Spasticity

Common Name(s)

Spasticity

Spasticity is a muscular condition characterized by involuntary movements and stiffness. Affected individuals will experience resistance when attempting movements due to muscles being involuntarily contracted. This condition may make small movements, such as buttoning a shirt, very difficult. Spasticity is caused by injury to the brain, spinal cord, or nerves as a result of trauma, stroke, or neuromuscular disorders. This injury results in abnormal signaling between the brain and muscles, causing the abnormal contraction of muscles. Many stroke survivors and over 80% of individuals with multiple sclerosis are affected by spasticity.

Common signs of spasticity include abnormal posture, a clenched fist, and flexed elbows, hands, or fingers. Individuals affected by spasticity may experience symptoms ranging from minor stiffness and inflexibility to involuntary and painful spasms. Other symptoms include difficulty speaking, jerky motions, pain with movement, and very strong reflexes. When an individual has severe spasticity for a long time, their muscle may decrease in size. This may lead to reduced range of motion or the inability to move a joint from a fixed position.

Diagnosis and treatment of spasticity are important to minimize symptoms in affected individuals. Proper treatment can reduce limitations, prevent further injury, and improve quality of life. Treatment for spasticity depends on the severity of the symptoms and overall health of the affected individual. Braces are often used to keep a muscle in a desired position. Physical therapy and exercises often help to strengthen muscles, maintain full range of motion, and reduce risk of permanent muscle damage. Medications taken as pills, injections, and/or implanted devices may be used to help relax muscles. If you or your child has been diagnosed with spasticity, talk to your doctor about the most current treatment options.

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Advocacy and Support Organizations

 

Condition Specific Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Spasticity" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Spasticity" returned 373 free, full-text research articles on human participants. First 3 results:

A pharmacokinetic-pharmacodynamic model for intrathecal baclofen in patients with severe spasticity.
 

Author(s): H W Heetla, J H Proost, B H Molmans, M J Staal, T van Laar

Journal: Br J Clin Pharmacol. 2016 Jan;81(1):101-12.

 

Intrathecal baclofen (ITB) has proven to be an effective and safe treatment for severe spasticity. However, although ITB is used extensively, clinical decisions are based on very scarce pharmacokinetic-pharmacodynamic (PKPD) data. The aim of this study was to measure baclofen CSF ...

Last Updated: 20 Apr 2016

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More than a black box of rehabilitation: Characterizing therapy programmes following botulinum toxin injections for spasticity in adults with stroke.
 

Author(s): Marina Demetrios, Caroline Brand, Julie Louie, Fary Khan

Journal: J Rehabil Med. 2016 Apr;48(5):426-34.

 

To describe ambulatory rehabilitation programmes (physical and occupational therapy activities and interventions) following botulinum toxin injections for post-stroke spasticity using a stroke rehabilitation taxonomy. To explore the relationship between therapy provided and injected ...

Last Updated: 28 Apr 2016

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Three Case Reports of Successful Vibration Therapy of the Plantar Fascia for Spasticity Due to Cerebral Palsy-Like Syndrome, Fetal-Type Minamata Disease.
 

Author(s): Fusako Usuki, Satsuki Tohyama

Journal: Medicine (Baltimore). 2016 Apr;95(15):e3385.

 

Fetal-type Minamata disease is caused by the exposure to high concentrations of methylmercury in the fetal period and shows cerebral palsy-like clinical features. Relief of spasticity is a major task of rehabilitation to improve their activities of daily living. Here we report the ...

Last Updated: 16 Apr 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Spasticity" returned 47 free, full-text review articles on human participants. First 3 results:

Transcranial direct current stimulation for improving spasticity after stroke: A systematic review with meta-analysis.
 

Author(s): Bernhard Elsner, Joachim Kugler, Marcus Pohl, Jan Mehrholz

Journal: J Rehabil Med. 2016 Jul;48(7):565-70.

 

To evaluate the evidence regarding transcranial direct current stimulation (tDCS) and to assess its impact on spasticity after stroke.

Last Updated: 18 Jul 2016

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Spotlight on botulinum toxin and its potential in the treatment of stroke-related spasticity.
 

Author(s): Michelle Kaku, David M Simpson

Journal:

 

Poststroke spasticity affects up to one-half of stroke patients and has debilitating effects, contributing to diminished activities of daily living, quality of life, pain, and functional impairments. Botulinum toxin (BoNT) is proven to be safe and effective in the treatment of focal ...

Last Updated: 29 Mar 2016

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Systematic Literature Review of AbobotulinumtoxinA in Clinical Trials for Lower Limb Spasticity.
 

Author(s): Khashayar Dashtipour, Jack J Chen, Heather W Walker, Michael Y Lee

Journal: Medicine (Baltimore). 2016 Jan;95(2):e2468.

 

To elucidate clinical trial efficacy, safety, and dosing practices of AbobotulinumtoxinA (ABO) treatment in adult patients with lower limb spasticity.A systematic literature review was performed to identify randomized controlled trials of ABO in the treatment of adult lower limb spasticity.Of ...

Last Updated: 15 Jan 2016

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Meditoxin® Treatment in Patients With Post Stroke Upper Limb Spasticity
 

Status: Not yet recruiting

Condition Summary: Muscle Spasticity

 

Last Updated: 29 Apr 2016

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Study of the Effects on Motor Recovery of Early Post-stroke Spasticity Treatment
 

Status: Recruiting

Condition Summary: Muscle Spasticity

 

Last Updated: 13 Dec 2016

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Intrathecal Baclofen (ITB) Delivery Location and Its Effect on Spasticity
 

Status: Recruiting

Condition Summary: Muscle Spasticity

 

Last Updated: 12 Sep 2016

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