Soft tissue sarcoma

Common Name(s)

Soft tissue sarcoma

Soft-tissue sarcomas are cancerous tumors that begin in the soft tissues of the body. This stype of sarcoma is rare in adults and not very common in children. Symptoms of soft-tissue sarcomas are not noticeable initially, but as the tumor grows, several of the following may develop: a lump or swelling, a blockage in the stomach or intestines if the tumor is located in the abdomen or digestive tract, and pain, particularly if the tumor sits on or near a bundle of nerves. Soft-tissue sarcomas can go by a variety of names, depending on the location of origination, and include disorders such as Kaposi’s sasrcoma, synovial sarcoma, liposarcoma, fibrosaroma, and neurofibrosarcoma.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Soft tissue sarcoma" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Soft tissue sarcoma" returned 542 free, full-text research articles on human participants. First 3 results:

A randomized, double-blind, placebo-controlled, Phase III study of pazopanib in patients with soft tissue sarcoma: results from the Japanese subgroup.
 

Author(s): Akira Kawai, Nobuhito Araki, Hiroaki Hiraga, Hideshi Sugiura, Akihiko Matsumine, Toshifumi Ozaki, Takafumi Ueda, Takeshi Ishii, Taito Esaki, Michiko Machida, Nobuaki Fukasawa

Journal: Jpn. J. Clin. Oncol.. 2016 Mar;46(3):248-53.

 

This analysis of the Japanese subpopulation of the PALETTE Phase III, randomized, placebo-controlled study investigated efficacy and safety of pazopanib in patients with metastatic soft tissue sarcoma after failure of standard chemotherapy.

Last Updated: 4 Mar 2016

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Epigenetic re-expression of HIF-2α suppresses soft tissue sarcoma growth.
 

Author(s): Michael S Nakazawa, T S Karin Eisinger-Mathason, Navid Sadri, Joshua D Ochocki, Terence P F Gade, Ruchi K Amin, M Celeste Simon

Journal:

 

In soft tissue sarcomas (STS), low intratumoural O2 (hypoxia) is a poor prognostic indicator. HIF-1α mediates key transcriptional responses to hypoxia, and promotes STS metastasis; however, the role of the related HIF-2α protein is unknown. Surprisingly, here we show that HIF-2α ...

Last Updated: 3 Feb 2016

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Combination of Cisplatin, Ifosfamide, and Adriamycin as Neoadjuvant Chemotherapy for Extremity Soft Tissue Sarcoma: A Report of Twenty-Eight Patients.
 

Author(s): Bing Wang, Xiuchun Yu, Songfeng Xu, Ming Xu

Journal: Medicine (Baltimore). 2016 Jan;95(4):e2611.

 

To investigate the clinical efficacy of neoadjuvant chemotherapy in the treatment of extremity soft tissue sarcomas (STSs). We retrospectively analyzed 28 patients with extremity STS that received 2 cycles of preoperative and 6 cycles of postoperative neoadjuvant chemotherapy between ...

Last Updated: 30 Jan 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Soft tissue sarcoma" returned 47 free, full-text review articles on human participants. First 3 results:

Significance of circulating tumor cells in soft tissue sarcoma.
 

Author(s): Chiara Nicolazzo, Angela Gradilone

Journal: Anal Cell Pathol (Amst). 2015 ;2015():697395.

 

Circulating tumor cells can be detected from the peripheral blood of cancer patients. Their prognostic value has been established in the last 10 years for metastatic colorectal, breast, and prostate cancer. On the contrary their presence in patients affected by sarcomas has been poorly ...

Last Updated: 13 Jul 2015

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Soft tissue sarcoma in France in 2015: Epidemiology, classification and organization of clinical care.
 

Author(s): C Honoré, P Méeus, E Stoeckle, S Bonvalot

Journal: J Visc Surg. 2015 Sep;152(4):223-30.

