Spinocerebellar ataxia 10

Common Name(s)

Spinocerebellar ataxia 10

The autosomal dominant cerebellar ataxias (ADCAs) are a clinically and genetically heterogeneous group of disorders characterized by ataxia, dysarthria, dysmetria, and intention tremor. All ADCAs involve some degree of cerebellar dysfunction and a varying degree of signs from other components of the nervous system. A commonly accepted clinical classification ({7:Harding, 1993}) divides ADCAs into 3 different groups based on the presence or absence of associated symptoms such as brainstem signs or retinopathy. The presence of pyramidal and extrapyramidal symptoms and ophthalmoplegia makes the diagnosis of ADCA I, the presence of retinopathy points to ADCA II, and the absence of associated signs to ADCA III. Genetic linkage and molecular analyses revealed that ADCAs are genetically heterogeneous even within the various subtypes.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Spinocerebellar ataxia 10" for support, advocacy or research.

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National Ataxia Foundation

The National Ataxia Foundation is dedicated to improving the lives of persons affected by ataxia through support, education, and research.

Last Updated: 12 Dec 2012

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Spinocerebellar ataxia 10" for support, advocacy or research.

Logo
National Ataxia Foundation

The National Ataxia Foundation is dedicated to improving the lives of persons affected by ataxia through support, education, and research.

http://www.ataxia.org

Last Updated: 12 Dec 2012

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Spinocerebellar ataxia 10" returned 13 free, full-text research articles on human participants. First 3 results:

Paradoxical effects of repeat interruptions on spinocerebellar ataxia type 10 expansions and repeat instability.
 

Author(s): Karen N McFarland, Jilin Liu, Ivette Landrian, Rui Gao, Partha S Sarkar, Salmo Raskin, Mariana Moscovich, Emilia M Gatto, Hélio A G Teive, Adriana Ochoa, Astrid Rasmussen, Tetsuo Ashizawa

Journal: Eur. J. Hum. Genet.. 2013 Nov;21(11):1272-6.

 

Spinocerebellar ataxia type 10 (SCA10) is an autosomal dominant neurodegenerative disorder caused by a noncoding ATTCT pentanucleotide expansion. An inverse correlation between SCA10 expansion size and age at onset has been reported, and genetic anticipation has been documented. Interruptions ...

Last Updated: 17 Oct 2013

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Acute onset of cerebellar ataxia in a spinocerebellar ataxia type 10 patient after use of steroids.
 

Author(s): Adriana Moro, Renato P Munhoz, Salmo Raskin, Torben C Bezerra, Mariana Moscovich, Tetsuo Ashizawa, Hélio A G Teive

Journal: Arq Neuropsiquiatr. 2013 Jan;71(1):66.

 

Last Updated: 22 Jan 2013

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Spinocerebellar ataxia type 10: disproportionate cerebellar symptoms among at-risk subjects induced by small amounts of alcohol.
 

Author(s): Hélio A G Teive, Renato P Munhoz, Tetsuo Ashizawa

Journal: Arq Neuropsiquiatr. 2011 Oct;69(5):841.

 

Last Updated: 1 Nov 2011

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Spinocerebellar ataxia 10" returned 0 free, full-text review articles on human participants.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

There are currently no open clinical trials for this condition.