Autoimmune Enteropathy

Common Name(s)

Autoimmune Enteropathy

Autoimmune Enteropathy is a condition in which the body’s immune system attacks itself and irritates the lining of the intestine, causing severe diarrhea. This condition can cause a severe lack of fluids, which may require an IV, and can affect the patient’s ability to absorb food and vitamins. Symptoms may include: diarrhea, poor weight gain and weight loss, decreased urine output, frequent infections, blood in the stool, and skin rashes. There are several different types of autoimmune enteropathy, some of which may be linked with other diseases like diabetes and kidney disease. This condition occurs most in infants and young children, although it can affect adults as well. Physicians can diagnose this condition by using blood tests or endoscopies (tests that look at the stomach and small intestines), or doctors can sometimes diagnose this condition by looking at the family’s medical history. Treatment typically involves medications to suppress the immune system (so that it will stop attacking itself), special diets, and very rarely surgery.

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Advocacy and Support Organizations

 

Condition Specific Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Autoimmune Enteropathy" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Autoimmune Enteropathy" returned 13 free, full-text research articles on human participants. First 3 results:

Mesenchymal stromal cell infusions as rescue therapy for corticosteroid-refractory adult autoimmune enteropathy.
 

Author(s): Rachele Ciccocioppo, Maria L Russo, Maria E Bernardo, Federico Biagi, Laura Catenacci, Maria A Avanzini, Costanza Alvisi, Alessandro Vanoli, Rachele Manca, Ombretta Luinetti, Franco Locatelli, Gino R Corazza

Journal: Mayo Clin. Proc.. 2012 Sep;87(9):909-14.

 

Adult autoimmune enteropathy (AIE) is a rare cause of malabsorption syndrome unresponsive to dietary restriction. Its diagnostic hallmarks are small-bowel villous atrophy and antienterocyte autoantibodies. Therapy is based mainly on nutritional support and immunosuppression. We treated ...

Last Updated: 10 Sep 2012

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Enteropathy-associated T-cell lymphoma type II complicated by autoimmune hemolytic anemia.
 

Author(s): Aiko Kato, Yoko Takiuchi, Kazunari Aoki, Yuichiro Ono, Hiroshi Arima, Seiji Nagano, Sumie Tabata, Soshi Yanagita, Akiko Matsushita, Hayato Maruoka, Masaya Wada, Yukihiro Imai, Takayuki Ishikawa, Takayuki Takahashi

Journal: J Clin Exp Hematop. 2011 ;51(2):119-23.

 

A 74-year-old man was admitted to hospital because of persistent fever, diarrhea, and abdominal pain. CT scanning showed extensive wall thickening of the colon. He was transferred to our hospital because he further developed ascites and paraaortic lymph node swelling. On presentation, ...

Last Updated: 22 Nov 2011

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Differential mucosal IL-17 expression in two gliadin-induced disorders: gluten sensitivity and the autoimmune enteropathy celiac disease.
 

Author(s): Anna Sapone, Karen M Lammers, Giuseppe Mazzarella, Irina Mikhailenko, Maria Cartenì, Vincenzo Casolaro, Alessio Fasano

Journal: Int. Arch. Allergy Immunol.. 2010 ;152(1):75-80.

 

The immune-mediated enteropathy, celiac disease (CD), and gluten sensitivity (GS) are two distinct clinical conditions that are both triggered by the ingestion of wheat gliadin. CD, but not GS, is associated with and possibly mediated by an autoimmune process. Recent studies show ...

Last Updated: 16 Apr 2010

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Autoimmune Enteropathy" returned 3 free, full-text review articles on human participants. First 3 results:

Immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) and IPEX-related disorders: an evolving web of heritable autoimmune diseases.
 

Author(s): James W Verbsky, Talal A Chatila

Journal: Curr. Opin. Pediatr.. 2013 Dec;25(6):708-14.

 

To summarize recent progress in our understanding of immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) and IPEX-related disorders.

Last Updated: 18 Nov 2013

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Autoimmune enteropathy: a review and update of clinical management.
 

Author(s): Nicole M Gentile, Joseph A Murray, Darrell S Pardi

Journal: Curr Gastroenterol Rep. 2012 Oct;14(5):380-5.

 

Autoimmune enteropathy (AIE) is a rare condition characterized by intractable diarrhea, histologic changes on small intestinal biopsy, and failed response to dietary manipulation that also may present with extraintestinal manifestations. In many patients, immunosuppressive therapies ...

Last Updated: 20 Sep 2012

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Autoimmune enteropathy with a CD8+ CD7- T-cell small bowel intraepithelial lymphocytosis: case report and literature review.
 

Author(s): Shrinivas Bishu, Violeta Arsenescu, Eun Y Lee, H David Vargas, Willem J S de Villiers, Razvan Arsenescu

Journal:

 

Adult onset autoimmune enteropathy (AIE) is a rare condition characterized by diarrhea refractory to dietary therapy diagnosed in patients with evidence of autoimmune conditions. Auto-antibodies to gut epithelial cells and other tissues are commonly demonstrated. Despite increasing ...

Last Updated: 28 Feb 2012

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Sirolimus for Autoimmune Disease of Blood Cells
 

Status: Recruiting

Condition Summary: Autoimmune Pancytopenia; Autoimmune Lymphoproliferative Syndrome (ALPS); Evans Syndrome; Idiopathic Thrombocytopenic Purpura; Anemia, Hemolytic, Autoimmune; Autoimmune Neutropenia; Lupus Erythematosus, Systemic; Inflammatory Bowel Disease; Rheumatoid Arthritis

 

Last Updated: 3 Feb 2014

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The 1200 Patients Project: Studying the Implementation of Clinical Pharmacogenomic Testing
 

Status: Recruiting

Condition Summary: Patients Undergoing Routine Health Care; Heart Diseases; Inflammatory Bowel Diseases; Autoimmune Disease; Inflammatory Disease; Blood Coagulation Disorders; Hepatitis C; Non-Metastatic Neoplasm

 

Last Updated: 3 Mar 2014

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Induction of Regulatory t Cells by Low Dose il2 in Autoimmune and Inflammatory Diseases
 

Status: Recruiting

Condition Summary: Rheumatoid Arthritis; Ankylosing Spondylitis; Systemic Lupus Erythematosus; Psoriasis; Behcet's Disease; Wegener's Granulomatosis; Takayasu's Disease; Crohn's Disease; Ulcerative Colitis; Autoimmune Hepatitis; Sclerosing Cholangitis

 

Last Updated: 6 Feb 2014

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