Autoimmune Myocarditis

Common Name(s)

Autoimmune Myocarditis

Autoimmune Myocarditis is an inflammation of the myocardium, the middle layer of the heart wall. Autoimmune myocarditis occurs when the body mistakingly used its own immune system to attack healthy heart cells. Signs and symptoms of myocarditis include chest pain, heart failure, abnormal heart rhythms, and shortness of breath during exercise. If myocarditis becomes severe, the pumping action of the heart weakens, and the heart won't be able to supply the rest of the body with enough blood. Clots also could form in the heart, leading to a stroke or heart attack. Several thousand people in the United Sates are diagnosed with myocarditis each year (but not necessarily autoimmune myocarditis). Diagnosis may include several different tests, including: EEG (to measure electrical activity of the heart), chest X-ray, heart biopsy, and cardiac MRI. Treatment typically involves medications to prevent heart failure. In addition, rest and low-salt diets are recommended, and steroids can be used to reduce inflammation.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Autoimmune Myocarditis" for support, advocacy or research.

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The Myocarditis Foundation

The Myocarditis Foundation is dedicated to providing information and support related to the causes, symptoms, diagnosis, and treatment of myocarditis. The Myocarditis Foundation's mission is to educate physicians and the public about this disease, support the patients and their families who have been affected by myocarditis, and ultimately fund research to find ways to better diagnose, treat, and prevent myocarditis.

Last Updated: 29 Nov 2013

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Autoimmune Myocarditis" for support, advocacy or research.

Logo
The Myocarditis Foundation

The Myocarditis Foundation is dedicated to providing information and support related to the causes, symptoms, diagnosis, and treatment of myocarditis. The Myocarditis Foundation's mission is to educate physicians and the public about this disease, support the patients and their families who have been affected by myocarditis, and ultimately fund research to find ways to better diagnose, treat, and prevent myocarditis.

http://www.myocarditisfoundation.org

Last Updated: 29 Nov 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Autoimmune Myocarditis" returned 22 free, full-text research articles on human participants. First 3 results:

Autoimmune myocarditis, valvulitis, and cardiomyopathy.
 

Author(s): Jennifer M Myers, DeLisa Fairweather, Sally A Huber, Madeleine W Cunningham

Journal: Curr Protoc Immunol. 2013 ;Chapter 15():Unit 15.14.1-51.

 

Myocarditis and valvulitis are inflammatory diseases affecting myocardium and valve. Myocarditis, a viral-induced disease of myocardium, may lead to dilated cardiomyopathy and loss of heart function. Valvulitis leads to deformed heart valves and altered blood flow in rheumatic heart ...

Last Updated: 8 Apr 2013

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Successful use of mRNA-nucleofection for overexpression of interleukin-10 in murine monocytes/macrophages for anti-inflammatory therapy in a murine model of autoimmune myocarditis.
 

Author(s): Oliver Zimmermann, Jörg M Homann, Anna Bangert, Anna-Maria Müller, Georgi Hristov, Stefan Goeser, Juliane M Wiehe, Stefan Zittrich, Wolfgang Rottbauer, Jan Torzewski, Gabriele Pfitzer, Hugo A Katus, Ziya Kaya

Journal: J Am Heart Assoc. 2012 Dec;1(6):e003293.

 

Overexpression of interleukin-10 (IL-10) in murine CD11b(+) monocytes/macrophages via GMP-adapted mRNA-nucleofection was expected to improve clinical outcome and reduce adverse side effects in autoimmune myocarditis. This study represents the proof of principle for a novel anti-inflammatory ...

Last Updated: 14 Jan 2013

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Comparison of IL-10 and MCP-1-7ND gene transfer with AAV9 vectors for protection from murine autoimmune myocarditis.
 

Author(s): Ziya Kaya, Christoph Leib, Stanislas Werfel, Stefan Göser, Renate Öttl, Barbara Leuchs, Gabriele Pfitzer, Hugo A Katus, Oliver J Müller

Journal: Cardiovasc. Res.. 2011 Jul;91(1):116-23.

 

Overexpression of therapeutic genes with potential disease-limiting effects, specifically at the site of inflammation, remains a major clinical challenge. In this study, we investigate the potential of adeno-associated virus (AAV)-9-mediated cardiac expression of the anti-inflammatory ...

Last Updated: 13 Jun 2011

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Autoimmune Myocarditis" returned 3 free, full-text review articles on human participants. First 3 results:

Genetic complexity of autoimmune myocarditis.
 

Author(s): Haiyan S Li, Davinna L Ligons, Noel R Rose

Journal: Autoimmun Rev. 2008 Jan;7(3):168-73.

 

Autoimmune myocarditis, a chronic stage of myocardial inflammation, occurs in a small subset of patients after acute cardiotropic viral infection and can lead to dilated cardiomyopathy (DCM). This disease can be recapitulated in susceptible mouse strains by infection with coxsackievirus ...

Last Updated: 14 Jan 2008

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Cytokines that regulate autoimmune myocarditis.
 

Author(s): Michael O Kurrer, Manfred Kopf, Josef M Penninger, Urs Eriksson

Journal: Swiss Med Wkly. 2002 Jul;132(29-30):408-13.

 

A growing body of evidence suggests that autoimmune responses are involved in the pathogenesis of myocarditis and postinfectious cardiomyopathy. Autoimmunity may also arise after ischaemic or traumatic damage to heart tissue. Myocarditis leading to heart failure can be mimicked in ...

Last Updated: 12 Nov 2002

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Cardiac myosin and the TH1/TH2 paradigm in autoimmune myocarditis.
 

Author(s): M W Cunningham

Journal: Am. J. Pathol.. 2001 Jul;159(1):5-12.

 

Last Updated: 4 Jul 2001

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Myocardial Inflammation in Systemic Lupus Erythematosus
 

Status: Recruiting

Condition Summary: SLE

 

Last Updated: 23 Jan 2014

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