Spastic paraparesis

Common Name(s)

Spastic paraparesis

Description for this condition is not yet available.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Spastic paraparesis" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Spastic paraparesis" returned 152 free, full-text research articles on human participants. First 3 results:

Visualization of HTLV-1-specific cytotoxic T lymphocytes in the spinal cords of patients with HTLV-1-associated myelopathy/tropical spastic paraparesis.
 

Author(s): Eiji Matsuura, Ryuji Kubota, Yuetsu Tanaka, Hiroshi Takashima, Shuji Izumo

Journal: J. Neuropathol. Exp. Neurol.. 2015 Jan;74(1):2-14.

 

Activated human T-lymphotropic virus type-1 (HTLV-1)-specific CD8-positive cytotoxic T lymphocytes (CTLs) are markedly increased in the periphery of patients with HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), an HTLV-1-induced inflammatory disease of the CNS. ...

Last Updated: 18 Dec 2014

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Interferon beta-1a treatment in HTLV-1-associated myelopathy/tropical spastic paraparesis: a case report.
 

Author(s): Graça Maria de Castro Viana, Marcos Antonio Custódio Neto da Silva, Victor Lima Souza, Natália Barbosa da Silva Lopes, Diego Luz Felipe da Silva, Maria do Desterro Soares Brandão Nascimento

Journal: Rev. Inst. Med. Trop. Sao Paulo. ;56(5):443-5.

 

Here a young patient (< 21 years of age) with a history of infective dermatitis is described. The patient was diagnosed with myelopathy associated with HTLV-1/tropical spastic paraparesis and treated with interferon beta-1a. The disease was clinically established as HTLV-1-associated ...

Last Updated: 18 Sep 2014

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Temporal lesions and widespread involvement of white matter associated with multi-organ inflammatory disease in human T-lymphotropic virus type 1-associated myelopathy/tropical spastic paraparesis (HAM/TSP).
 

Author(s): Gustavo B Mendes, Rosangela S Kalil, Carolina Rosadas, Marcos R G de Freitas, Marzia Puccioni-Sohler

Journal: Int. J. Infect. Dis.. 2014 Aug;25():1-3.

 

Human T-lymphotropic virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a chronic inflammatory disease of the spinal cord, characterized by spastic paraparesis, back pain, and sphincter disorders. Involvement of multiple organs and encephalopathy ...

Last Updated: 23 Jul 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Spastic paraparesis" returned 10 free, full-text review articles on human participants. First 3 results:

[Tropical spastic paraparesis: a report of a new case in Spain].
 

Author(s): Luciana Midaglia, Antonio Pato-Pato, Iria Rodriguez-Constenla, Eloísa Santos-Armentia, Iciar Cimas-Hernando, María Lopez-Fernandez, Delicias Munoz-Garcia, Candelas Valeiras-Munoz, José R Lorenzo-Gonzalez

Journal: Rev Neurol. 2014 Jun;58(12):573-5.

 

Last Updated: 11 Jun 2014

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Treatment of HTLV-I-associated myelopathy/tropical spastic paraparesis: toward rational targeted therapy.
 

Author(s): Unsong Oh, Steven Jacobson

Journal: Neurol Clin. 2008 Aug;26(3):781-97, ix-x.

 

The treatment of HAM/TSP is a challenge. No agent has shown to significantly modify the long-term disability associated with HAM/TSP. Advances in our understanding of the pathogenesis of HAM/TSP have led to the identification of several biomarkers and therapeutic targets. Clinical ...

Last Updated: 28 Jul 2008

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Adrenomyeloneuropathy as a cause of primary adrenal insufficiency and spastic paraparesis.
 

Author(s): Monika Spurek, Regina Taylor-Gjevre, Stan Van Uum, Hasnain M Khandwala

Journal: CMAJ. 2004 Oct;171(9):1073-7.

 

Adrenomyeloneuropathy is a varient of adrenoleukodystrophy, both of which are rare inherited disorders of peroxisomes characterized by the accumulation of very-long-chain fatty acids in plasma, the central and peripheral nervous systems, adrenal glands and testes, which leads to dysfunction ...

Last Updated: 26 Oct 2004

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Evaluation of Patients With HAM/TSP
 

Status: Recruiting

Condition Summary: HTLV-I Infection; Tropical Spastic Paraparesis

 

Last Updated: 30 Jul 2015

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Last Updated: 9 Jul 2015

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Raltegravir for HAM/TSP
 

Status: Recruiting

Condition Summary: HAM/TSP; HTLV-1

 

Last Updated: 2 Apr 2015

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