Spasmodic dysphonia

Common Name(s)

Spasmodic dysphonia

Spasmodic dysphonia is a voice disorder caused by involuntary movements of one or more muscles of the larynx or voice box. Individuals who have spasmodic dysphonia may have occasional difficulty saying a word or two or they may experience sufficient difficulty to interfere with communication. Spasmodic dysphonia causes the voice to break or to have a tight, strained or strangled quality. While the cause of spasmodic dysphonia is unknown, most cases are believed to be neurogenic (having to do with the nervous system) in nature. Some cases occur along with movement disorders and some may be inherited. While anyone can be affected, spasmodic dysphonia more often affects women and begins in those between the ages of 30 and 50.  

There are three different types of spasmodic dysphonia:  

Adductor spasmodic dysphonia (causes the vocal cords to slam together and stiffen) Abductor spasmodic dysphonia (causes the vocal cords to open)  Mixed spasmodic dysphonia (causes the vocal cords to open and close)
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Spasmodic dysphonia" for support, advocacy or research.

National Spasmodic Dysphonia Association

The mission of the National Spasmodic Dysphonia Association is to advance medical research into the causes of and treatments for spasmodic dysphonia, promote physician and public awareness of the disorder, and provide support to those affected by spasmodic dysphonia.

Last Updated: 9 Nov 2012

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Spasmodic dysphonia" for support, advocacy or research.

National Spasmodic Dysphonia Association

The mission of the National Spasmodic Dysphonia Association is to advance medical research into the causes of and treatments for spasmodic dysphonia, promote physician and public awareness of the disorder, and provide support to those affected by spasmodic dysphonia.

http://www.dysphonia.org/

Last Updated: 9 Nov 2012

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Spasmodic dysphonia" returned 27 free, full-text research articles on human participants. First 3 results:

Abnormal striatal dopaminergic neurotransmission during rest and task production in spasmodic dysphonia.
 

Author(s): Kristina Simonyan, Brian D Berman, Peter Herscovitch, Mark Hallett

Journal: J. Neurosci.. 2013 Sep;33(37):14705-14.

 

Spasmodic dysphonia is a primary focal dystonia characterized by involuntary spasms in the laryngeal muscles during speech production. The pathophysiology of spasmodic dysphonia is thought to involve structural and functional abnormalities in the basal ganglia-thalamo-cortical circuitry; ...

Last Updated: 12 Sep 2013

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Tridimensional assessment of adductor spasmodic dysphonia pre- and post-treatment with Botulinum toxin.
 

Author(s): P H Dejonckere, K J Neumann, M B J Moerman, J P Martens, A Giordano, C Manfredi

Journal: Eur Arch Otorhinolaryngol. 2012 Apr;269(4):1195-203.

 

Spasmodic dysphonia voices form, in the same way as substitution voices, a particular category of dysphonia that seems not suited for a standardized basic multidimensional assessment protocol, like the one proposed by the European Laryngological Society. Thirty-three exhaustive analyses ...

Last Updated: 26 Mar 2012

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Coprevalence of anxiety and depression with spasmodic dysphonia: a case-control study.
 

Author(s): Laura J White, Edie R Hapner, Adam M Klein, John M Delgaudio, John J Hanfelt, H A Jinnah, Michael M Johns

Journal: J Voice. 2012 Sep;26(5):667.e1-6.

 

There is evidence supporting an association between depression and anxiety in patients with chronic disease. Spasmodic dysphonia (SD) is a chronic, incurable, and disabling voice disorder. Reported rates of depression and anxiety in SD range from 7.1% to 72%, with a maximum number ...

Last Updated: 7 Sep 2012

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Spasmodic dysphonia" returned 4 free, full-text review articles on human participants. First 3 results:

Spasmodic dysphonia: a laryngeal control disorder specific to speech.
 

Author(s): Christy L Ludlow

Journal: J. Neurosci.. 2011 Jan;31(3):793-7.

 

Spasmodic dysphonia (SD) is a rare neurological disorder that emerges in middle age, is usually sporadic, and affects intrinsic laryngeal muscle control only during speech. Spasmodic bursts in particular laryngeal muscles disrupt voluntary control during vowel sounds in adductor SD ...

Last Updated: 20 Jan 2011

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Treatment for spasmodic dysphonia: limitations of current approaches.
 

Author(s): Christy L Ludlow

Journal: Curr Opin Otolaryngol Head Neck Surg. 2009 Jun;17(3):160-5.

 

Although botulinum toxin injection is the gold standard for treatment of spasmodic dysphonia, surgical approaches aimed at providing long-term symptom control have been advancing over recent years.

Last Updated: 20 May 2009

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Research priorities in spasmodic dysphonia.
 

Author(s): Christy L Ludlow, Charles H Adler, Gerald S Berke, Steven A Bielamowicz, Andrew Blitzer, Susan B Bressman, Mark Hallett, H A Jinnah, Uwe Juergens, Sandra B Martin, Joel S Perlmutter, Christine Sapienza, Andrew Singleton, Caroline M Tanner, Gayle E Woodson

Journal: Otolaryngol Head Neck Surg. 2008 Oct;139(4):495-505.

 

To identify research priorities to increase understanding of the pathogenesis, diagnosis, and improved treatment of spasmodic dysphonia.

Last Updated: 16 Oct 2008

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Examining the Spasmodic Dysphonia Diagnosis and Assessment Procedure (SD-DAP) for Measuring Symptom Change
 

Status: Not yet recruiting

Condition Summary: Spasmodic Dysphonia; Laryngeal Dystonia

 

Last Updated: 5 Aug 2014

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Effect of Vocal Exercise After Botulinum Toxin Injection for Spasmodic Dysphonia
 

Status: Recruiting

Condition Summary: Spasmodic Dysphonia; Dystonia

 

Last Updated: 26 Jul 2011

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Voice Tremor in Spasmodic Dysphonia: Central Mechanisms and Treatment Response
 

Status: Recruiting

Condition Summary: Spasmodic Dysphonia; Voice Tremor

 

Last Updated: 15 Apr 2014

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