Smallpox

Common Name(s)

Smallpox

Smallpox was an infectious disease caused by the variola viruses. The virus was present in the small blood vessels of the skin, mouth, and throat. Variola major caused a more aggressive disease while variola minor's smallpox was less dangerous. Smallpox produced a rash and then raised fluid-filled blisters on the skin as the disease progressed. The mortality rate for variola major was approximately 30-60% in all people, and 80% in children. Variola minor only caused deaths in 1% of its hosts. The World Health Organization officially eradicated smallpox in 1977 after a massive vaccine campaign. This means that the variola virus is no longer present in the world. Smallpox is one of only two diseases to be completely eradicated.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Smallpox" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Smallpox" returned 554 free, full-text research articles on human participants. First 3 results:

'Defying providence': a salutary new look at the history of smallpox.
 

Author(s): Alfredo Morabia

Journal: J R Soc Med. 2013 Sep;106(9):373-4.

 

Last Updated: 13 Oct 2013

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Population-level differences in disease transmission: a Bayesian analysis of multiple smallpox epidemics.
 

Author(s): Bret D Elderd, Greg Dwyer, Vanja Dukic

Journal: Epidemics. 2013 Sep;5(3):146-56.

 

Estimates of a disease's basic reproductive rate R0 play a central role in understanding outbreaks and planning intervention strategies. In many calculations of R0, a simplifying assumption is that different host populations have effectively identical transmission rates. This assumption ...

Last Updated: 11 Sep 2013

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An open-label, single arm, phase III clinical study to evaluate the efficacy and safety of CJ smallpox vaccine in previously vaccinated healthy adults.
 

Author(s): Nak-Hyun Kim, Yu Min Kang, Gayeon Kim, Pyoeng Gyun Choe, Jin Su Song, Kwang-Hee Lee, Baik-Lin Seong, Wan Beom Park, Nam Joong Kim, Myoung-don Oh

Journal: Vaccine. 2013 Oct;31(45):5239-42.

 

The increased possibility of bioterrorism has led to reinitiation of smallpox vaccination. In Korea, more than 30 years have passed since the last smallpox vaccinations, and even people who were previously vaccinated are not regarded as adequately protected against smallpox. We evaluated ...

Last Updated: 25 Oct 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Smallpox" returned 46 free, full-text review articles on human participants. First 3 results:

Smallpox: can we still learn from the journey to eradication?
 

Author(s): Kendall A Smith

Journal: Indian J. Med. Res.. 2013 May;137(5):895-9.

 

One of the most celebrated achievements of immunology and modern medicine is the eradication of the dreaded plague smallpox. From the introduction of smallpox vaccination by Edward Jenner, to its popularization by Louis Pasteur, to the eradication effort led by Donald Henderson, this ...

Last Updated: 13 Jun 2013

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What was the primary mode of smallpox transmission? Implications for biodefense.
 

Author(s): Donald K Milton

Journal:

 

The mode of infection transmission has profound implications for effective containment by public health interventions. The mode of smallpox transmission was never conclusively established. Although, "respiratory droplet" transmission was generally regarded as the primary mode of transmission, ...

Last Updated: 11 Dec 2012

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Comparative pathology of smallpox and monkeypox in man and macaques.
 

Author(s): J A Cann, P B Jahrling, L E Hensley, V Wahl-Jensen

Journal: J. Comp. Pathol.. 2013 Jan;148(1):6-21.

 

In the three decades since the eradication of smallpox and cessation of routine vaccination, the collective memory of the devastating epidemics caused by this orthopoxvirus has waned, and the human population has become increasingly susceptible to a disease that remains high on the ...

Last Updated: 29 Jan 2013

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Safety Surveillance Cohort Study of Vaccinia Vaccine (ACAM2000®)
 

Status: Recruiting

Condition Summary: Smallpox

 

Last Updated: 21 Apr 2014

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Safety Surveillance Study of ACAM2000® Vaccinia Vaccine
 

Status: Recruiting

Condition Summary: Smallpox

 

Last Updated: 15 Jul 2014

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