Spondyloarthritis

Common Name(s)

Spondyloarthritis, Spondyloarthropathy

Spondyloarthritis (or spondyloarthropathy) is a group of inflammatory diseases that cause arthritis in the sites where tendons and ligaments attach to bones (entheses). There are six forms of spondyloarthritis. The most common is ankylosing spondylitis, which mainly affects the spine. Other diseases in the spondyloarthritis family include axial spondyloarthritis (which affects mainly the spine and pelvic joints), peripheral spondyloarthritis (which affects mostly the arms and legs), reactive arthritis (Reiter’s syndrome), psoriatic arthritis, and enteropathic arthritis/spondylitis associated with inflammatory bowel diseases.

Signs and symptoms of spondyloarthritis varies depending on the disease. However, symptoms typically present with redness and swelling (inflammation) that causes pain and stiffness, usually in the spine. Some forms can affect the hands, feet, arms and legs. Another symptom includes destruction of bone that causes spine abnormalities (deformity). Additional complications of spondyloarthritis may include eye inflammation, compression fractures and heart problems. Symptoms usually begin around late adolescence or early adulthood. The exact cause of the spondyloarthritis group of diseases is unknown. They are believed to be due to a combination of genetic and environmental factors. Individuals with the HLA-B27 form of the HLA-B gene are at greater risk of developing ankylosing spondylitis, the most common type of spondyloarthritis.

To diagnose spondyloarthritis, your doctor will gather a medical history and perform a physical exam. In addition, they may collect images of the affected areas. There is no cure for spondyloarthritis, but treatment can include medications to decrease pain. If you or your child has been diagnosed with spondyloarthritis, talk with your doctor to discuss the current treatment options. Support groups can provide additional information and connect you with others.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Spondyloarthritis" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Spondyloarthritis" returned 217 free, full-text research articles on human participants. First 3 results:

Gender differences among patients with primary ankylosing spondylitis and spondylitis associated with psoriasis and inflammatory bowel disease in an iberoamerican spondyloarthritis cohort.
 

Author(s): Margarita Landi, Hernán Maldonado-Ficco, Rodolfo Perez-Alamino, José A Maldonado-Cocco, Gustavo Citera, Pablo Arturi, Percival D Sampaio-Barros, Diana E Flores Alvarado, Rubén Burgos-Vargas, Elena Santos, Daniel Palleiro, Miguel A Gutiérrez, Elsa Vieira-Sousa, Fernando Pimentel-Santos, Sergio O Paira, Alberto Berman, Claudia Vera Barrezueta, Janitzia Vazquez-Mellado, Eduardo Collantes-Estevez,

Journal: Medicine (Baltimore). 2016 12;95(51):e5652.

 

The aim of the study was to compare clinical manifestations, disease activity, functional capacity, spinal mobility, and radiological findings between men and women from a multicenter, multiethnic Ibero-American cohort of patients with Spondyloarthritis (SpA).This observational cross-section ...

Last Updated: 21 Dec 2016

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Candida arthritis in a patient diagnosed with spondyloarthritis.
 

Author(s): Remzi Çevik, Recep Tekin, Mehmet Gem

Journal: Rev. Soc. Bras. Med. Trop.. ;49(6):793-795.

 

Candida arthritis is an unusual manifestation that usually affects the knees. A 35-year-old man presented with a 2-month history of pain and swelling in the right knee. Swelling persisted after anti-inflammatory treatment. Peripheric spondyloarthritis was considered, but methotrexate, ...

Last Updated: 21 Dec 2016

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Low-dose modified-release prednisone in axial spondyloarthritis: 3-month efficacy and tolerability.
 

Author(s): Francesca Bandinelli, Francesco Scazzariello, Emanuela Pimenta da Fonseca, Mittermayer Barreto Santiago, Claudio Marcassa, Francesca Nacci, Marco Matucci Cerinic

Journal:

 

Oral glucocorticoids (GCs) have been shown to be effective in reducing the inflammatory symptoms of rheumatoid arthritis, but their use is not supported by evidence in spondyloarthritis (SpA). Modified-release (MR) oral prednisone taken at bedtime has been shown to be more effective ...

Last Updated: 24 Nov 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Spondyloarthritis" returned 56 free, full-text review articles on human participants. First 3 results:

Progression rate of ankylosing spondylitis in patients with undifferentiated spondyloarthritis: A systematic review and meta-analysis.
 

Author(s): Qing Xia, Dazhi Fan, Xiao Yang, Xiaona Li, Xu Zhang, Mengmeng Wang, Shengqian Xu, Faming Pan

Journal: Medicine (Baltimore). 2017 Jan;96(4):e5960.

 

The idea that undifferentiated spondyloarthritis (uSpA) represents the early undifferentiated stage of ankylosing spondylitis (AS) and other well-defined SpA subtypes is well known. The gist of this study is to assess the rate estimate of patients with uSpA evolved to AS during long-term follow-up.

Last Updated: 25 Jan 2017

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Electronic assessment of disease activity and functioning in patients with axial spondyloarthritis: challenges and unmet needs.
 

Author(s): Uta Kiltz, Annelies Boonen, Juergen Braun, Jutta G Richter

Journal: Clin. Exp. Rheumatol.. ;34(5 Suppl 101):S57-S61.

 

The dynamic clinical course of rheumatic conditions indicates a need for regular collection of information on health status to monitor disease activity and functional status. Patient-reported outcomes measures (PROMs) are playing a key role in the evaluation of symptoms and functioning ...

Last Updated: 20 Oct 2016

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An appraisal of golimumab in the treatment of severe, active nonradiographic axial spondyloarthritis.
 

Author(s): Julien Paccou, René-Marc Flipo

Journal:

 

Golimumab (Simponi(®)) is a fully human tumor necrosis factor α inhibitor (TNFi) antibody administered subcutaneously. In the European Union, golimumab is indicated for the treatment of adults with severe, active axial spondyloarthritis (axSpA), which includes both ankylosing spondylitis ...

Last Updated: 29 Jul 2016

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Last Updated: 17 Mar 2015

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Last Updated: 18 Nov 2016

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A Study of Ixekizumab (LY2439821) in Participants With Nonradiographic Axial Spondyloarthritis
 

Status: Recruiting

Condition Summary: Axial Spondyloarthritis

 

Last Updated: 19 Apr 2017

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