Soft tissue sarcoma

Common Name(s)

Soft tissue sarcoma

Soft-tissue sarcomas are cancerous tumors that begin in the soft tissues of the body. This stype of sarcoma is rare in adults and not very common in children. Symptoms of soft-tissue sarcomas are not noticeable initially, but as the tumor grows, several of the following may develop: a lump or swelling, a blockage in the stomach or intestines if the tumor is located in the abdomen or digestive tract, and pain, particularly if the tumor sits on or near a bundle of nerves. Soft-tissue sarcomas can go by a variety of names, depending on the location of origination, and include disorders such as Kaposi’s sasrcoma, synovial sarcoma, liposarcoma, fibrosaroma, and neurofibrosarcoma.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Soft tissue sarcoma" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Soft tissue sarcoma" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Soft tissue sarcoma" returned 374 free, full-text research articles on human participants. First 3 results:

Alarm symptoms of soft-tissue and bone sarcoma in patients referred to a specialist center.
 

Author(s): Heidi B Dyrop, Peter Vedsted, Akmal Safwat, Katja Maretty-Nielsen, Bjarne H Hansen, Peter H Jørgensen, Thomas Baad-Hansen, Johnny Keller

Journal: Acta Orthop. 2014 Dec;85(6):657-62.

 

The Danish Cancer Patient Pathway for sarcoma defines a set of alarm symptoms as criteria for referral to a sarcoma center. This may exclude cancer patients without alarm symptoms, so we investigated the presence of alarm symptoms (defined as being indicative of a sarcoma) in patients ...

Last Updated: 21 Nov 2014

Go To URL
MicroRNA response to hypoxic stress in soft tissue sarcoma cells: microRNA mediated regulation of HIF3α.
 

Author(s): Caroline M M Gits, Patricia F van Kuijk, Jonneke C W M de Rijck, Nikky Muskens, Moniek B E Jonkers, Wilfred F van IJcken, Ron H J Mathijssen, Jaap Verweij, Stefan Sleijfer, Erik A C Wiemer

Journal:

 

Hypoxia is often encountered in solid tumors and known to contribute to aggressive tumor behavior, radiation- and chemotherapy resistance resulting in a poor prognosis for the cancer patient. MicroRNAs (miRNAs) play a role in the regulation of the tumor cell response to hypoxia, however, ...

Last Updated: 23 Jun 2014

Go To URL
A randomized phase II/III trial of perioperative chemotherapy with adriamycin plus ifosfamide versus gemcitabine plus docetaxel for high-grade soft tissue sarcoma: Japan Clinical Oncology Group Study JCOG1306.
 

Author(s): Kozo Kataoka, Kazuhiro Tanaka, Junki Mizusawa, Aya Kimura, Hiroaki Hiraga, Akira Kawai, Tomoya Matsunobu, Akihiko Matsumine, Nobuhito Araki, Yoshinao Oda, Haruhiko Fukuda, Yukihide Iwamoto,

Journal: Jpn. J. Clin. Oncol.. 2014 Aug;44(8):765-9.

 

A randomized Phase II/III trial was planned to commence in March 2014. Perioperative chemotherapy with adriamycin plus ifosfamide is the current standard treatment for T2bN0M0 high-grade non-round cell soft tissue sarcoma. The purpose of this study is to confirm the non-inferiority ...

Last Updated: 1 Aug 2014

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Soft tissue sarcoma" returned 31 free, full-text review articles on human participants. First 3 results:

Soft tissue sarcoma: an update on systemic treatment options for patients with advanced disease.
 

Author(s): Patrick Schöffski, Jasmien Cornillie, Agnieszka Wozniak, Haifu Li, Daphne Hompes

Journal: Oncol Res Treat. 2014 ;37(6):355-62.

 

Sarcomas are a group of rare solid tumours arising from mesenchymal or connective tissue. This review focuses on soft tissue sarcoma and covers general topics such as the epidemiology, age distribution, site of disease, histogenesis, histological subtypes, prognosis and outcome of ...

Last Updated: 6 Jun 2014

Go To URL
Multidisciplinary management of soft tissue sarcoma.
 

Author(s): Lukas M Nystrom, Nickolas B Reimer, John D Reith, Long Dang, Robert A Zlotecki, Mark T Scarborough, C Parker Gibbs

Journal:

 

Soft tissue sarcoma is a rare malignancy, with approximately 11,000 cases per year encountered in the United States. It is primarily encountered in adults but can affect patients of any age. There are many histologic subtypes and the malignancy can be low or high grade. Appropriate ...

Last Updated: 28 Aug 2013

Go To URL
Efficacy and safety of pharmacological interventions in second- or later-line treatment of patients with advanced soft tissue sarcoma: a systematic review.
 

