Spondyloarthritis

Common Name(s)

Spondyloarthritis, Spondyloarthropathy

Spondyloarthritis (or spondyloarthropathy) is a group of inflammatory diseases that cause arthritis in the sites where tendons and ligaments attach to bones (entheses). There are six forms of spondyloarthritis. The most common is ankylosing spondylitis, which mainly affects the spine. Other diseases in the spondyloarthritis family include axial spondyloarthritis (which affects mainly the spine and pelvic joints), peripheral spondyloarthritis (which affects mostly the arms and legs), reactive arthritis (Reiter’s syndrome), psoriatic arthritis, and enteropathic arthritis/spondylitis associated with inflammatory bowel diseases.

Signs and symptoms of spondyloarthritis varies depending on the disease. However, symptoms typically present with redness and swelling (inflammation) that causes pain and stiffness, usually in the spine. Some forms can affect the hands, feet, arms and legs. Another symptom includes destruction of bone that causes spine abnormalities (deformity). Additional complications of spondyloarthritis may include eye inflammation, compression fractures and heart problems. Symptoms usually begin around late adolescence or early adulthood. The exact cause of the spondyloarthritis group of diseases is unknown. They are believed to be due to a combination of genetic and environmental factors. Individuals with the HLA-B27 form of the HLA-B gene are at greater risk of developing ankylosing spondylitis, the most common type of spondyloarthritis.

To diagnose spondyloarthritis, your doctor will gather a medical history and perform a physical exam. In addition, they may collect images of the affected areas. There is no cure for spondyloarthritis, but treatment can include medications to decrease pain. If you or your child has been diagnosed with spondyloarthritis, talk with your doctor to discuss the current treatment options. Support groups can provide additional information and connect you with others.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Spondyloarthritis" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Spondyloarthritis" returned 119 free, full-text research articles on human participants. First 3 results:

Randomized controlled trial of adalimumab in patients with nonpsoriatic peripheral spondyloarthritis.
 

Author(s): Philip Mease, Joachim Sieper, Filip Van den Bosch, Proton Rahman, P Mahinda Karunaratne, Aileen L Pangan

Journal: Arthritis Rheumatol. 2015 Apr;67(4):914-23.

 

To evaluate the efficacy and safety of adalimumab in patients with active nonpsoriatic peripheral spondyloarthritis (SpA).

Last Updated: 30 Mar 2015

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Effect of certolizumab pegol over ninety-six weeks in patients with axial spondyloarthritis: results from a phase III randomized trial.
 

Author(s): J Sieper, R Landewé, M Rudwaleit, D van der Heijde, M Dougados, P J Mease, J Braun, A Deodhar, A Kivitz, J Walsh, B Hoepken, T Nurminen, W P Maksymowych

Journal: Arthritis Rheumatol. 2015 Mar;67(3):668-77.

 

Previous reports of the RAPID-axSpA trial (NCT01087762) described the efficacy and safety of certolizumab pegol (CZP) over 24 weeks in patients with axial spondyloarthritis (SpA), including ankylosing spondylitis (AS) and nonradiographic axial SpA. We report efficacy and safety data ...

Last Updated: 26 Feb 2015

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Prevalence of chronic axial pain, inflammatory back pain, and spondyloarthritis in diagnosed psoriasis.
 

Author(s): Nicole Thom, Christopher T Ritchlin, Xiao Zhang, John Reveille, Michael H Weisman

Journal: Arthritis Care Res (Hoboken). 2015 May;67(6):829-35.

 

To provide prevalence estimates for inflammatory back pain (IBP) and spondyloarthritis (SpA) in those subjects with psoriasis using 2009-2010 National Health and Nutrition Examination Survey (NHANES) data.

Last Updated: 27 May 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Spondyloarthritis" returned 39 free, full-text review articles on human participants. First 3 results:

EULAR recommendations for the use of imaging in the diagnosis and management of spondyloarthritis in clinical practice.
 

Author(s): P Mandl, V Navarro-Compán, L Terslev, P Aegerter, D van der Heijde, M A D'Agostino, X Baraliakos, S J Pedersen, A G Jurik, E Naredo, C Schueller-Weidekamm, U Weber, M C Wick, P A C Bakker, E Filippucci, P G Conaghan, M Rudwaleit, G Schett, J Sieper, S Tarp, H Marzo-Ortega, M Østergaard,

Journal: Ann. Rheum. Dis.. 2015 Jul;74(7):1327-39.

 

A taskforce comprised of an expert group of 21 rheumatologists, radiologists and methodologists from 11 countries developed evidence-based recommendations on the use of imaging in the clinical management of both axial and peripheral spondyloarthritis (SpA). Twelve key questions on ...

Last Updated: 11 Jun 2015

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Role of sonography and magnetic resonance imaging in detecting deltoideal acromial enthesopathy: an early finding in the diagnosis of spondyloarthritis and an under-recognized cause of posterior shoulder pain.
 

Author(s): Carlos Frederico Arend

Journal: J Ultrasound Med. 2014 Apr;33(4):557-61.

 

The acromial origin of the deltoid is a target structure of ankylosing spondylitis and related spondyloarthritis, which are often overlooked and underdiagnosed as causes of posterior shoulder pain. The objective of this article is to review the roles of sonography and magnetic resonance ...

Last Updated: 24 Mar 2014

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Reporting of patient-perceived impact of rheumatoid arthritis and axial spondyloarthritis over 10 years: a systematic literature review.
 

Author(s): Laure Gossec, Francis Berenbaum, Pierre Chauvin, Karine Lamiraud, Francoise Russo-Marie, Jean-Michel Joubert, Alain Saraux

Journal: Rheumatology (Oxford). 2014 Jul;53(7):1274-81.

 

RA and axial SpA have an important impact on patients' lives. The objective of this study was to explore the reporting of different aspects of that impact in publications, with a focus on differences between diseases and over time.

Last Updated: 21 Jun 2014

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Last Updated: 5 Aug 2015

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Last Updated: 17 Mar 2015

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