Autoimmune Enteropathy

Common Name(s)

Autoimmune Enteropathy

Autoimmune Enteropathy is a condition in which the body’s immune system attacks itself and irritates the lining of the intestine, causing severe diarrhea. This condition can cause a severe lack of fluids, which may require an IV, and can affect the patient’s ability to absorb food and vitamins. Symptoms may include: diarrhea, poor weight gain and weight loss, decreased urine output, frequent infections, blood in the stool, and skin rashes. There are several different types of autoimmune enteropathy, some of which may be linked with other diseases like diabetes and kidney disease. This condition occurs most in infants and young children, although it can affect adults as well. Physicians can diagnose this condition by using blood tests or endoscopies (tests that look at the stomach and small intestines), or doctors can sometimes diagnose this condition by looking at the family’s medical history. Treatment typically involves medications to suppress the immune system (so that it will stop attacking itself), special diets, and very rarely surgery.

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Advocacy and Support Organizations

 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Autoimmune Enteropathy" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Autoimmune Enteropathy" returned 16 free, full-text research articles on human participants. First 3 results:

Glutamine-supplemented parenteral nutrition and probiotics in four adult autoimmune enteropathy patients.
 

Author(s): Ren Ying Xu, Yan Ping Wan, Yi Quan Zhou, Li Ping Lu, Zhi Qi Chen, Ying Jie Wu, Wei Cai

Journal: Gut Liver. 2014 May;8(3):324-8.

 

To evaluate the effects of glutamine-supplemented parenteral nutrition (PN) and probiotics in adult autoimmune enteropathy (AIE) patients. Four adult AIE patients were identified from April 2006 to January 2012. Clinical and nutritional data were obtained from the patients' medical ...

Last Updated: 15 May 2014

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Pediatric autoimmune enteropathy: an entity frequently associated with immunodeficiency disorders.
 

Author(s): Aatur D Singhi, Alka Goyal, Jon M Davison, Miguel D Regueiro, Robyn L Roche, Sarangarajan Ranganathan

Journal: Mod. Pathol.. 2014 Apr;27(4):543-53.

 

The term pediatric autoimmune enteropathy was originally applied to a form of intractable diarrhea seen in children under the age of 6 months and characterized by male predominance, concurrent autoimmune-associated disorders, circulating gut autoantibodies, a lack of severe immunodeficiency ...

Last Updated: 2 Apr 2014

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Abatacept: a new treatment option for refractory adult autoimmune enteropathy.
 

Author(s): Nitin K Gupta, Omer Yilmaz, Mark Fisher, Vijay Yajnik

Journal: J. Clin. Gastroenterol.. 2014 Jan;48(1):55-8.

 

Autoimmune enteropathy (AIE) is a rare disease that has been observed in both children and adults. It typically manifests with symptoms of diarrhea, requiring long-term immunosuppression. Endoscopically, the duodenum typically exhibits villous blunting with partial or complete villous ...

Last Updated: 16 Dec 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Autoimmune Enteropathy" returned 3 free, full-text review articles on human participants. First 3 results:

Immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) and IPEX-related disorders: an evolving web of heritable autoimmune diseases.
 

Author(s): James W Verbsky, Talal A Chatila

Journal: Curr. Opin. Pediatr.. 2013 Dec;25(6):708-14.

 

To summarize recent progress in our understanding of immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) and IPEX-related disorders.

Last Updated: 18 Nov 2013

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Autoimmune enteropathy: a review and update of clinical management.
 

Author(s): Nicole M Gentile, Joseph A Murray, Darrell S Pardi

Journal: Curr Gastroenterol Rep. 2012 Oct;14(5):380-5.

 

Autoimmune enteropathy (AIE) is a rare condition characterized by intractable diarrhea, histologic changes on small intestinal biopsy, and failed response to dietary manipulation that also may present with extraintestinal manifestations. In many patients, immunosuppressive therapies ...

Last Updated: 20 Sep 2012

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Autoimmune enteropathy with a CD8+ CD7- T-cell small bowel intraepithelial lymphocytosis: case report and literature review.
 

Author(s): Shrinivas Bishu, Violeta Arsenescu, Eun Y Lee, H David Vargas, Willem J S de Villiers, Razvan Arsenescu

Journal:

 

Adult onset autoimmune enteropathy (AIE) is a rare condition characterized by diarrhea refractory to dietary therapy diagnosed in patients with evidence of autoimmune conditions. Auto-antibodies to gut epithelial cells and other tissues are commonly demonstrated. Despite increasing ...

Last Updated: 28 Feb 2012

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Sirolimus for Autoimmune Disease of Blood Cells
 

Status: Recruiting

Condition Summary: Autoimmune Pancytopenia; Autoimmune Lymphoproliferative Syndrome (ALPS); Evans Syndrome; Idiopathic Thrombocytopenic Purpura; Anemia, Hemolytic, Autoimmune; Autoimmune Neutropenia; Lupus Erythematosus, Systemic; Inflammatory Bowel Disease; Rheumatoid Arthritis

 

Last Updated: 20 Apr 2015

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The 1200 Patients Project: Studying the Implementation of Clinical Pharmacogenomic Testing
 

Status: Recruiting

Condition Summary: Patients Undergoing Routine Health Care; Heart Diseases; Inflammatory Bowel Diseases; Autoimmune Disease; Inflammatory Disease; Blood Coagulation Disorders; Hepatitis C; Non-Metastatic Neoplasm

 

Last Updated: 22 Jun 2015

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Autoimmune Paradoxical Reactions in IBD Longitudinal Cohort
 

Status: Not yet recruiting

Condition Summary: Inflammatory Bowel Diseases; Crohns Disease; Ulcerative Colitis; Colitis

 

Last Updated: 20 Jul 2015

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