Sjogren's Syndrome

Common Name(s)

Sjogren's Syndrome

Sjogren's syndrome is an autoimmune disease which most commonly causes dry eyes and mouth. Our immune system protects us against infections from viruses and bacteria. Sometimes a person’s immune system attacks the person’s own tissues and organs by mistake. In this case, the immune system attacks the glands which produce moisture, especially those which produce tears and saliva. In addition to dry eyes and mouth, other symptoms may include dry skin, skin rashes, chronic dry cough, thyroid problems, joint and muscle pain, vaginal dryness and numbness and tingling in the arms and legs. The syndrome may also make the person feel very tired. Other complications may include vision and dental problems as well as more serious damage to the liver, kidneys or lungs. A small percentage of people with Sjogren’s develop lymphoma. Overall all symptoms may stay the same or worsen with time and may range from mild to debilitating (unable to do daily tasks). About half the time, a person with Sjogren’s syndrome will also have another autoimmune disease such as arthritis, lupus or scleroderma. Sjogren's syndrome may occur at any age, but is more common in women and people above the age of 40 years old. The cause of Sjorgren’s syndrome is unknown but may be a combination of genetics and bacterial or viral infection. Diagnosis is usually made through a physical exam, special test of the eyes and mouth and blood tests. Treatments for this condition depend on the symptoms present. Dry mouth and eyes may be treated with medications. Medication is also available to help lessen the joint and muscle pain, suppress the immune system and decrease inflammation or swelling. Early diagnosis and treatment may help prevent the more serious complications. Talk with your doctor if you or a family member has been diagnosed with Sjogren’s syndrome to decide on the best treatment. Support groups are also a good source of support and information.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Sjogren's Syndrome" for support, advocacy or research.

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Ben's Friends

Our mission is to ensure that everyone in the world with a rare disease has a safe place to go and connect with others like them.

Last Updated: 11 Jul 2016

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HealthyWomen

HealthyWomen (HW) is the nation's leading independent health information source for women. Our core mission is to educate, inform and empower women to make smart health choices for themselves and their families. For more than 20 years, millions of women have been coming to HW for answers to their most pressing and personal health care questions. Through our wide array of online and print publications, HW provides health information that is original, objective, reviewed by medical experts and reflective of the advances in evidence-based health research.

Last Updated: 9 Jul 2015

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International Scleroderma Network

Our mission is to provide stellar worldwide research, support, education and awareness for scleroderma and related illnesses.

Last Updated: 18 Apr 2010

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Sjögren's Syndrome Foundation, Inc.

The Foundation's mission is to: •Educate patients and their families about Sjögren's. •Increase public and professional awareness of Sjögren's. •Encourage research into new treatments and a cure.

Last Updated: 30 Apr 2014

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Sjogren's Syndrome" for support, advocacy or research.

Logo
Ben's Friends

Our mission is to ensure that everyone in the world with a rare disease has a safe place to go and connect with others like them.

http://www.bensfriends.org

Last Updated: 11 Jul 2016

View Details
HealthyWomen

HealthyWomen (HW) is the nation's leading independent health information source for women. Our core mission is to educate, inform and empower women to make smart health choices for themselves and their families. For more than 20 years, millions of women have been coming to HW for answers to their most pressing and personal health care questions. Through our wide array of online and print publications, HW provides health information that is original, objective, reviewed by medical experts and reflective of the advances in evidence-based health research.

http://www.healthywomen.org

Last Updated: 9 Jul 2015

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International Scleroderma Network

Our mission is to provide stellar worldwide research, support, education and awareness for scleroderma and related illnesses.

http://www.sclero.org/

Last Updated: 18 Apr 2010

View Details
Sjögren's Syndrome Foundation, Inc.

The Foundation's mission is to: •Educate patients and their families about Sjögren's. •Increase public and professional awareness of Sjögren's. •Encourage research into new treatments and a cure.

http://www.sjogrens.org

Last Updated: 30 Apr 2014

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Sjogren's Syndrome" returned 1359 free, full-text research articles on human participants. First 3 results:

Combination of Salivary Gland Ultrasonography and Virtual Touch Quantification for Diagnosis of Sjögren's Syndrome: A Preliminary Study.
 

