Smallpox

Common Name(s)

Smallpox

Smallpox was an infectious disease caused by the variola viruses. The virus was present in the small blood vessels of the skin, mouth, and throat. Variola major caused a more aggressive disease while variola minor's smallpox was less dangerous. Smallpox produced a rash and then raised fluid-filled blisters on the skin as the disease progressed. The mortality rate for variola major was approximately 30-60% in all people, and 80% in children. Variola minor only caused deaths in 1% of its hosts. The World Health Organization officially eradicated smallpox in 1977 after a massive vaccine campaign. This means that the variola virus is no longer present in the world. Smallpox is one of only two diseases to be completely eradicated.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Smallpox" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Smallpox" returned 652 free, full-text research articles on human participants. First 3 results:

Smallpox Vaccination of Laboratory Workers at US Variola Testing Sites.
 

Author(s): Sharon Medcalf, Laura Bilek, Teresa Hartman, Peter C Iwen, Patricia Leuschen, Hannah Miller, Anne O'Keefe, Harlan Sayles, Philip W Smith

Journal: Emerging Infect. Dis.. 2015 Aug;21(8):1437-9.

 

To evaluate the need to revaccinate laboratory workers against smallpox, we assessed regular revaccination at the US Laboratory Response Network's variola testing sites by examining barriers to revaccination and the potential for persistence of immunity. Our data do not provide evidence ...

Last Updated: 22 Jul 2015

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[The journey of the vaccine against smallpox: one expedition, two oceans, three continents, and thousands of children].
 

Author(s): José Tuells, José Luis Duro-Torrijos

Journal: Gac Med Mex. ;151(3):416-25.

 

Spain encouraged, during the Bourbon dynasty, the formation of scientific expeditions, among which was the Royal Philanthropic Vaccine Expedition, an example of biopolitics applied by the state in order to protect health. The expedition went all over the world, using children as a ...

Last Updated: 19 Jun 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Smallpox" returned 50 free, full-text review articles on human participants. First 3 results:

[The late media emergency of smallpox vaccine, news coverage of Spanish press (1999-2004)].
 

Author(s): Pedro Javier Martínez-Martínez, José Tuells, Gema Colmenar-Jarillo

Journal: Rev Esp Quimioter. 2015 Jun;28(3):125-31.

 

Discussions on the need for smallpox virus preservation in 1999 focused attention on an eradicated disease 20 years ago. Smallpox was replaced as a potential candidate to be used as a bioterrorist weapon because of the international alarm scenario produced after the 11/9 events in ...

Last Updated: 2 Jun 2015

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The prevention and eradication of smallpox: a commentary on Sloane (1755) 'An account of inoculation'.
 

Author(s): Robin A Weiss, José Esparza

Journal: Philos. Trans. R. Soc. Lond., B, Biol. Sci.. 2015 Apr;370(1666):.

 

Sir Hans Sloane's account of inoculation as a means to protect against smallpox followed several earlier articles published in Philosophical Transactions on this procedure. Inoculation (also called 'variolation') involved the introduction of small amounts of infectious material from ...

Last Updated: 9 Mar 2015

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Cytokine production associated with smallpox vaccine responses.
 

Author(s): Whitney L Simon, Hannah M Salk, Inna G Ovsyannikova, Richard B Kennedy, Gregory A Poland

Journal: Immunotherapy. 2014 ;6(10):1097-112.

 

Smallpox was eradicated 34 years ago due to the success of the smallpox vaccine; yet, the vaccine continues to be studied because of its importance in responding to potential biological warfare and the adverse events associated with current smallpox vaccines. Interindividual variations ...

Last Updated: 27 Nov 2014

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Safety Surveillance Study of ACAM2000® Vaccinia Vaccine
 

Status: Recruiting

Condition Summary: Smallpox

 

Last Updated: 16 Mar 2016

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Last Updated: 24 May 2016

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Tecovirimat (ST-246) Treatment for Orthopox Virus Exposure
 

Status: Available

Condition Summary: Smallpox; Monkeypox

 

Last Updated: 28 Oct 2015

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