Spinocerebellar ataxia 10

Common Name(s)

Spinocerebellar ataxia 10

The autosomal dominant cerebellar ataxias (ADCAs) are a clinically and genetically heterogeneous group of disorders characterized by ataxia, dysarthria, dysmetria, and intention tremor. All ADCAs involve some degree of cerebellar dysfunction and a varying degree of signs from other components of the nervous system. A commonly accepted clinical classification ({7:Harding, 1993}) divides ADCAs into 3 different groups based on the presence or absence of associated symptoms such as brainstem signs or retinopathy. The presence of pyramidal and extrapyramidal symptoms and ophthalmoplegia makes the diagnosis of ADCA I, the presence of retinopathy points to ADCA II, and the absence of associated signs to ADCA III. Genetic linkage and molecular analyses revealed that ADCAs are genetically heterogeneous even within the various subtypes.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Spinocerebellar ataxia 10" for support, advocacy or research.

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National Ataxia Foundation

The National Ataxia Foundation is dedicated to improving the lives of persons affected by ataxia through support, education, and research.

Last Updated: 12 Dec 2012

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Spinocerebellar ataxia 10" for support, advocacy or research.

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National Ataxia Foundation

The National Ataxia Foundation is dedicated to improving the lives of persons affected by ataxia through support, education, and research.

http://www.ataxia.org

Last Updated: 12 Dec 2012

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Spinocerebellar ataxia 10" returned 16 free, full-text research articles on human participants. First 3 results:

Expansion of the Spinocerebellar ataxia type 10 (SCA10) repeat in a patient with Sioux Native American ancestry.
 

Author(s): Khalaf Bushara, Matthew Bower, Jilin Liu, Karen N McFarland, Ivette Landrian, Diane Hutter, Hélio A G Teive, Astrid Rasmussen, Connie J Mulligan, Tetsuo Ashizawa

Journal:

 

Spinocerebellar ataxia type 10 (SCA10), an autosomal dominant cerebellar ataxia, is caused by the expansion of the non-coding ATTCT pentanucleotide repeat in the ATAXIN 10 gene. To date, all cases of SCA10 are restricted to patients with ancestral ties to Latin American countries. ...

Last Updated: 26 Nov 2013

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Spinocerebellar ataxia type 10: from Amerindians to Latin Americans.
 

Author(s): Hélio A G Teive, Tetsuo Ashizawa

Journal: Curr Neurol Neurosci Rep. 2013 Nov;13(11):393.

 

Last Updated: 12 Sep 2013

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Purkinje cell loss is the major brain pathology of spinocerebellar ataxia type 10.
 

Author(s): Guangbin Xia, Karen N McFarland, Kang Wang, Partha S Sarkar, Anthony T Yachnis, Tetsuo Ashizawa

Journal: J. Neurol. Neurosurg. Psychiatr.. 2013 Dec;84(12):1409-11.

 

Last Updated: 15 Nov 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Spinocerebellar ataxia 10" returned 0 free, full-text review articles on human participants.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

There are currently no open clinical trials for this condition.