Spondyloarthritis

Common Name(s)

Spondyloarthritis, Spondyloarthropathy

Spondyloarthritis (or spondyloarthropathy) is a group of inflammatory diseases that cause arthritis in the sites where tendons and ligaments attach to bones (entheses). There are six forms of spondyloarthritis. The most common is ankylosing spondylitis, which mainly affects the spine. Other diseases in the spondyloarthritis family include axial spondyloarthritis (which affects mainly the spine and pelvic joints), peripheral spondyloarthritis (which affects mostly the arms and legs), reactive arthritis (Reiter’s syndrome), psoriatic arthritis, and enteropathic arthritis/spondylitis associated with inflammatory bowel diseases.

Signs and symptoms of spondyloarthritis varies depending on the disease. However, symptoms typically present with redness and swelling (inflammation) that causes pain and stiffness, usually in the spine. Some forms can affect the hands, feet, arms and legs. Another symptom includes destruction of bone that causes spine abnormalities (deformity). Additional complications of spondyloarthritis may include eye inflammation, compression fractures and heart problems. Symptoms usually begin around late adolescence or early adulthood. The exact cause of the spondyloarthritis group of diseases is unknown. They are believed to be due to a combination of genetic and environmental factors. Individuals with the HLA-B27 form of the HLA-B gene are at greater risk of developing ankylosing spondylitis, the most common type of spondyloarthritis.

To diagnose spondyloarthritis, your doctor will gather a medical history and perform a physical exam. In addition, they may collect images of the affected areas. There is no cure for spondyloarthritis, but treatment can include medications to decrease pain. If you or your child has been diagnosed with spondyloarthritis, talk with your doctor to discuss the current treatment options. Support groups can provide additional information and connect you with others.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Spondyloarthritis" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Spondyloarthritis" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Spondyloarthritis" returned 123 free, full-text research articles on human participants. First 3 results:

Randomized controlled trial of adalimumab in patients with nonpsoriatic peripheral spondyloarthritis.
 

Author(s): Philip Mease, Joachim Sieper, Filip Van den Bosch, Proton Rahman, P Mahinda Karunaratne, Aileen L Pangan

Journal: Arthritis Rheumatol. 2015 Apr;67(4):914-23.

 

To evaluate the efficacy and safety of adalimumab in patients with active nonpsoriatic peripheral spondyloarthritis (SpA).

Last Updated: 30 Mar 2015

Go To URL
Effect of certolizumab pegol over ninety-six weeks in patients with axial spondyloarthritis: results from a phase III randomized trial.
 

Author(s): J Sieper, R Landewé, M Rudwaleit, D van der Heijde, M Dougados, P J Mease, J Braun, A Deodhar, A Kivitz, J Walsh, B Hoepken, T Nurminen, W P Maksymowych

Journal: Arthritis Rheumatol. 2015 Mar;67(3):668-77.

 

Previous reports of the RAPID-axSpA trial (NCT01087762) described the efficacy and safety of certolizumab pegol (CZP) over 24 weeks in patients with axial spondyloarthritis (SpA), including ankylosing spondylitis (AS) and nonradiographic axial SpA. We report efficacy and safety data ...

Last Updated: 26 Feb 2015

Go To URL
MRI of spinal ligament enthesitis in a patient with spondyloarthritis.
 

Author(s): Koichi Takeda, Takeo Sato, Eiji Sugimoto, Seiji Minota

Journal: Intern. Med.. 2014 ;53(22):2657-8.

 

Last Updated: 17 Nov 2014

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Spondyloarthritis" returned 39 free, full-text review articles on human participants. First 3 results:

Role of sonography and magnetic resonance imaging in detecting deltoideal acromial enthesopathy: an early finding in the diagnosis of spondyloarthritis and an under-recognized cause of posterior shoulder pain.
 

Author(s): Carlos Frederico Arend

Journal: J Ultrasound Med. 2014 Apr;33(4):557-61.

 

The acromial origin of the deltoid is a target structure of ankylosing spondylitis and related spondyloarthritis, which are often overlooked and underdiagnosed as causes of posterior shoulder pain. The objective of this article is to review the roles of sonography and magnetic resonance ...

Last Updated: 24 Mar 2014

Go To URL
Reporting of patient-perceived impact of rheumatoid arthritis and axial spondyloarthritis over 10 years: a systematic literature review.
 

Author(s): Laure Gossec, Francis Berenbaum, Pierre Chauvin, Karine Lamiraud, Francoise Russo-Marie, Jean-Michel Joubert, Alain Saraux

Journal: Rheumatology (Oxford). 2014 Jul;53(7):1274-81.

 

RA and axial SpA have an important impact on patients' lives. The objective of this study was to explore the reporting of different aspects of that impact in publications, with a focus on differences between diseases and over time.

Last Updated: 21 Jun 2014

Go To URL
[Bone remodeling in spondyloarthritis].
 

Author(s): Wilson Bautista-Molano, Consuelo Romero-Sánchez, Juliette De Ávila, John Londoño, Rafael Valle-Oñate

Journal: Rev Med Chil. 2013 Sep;141(9):1182-9.

 

Spondyloarthritis is a group of several related but phenotypically distinct chronic inflammatory diseases, characterized by progressive new bone formation which leads to ankylosis and functional disability. Radiographic images evidence not only erosive changes but also overgrowth ...

Last Updated: 13 Feb 2014

Go To URL
 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Last Updated: 8 Jun 2015

Go to URL

Last Updated: 17 Mar 2015

Go to URL

Last Updated: 27 Mar 2012

Go to URL