Smallpox

Common Name(s)

Smallpox

Smallpox was an infectious disease caused by the variola viruses. The virus was present in the small blood vessels of the skin, mouth, and throat. Variola major caused a more aggressive disease while variola minor's smallpox was less dangerous. Smallpox produced a rash and then raised fluid-filled blisters on the skin as the disease progressed. The mortality rate for variola major was approximately 30-60% in all people, and 80% in children. Variola minor only caused deaths in 1% of its hosts. The World Health Organization officially eradicated smallpox in 1977 after a massive vaccine campaign. This means that the variola virus is no longer present in the world. Smallpox is one of only two diseases to be completely eradicated.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Smallpox" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Smallpox" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Smallpox" returned 560 free, full-text research articles on human participants. First 3 results:

Clinical guidance for smallpox vaccine use in a postevent vaccination program.
 

Author(s): Brett W Petersen, Inger K Damon, Carol A Pertowski, Dana Meaney-Delman, Julie T Guarnizo, Richard H Beigi, Kathryn M Edwards, Margaret C Fisher, Sharon E Frey, Ruth Lynfield, Rodney E Willoughby

Journal: MMWR Recomm Rep. 2015 Feb;64(RR-02):1-26.

 

This report outlines recommendations for the clinical use of the three smallpox vaccines stored in the U.S. Strategic National Stockpile for persons who are exposed to smallpox virus or at high risk for smallpox infection during a postevent vaccination program following an intentional ...

Last Updated: 20 Feb 2015

Go To URL
HLA alleles associated with the adaptive immune response to smallpox vaccine: a replication study.
 

Author(s): Inna G Ovsyannikova, V Shane Pankratz, Hannah M Salk, Richard B Kennedy, Gregory A Poland

Journal: Hum. Genet.. 2014 Sep;133(9):1083-92.

 

We previously reported HLA allelic associations with vaccinia virus (VACV)-induced adaptive immune responses in a cohort of healthy individuals (n = 1,071 subjects) after a single dose of the licensed smallpox (Dryvax) vaccine. This study demonstrated that specific HLA alleles were ...

Last Updated: 9 Aug 2014

Go To URL
Are we there yet? The smallpox research agenda using variola virus.
 

Author(s): Inger K Damon, Clarissa R Damaso, Grant McFadden

Journal:

 

Last Updated: 5 May 2014

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Smallpox" returned 46 free, full-text review articles on human participants. First 3 results:

Cytokine production associated with smallpox vaccine responses.
 

Author(s): Whitney L Simon, Hannah M Salk, Inna G Ovsyannikova, Richard B Kennedy, Gregory A Poland

Journal: Immunotherapy. 2014 ;6(10):1097-112.

 

Smallpox was eradicated 34 years ago due to the success of the smallpox vaccine; yet, the vaccine continues to be studied because of its importance in responding to potential biological warfare and the adverse events associated with current smallpox vaccines. Interindividual variations ...

Last Updated: 27 Nov 2014

Go To URL
The rediscovery of smallpox.
 

Author(s): C Thèves, P Biagini, E Crubézy

Journal: Clin. Microbiol. Infect.. 2014 Mar;20(3):210-8.

 

Smallpox is an infectious disease that is unique to humans, caused by a poxvirus. It is one of the most lethal of diseases; the virus variant Variola major has a mortality rate of 30%. People surviving this disease have life-long consequences, but also assured immunity. Historically, ...

Last Updated: 13 Feb 2014

Go To URL
Smallpox: can we still learn from the journey to eradication?
 

Author(s): Kendall A Smith

Journal: Indian J. Med. Res.. 2013 May;137(5):895-9.

 

One of the most celebrated achievements of immunology and modern medicine is the eradication of the dreaded plague smallpox. From the introduction of smallpox vaccination by Edward Jenner, to its popularization by Louis Pasteur, to the eradication effort led by Donald Henderson, this ...

Last Updated: 13 Jun 2013

Go To URL
 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Safety Surveillance Study of ACAM2000® Vaccinia Vaccine
 

Status: Recruiting

Condition Summary: Smallpox

 

Last Updated: 27 Nov 2014

Go to URL
Determining Prevalence of Acute Bilirubin Encephalopathy in Developing Countries
 

Status: Recruiting

Condition Summary: Demonstrate BIND II Score of >=5, is Valid for Detecting Moderate to Severe ABE in Neonates <14 Days Old.; Demonstrate Community-BIND Instrument, a Modified BIND II, is a Valid and Reliable Tool for Detecting ABE.; Demonstrate That Community-BIND Can be Used for Acquiring Population-based Prevalence of ABE in the Community.

 

Last Updated: 3 Dec 2014

Go to URL