(s): Ivan Georgiev Baltadzhiev, Slavi Dimitrov Delchev

Journal: Folia Histochem. Cytobiol.. 2013 ;51(2):121-6.

 

Mediterranean spotted fever (MSF) is widely prevalent in many endemic regions in Bulgaria. The disease is still not quite thoroughly studied as to some aspects of its pathogenesis and especially to issues that concern the crucial signals for apoptosis in the target microvascular endothelial ...

Last Updated: 2 Aug 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Spotted fever" returned 13 free, full-text review articles on human participants. First 3 results:

Ecology, biology and distribution of spotted-fever tick vectors in Brazil.
 

Author(s): Matias P J Szabó, Adriano Pinter, Marcelo B Labruna

Journal:

 

Spotted-fever-caused Rickettsia rickettsii infection is in Brazil the major tick-borne zoonotic disease. Recently, a second and milder human rickettsiosis caused by an agent genetically related to R. parkeri was discovered in the country (Atlantic rainforest strain). Both diseases ...

Last Updated: 22 Jul 2013

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Q fever and Mediterranean spotted fever associated with hemophagocytic syndrome: case study and literature review.
 

Author(s): M Lecronier, V Prendki, M Gerin, M Schneerson, A Renvoisé, C Larroche, M Ziol, O Fain, A Mekinian

Journal: Int. J. Infect. Dis.. 2013 Aug;17(8):e629-33.

 

Hemophagocytosis during Q fever (QF) and Mediterranean spotted fever (MSF) is rare and only a few cases have been reported. We aimed to investigate the characteristics, outcome, and treatment of QF/MSF-associated hemophagocytosis.

Last Updated: 17 Jun 2013

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A case of Japanese spotted fever complicated with central nervous system involvement and multiple organ failure.
 

Author(s): Ruka Nakata, Masakatsu Motomura, Masahiro Tokuda, Hideki Nakajima, Tomoko Masuda, Taku Fukuda, Akira Tsujino, Toshiro Yoshimura, Atsushi Kawakami

Journal: Intern. Med.. 2012 ;51(7):783-6.

 

Japanese spotted fever (JSF), first reported in 1984, is a rickettsial disease characterized by high fever, rash, and eschar formation. A 61-year-old man was admitted to a local hospital in Nagasaki City, Japan, after several days of high fever and generalized skin erythema. His condition ...

Last Updated: 2 Apr 2012

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Laboratory Diagnosis of of Rickettsial and Rickettsia-like Diseases
 

Status: Recruiting

Condition Summary: Rickettsioses

 

Last Updated: 28 Sep 2012

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Pharmacokinetics of Understudied Drugs Administered to Children Per Standard of Care
 

Status: Recruiting

Condition Summary: Infection; Hypertension; Anesthesia; Pain; Reflux; Nausea; Edema; Hyperlipidemia; Hypotension; Hypercholesterolemia; Sedation; Anxiolysis; Benzodiazepine Withdrawal; Bipolar Disorder; Autistic Disorder; Schizophrenia; Influenza Treatment or Prophylaxis; Acute Decompensated Heart Failure; Stable Angina; Life-threatening Fungal Infections; Nosocomial Pneumonia; Community Acquired Pneumonia; Acute Bacterial Exacerbation of Chronic Bronchitis; Complicated Skin and Skin Structure Infections; Uncomplicated Skin and Skin Structure Infections; Chronic Bacterial Prostatitis; Complicated Urinary Tract Infections; Acute Pyelonephritis; Uncomplicated Urinary Tract Infections; Inhalational Anthrax (Post-Exposure)

 

Last Updated: 30 Jul 2014

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