Smallpox

Common Name(s)

Smallpox

Smallpox was an infectious disease caused by the variola viruses. The virus was present in the small blood vessels of the skin, mouth, and throat. Variola major caused a more aggressive disease while variola minor's smallpox was less dangerous. Smallpox produced a rash and then raised fluid-filled blisters on the skin as the disease progressed. The mortality rate for variola major was approximately 30-60% in all people, and 80% in children. Variola minor only caused deaths in 1% of its hosts. The World Health Organization officially eradicated smallpox in 1977 after a massive vaccine campaign. This means that the variola virus is no longer present in the world. Smallpox is one of only two diseases to be completely eradicated.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Smallpox" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Smallpox" returned 666 free, full-text research articles on human participants. First 3 results:

Smallpox in the post eradication era.
 

Author(s):

Journal: Wkly. Epidemiol. Rec.. 2016 May;91(20):257-64.

 

Last Updated: 20 May 2016

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Use of Vaccinia Virus Smallpox Vaccine in Laboratory and Health Care Personnel at Risk for Occupational Exposure to Orthopoxviruses - Recommendations of the Advisory Committee on Immunization Practices (ACIP), 2015.
 

Author(s): Brett W Petersen, Tiara J Harms, Mary G Reynolds, Lee H Harrison

Journal:

 

On June 25, 2015, the Advisory Committee on Immunization Practices (ACIP) recommended routine vaccination with live smallpox (vaccinia) vaccine (ACAM2000) for laboratory personnel who directly handle 1) cultures or 2) animals contaminated or infected with replication-competent vaccinia ...

Last Updated: 18 Mar 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Smallpox" returned 51 free, full-text review articles on human participants. First 3 results:

[The late media emergency of smallpox vaccine, news coverage of Spanish press (1999-2004)].
 

Author(s): Pedro Javier Martínez-Martínez, José Tuells, Gema Colmenar-Jarillo

Journal: Rev Esp Quimioter. 2015 Jun;28(3):125-31.

 

Discussions on the need for smallpox virus preservation in 1999 focused attention on an eradicated disease 20 years ago. Smallpox was replaced as a potential candidate to be used as a bioterrorist weapon because of the international alarm scenario produced after the 11/9 events in ...

Last Updated: 2 Jun 2015

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Risks Associated With Smallpox Vaccination in Pregnancy: A Systematic Review and Meta-analysis.
 

Author(s): Martina L Badell, Dana Meaney-Delman, Methodius G Tuuli, Sonja A Rasmussen, Brett W Petersen, Jeanne S Sheffield, Richard H Beigi, Inger K Damon, Denise J Jamieson

Journal: Obstet Gynecol. 2015 Jun;125(6):1439-51.

 

To estimate the maternal and fetal risks of smallpox vaccination during pregnancy.

Last Updated: 24 May 2015

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The prevention and eradication of smallpox: a commentary on Sloane (1755) 'An account of inoculation'.
 

Author(s): Robin A Weiss, José Esparza

Journal: Philos. Trans. R. Soc. Lond., B, Biol. Sci.. 2015 Apr;370(1666):.

 

Sir Hans Sloane's account of inoculation as a means to protect against smallpox followed several earlier articles published in Philosophical Transactions on this procedure. Inoculation (also called 'variolation') involved the introduction of small amounts of infectious material from ...

Last Updated: 9 Mar 2015

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Safety Surveillance Study of ACAM2000® Vaccinia Vaccine
 

Status: Recruiting

Condition Summary: Smallpox

 

Last Updated: 16 Mar 2016

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Tecovirimat (ST-246) Treatment for Orthopox Virus Exposure
 

Status: Available

Condition Summary: Smallpox; Monkeypox

 

Last Updated: 24 Aug 2016

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VA-008 ACAM2000® Vaccination of Plasma Donors for the Production of VIGIV
 

Status: Recruiting

Condition Summary: Smallpox Vaccine Adverse Reaction

 

Last Updated: 19 Aug 2016

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