Autoimmune Polyglandular Syndrome Type 1

Common Name(s)

Autoimmune Polyglandular Syndrome Type 1

Autoimmune polyglandular syndrome type 1 is an inherited autoimmune condition that affects many of the body's organs. Symptoms often begin in childhood or adolescence and may include mucocutaneous candidiasis, hypoparathyroidism, and Addison disease. Affected individuals typically have at least two of these features, and many have all three. This syndrome can cause a variety of additional signs and symptoms, although they occur less often. Complications of this disorder can affect the skin and nails, the gonads (ovaries and testicles), the eyes, the thyroid, and the digestive system. Type 1 diabetes also occurs in some patients with this condition. Mutations in the AIRE gene cause autoimmune polyglandular syndrome, type 1. This condition is inherited in an autosomal recessive fashion.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Autoimmune Polyglandular Syndrome Type 1" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Autoimmune Polyglandular Syndrome Type 1" returned 10 free, full-text research articles on human participants. First 3 results:

Meta-analysis of STAT4 and IFIH1 polymorphisms in type 1 diabetes mellitus patients with autoimmune polyglandular syndrome type III.
 

Author(s): J de Azevêdo Silva, N A C Tavares, M M S Santos, R Moura, R L Guimarães, J Araújo, S Crovella, L A C Brandão

Journal:

 

Type 1 diabetes mellitus (T1D) is an organ-specific autoimmune disease characterized by T-cell mediated self-destruction of insulin-producing β cells in the pancreas. T1D patients are prone to develop other glandular autoimmune disorders, such as autoimmune thyroid disease that occurs ...

Last Updated: 19 Jan 2016

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Induction of thyroid remission using rituximab in a patient with type 3 autoimmune polyglandular syndrome including Graves' disease and type 1 diabetes mellitus: a case report.
 

Author(s): Akira Kurozumi, Yosuke Okada, Tadashi Arao, Manabu Narisawa, Keiichi Torimoto, Sunao Yamamoto, Yoshiya Tanaka

Journal: Endocr. J.. 2015 ;62(1):69-75.

 

Rituximab (RTX) is a monoclonal antibody that targets the B-cell-specific CD20 antigen. Recent reports indicate that RTX is effective against type 1 diabetes mellitus (T1DM) and hematologic as well as autoimmune diseases. Other studies have indicated that RTX therapy leads to the ...

Last Updated: 6 Mar 2015

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A case of autoimmune urticaria accompanying autoimmune polyglandular syndrome type III associated with Hashimoto's disease, type 1 diabetes mellitus, and vitiligo.
 

Author(s): Jacek Kasznicki, Józef Drzewoski

Journal: Endokrynol Pol. 2014 ;65(4):320-3.

 

We present a case of autoimmune polyglandular syndrome type III (APS III) associated with Hashimoto's disease, type 1 diabetes mellitus, vitiligo and autoimmune urticaria. This rare genetic disorder occurs with unknown frequency in the Polish population. It is characterised by endocrine ...

Last Updated: 4 Sep 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Autoimmune Polyglandular Syndrome Type 1" returned 1 free, full-text review articles on human participants. First 3 results:

Type 1 diabetes and autoimmune polyglandular syndrome: a clinical review.
 

Author(s): A Van den Driessche, V Eenkhoorn, L Van Gaal, C De Block

Journal: Neth J Med. 2009 Dec;67(11):376-87.

 

Type 1 diabetes mellitus (T1DM) results from autoimmune destruction of insulin-producing beta cells and is characterised by the presence of insulitis and &and beta-cell autoantibodies. Up to one third of patients develop an autoimmune polyglandular syndrome. Fifteen to 30% of T1DM ...

Last Updated: 16 Dec 2009

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

CAMB/MAT2203 in Patients With Mucocutaneous Candidiasis
 

Status: Recruiting

Condition Summary: Candidiasis, Chronic Mucocutaneous

 

Last Updated: 10 Nov 2016

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