Sjogren Syndrome

Common Name(s)

Sjogren Syndrome

Sjšgren syndrome is an autoimmune disorder in which immune cells attack and destroy the glands that produce tears and saliva. Sjšgren syndrome is also associated with rheumatic disorders such as rheumatoid arthritis. The hallmark symptoms of the disorder are dry mouth and dry eyes. In addition, Sjogren syndrome may cause skin, nose, and vaginal dryness, and may affect other organs of the body including the kidneys, blood vessels, lungs, liver, pancreas, and brain. Treatment is symptomatic and supportive and may include moisture replacement therapies, nonsteroidal anti-inflammatory drugs and, in severe cases, corticosteroids or immunosuppressive drugs.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Sjogren Syndrome" for support, advocacy or research.

HealthyWomen

HealthyWomen (HW) is the nation's leading independent health information source for women. Our core mission is to educate, inform and empower women to make smart health choices for themselves and their families. For more than 20 years, millions of women have been coming to HW for answers to their most pressing and personal health care questions. Through our wide array of online and print publications, HW provides health information that is original, objective, reviewed by medical experts and reflective of the advances in evidence-based health research.

Last Updated: 3 Oct 2013

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International Scleroderma Network

Our mission is to provide stellar worldwide research, support, education and awareness for scleroderma and related illnesses.

Last Updated: 18 Apr 2010

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Sjögren's Syndrome Foundation, Inc.

The Foundation's mission is to: •Educate patients and their families about Sjögren's. •Increase public and professional awareness of Sjögren's. •Encourage research into new treatments and a cure.

Last Updated: 30 Apr 2014

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Sjogren Syndrome" for support, advocacy or research.

HealthyWomen

HealthyWomen (HW) is the nation's leading independent health information source for women. Our core mission is to educate, inform and empower women to make smart health choices for themselves and their families. For more than 20 years, millions of women have been coming to HW for answers to their most pressing and personal health care questions. Through our wide array of online and print publications, HW provides health information that is original, objective, reviewed by medical experts and reflective of the advances in evidence-based health research.

http://www.healthywomen.org

Last Updated: 3 Oct 2013

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International Scleroderma Network

Our mission is to provide stellar worldwide research, support, education and awareness for scleroderma and related illnesses.

http://www.sclero.org/

Last Updated: 18 Apr 2010

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Sjögren's Syndrome Foundation, Inc.

The Foundation's mission is to: •Educate patients and their families about Sjögren's. •Increase public and professional awareness of Sjögren's. •Encourage research into new treatments and a cure.

http://www.sjogrens.org

Last Updated: 30 Apr 2014

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Sjogren Syndrome" returned 95 free, full-text research articles on human participants. First 3 results:

Neurological involvement in Primary Sjögren Syndrome.
 

Author(s): Filipa Teixeira, Isabel Moreira, Ana Martins Silva, Carlos Vasconcelos, Fátima Farinha, Ernestina Santos

Journal: Acta Reumatol Port. ;38(1):29-36.

 

To perform an observational retrospective cross-sectional case-control study to evaluate prevalence, clinical patterns and outcomes of neurological involvement in a cohort of Primary Sjögren Syndrome (pSS) patients followed up in a single center.

Last Updated: 17 Oct 2013

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Primary Sjögren syndrome presenting with hemolytic anemia and pure red cell aplasia following delivery due to Coombs-negative autoimmune hemolytic anemia and hemophagocytosis.
 

Author(s): Yohei Komaru, Takakazu Higuchi, Ryosuke Koyamada, Youichiro Haji, Masato Okada, Toyomi Kamesaki, Sadamu Okada

Journal: Intern. Med.. 2013 ;52(20):2343-6.

 

A 36-year-old woman presented with hemolytic anemia without a reticulocyte response 38 days after delivery. A marked reduction in erythroid cells and an increase in macrophages with active hemophagocytosis were noted in the bone marrow. While conventional Coombs' tests were negative, ...

Last Updated: 15 Oct 2013

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Sporadic VACTERL association in a Japanese family with Sjögren-Larsson syndrome.
 

Author(s): Takuya Takeichi, Kazumitsu Sugiura, Hidee Arai, Ken Ishii, Michihiro Kono, Masashi Akiyama

Journal: Acta Derm. Venereol.. 2013 Sep;93(5):579-80.

 

Last Updated: 4 Sep 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Sjogren Syndrome" returned 11 free, full-text review articles on human participants. First 3 results:

Childhood Sjögren syndrome: insights from adults and animal models.
 

Author(s): Scott M Lieberman

Journal: Curr Opin Rheumatol. 2013 Sep;25(5):651-7.

 

Sjögren syndrome is a chronic autoimmune disease affecting lacrimal and salivary glands that often is accompanied by extraglandular disease manifestations. Although common in adults, the prevalence and prognosis of childhood Sjögren syndrome are unknown, in part due to lack of child-specific ...

Last Updated: 6 Aug 2013

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Sjögren syndrome: advances in the pathogenesis from animal models.
 

Author(s): J A Chiorini, D Cihakova, C E Ouellette, P Caturegli

Journal: J. Autoimmun.. ;33(3-4):190-6.

 

Sjögren syndrome is an autoimmune disease characterized by hyposecretion of the lacrimal and salivary glands, resulting in dryness of the eyes and mouth. Individuals may experience primary Sjögren syndrome or a secondary form accompanying another rheumatic autoimmune disease, such ...

Last Updated: 16 Nov 2009

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Unraveling the pathophysiology of Sjogren syndrome-associated dry eye disease.
 

Author(s): Cuong Q Nguyen, Ammon B Peck

Journal: Ocul Surf. 2009 Jan;7(1):11-27.

 

Sjogren syndrome (SS) is one of the most common autoimmune diseases. Early clinical manifestations of SS are primarily decreased tear and saliva secretion, leading to dry eye and dry mouth syndromes, but in its later stages, it can become systemic, even resulting in B cell lymphomas. ...

Last Updated: 13 Feb 2009

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Abatacept for Patients With Inflammatory Arthritis Associated With Sjögren's Syndrome: an Open-Label Phase II Study
 

Status: Recruiting

Condition Summary: Primary Sjogren's Syndrome; Secondary Sjogren's Syndrome; Inflammatory Arthritis; Rheumatoid Arthritis

 

Last Updated: 2 Jan 2014

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Laser Therapy to Treat the Dry Mouth of Sjogren's Syndrome
 

Status: Recruiting

Condition Summary: KERATOCONJUNCTIVITIS SICCA; XEROSTOMIA; SICCA SYNDROME; PRIMARY SJOGREN SYNDROME

 

Last Updated: 19 Feb 2014

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Endoscopic Treatment of Salivary Glands Affected by Sjögren's Syndrome
 

Status: Recruiting

Condition Summary: Sjögren's Syndrome

 

Last Updated: 3 Jun 2014

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