Autoimmune Myocarditis

Common Name(s)

Autoimmune Myocarditis

Autoimmune Myocarditis is an inflammation of the myocardium, the middle layer of the heart wall. Autoimmune myocarditis occurs when the body mistakingly used its own immune system to attack healthy heart cells. Signs and symptoms of myocarditis include chest pain, heart failure, abnormal heart rhythms, and shortness of breath during exercise. If myocarditis becomes severe, the pumping action of the heart weakens, and the heart won't be able to supply the rest of the body with enough blood. Clots also could form in the heart, leading to a stroke or heart attack. Several thousand people in the United Sates are diagnosed with myocarditis each year (but not necessarily autoimmune myocarditis). Diagnosis may include several different tests, including: EEG (to measure electrical activity of the heart), chest X-ray, heart biopsy, and cardiac MRI. Treatment typically involves medications to prevent heart failure. In addition, rest and low-salt diets are recommended, and steroids can be used to reduce inflammation.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Autoimmune Myocarditis" for support, advocacy or research.

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The Myocarditis Foundation

The Myocarditis Foundation is dedicated to providing information and support related to the causes, symptoms, diagnosis, and treatment of myocarditis. The Myocarditis Foundation's mission is to educate physicians and the public about this disease, support the patients and their families who have been affected by myocarditis, and ultimately fund research to find ways to better diagnose, treat, and prevent myocarditis.

Last Updated: 29 Nov 2013

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Autoimmune Myocarditis" for support, advocacy or research.

Logo
The Myocarditis Foundation

The Myocarditis Foundation is dedicated to providing information and support related to the causes, symptoms, diagnosis, and treatment of myocarditis. The Myocarditis Foundation's mission is to educate physicians and the public about this disease, support the patients and their families who have been affected by myocarditis, and ultimately fund research to find ways to better diagnose, treat, and prevent myocarditis.

http://www.myocarditisfoundation.org

Last Updated: 29 Nov 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Autoimmune Myocarditis" returned 27 free, full-text research articles on human participants. First 3 results:

The Impact of Circulating Mitochondrial DNA on Cardiomyocyte Apoptosis and Myocardial Injury After TLR4 Activation in Experimental Autoimmune Myocarditis.
 

Author(s): Bangwei Wu, Huanchun Ni, Jian Li, Xinyu Zhuang, Jinjin Zhang, Zhiyong Qi, Qiying Chen, Zhichao Wen, Haiming Shi, Xinping Luo, Bo Jin

Journal: Cell. Physiol. Biochem.. 2017 ;42(2):713-728.

 

Mitochondrial DNA (mtDNA), acting as a newly found 'danger-associated molecular patterns' (DAMPs), is released into circulation upon tissue injury and performs as a considerable activator of inflammation and immune response. However, the role of circulating mtDNA in experimental autoimmune ...

Last Updated: 31 Dec 1969

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FTY720 (Gilenya) treatment prevents spontaneous autoimmune myocarditis and dilated cardiomyopathy in transgenic HLA-DQ8-BALB/c mice.
 

Author(s): Ferenc Boldizsar, Oktavia Tarjanyi, Katalin Olasz, Akos Hegyi, Katalin Mikecz, Tibor T Glant, Tibor A Rauch

Journal: Cardiovasc. Pathol.. ;25(5):353-61.

 

Although dilated cardiomyopathy (DCM) is often caused by viral infections, it frequently involves autoimmune mechanisms associated with particular HLA-DR and DQ alleles. Our homozygous HLA-DQ8Ab(0) transgenic mice in the BALB/c background (HLA-DQ8(BALB/c)-Tg) developed early and progressive ...

Last Updated: 31 Dec 1969

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Biopsy-proven autoimmune myocarditis in HIV-associated dilated cardiomyopathy.
 

Author(s): Andrea Frustaci, Nicola Petrosillo, Marco Francone, Romina Verardo, Giuseppe Ippolito, Cristina Chimenti

Journal:

 

Dilated cardiomyopathy occurring in HIV-infected patients raises both diagnostic and therapeutic challenging problems. Indeed myocardial involvement in HIV infection has been variously attributed to several causes, including viral, toxic, nutritional and autoimmune, but no specific ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Autoimmune Myocarditis" returned 4 free, full-text review articles on human participants. First 3 results:

Unresolved issues in theories of autoimmune disease using myocarditis as a framework.
 

Author(s): Robert Root-Bernstein, DeLisa Fairweather

Journal: J. Theor. Biol.. 2015 Jun;375():101-23.

 

Many theories of autoimmune disease have been proposed since the discovery that the immune system can attack the body. These theories include the hidden or cryptic antigen theory, modified antigen theory, T cell bypass, T cell-B cell mismatch, epitope spread or drift, the bystander ...

Last Updated: 31 Dec 1969

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Future therapeutic strategies in inflammatory cardiomyopathy: insights from the experimental autoimmune myocarditis model.
 

Author(s): Przemyslaw Blyszczuk, Alan Valaperti, Urs Eriksson

Journal: Cardiovasc Hematol Disord Drug Targets. 2008 Dec;8(4):313-21.

 

Inflammatory cardiomyopathy is a common cause of heart failure developing on a basis of cardiac inflammation. Cardiac inflammation - or myocarditis - is usually triggered by infections or cardiac damage of any cause. Experimental autoimmune myocarditis refers to a CD4(+) T cell-mediated ...

Last Updated: 31 Dec 1969

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Genetic complexity of autoimmune myocarditis.
 

Author(s): Haiyan S Li, Davinna L Ligons, Noel R Rose

Journal: Autoimmun Rev. 2008 Jan;7(3):168-73.

 

Autoimmune myocarditis, a chronic stage of myocardial inflammation, occurs in a small subset of patients after acute cardiotropic viral infection and can lead to dilated cardiomyopathy (DCM). This disease can be recapitulated in susceptible mouse strains by infection with coxsackievirus ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

There are currently no open clinical trials for this condition.