Spondyloarthritis

Common Name(s)

Spondyloarthritis, Spondyloarthropathy

Spondyloarthritis (or spondyloarthropathy) is a group of inflammatory diseases that cause arthritis in the sites where tendons and ligaments attach to bones (entheses). There are six forms of spondyloarthritis. The most common is ankylosing spondylitis, which mainly affects the spine. Other diseases in the spondyloarthritis family include axial spondyloarthritis (which affects mainly the spine and pelvic joints), peripheral spondyloarthritis (which affects mostly the arms and legs), reactive arthritis (Reiter’s syndrome), psoriatic arthritis, and enteropathic arthritis/spondylitis associated with inflammatory bowel diseases.

Signs and symptoms of spondyloarthritis varies depending on the disease. However, symptoms typically present with redness and swelling (inflammation) that causes pain and stiffness, usually in the spine. Some forms can affect the hands, feet, arms and legs. Another symptom includes destruction of bone that causes spine abnormalities (deformity). Additional complications of spondyloarthritis may include eye inflammation, compression fractures and heart problems. Symptoms usually begin around late adolescence or early adulthood. The exact cause of the spondyloarthritis group of diseases is unknown. They are believed to be due to a combination of genetic and environmental factors. Individuals with the HLA-B27 form of the HLA-B gene are at greater risk of developing ankylosing spondylitis, the most common type of spondyloarthritis.

To diagnose spondyloarthritis, your doctor will gather a medical history and perform a physical exam. In addition, they may collect images of the affected areas. There is no cure for spondyloarthritis, but treatment can include medications to decrease pain. If you or your child has been diagnosed with spondyloarthritis, talk with your doctor to discuss the current treatment options. Support groups can provide additional information and connect you with others.

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Advocacy and Support Organizations

 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Spondyloarthritis" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Spondyloarthritis" returned 232 free, full-text research articles on human participants. First 3 results:

Clinimetric properties of the ASAS health index in a cohort of Italian patients with axial spondyloarthritis.
 

Author(s): Marco Di Carlo, Valentina Lato, Marina Carotti, Fausto Salaffi

Journal:

 

The impact of axial spondyloarthritis (axSpA) is considerable in many aspects of the life. Over the last decades, many efforts have been conducted to develop useful tools for the evaluation of disease activity. However, since the development of Assessment of SpondyloArthritis international ...

Last Updated: 18 May 2016

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Patient-reported impact of spondyloarthritis on work disability and working life: the ATLANTIS survey.
 

Author(s): Roberta Ramonda, Antonio Marchesoni, Antonio Carletto, Gerolamo Bianchi, Maurizio Cutolo, Gianfranco Ferraccioli, Enrico Fusaro, Salvatore De Vita, Mauro Galeazzi, Roberto Gerli, Marco Matucci-Cerinic, Giovanni Minisola, Carlomaurizio Montecucco, Raffaele Pellerito, Fausto Salaffi, Giuseppe Paolazzi, Piercarlo Sarzi-Puttini, Raffaele Scarpa, Gianfilippo Bagnato, Giovanni Triolo, Guido Valesini, Leonardo Punzi, Ignazio Olivieri,

Journal:

 

The aim was to establish how patients experience the impact of spondyloarthritis (SpA) on work disability and working life.

Last Updated: 2 Apr 2016

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Back pain and health status in patients with clinically diagnosed ankylosing spondylitis, psoriatic arthritis and other spondyloarthritis: a cross-sectional population-based study.
 

Author(s): Ulf Lindström, Ann Bremander, Emma Haglund, Stefan Bergman, Ingemar F Petersson, Lennart T H Jacobsson

Journal:

 

In the broader spectrum of back pain, inflammatory back pain (IBP) is a symptom that may indicate axial spondyloarthritis (SpA). The objectives of this study were to determine the frequency of current IBP, as a hallmark sign of possible axial SpA, in patients with ankylosing spondylitis ...

Last Updated: 29 Feb 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Spondyloarthritis" returned 54 free, full-text review articles on human participants. First 3 results:

Non-Radiographic Axial Spondyloarthritis.
 

Author(s): Gleb Slobodin, Iris Eshed

Journal: Isr. Med. Assoc. J.. 2015 Dec;17(12):770-6.

 

The term non-radiographic axial spondyloarthritis (nrAxSpA) was coined for patients who have a clinical picture of ankylosing spondylitis (AS) but do not exhibit radiographic sacroiliitis. The ASAS classification criteria for nrAxSpA, ensuring the recruitment of homogenous study cohorts, ...

Last Updated: 22 Feb 2016

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Tumour necrosis factor-α inhibitors for ankylosing spondylitis and non-radiographic axial spondyloarthritis: a systematic review and economic evaluation.
 

Author(s): Mark Corbett, Marta Soares, Gurleen Jhuti, Stephen Rice, Eldon Spackman, Eleftherios Sideris, Thirimon Moe-Byrne, Dave Fox, Helena Marzo-Ortega, Lesley Kay, Nerys Woolacott, Stephen Palmer

Journal: Health Technol Assess. 2016 Feb;20(9):1-334, v-vi.

 

Tumour necrosis factor (TNF)-α inhibitors (anti-TNFs) are typically used when the inflammatory rheumatologic diseases ankylosing spondylitis (AS) and non-radiographic axial spondyloarthritis (nr-AxSpA) have not responded adequately to conventional therapy. Current National Institute ...

Last Updated: 5 Feb 2016

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Interleukin-17 targeted therapies in axial spondyloarthritis.
 

Author(s): Daniel Wendling

Journal: Immunotherapy. 2015 ;7(11):1125-8.

 

Last Updated: 25 Nov 2015

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Last Updated: 17 Mar 2015

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Last Updated: 18 Nov 2016

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A Study of Ixekizumab (LY2439821) in Participants With Nonradiographic Axial Spondyloarthritis
 

Status: Recruiting

Condition Summary: Axial Spondyloarthritis

 

Last Updated: 17 Nov 2016

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