Soft tissue sarcoma

Common Name(s)

Soft tissue sarcoma

Soft-tissue sarcomas are cancerous tumors that begin in the soft tissues of the body. This stype of sarcoma is rare in adults and not very common in children. Symptoms of soft-tissue sarcomas are not noticeable initially, but as the tumor grows, several of the following may develop: a lump or swelling, a blockage in the stomach or intestines if the tumor is located in the abdomen or digestive tract, and pain, particularly if the tumor sits on or near a bundle of nerves. Soft-tissue sarcomas can go by a variety of names, depending on the location of origination, and include disorders such as Kaposi’s sasrcoma, synovial sarcoma, liposarcoma, fibrosaroma, and neurofibrosarcoma.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Soft tissue sarcoma" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Soft tissue sarcoma" returned 317 free, full-text research articles on human participants. First 3 results:

Sesquiterpene lactones downregulate G2/M cell cycle regulator proteins and affect the invasive potential of human soft tissue sarcoma cells.
 

Author(s): Birgit Lohberger, Beate Rinner, Nicole Stuendl, Heike Kaltenegger, Bibiane Steinecker-Frohnwieser, Eva Bernhart, Ehsan Bonyadi Rad, Annelie Martina Weinberg, Andreas Leithner, Rudolf Bauer, Nadine Kretschmer

Journal:

 

Soft tissue sarcomas (STS) represent a rare group of malignant tumors that frequently exhibit chemotherapeutic resistance and increased metastatic potential. Many studies have demonstrated the great potential of plant-derived agents in the treatment of various malignant entities. ...

Last Updated: 26 Jun 2013

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Incidence of soft tissue sarcoma focusing on gastrointestinal stromal sarcoma in Osaka, Japan, during 1978-2007.
 

Author(s): Etsuko Nomura, Akiko Ioka, Hideaki Tsukuma

Journal: Jpn. J. Clin. Oncol.. 2013 Aug;43(8):841-5.

 

To clarify the incidence of soft tissue sarcoma and gastrointestinal stromal sarcoma in Osaka, Japan, we analyzed Osaka Cancer Registry's data. We identified a total of 6998 cases, except for those of bones and joints, during 1978-2007. The age-adjusted incidence rate of those sarcomas ...

Last Updated: 29 Jul 2013

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Dense pattern of embryonal rhabdomyosarcoma, a lesion easily confused with alveolar rhabdomyosarcoma: a report from the Soft Tissue Sarcoma Committee of the Children's Oncology Group.
 

Author(s): Erin R Rudzinski, Lisa A Teot, James R Anderson, Julie Moore, Julia A Bridge, Frederic G Barr, Julie M Gastier-Foster, Stephen X Skapek, Douglas S Hawkins, David M Parham

Journal: Am. J. Clin. Pathol.. 2013 Jul;140(1):82-90.

 

To examine whether the frequency of fusion-negative alveolar rhabdomyosarcoma (ARMSn) increased coincident with changes in the definition of alveolar histology.

Last Updated: 14 Jun 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Soft tissue sarcoma" returned 27 free, full-text review articles on human participants. First 3 results:

Multidisciplinary management of soft tissue sarcoma.
 

Author(s): Lukas M Nystrom, Nickolas B Reimer, John D Reith, Long Dang, Robert A Zlotecki, Mark T Scarborough, C Parker Gibbs

Journal:

 

Soft tissue sarcoma is a rare malignancy, with approximately 11,000 cases per year encountered in the United States. It is primarily encountered in adults but can affect patients of any age. There are many histologic subtypes and the malignancy can be low or high grade. Appropriate ...

Last Updated: 28 Aug 2013

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Efficacy and safety of pharmacological interventions in second- or later-line treatment of patients with advanced soft tissue sarcoma: a systematic review.
 

Author(s): Sheetal Sharma, Shweta Takyar, Stephanie C Manson, Sarah Powell, Nicolas Penel

Journal:

 

Current guidelines recommend anthracycline-based chemotherapy primarily with doxorubicin either as monotherapy or in combination with ifosfamide as the first-line treatment for most advanced STS subtypes. Therapeutic options after failure of doxorubicin and/or ifosfamide are limited. ...

Last Updated: 26 Aug 2013

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Occupational cancer in Britain. Remaining cancer sites: brain, bone, soft tissue sarcoma and thyroid.
 

