Spondyloarthritis

Common Name(s)

Spondyloarthritis, Spondyloarthropathy

Spondyloarthritis (or spondyloarthropathy) is a group of inflammatory diseases that cause arthritis in the sites where tendons and ligaments attach to bones (entheses). There are six forms of spondyloarthritis. The most common is ankylosing spondylitis, which mainly affects the spine. Other diseases in the spondyloarthritis family include axial spondyloarthritis (which affects mainly the spine and pelvic joints), peripheral spondyloarthritis (which affects mostly the arms and legs), reactive arthritis (Reiter’s syndrome), psoriatic arthritis, and enteropathic arthritis/spondylitis associated with inflammatory bowel diseases.

Signs and symptoms of spondyloarthritis varies depending on the disease. However, symptoms typically present with redness and swelling (inflammation) that causes pain and stiffness, usually in the spine. Some forms can affect the hands, feet, arms and legs. Another symptom includes destruction of bone that causes spine abnormalities (deformity). Additional complications of spondyloarthritis may include eye inflammation, compression fractures and heart problems. Symptoms usually begin around late adolescence or early adulthood. The exact cause of the spondyloarthritis group of diseases is unknown. They are believed to be due to a combination of genetic and environmental factors. Individuals with the HLA-B27 form of the HLA-B gene are at greater risk of developing ankylosing spondylitis, the most common type of spondyloarthritis.

To diagnose spondyloarthritis, your doctor will gather a medical history and perform a physical exam. In addition, they may collect images of the affected areas. There is no cure for spondyloarthritis, but treatment can include medications to decrease pain. If you or your child has been diagnosed with spondyloarthritis, talk with your doctor to discuss the current treatment options. Support groups can provide additional information and connect you with others.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Spondyloarthritis" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Spondyloarthritis" returned 167 free, full-text research articles on human participants. First 3 results:

Effectiveness of Adalimumab in Non-radiographic Axial Spondyloarthritis: Evaluation of Clinical and Magnetic Resonance Imaging Outcomes in a Monocentric Cohort.
 

Author(s): Luca Cantarini, Marta Fabbroni, Rosaria Talarico, Luisa Costa, Francesco Caso, Gian Luca Cuneo, Bruno Frediani, Gabriele Faralli, Antonio Vitale, Maria Giuseppina Brizi, Luciano Sabadini, Mauro Galeazzi

Journal: Medicine (Baltimore). 2015 Jul;94(30):e1170.

 

The primary aim of the study was to evaluate the long-term effectiveness of adalimumab (ADA) in a cohort of non-radiographic axial spondyloarthritis (nr-axSpA), and the secondary aims were to identify predictive factors of response and evaluate radiological progression.We evaluated ...

Last Updated: 30 Jul 2015

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Relationship between optimism and quality of life in patients with two chronic rheumatic diseases: axial spondyloarthritis and chronic low back pain: a cross sectional study of 288 patients.
 

Author(s): Sarah Kreis, Anna Molto, Florian Bailly, Sabrina Dadoun, Stéphanie Fabre, Christopher Rein, Christophe Hudry, Franck Zenasni, Sylvie Rozenberg, Edouard Pertuiset, Bruno Fautrel, Laure Gossec

Journal:

 

Axial Spondyloarthritis (AxSpA) and chronic low back pain are rheumatic diseases that impact patients' health-related quality of life (HRQoL). In other chronic conditions, HRQoL was positively associated with dispositional optimism, a personality trait. The objective was to explore ...

Last Updated: 7 Jul 2015

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The usefulness of bone SPECT/CT imaging with volume of interest analysis in early axial spondyloarthritis.
 

Author(s): Yong-il Kim, Minseok Suh, Yu Kyeong Kim, Ho-Young Lee, Kichul Shin

Journal:

 

The role of conventional bone scintigraphy in diagnosing early axial spondyloarthritis (SpA) is yet controversial. Single positron emission computed tomography (SPECT) plus CT is an imaging modality that adds better anatomical information to scintigraphy of the sacroiliac (SI) joint. ...

Last Updated: 18 Apr 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Spondyloarthritis" returned 45 free, full-text review articles on human participants. First 3 results:

Clinical Tools to Assess and Monitor Spondyloarthritis.
 

Author(s): Robert Landewé, Astrid van Tubergen

Journal: Curr Rheumatol Rep. 2015 Jul;17(7):47.

 

Assessment and monitoring is important in diseases affecting multiple sites and organs, such as axial spondyloarthritis (axSpA) that may have several signs and symptoms, and for which several treatments are available. Instruments for assessment and monitoring should be appropriately ...

Last Updated: 11 Jun 2015

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EULAR recommendations for the use of imaging in the diagnosis and management of spondyloarthritis in clinical practice.
 

Author(s): P Mandl, V Navarro-Compán, L Terslev, P Aegerter, D van der Heijde, M A D'Agostino, X Baraliakos, S J Pedersen, A G Jurik, E Naredo, C Schueller-Weidekamm, U Weber, M C Wick, P A C Bakker, E Filippucci, P G Conaghan, M Rudwaleit, G Schett, J Sieper, S Tarp, H Marzo-Ortega, M Østergaard,

Journal: Ann. Rheum. Dis.. 2015 Jul;74(7):1327-39.

 

A taskforce comprised of an expert group of 21 rheumatologists, radiologists and methodologists from 11 countries developed evidence-based recommendations on the use of imaging in the clinical management of both axial and peripheral spondyloarthritis (SpA). Twelve key questions on ...

Last Updated: 11 Jun 2015

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Spontaneous, drug-induced, and drug-free remission in peripheral and axial spondyloarthritis.
 

Author(s): Denis Poddubnyy, Lianne S Gensler

Journal: Best Pract Res Clin Rheumatol. 2014 Oct;28(5):807-18.

 

In spondyloarthritis (SpA), spontaneous remission is best described in reactive arthritis, a form of peripheral SpA. Prior SpA observational studies suggested that a significant percentage of patients reached spontaneous remission; however, these patients were followed up under older, ...

Last Updated: 9 Dec 2014

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Last Updated: 14 Jan 2016

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Last Updated: 17 Mar 2015

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Last Updated: 29 Jul 2015

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