Spinocerebellar Ataxia

Common Name(s)

Spinocerebellar Ataxia

Description for this condition is not yet available.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Spinocerebellar Ataxia" for support, advocacy or research.

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National Ataxia Foundation

The National Ataxia Foundation is dedicated to improving the lives of persons affected by ataxia through support, education, and research.

Last Updated: 12 Dec 2012

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Spinocerebellar Ataxia" for support, advocacy or research.

Logo
National Ataxia Foundation

The National Ataxia Foundation is dedicated to improving the lives of persons affected by ataxia through support, education, and research.

http://www.ataxia.org

Last Updated: 12 Dec 2012

View Details

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Spinocerebellar Ataxia" returned 338 free, full-text research articles on human participants. First 3 results:

Spinocerebellar ataxia type-7: Report of a family in Northwest Nigeria.
 

Author(s): Nura Hamidu Alkali, Sunday A Bwala, Saeed A Alimi, Shyngle I Oyakhire

Journal: Ann Afr Med. ;15(2):87-90.

 

Spinocerebellar ataxia type-7 (SCA7) is a cytosine-adenine-guanine (CAG) repeat polyglutamine disorder characterized by progressive degeneration of the cerebellum, brainstem, spinal cord, and retina. Clinical features include progressive ataxia, visual loss, pyramidal weakness, sensory ...

Last Updated: 5 Apr 2016

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Treatment with a Ginkgo biloba extract, EGb 761, inhibits excitotoxicity in an animal model of spinocerebellar ataxia type 17.
 

Author(s): Ding-Siang Huang, Hsuan-Yuan Lin, Guey-Jen Lee-Chen, Hsiu-Mei Hsieh-Li, Chung-Hsin Wu, Jung-Yaw Lin

Journal:

 

Spinocerebellar ataxia type 17 (SCA 17) is a polyglutamine disease caused by the expansion of CAG/CAA repeats in the TATA box-binding protein (TBP) gene. The Ginkgo biloba extract, EGb 761, contains flavonoids and terpenoids with a potential use for the treatment of neurodegenerative ...

Last Updated: 3 Mar 2016

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Ataxin-3 phosphorylation decreases neuronal defects in spinocerebellar ataxia type 3 models.
 

Author(s): Carlos A Matos, Clévio Nóbrega, Susana R Louros, Bruno Almeida, Elisabete Ferreiro, Jorge Valero, Luís Pereira de Almeida, Sandra Macedo-Ribeiro, Ana Luísa Carvalho

Journal: J. Cell Biol.. 2016 Feb;212(4):465-80.

 

Different neurodegenerative diseases are caused by aberrant elongation of repeated glutamine sequences normally found in particular human proteins. Although the proteins involved are ubiquitously distributed in human tissues, toxicity targets only defined neuronal populations. Changes ...

Last Updated: 16 Feb 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Spinocerebellar Ataxia" returned 20 free, full-text review articles on human participants. First 3 results:

Parkinsonism in spinocerebellar ataxia.
 

Author(s): Hyeyoung Park, Han-Joon Kim, Beom S Jeon

Journal: Biomed Res Int. 2015 ;2015():125273.

 

Spinocerebellar ataxia (SCA) presents heterogeneous clinical phenotypes, and parkinsonism is reported in diverse SCA subtypes. Both levodopa responsive Parkinson disease (PD) like phenotype and atypical parkinsonism have been described especially in SCA2, SCA3, and SCA17 with geographic ...

Last Updated: 13 Apr 2015

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Motor training in degenerative spinocerebellar disease: ataxia-specific improvements by intensive physiotherapy and exergames.
 

Author(s): Matthis Synofzik, Winfried Ilg

Journal: Biomed Res Int. 2014 ;2014():583507.

 

The cerebellum is essentially involved in movement control and plays a critical role in motor learning. It has remained controversial whether patients with degenerative cerebellar disease benefit from high-intensity coordinative training. Moreover, it remains unclear by which training ...

Last Updated: 30 May 2014

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Beyond the glutamine expansion: influence of posttranslational modifications of ataxin-1 in the pathogenesis of spinocerebellar ataxia type 1.
 

Author(s): Hyoungseok Ju, Hiroshi Kokubu, Janghoo Lim

Journal: Mol. Neurobiol.. 2014 Dec;50(3):866-74.

 

Posttranslational modifications are crucial mechanisms that modulate various cellular signaling pathways, and their dysregulation is associated with many human diseases. Spinocerebellar ataxia type 1 (SCA1) is a dominantly inherited neurodegenerative disease characterized by progressive ...

Last Updated: 10 Nov 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Natural History of Spinocerebellar Ataxia Type 7 (SCA7)
 

Status: Recruiting

Condition Summary: Spinocerebellar Ataxia

 

Last Updated: 31 Aug 2016

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An Open-label Trial of Intravenous Immune Globulin (IVIG)in Treating Spinocerebellar Ataxias
 

Status: Recruiting

Condition Summary: Spinocerebellar Ataxias

 

Last Updated: 6 Jun 2016

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Functional and Structural Imaging and Motor Control in Spinocerebellar Ataxia
 

Status: Recruiting

Condition Summary: Spinocerebellar Ataxia

 

Last Updated: 18 Oct 2016

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