Author(s): Terry Brown, Charlotte Young, Lesley Rushton,

Journal: Br. J. Cancer. 2012 Jun;107 Suppl 1():S85-91.

 

Last Updated: 19 Jun 2012

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Gemcitabine Hydrochloride With or Without Pazopanib Hydrochloride in Treating Patients With Refractory Soft Tissue Sarcoma
 

Status: Recruiting

Condition Summary: Adult Alveolar Soft-part Sarcoma; Adult Angiosarcoma; Adult Desmoplastic Small Round Cell Tumor; Adult Epithelioid Hemangioendothelioma; Adult Epithelioid Sarcoma; Adult Extraskeletal Chondrosarcoma; Adult Extraskeletal Osteosarcoma; Adult Fibrosarcoma; Adult Leiomyosarcoma; Adult Liposarcoma; Adult Malignant Fibrous Histiocytoma; Adult Malignant Hemangiopericytoma; Adult Malignant Mesenchymoma; Adult Neurofibrosarcoma; Adult Rhabdomyosarcoma; Adult Synovial Sarcoma; Childhood Alveolar Soft-part Sarcoma; Childhood Angiosarcoma; Childhood Desmoplastic Small Round Cell Tumor; Childhood Epithelioid Hemangioendothelioma; Childhood Epithelioid Sarcoma; Childhood Fibrosarcoma; Childhood Leiomyosarcoma; Childhood Liposarcoma; Childhood Malignant Hemangiopericytoma; Childhood Malignant Mesenchymoma; Childhood Neurofibrosarcoma; Childhood Synovial Sarcoma; Dermatofibrosarcoma Protuberans; Metastatic Childhood Soft Tissue Sarcoma; Nonmetastatic Childhood Soft Tissue Sarcoma; Recurrent Adult Soft Tissue Sarcoma; Recurrent Childhood Soft Tissue Sarcoma; Stage III Adult Soft Tissue Sarcoma; Stage IV Adult Soft Tissue Sarcoma

 

Last Updated: 3 Jun 2014

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Pazopanib Hydrochloride Followed By Chemotherapy and Surgery in Treating Patients With Soft Tissue Sarcoma
 

Status: Recruiting

Condition Summary: Adult Angiosarcoma; Adult Desmoplastic Small Round Cell Tumor; Adult Epithelioid Hemangioendothelioma; Adult Epithelioid Sarcoma; Adult Extraskeletal Chondrosarcoma; Adult Fibrosarcoma; Adult Leiomyosarcoma; Adult Liposarcoma; Adult Malignant Fibrous Histiocytoma; Adult Malignant Hemangiopericytoma; Adult Malignant Mesenchymoma; Adult Neurofibrosarcoma; Adult Synovial Sarcoma; Dermatofibrosarcoma Protuberans; Stage IIA Adult Soft Tissue Sarcoma; Stage III Adult Soft Tissue Sarcoma; Stage IV Adult Soft Tissue Sarcoma

 

Last Updated: 16 Jun 2014

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Radiation Therapy With or Without Combination Chemotherapy or Pazopanib Hydrochloride Before Surgery in Treating Patients With Newly Diagnosed Non-Rhabdomyosarcoma Soft Tissue Sarcomas That Can be Removed by Surgery
 

Status: Recruiting

Condition Summary: Adult Alveolar Soft-part Sarcoma; Adult Angiosarcoma; Adult Epithelioid Sarcoma; Adult Extraskeletal Chondrosarcoma; Adult Extraskeletal Osteosarcoma; Adult Fibrosarcoma; Adult Leiomyosarcoma; Adult Liposarcoma; Adult Malignant Fibrous Histiocytoma; Adult Malignant Mesenchymoma; Adult Synovial Sarcoma; Childhood Alveolar Soft-part Sarcoma; Childhood Angiosarcoma; Childhood Epithelioid Sarcoma; Childhood Leiomyosarcoma; Childhood Liposarcoma; Childhood Malignant Mesenchymoma; Childhood Synovial Sarcoma; Nonmetastatic Childhood Soft Tissue Sarcoma; Stage IB Adult Soft Tissue Sarcoma; Stage IIB Adult Soft Tissue Sarcoma; Stage III Adult Soft Tissue Sarcoma; Stage IV Adult Soft Tissue Sarcoma

 

Last Updated: 18 Jul 2014

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