 

Four thousand new cases of soft tissue sarcomas are diagnosed each year in France, 23% of which are localized in the abdomen and pelvis; the treatment of non-metastatic tumor is based on wide surgical resection, the quality of which determines the long-term outcome. To ensure appropriate ...

Last Updated: 31 Aug 2015

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Adjuvant chemotherapy for soft tissue sarcoma.
 

Author(s): Paolo G Casali

Journal: Am Soc Clin Oncol Educ Book. 2015 ;():e629-33.

 

Adjuvant chemotherapy is not standard treatment in soft tissue sarcoma (STS). However, when the risk of relapse is high, it is an option for shared decision making with the patient in conditions of uncertainty. This is because available evidence is conflicting, even if several randomized ...

Last Updated: 21 May 2015

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Radiation Therapy With or Without Combination Chemotherapy or Pazopanib Hydrochloride Before Surgery in Treating Patients With Newly Diagnosed Non-Rhabdomyosarcoma Soft Tissue Sarcomas That Can Be Removed by Surgery
 

Status: Recruiting

Condition Summary: Adult Fibrosarcoma; Alveolar Soft Part Sarcoma; Angiomatoid Fibrous Histiocytoma; Atypical Fibroxanthoma; Clear Cell Sarcoma of Soft Tissue; Epithelioid Malignant Peripheral Nerve Sheath Tumor; Epithelioid Sarcoma; Extraskeletal Myxoid Chondrosarcoma; Extraskeletal Osteosarcoma; Fibrohistiocytic Neoplasm; Glomus Tumor of the Skin; Inflammatory Myofibroblastic Tumor; Intimal Sarcoma; Leiomyosarcoma; Liposarcoma; Low Grade Fibromyxoid Sarcoma; Low Grade Myofibroblastic Sarcoma; Malignant Cutaneous Granular Cell Tumor; Malignant Peripheral Nerve Sheath Tumor; Malignant Triton Tumor; Mesenchymal Chondrosarcoma; Myxofibrosarcoma; Myxoid Chondrosarcoma; Myxoinflammatory Fibroblastic Sarcoma; Nerve Sheath Neoplasm; PEComa; Pericytic Neoplasm; Plexiform Fibrohistiocytic Tumor; Sclerosing Epithelioid Fibrosarcoma; Stage IB Soft Tissue Sarcoma; Stage IIB Soft Tissue Sarcoma; Stage III Soft Tissue Sarcoma; Stage IV Soft Tissue Sarcoma; Synovial Sarcoma; Undifferentiated (Embryonal) Sarcoma; Undifferentiated High Grade Pleomorphic Sarcoma of Bone

 

Last Updated: 21 Sep 2016

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Gemcitabine Hydrochloride With or Without Pazopanib Hydrochloride in Treating Patients With Refractory Soft Tissue Sarcoma
 

Status: Recruiting

Condition Summary: Adult Alveolar Soft Part Sarcoma; Adult Angiosarcoma; Adult Desmoplastic Small Round Cell Tumor; Adult Epithelioid Hemangioendothelioma; Adult Epithelioid Sarcoma; Adult Extraskeletal Myxoid Chondrosarcoma; Adult Extraskeletal Osteosarcoma; Adult Fibrosarcoma; Adult Leiomyosarcoma; Adult Liposarcoma; Adult Malignant Mesenchymoma; Adult Malignant Peripheral Nerve Sheath Tumor; Adult Rhabdomyosarcoma; Adult Synovial Sarcoma; Adult Undifferentiated Pleomorphic Sarcoma; Malignant Adult Hemangiopericytoma; Recurrent Adult Soft Tissue Sarcoma; Stage III Adult Soft Tissue Sarcoma; Stage IV Adult Soft Tissue Sarcoma

 

Last Updated: 5 Apr 2016

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Axitinib and Pembrolizumab in Subjects With Advanced Alveolar Soft Part Sarcoma and Other Soft Tissue Sarcomas
 

Status: Recruiting

Condition Summary: Alveolar Soft Part Sarcoma; Soft Tissue Sarcomas

 

Last Updated: 1 Sep 2016

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