Autoimmune Enteropathy

Common Name(s)

Autoimmune Enteropathy

Autoimmune Enteropathy is a condition in which the body’s immune system attacks itself and irritates the lining of the intestine, causing severe diarrhea. This condition can cause a severe lack of fluids, which may require an IV, and can affect the patient’s ability to absorb food and vitamins. Symptoms may include: diarrhea, poor weight gain and weight loss, decreased urine output, frequent infections, blood in the stool, and skin rashes. There are several different types of autoimmune enteropathy, some of which may be linked with other diseases like diabetes and kidney disease. This condition occurs most in infants and young children, although it can affect adults as well. Physicians can diagnose this condition by using blood tests or endoscopies (tests that look at the stomach and small intestines), or doctors can sometimes diagnose this condition by looking at the family’s medical history. Treatment typically involves medications to suppress the immune system (so that it will stop attacking itself), special diets, and very rarely surgery.

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Advocacy and Support Organizations

 

Condition Specific Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Autoimmune Enteropathy" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Autoimmune Enteropathy" returned 20 free, full-text research articles on human participants. First 3 results:

Gastrointestinal Disorder Associated with Olmesartan Mimics Autoimmune Enteropathy.
 

Author(s): Sophie Scialom, Georgia Malamut, Bertrand Meresse, Nicolas Guegan, Nicole Brousse, Virginie Verkarre, Coralie Derrieux, Elizabeth Macintyre, Philippe Seksik, Guillaume Savoye, Guillaume Cadiot, Lucine Vuitton, Lysiane Marthey, Franck Carbonnel, Nadine Cerf-Bensussan, Christophe Cellier

Journal:

 

Anti-hypertensive treatment with the angiotensin II receptor antagonist olmesartan is a rare cause of severe Sprue-like enteropathy. To substantiate the hypothesis that olmesartan interferes with gut immune homeostasis, clinical, histopathological and immune features were compared ...

Last Updated: 24 Jun 2015

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Recalcitrant hypocalcaemia in autoimmune enteropathy.
 

Author(s): Myfanwy Geyer, Jan Fairchild, David Moore, Lynette Moore, Paul Henning, Elaine Tham

Journal: Pediatrics. 2014 Dec;134(6):e1720-6.

 

Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy syndrome is a monogenic disorder associated with autoimmune destruction of both endocrine and nonendocrine tissues. The classic triad includes candidiasis, hypoparathyroidism, and Addison disease. Up to 25% of patients ...

Last Updated: 2 Dec 2014

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Gastrointestinal biopsy findings of autoimmune enteropathy: a review of 25 cases.
 

Author(s): Ricard Masia, Stephen Peyton, Gregory Y Lauwers, Ian Brown

Journal: Am. J. Surg. Pathol.. 2014 Oct;38(10):1319-29.

 

Autoimmune enteropathy (AIE) is a rare disorder characterized by severe diarrhea and small intestinal mucosal atrophy resulting from immune-mediated injury. It remains a challenging diagnosis because of its clinicopathologic variability. To better understand its histopathologic features, ...

Last Updated: 12 Sep 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Autoimmune Enteropathy" returned 3 free, full-text review articles on human participants. First 3 results:

Immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) and IPEX-related disorders: an evolving web of heritable autoimmune diseases.
 

Author(s): James W Verbsky, Talal A Chatila

Journal: Curr. Opin. Pediatr.. 2013 Dec;25(6):708-14.

 

To summarize recent progress in our understanding of immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) and IPEX-related disorders.

Last Updated: 18 Nov 2013

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Autoimmune enteropathy: a review and update of clinical management.
 

Author(s): Nicole M Gentile, Joseph A Murray, Darrell S Pardi

Journal: Curr Gastroenterol Rep. 2012 Oct;14(5):380-5.

 

Autoimmune enteropathy (AIE) is a rare condition characterized by intractable diarrhea, histologic changes on small intestinal biopsy, and failed response to dietary manipulation that also may present with extraintestinal manifestations. In many patients, immunosuppressive therapies ...

Last Updated: 20 Sep 2012

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Autoimmune enteropathy with a CD8+ CD7- T-cell small bowel intraepithelial lymphocytosis: case report and literature review.
 

Author(s): Shrinivas Bishu, Violeta Arsenescu, Eun Y Lee, H David Vargas, Willem J S de Villiers, Razvan Arsenescu

Journal:

 

Adult onset autoimmune enteropathy (AIE) is a rare condition characterized by diarrhea refractory to dietary therapy diagnosed in patients with evidence of autoimmune conditions. Auto-antibodies to gut epithelial cells and other tissues are commonly demonstrated. Despite increasing ...

Last Updated: 28 Feb 2012

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Study of a Monoclonal Antibody KHK4083 in Moderate Ulcerative Colitis
 

Status: Recruiting

Condition Summary: Ulcerative Colitis; Digestive System Diseases; Colitis, Ulcerative; Colitis; Gastrointestinal Diseases; Inflammatory Bowel Diseases; Intestinal Diseases; Colonic Diseases; Autoimmune Disease; Abdominal Pain

 

Last Updated: 9 Aug 2016

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The 1200 Patients Project: Studying the Implementation of Clinical Pharmacogenomic Testing
 

Status: Recruiting

Condition Summary: Patients Undergoing Routine Health Care; Heart Diseases; Inflammatory Bowel Diseases; Autoimmune Disease; Inflammatory Disease; Blood Coagulation Disorders; Hepatitis C; Non-Metastatic Neoplasm

 

Last Updated: 20 Jul 2016

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Autoimmune Paradoxical Reactions in IBD Longitudinal Cohort
 

Status: Recruiting

Condition Summary: Inflammatory Bowel Diseases; Crohns Disease; Ulcerative Colitis; Colitis

 

Last Updated: 9 Mar 2016

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