Spondyloarthritis

Common Name(s)

Spondyloarthritis, Spondyloarthropathy

Spondyloarthritis (or spondyloarthropathy) is a group of inflammatory diseases that cause arthritis in the sites where tendons and ligaments attach to bones (entheses). There are six forms of spondyloarthritis. The most common is ankylosing spondylitis, which mainly affects the spine. Other diseases in the spondyloarthritis family include axial spondyloarthritis (which affects mainly the spine and pelvic joints), peripheral spondyloarthritis (which affects mostly the arms and legs), reactive arthritis (Reiter’s syndrome), psoriatic arthritis, and enteropathic arthritis/spondylitis associated with inflammatory bowel diseases.

Signs and symptoms of spondyloarthritis varies depending on the disease. However, symptoms typically present with redness and swelling (inflammation) that causes pain and stiffness, usually in the spine. Some forms can affect the hands, feet, arms and legs. Another symptom includes destruction of bone that causes spine abnormalities (deformity). Additional complications of spondyloarthritis may include eye inflammation, compression fractures and heart problems. Symptoms usually begin around late adolescence or early adulthood. The exact cause of the spondyloarthritis group of diseases is unknown. They are believed to be due to a combination of genetic and environmental factors. Individuals with the HLA-B27 form of the HLA-B gene are at greater risk of developing ankylosing spondylitis, the most common type of spondyloarthritis.

To diagnose spondyloarthritis, your doctor will gather a medical history and perform a physical exam. In addition, they may collect images of the affected areas. There is no cure for spondyloarthritis, but treatment can include medications to decrease pain. If you or your child has been diagnosed with spondyloarthritis, talk with your doctor to discuss the current treatment options. Support groups can provide additional information and connect you with others.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Spondyloarthritis" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Spondyloarthritis" returned 258 free, full-text research articles on human participants. First 3 results:

Association between circulating miRNAs and spinal involvement in patients with axial spondyloarthritis.
 

Author(s): Klára Prajzlerová, Kristýna Grobelná, Markéta Hušáková, Šárka Forejtová, Astrid Jüngel, Steffen Gay, Jiří Vencovský, Karel Pavelka, Ladislav Šenolt, Mária Filková

Journal:

 

Dysregulation of miRNAs and their target genes contributes to the pathophysiology of autoimmune diseases. Circulating miRNAs may serve as diagnostic/prognostic biomarkers. We aimed to investigate the association between circulating miRNAs, disease activity and spinal involvement in ...

Last Updated: 22 Sep 2017

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Fever as an initial manifestation of spondyloarthritis: A retrospective study.
 

Author(s): Se Jin Byun, William Han Bae, Seung Min Jung, Sang-Won Lee, Yong-Beom Park, Jason Jungsik Song

Journal:

 

We aimed to evaluate a wide spectrum of clinical features of adult patients with spondyloarthritis (SpA) whose initial manifestation was fever, using the Assessment of SpondyloArthritis international Society (ASAS) classification criteria.

Last Updated: 14 Sep 2017

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Sacroiliac radiographic progression in recent onset axial spondyloarthritis: the 5-year data of the DESIR cohort.
 

Author(s): Maxime Dougados, Alexandre Sepriano, Anna Molto, Miranda van Lunteren, Sofia Ramiro, Manouk de Hooge, Rosaline van den Berg, Victoria Navarro Compan, Christophe Demattei, Robert Landewé, Désirée van der Heijde

Journal: Ann. Rheum. Dis.. 2017 Nov;76(11):1823-1828.

 

To estimate sacroiliac joint radiographic (X-SIJ) progression in patients with axial spondyloarthritis (axSpA) and to evaluate the effects of inflammation on MRI (MRI-SIJ) on X-SIJ progression.

Last Updated: 7 Jul 2017

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Spondyloarthritis" returned 62 free, full-text review articles on human participants. First 3 results:

Spondyloarthritis: Matrix Metalloproteinasesas Biomarkers of Pathogenesis and Response to Tumor Necrosis Factor (TNF) Inhibitors.
 

Author(s): Stefania Moz, Ada Aita, Daniela Basso, Roberta Ramonda, Mario Plebani, Leonardo Punzi

Journal:

 

The term spondyloarthritis (SpA) is used to describe a group of multifactorial chronic inflammatory diseases characterized by a predisposing genetic background and clinical manifestations typically involving the sacroiliac joint. The absence of pathognomonic clinical and/or laboratory ...

Last Updated: 19 Apr 2017

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One year in review 2016: spondyloarthritis.
 

Author(s): Alice Parma, Laura Cometi, Maria Comasia Leone, Gemma Lepri, Rosaria Talarico, Serena Guiducci

Journal: Clin. Exp. Rheumatol.. ;35(1):3-17.

 

Spondyloarthritis represents a heterogeneous group of articular inflammatory diseases that share common genetic, clinical and radiological features. Recently, novel insights into the epidemiology, pathogenesis and treatment of these diseases have been provided. Herewith, we present ...

Last Updated: 2 Feb 2017

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Progression rate of ankylosing spondylitis in patients with undifferentiated spondyloarthritis: A systematic review and meta-analysis.
 

Author(s): Qing Xia, Dazhi Fan, Xiao Yang, Xiaona Li, Xu Zhang, Mengmeng Wang, Shengqian Xu, Faming Pan

Journal: Medicine (Baltimore). 2017 Jan;96(4):e5960.

 

The idea that undifferentiated spondyloarthritis (uSpA) represents the early undifferentiated stage of ankylosing spondylitis (AS) and other well-defined SpA subtypes is well known. The gist of this study is to assess the rate estimate of patients with uSpA evolved to AS during long-term follow-up.

Last Updated: 25 Jan 2017

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Last Updated: 12 Jun 2017

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A Study of Ixekizumab (LY2439821) in Participants With Nonradiographic Axial Spondyloarthritis
 

Status: Recruiting

Condition Summary: Axial Spondyloarthritis

 

Last Updated: 2 Nov 2017

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Study of Efficacy and Safety of Secukinumab in Patients With Non-radiographic Axial Spondyloarthritis
 

Status: Recruiting

Condition Summary: Non-radiographic Spondyloarthritis

 

Last Updated: 14 Nov 2017

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