Spasticity

Common Name(s)

Spasticity

Spasticity is a muscular condition characterized by involuntary movements and stiffness. Affected individuals will experience resistance when attempting movements due to muscles being involuntarily contracted. This condition may make small movements, such as buttoning a shirt, very difficult. Spasticity is caused by injury to the brain, spinal cord, or nerves as a result of trauma, stroke, or neuromuscular disorders. This injury results in abnormal signaling between the brain and muscles, causing the abnormal contraction of muscles. Many stroke survivors and over 80% of individuals with multiple sclerosis are affected by spasticity.

Common signs of spasticity include abnormal posture, a clenched fist, and flexed elbows, hands, or fingers. Individuals affected by spasticity may experience symptoms ranging from minor stiffness and inflexibility to involuntary and painful spasms. Other symptoms include difficulty speaking, jerky motions, pain with movement, and very strong reflexes. When an individual has severe spasticity for a long time, their muscle may decrease in size. This may lead to reduced range of motion or the inability to move a joint from a fixed position.

Diagnosis and treatment of spasticity are important to minimize symptoms in affected individuals. Proper treatment can reduce limitations, prevent further injury, and improve quality of life. Treatment for spasticity depends on the severity of the symptoms and overall health of the affected individual. Braces are often used to keep a muscle in a desired position. Physical therapy and exercises often help to strengthen muscles, maintain full range of motion, and reduce risk of permanent muscle damage. Medications taken as pills, injections, and/or implanted devices may be used to help relax muscles. If you or your child has been diagnosed with spasticity, talk to your doctor about the most current treatment options.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Spasticity" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Spasticity" returned 373 free, full-text research articles on human participants. First 3 results:

Safety and efficacy of incobotulinumtoxinA doses up to 800 U in limb spasticity: The TOWER study.
 

Author(s): Jörg Wissel, Djamel Bensmail, Joaquim J Ferreira, Franco Molteni, Lalith Satkunam, Susana Moraleda, Tiina Rekand, John McGuire, Astrid Scheschonka, Birgit Flatau-Baqué, Olivier Simon, Edward T J Rochford, Dirk Dressler, David M Simpson,

Journal: Neurology. 2017 Apr;88(14):1321-1328.

 

To evaluate safety (primary objective) and efficacy of increasing doses (400 U up to 800 U) of incobotulinumtoxinA (Xeomin, Merz Pharmaceuticals GmbH) for patients with limb spasticity.

Last Updated: 11 Mar 2017

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Changes in body composition after spasticity treatment with intrathecal baclofen.
 

Author(s): Olle Skogberg, Kersti Samuelsson, Per Ertzgaard, Richard Levi

Journal: J Rehabil Med. 2017 Jan;49(1):36-39.

 

To assess changes in body composition, body weight and resting metabolic rate in patients who received intrathecal baclofen therapy for spasticity.

Last Updated: 19 Jan 2017

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A Potential New Indication for Botulinum Toxin Injection: A Case Study of Spasticity with Mirror Movements.
 

Author(s): Yu-Lan Zhu, Bei Zhang, Fang Li

Journal: Chin. Med. J.. 2016 10;129(20):2514-2515.

 

Last Updated: 17 Oct 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Spasticity" returned 49 free, full-text review articles on human participants. First 3 results:

Efficacy and safety of oral baclofen in the management of spasticity: A rationale for intrathecal baclofen.
 

Author(s): Per Ertzgaard, Claudia Campo, Alessandra Calabrese

Journal: J Rehabil Med. 2017 Mar;49(3):193-203.

 

Oral baclofen has long been a mainstay in the management of spasticity. This review looks at the clinical evidence for the efficacy and safety of oral baclofen in patients with spasticity of any origin or severity, to determine whether there is a rationale for the use of intrathecal ...

Last Updated: 24 Feb 2017

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Assessing and treating pain associated with stroke, multiple sclerosis, cerebral palsy, spinal cord injury and spasticity. Evidence and recommendations from the Italian Consensus Conference on Pain in Neurorehabilitation.
 

Author(s): Stefano Paolucci, Andrea Martinuzzi, Giorgio Scivoletto, Nicola Smania, Claudio Solaro, Irene Aprile, Michela Armando, Roberto Bergamaschi, Eliana Berra, Giulia Berto, Elena Carraro, Monica Cella, Marialuisa Gandolfi, Marcella Masciullo, Marco Molinari, Emanuela Pagliano, Cristiano Pecchioli, Laura Roncari, Monica Torre, Erika Trabucco, Gabriella Vallies, Paolo Zerbinati, Stefano Tamburin,

Journal: Eur J Phys Rehabil Med. 2016 Dec;52(6):827-840.

 

Pain is a common and disabling symptom in patients with stroke, multiple sclerosis (MS), cerebral palsy (CP), spinal cord injury (SCI) and other conditions associated with spasticity, but data on its prevalence, and natural history, as well as guidelines on its assessment and treatment ...

Last Updated: 6 Sep 2016

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Baclofen in the Therapeutic of Sequele of Traumatic Brain Injury: Spasticity.
 

Author(s): Adán Pérez-Arredondo, Eduardo Cázares-Ramírez, Paul Carrillo-Mora, Marina Martínez-Vargas, Noemí Cárdenas-Rodríguez, Elvia Coballase-Urrutia, Radamés Alemón-Medina, Aristides Sampieri, Luz Navarro, Liliana Carmona-Aparicio

Journal: Clin Neuropharmacol. ;39(6):311-319.

 

Traumatic brain injury (TBI) is an alteration in brain function, caused by an external force, which may be a hit on the skull, rapid acceleration or deceleration, penetration of an object, or shock waves from an explosion. Traumatic brain injury is a major cause of morbidity and mortality ...

Last Updated: 26 Aug 2016

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Meditoxin® Treatment in Patients With Post Stroke Upper Limb Spasticity
 

Status: Not yet recruiting

Condition Summary: Muscle Spasticity

 

Last Updated: 29 Apr 2016

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Study of the Effects on Motor Recovery of Early Post-stroke Spasticity Treatment
 

Status: Recruiting

Condition Summary: Muscle Spasticity

 

Last Updated: 13 Dec 2016

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Intrathecal Baclofen (ITB) Delivery Location and Its Effect on Spasticity
 

Status: Recruiting

Condition Summary: Muscle Spasticity

 

Last Updated: 12 Sep 2016

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