Author(s): Shaoqi Chen, Yukai Wang, Guohong Zhang, Shigao Chen

Journal: Biomed Res Int. 2016 ;2016():2793898.

 

A total of 136 subjects (51 SS patients, 35 sicca syndrome patients without SS, and 50 healthy volunteers) were enrolled in this study. The mean SWV value for salivary glands of SS patients was statistically higher than that of controls (2.81 ± 0.66 m/s versus 1.85 ± 0.28 m/s ...

Last Updated: 12 Jan 2017

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Secondary Sjogren's Syndrome in 83 Patients With Rheumatoid Arthritis.
 

Author(s): Asghar Hajiabbasi, Irandokht Shenavar Masooleh, Yousef Alizadeh, Amir Sadredin Banikarimi, Pooneh Ghavidel Parsa

Journal: Acta Med Iran. 2016 Jul;54(7):448-53.

 

Sjogren syndrome (SS) can occur alone, primary Sjogren syndrome, or in association with other rheumatic diseases, secondary Sjogren syndrome (sSS), such as Rheumatoid arthritis (RA). The occurrence of Sjogren syndrome with RA makes it course worse and increases high morbidity and ...

Last Updated: 18 Jul 2016

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Autoimmune/Inflammatory Syndrome Induced by Adjuvants and Sjögren's Syndrome.
 

Author(s): Serena Colafrancesco, Carlo Perricone, Yehuda Shoenfeld

Journal: Isr. Med. Assoc. J.. ;18(3-4):150-3.

 

Sjögren's syndrome (SS), a chronic systemic autoimmune inflammatory condition involving the exocrine glands, has been suggested to be part of the spectrum of the Autoimmune/ inflammatory Syndrome Induced by Adjuvants (ASIA). ASIA incorporates an umbrella of clinical conditions including ...

Last Updated: 27 May 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Sjogren's Syndrome" returned 134 free, full-text review articles on human participants. First 3 results:

Sjögren's syndrome: from pathogenesis to novel therapeutic targets.
 

Author(s): Francesca Barone, Serena Colafrancesco

Journal: Clin. Exp. Rheumatol.. ;34(4 Suppl 98):58-62.

 

Primary Sjögren's syndrome (pSS) is a chronic inflammatory autoimmune disease, characterised by a chronic infiltration of exocrine glands, mainly salivary glands, with the histological features of focal lymphocytic sialoadenitis. Disease spectrum is broad and the occurrence of several ...

Last Updated: 2 Sep 2016

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[Sjögren's syndrome (SS), a review of the subject and saliva as a diagnostic method].
 

Author(s): Janett Carmen Luzmila Riega-Torres, Antonio Jaime Villarreal-Gonzalez, Luis Ángel Ceceñas-Falcon, Julio Cesar Salas-Alanis

Journal: Gac Med Mex. ;152(3):371-80.

 

Sjögren's syndrome is a chronic autoimmune disease whose main clinical manifestation is oral dryness (xerostomia) and ocular dryness (xerophthalmia). It is characterized by progressive mononuclear infiltration of the exocrine glands and can affect a variety of organ systems. The ...

Last Updated: 23 Jun 2016

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Salivary Gland Ultrasonography in Sjögren's Syndrome: Clinical Usefulness and Future Perspectives.
 

Author(s): Chiara Baldini, Nicoletta Luciano, Marta Mosca, Stefano Bombardieri

Journal: Isr. Med. Assoc. J.. ;18(3-4):193-6.

 

In recent years, salivary gland ultrasonography (SGUS) has emerged as a promising tool for the diagnosis and prognostic stratification of patients with primary and secondary Sjögren's syndrome. Several studies have emphasized that salivary ultrasonography could be a highly specific ...

Last Updated: 27 May 2016

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Implantology and Sjögren's Syndrome
 

Status: Recruiting

Condition Summary: Sjogren's Syndrome

 

Last Updated: 18 Jan 2016

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Study of Iguratimod in Sjögren's Syndrome
 

Status: Recruiting

Condition Summary: Sjogren's Syndrome

 

Last Updated: 15 Jan 2017

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Safety, Pharmacokinetics and Preliminary Efficacy Study of CFZ533 in Patients With Primary Sjögren's Syndrome
 

Status: Recruiting

Condition Summary: Primary Sjögren's Syndrome

 

Last Updated: 27 Oct 2016

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