Spondyloarthritis

Common Name(s)

Spondyloarthritis, Spondyloarthropathy

Spondyloarthritis (or spondyloarthropathy) is a group of inflammatory diseases that cause arthritis in the sites where tendons and ligaments attach to bones (entheses). There are six forms of spondyloarthritis. The most common is ankylosing spondylitis, which mainly affects the spine. Other diseases in the spondyloarthritis family include axial spondyloarthritis (which affects mainly the spine and pelvic joints), peripheral spondyloarthritis (which affects mostly the arms and legs), reactive arthritis (Reiter’s syndrome), psoriatic arthritis, and enteropathic arthritis/spondylitis associated with inflammatory bowel diseases.

Signs and symptoms of spondyloarthritis varies depending on the disease. However, symptoms typically present with redness and swelling (inflammation) that causes pain and stiffness, usually in the spine. Some forms can affect the hands, feet, arms and legs. Another symptom includes destruction of bone that causes spine abnormalities (deformity). Additional complications of spondyloarthritis may include eye inflammation, compression fractures and heart problems. Symptoms usually begin around late adolescence or early adulthood. The exact cause of the spondyloarthritis group of diseases is unknown. They are believed to be due to a combination of genetic and environmental factors. Individuals with the HLA-B27 form of the HLA-B gene are at greater risk of developing ankylosing spondylitis, the most common type of spondyloarthritis.

To diagnose spondyloarthritis, your doctor will gather a medical history and perform a physical exam. In addition, they may collect images of the affected areas. There is no cure for spondyloarthritis, but treatment can include medications to decrease pain. If you or your child has been diagnosed with spondyloarthritis, talk with your doctor to discuss the current treatment options. Support groups can provide additional information and connect you with others.

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Condition Specific Organizations

Following organizations serve the condition "Spondyloarthritis" for support, advocacy or research.

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Spondyloarthritis" returned 208 free, full-text research articles on human participants. First 3 results:

Activity of JAK/STAT and NF-kB in patients with axial spondyloarthritis.
 

Author(s): Jerzy Świerkot, Renata Sokolik, Anna Czarny, Ewa Zaczyńska, Beata Nowak, Arkadiusz Chlebicki, Lucyna Korman, Marta Madej, Patryk Wojtala, Łukasz Lubiński, Piotr Wiland

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The etiology of axial spondyloarthritis (axSpA) is not fully elucidated. Research continues in determining the mechanisms responsible for initiation of the disease process, its maintenance and development.

Last Updated: 16 Dec 2015

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Does evaluation of the ligamentous compartment enhance diagnostic utility of sacroiliac joint MRI in axial spondyloarthritis?
 

Author(s): Ulrich Weber, Walter P Maksymowych, Stanley M Chan, Kaspar Rufibach, Susanne J Pedersen, Zheng Zhao, Veronika Zubler, Mikkel Østergaard, Robert G W Lambert

Journal:

 

Inflammation of the sacroiliac joints (SIJ) is a fundamental clinical feature of axial spondyloarthritis (SpA). The anatomy of the irregularly shaped SIJ is complex with an antero-inferior cartilaginous compartment containing central hyaline and peripheral fibrocartilage, and a dorso-superior ...

Last Updated: 14 Sep 2015

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Bone loss in patients with early inflammatory back pain suggestive of spondyloarthritis: results from the prospective DESIR cohort.
 

Author(s): Karine Briot, Adrien Etcheto, Corinne Miceli-Richard, Maxime Dougados, Christian Roux

Journal: Rheumatology (Oxford). 2016 Feb;55(2):335-42.

 

The objectives of the study were to assess the 2 year BMD changes and their determinants in patients with early inflammatory back pain suggestive of axial spondyloarthritis (SpA) (DESIR cohort).

Last Updated: 14 Jan 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Spondyloarthritis" returned 50 free, full-text review articles on human participants. First 3 results:

Non-Radiographic Axial Spondyloarthritis.
 

Author(s): Gleb Slobodin, Iris Eshed

Journal: Isr. Med. Assoc. J.. 2015 Dec;17(12):770-6.

 

The term non-radiographic axial spondyloarthritis (nrAxSpA) was coined for patients who have a clinical picture of ankylosing spondylitis (AS) but do not exhibit radiographic sacroiliitis. The ASAS classification criteria for nrAxSpA, ensuring the recruitment of homogenous study cohorts, ...

Last Updated: 22 Feb 2016

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Clinical Tools to Assess and Monitor Spondyloarthritis.
 

Author(s): Robert Landewé, Astrid van Tubergen

Journal: Curr Rheumatol Rep. 2015 Jul;17(7):47.

 

Assessment and monitoring is important in diseases affecting multiple sites and organs, such as axial spondyloarthritis (axSpA) that may have several signs and symptoms, and for which several treatments are available. Instruments for assessment and monitoring should be appropriately ...

Last Updated: 11 Jun 2015

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Are patient-reported outcome instruments for ankylosing spondylitis fit for purpose for the axial spondyloarthritis patient? A qualitative and psychometric analysis.
 

Author(s): Astrid van Tubergen, Peter M Black, Geoffroy Coteur

Journal: Rheumatology (Oxford). 2015 Oct;54(10):1842-51.

 

Several patient-reported outcome (PRO) instruments have been validated in AS. This study aims to evaluate several measurement properties of such PROs in a broad axial SpA (axSpA) population, including both AS and non-radiographic axSpA (nr-axSpA) subpopulations.

Last Updated: 17 Sep 2015

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Last Updated: 3 Jun 2016

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Last Updated: 17 Mar 2015

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Last Updated: 10 May 2016

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