Spondyloarthritis

Common Name(s)

Spondyloarthritis, Spondyloarthropathy

Spondyloarthritis (or spondyloarthropathy) is a group of inflammatory diseases that cause arthritis in the sites where tendons and ligaments attach to bones (entheses). There are six forms of spondyloarthritis. The most common is ankylosing spondylitis, which mainly affects the spine. Other diseases in the spondyloarthritis family include axial spondyloarthritis (which affects mainly the spine and pelvic joints), peripheral spondyloarthritis (which affects mostly the arms and legs), reactive arthritis (Reiter’s syndrome), psoriatic arthritis, and enteropathic arthritis/spondylitis associated with inflammatory bowel diseases.

Signs and symptoms of spondyloarthritis varies depending on the disease. However, symptoms typically present with redness and swelling (inflammation) that causes pain and stiffness, usually in the spine. Some forms can affect the hands, feet, arms and legs. Another symptom includes destruction of bone that causes spine abnormalities (deformity). Additional complications of spondyloarthritis may include eye inflammation, compression fractures and heart problems. Symptoms usually begin around late adolescence or early adulthood. The exact cause of the spondyloarthritis group of diseases is unknown. They are believed to be due to a combination of genetic and environmental factors. Individuals with the HLA-B27 form of the HLA-B gene are at greater risk of developing ankylosing spondylitis, the most common type of spondyloarthritis.

To diagnose spondyloarthritis, your doctor will gather a medical history and perform a physical exam. In addition, they may collect images of the affected areas. There is no cure for spondyloarthritis, but treatment can include medications to decrease pain. If you or your child has been diagnosed with spondyloarthritis, talk with your doctor to discuss the current treatment options. Support groups can provide additional information and connect you with others.

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Advocacy and Support Organizations

 

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Condition Specific Organizations

Following organizations serve the condition "Spondyloarthritis" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Spondyloarthritis" returned 185 free, full-text research articles on human participants. First 3 results:

[A brief magnetic resonance imaging protocol for spondyloarthritis].
 

Author(s): Giancarlo Schiappacasse F, Jorge Díaz J, Pablo Alvayay Q

Journal: Rev Med Chil. 2015 Jul;143(7):905-12.

 

Spondyloarthritis is a group of diseases that seriously hampers quality of life. Diagnostic criteria, in which images play an important role, have evolved over time. The most recent diagnostic criteria, published in 2009, included magnetic resonance imaging (MRI) of the sacroiliac ...

Last Updated: 12 Sep 2015

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Acute anterior uveitis and other extra-articular manifestations of spondyloarthritis.
 

Author(s): T C Mitulescu, C Popescu, A Naie, D Predeţeanu, V Popescu, C Alexandrescu, L M Voinea

Journal: J Med Life. ;8(3):319-25.

 

Spondyloarthritis (SpA) is associated with an array of peripheral manifestations. Our study aims to evaluate extra-articular manifestations of SpA in a Romanian academic clinical setting and to observe their associations with different disease measures.

Last Updated: 9 Sep 2015

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ASAS40 and ASDAS clinical responses in the ABILITY-1 clinical trial translate to meaningful improvements in physical function, health-related quality of life and work productivity in patients with non-radiographic axial spondyloarthritis.
 

Author(s): Désirée van der Heijde, Avani Joshi, Aileen L Pangan, Naijun Chen, Keith Betts, Manish Mittal, Yanjun Bao

Journal: Rheumatology (Oxford). 2016 Jan;55(1):80-8.

 

To assess the impact of achieving Assessment in SpondyloArthritis international Society 40% (ASAS40) response or an Ankylosing Spondylitis Disease Activity Score inactive disease (ASDAS-ID) state on patient-reported outcomes (PROs) among patients with non-radiographic axial SpA (nr-axSpA).

Last Updated: 15 Dec 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Spondyloarthritis" returned 47 free, full-text review articles on human participants. First 3 results:

Non-Radiographic Axial Spondyloarthritis.
 

Author(s): Gleb Slobodin, Iris Eshed

Journal: Isr. Med. Assoc. J.. 2015 Dec;17(12):770-6.

 

The term non-radiographic axial spondyloarthritis (nrAxSpA) was coined for patients who have a clinical picture of ankylosing spondylitis (AS) but do not exhibit radiographic sacroiliitis. The ASAS classification criteria for nrAxSpA, ensuring the recruitment of homogenous study cohorts, ...

Last Updated: 22 Feb 2016

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Clinical Tools to Assess and Monitor Spondyloarthritis.
 

Author(s): Robert Landewé, Astrid van Tubergen

Journal: Curr Rheumatol Rep. 2015 Jul;17(7):47.

 

Assessment and monitoring is important in diseases affecting multiple sites and organs, such as axial spondyloarthritis (axSpA) that may have several signs and symptoms, and for which several treatments are available. Instruments for assessment and monitoring should be appropriately ...

Last Updated: 11 Jun 2015

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Biomarkers for diagnosis, monitoring of progression, and treatment responses in ankylosing spondylitis and axial spondyloarthritis.
 

Author(s): John D Reveille

Journal: Clin. Rheumatol.. 2015 Jun;34(6):1009-18.

 

With the growing awareness of the impact of chronic back pain and axial spondyloarthritis and recent breakthroughs in genetics and the development of novel treatments which may impact best on early disease, the need for markers that can facilitate early diagnosis and profiling those ...

Last Updated: 27 May 2015

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Last Updated: 2 May 2016

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Last Updated: 17 Mar 2015

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Last Updated: 29 Jul 2015

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