Smallpox

Common Name(s)

Smallpox

Smallpox was an infectious disease caused by the variola viruses. The virus was present in the small blood vessels of the skin, mouth, and throat. Variola major caused a more aggressive disease while variola minor's smallpox was less dangerous. Smallpox produced a rash and then raised fluid-filled blisters on the skin as the disease progressed. The mortality rate for variola major was approximately 30-60% in all people, and 80% in children. Variola minor only caused deaths in 1% of its hosts. The World Health Organization officially eradicated smallpox in 1977 after a massive vaccine campaign. This means that the variola virus is no longer present in the world. Smallpox is one of only two diseases to be completely eradicated.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Smallpox" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Smallpox" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Smallpox" returned 609 free, full-text research articles on human participants. First 3 results:

Humoral Immunity to Primary Smallpox Vaccination: Impact of Childhood versus Adult Immunization on Vaccinia Vector Vaccine Development in Military Populations.
 

Author(s): Bonnie M Slike, Matthew Creegan, Mary Marovich, Viseth Ngauy

Journal:

 

Modified Vaccinia virus has been shown to be a safe and immunogenic vector platform for delivery of HIV vaccines. Use of this vector is of particular importance to the military, with the implementation of a large scale smallpox vaccination campaign in 2002 in active duty and key civilian ...

Last Updated: 3 Jan 2017

Go To URL
A New Document on Smallpox Vaccination.
 

Author(s): Zahra Tayarani-Najaran, Nilufar Tayarani-Najaran, Amirhossein Sahebkar, Seyed Ahmad Emami

Journal: J Acupunct Meridian Stud. 2016 Dec;9(6):287-289.

 

Modern medicine owes much to the invaluable heritage of the practices of past generations and their achievements that have now become medical rules. In the case of vaccination, there is evidence that the nomads of Baluchistan (Southeast Iran) demonstrated natural immunization against ...

Last Updated: 24 Dec 2016

Go To URL
Smallpox as an actual biothreat: lessons learned from its outbreak in ex-Yugoslavia in 1972.
 

Author(s): Elizabeta Ristanovic, Ana Gligic, Sonja Atanasievska, Vesna Protic-Djokic, Dragutin Jovanovic, Miodrag Radunovic

Journal: Ann. Ist. Super. Sanita. ;52(4):587-597.

 

Variola (smallpox) virus is classified as class A of potential biological weapons, due to its microbiological, genetic, antigenic and epidemiological characteristics. The potential danger is more real because vaccination against smallpox has stopped since disease eradication in 1979. ...

Last Updated: 21 Dec 2016

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Smallpox" returned 49 free, full-text review articles on human participants. First 3 results:

Defending against smallpox: a focus on vaccines.
 

Author(s): Emily A Voigt, Richard B Kennedy, Gregory A Poland

Journal: Expert Rev Vaccines. 2016 Sep;15(9):1197-211.

 

Smallpox has shaped human history, from the earliest human civilizations well into the 20th century. With high mortality rates, rapid transmission, and serious long-term effects on survivors, smallpox was a much-feared disease. The eradication of smallpox represents an unprecedented ...

Last Updated: 19 Aug 2016

Go To URL
[The late media emergency of smallpox vaccine, news coverage of Spanish press (1999-2004)].
 

Author(s): Pedro Javier Martínez-Martínez, José Tuells, Gema Colmenar-Jarillo

Journal: Rev Esp Quimioter. 2015 Jun;28(3):125-31.

 

Discussions on the need for smallpox virus preservation in 1999 focused attention on an eradicated disease 20 years ago. Smallpox was replaced as a potential candidate to be used as a bioterrorist weapon because of the international alarm scenario produced after the 11/9 events in ...

Last Updated: 2 Jun 2015

Go To URL
Risks Associated With Smallpox Vaccination in Pregnancy: A Systematic Review and Meta-analysis.
 

Author(s): Martina L Badell, Dana Meaney-Delman, Methodius G Tuuli, Sonja A Rasmussen, Brett W Petersen, Jeanne S Sheffield, Richard H Beigi, Inger K Damon, Denise J Jamieson

Journal: Obstet Gynecol. 2015 Jun;125(6):1439-51.

 

To estimate the maternal and fetal risks of smallpox vaccination during pregnancy.

Last Updated: 24 May 2015

Go To URL
 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

VA-008 ACAM2000® Vaccination of Plasma Donors for the Production of VIGIV
 

Status: Recruiting

Condition Summary: Smallpox Vaccine Adverse Reaction

 

Last Updated: 19 Aug 2016

Go to URL
Tecovirimat (ST-246) Treatment for Orthopox Virus Exposure
 

Status: Available

Condition Summary: Smallpox; Monkeypox

 

Last Updated: 10 Nov 2016

Go to URL

Last Updated: 27 Feb 2017

Go to URL