Author(s): Sheetal Sharma, Shweta Takyar, Stephanie C Manson, Sarah Powell, Nicolas Penel

Journal:

 

Current guidelines recommend anthracycline-based chemotherapy primarily with doxorubicin either as monotherapy or in combination with ifosfamide as the first-line treatment for most advanced STS subtypes. Therapeutic options after failure of doxorubicin and/or ifosfamide are limited. ...

Last Updated: 26 Aug 2013

Go To URL
 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Gemcitabine Hydrochloride With or Without Pazopanib Hydrochloride in Treating Patients With Refractory Soft Tissue Sarcoma
 

Status: Recruiting

Condition Summary: Adult Alveolar Soft-part Sarcoma; Adult Angiosarcoma; Adult Desmoplastic Small Round Cell Tumor; Adult Epithelioid Hemangioendothelioma; Adult Epithelioid Sarcoma; Adult Extraskeletal Chondrosarcoma; Adult Extraskeletal Osteosarcoma; Adult Fibrosarcoma; Adult Leiomyosarcoma; Adult Liposarcoma; Adult Malignant Fibrous Histiocytoma; Adult Malignant Hemangiopericytoma; Adult Malignant Mesenchymoma; Adult Neurofibrosarcoma; Adult Rhabdomyosarcoma; Adult Synovial Sarcoma; Childhood Alveolar Soft-part Sarcoma; Childhood Angiosarcoma; Childhood Desmoplastic Small Round Cell Tumor; Childhood Epithelioid Hemangioendothelioma; Childhood Epithelioid Sarcoma; Childhood Fibrosarcoma; Childhood Leiomyosarcoma; Childhood Liposarcoma; Childhood Malignant Hemangiopericytoma; Childhood Malignant Mesenchymoma; Childhood Neurofibrosarcoma; Childhood Synovial Sarcoma; Dermatofibrosarcoma Protuberans; Metastatic Childhood Soft Tissue Sarcoma; Nonmetastatic Childhood Soft Tissue Sarcoma; Recurrent Adult Soft Tissue Sarcoma; Recurrent Childhood Soft Tissue Sarcoma; Stage III Adult Soft Tissue Sarcoma; Stage IV Adult Soft Tissue Sarcoma

 

Last Updated: 5 Jan 2015

Go to URL
Radiation Therapy With or Without Combination Chemotherapy or Pazopanib Hydrochloride Before Surgery in Treating Patients With Newly Diagnosed Non-Rhabdomyosarcoma Soft Tissue Sarcomas That Can be Removed by Surgery
 

Status: Recruiting

Condition Summary: Adult Alveolar Soft Part Sarcoma; Adult Angiosarcoma; Adult Epithelioid Sarcoma; Adult Extraskeletal Myxoid Chondrosarcoma; Adult Extraskeletal Osteosarcoma; Adult Fibrosarcoma; Adult Leiomyosarcoma; Adult Liposarcoma; Adult Malignant Mesenchymoma; Adult Synovial Sarcoma; Adult Unclassified Pleomorphic Sarcoma; Childhood Alveolar Soft Part Sarcoma; Childhood Angiosarcoma; Childhood Epithelioid Sarcoma; Childhood Leiomyosarcoma; Childhood Liposarcoma; Childhood Malignant Mesenchymoma; Childhood Synovial Sarcoma; Non-Metastatic Childhood Soft Tissue Sarcoma; Stage IB Adult Soft Tissue Sarcoma; Stage IIB Adult Soft Tissue Sarcoma; Stage III Adult Soft Tissue Sarcoma; Stage IV Adult Soft Tissue Sarcoma

 

Last Updated: 25 Feb 2015

Go to URL
Collecting and Storing Tissue, Blood, and Bone Marrow Samples From Patients With Rhabdomyosarcoma or Other Soft Tissue Sarcoma
 

Status: Recruiting

Condition Summary: Adult Rhabdomyosarcoma; Childhood Desmoplastic Small Round Cell Tumor; Chordoma; Desmoid Tumor; Metastatic Childhood Soft Tissue Sarcoma; Nonmetastatic Childhood Soft Tissue Sarcoma; Previously Treated Childhood Rhabdomyosarcoma; Previously Untreated Childhood Rhabdomyosarcoma; Recurrent Adult Soft Tissue Sarcoma; Recurrent Childhood Rhabdomyosarcoma; Recurrent Childhood Soft Tissue Sarcoma; Stage I Adult Soft Tissue Sarcoma; Stage II Adult Soft Tissue Sarcoma; Stage III Adult Soft Tissue Sarcoma; Stage IV Adult Soft Tissue Sarcoma

 

Last Updated: 12 Aug 2014

Go to URL