Sjogren's Syndrome

Common Name(s)

Sjogren's Syndrome

Sjogren's syndrome is an autoimmune disease which most commonly causes dry eyes and mouth. Our immune system protects us against infections from viruses and bacteria. Sometimes a person’s immune system attacks the person’s own tissues and organs by mistake. In this case, the immune system attacks the glands which produce moisture, especially those which produce tears and saliva. In addition to dry eyes and mouth, other symptoms may include dry skin, skin rashes, chronic dry cough, thyroid problems, joint and muscle pain, vaginal dryness and numbness and tingling in the arms and legs. The syndrome may also make the person feel very tired. Other complications may include vision and dental problems as well as more serious damage to the liver, kidneys or lungs. A small percentage of people with Sjogren’s develop lymphoma. Overall all symptoms may stay the same or worsen with time and may range from mild to debilitating (unable to do daily tasks). About half the time, a person with Sjogren’s syndrome will also have another autoimmune disease such as arthritis, lupus or scleroderma. Sjogren's syndrome may occur at any age, but is more common in women and people above the age of 40 years old. The cause of Sjorgren’s syndrome is unknown but may be a combination of genetics and bacterial or viral infection. Diagnosis is usually made through a physical exam, special test of the eyes and mouth and blood tests. Treatments for this condition depend on the symptoms present. Dry mouth and eyes may be treated with medications. Medication is also available to help lessen the joint and muscle pain, suppress the immune system and decrease inflammation or swelling. Early diagnosis and treatment may help prevent the more serious complications. Talk with your doctor if you or a family member has been diagnosed with Sjogren’s syndrome to decide on the best treatment. Support groups are also a good source of support and information.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Sjogren's Syndrome" for support, advocacy or research.

HealthyWomen

HealthyWomen (HW) is the nation's leading independent health information source for women. Our core mission is to educate, inform and empower women to make smart health choices for themselves and their families. For more than 20 years, millions of women have been coming to HW for answers to their most pressing and personal health care questions. Through our wide array of online and print publications, HW provides health information that is original, objective, reviewed by medical experts and reflective of the advances in evidence-based health research.

Last Updated: 9 Jul 2015

View Details
International Scleroderma Network

Our mission is to provide stellar worldwide research, support, education and awareness for scleroderma and related illnesses.

Last Updated: 18 Apr 2010

View Details
Sjögren's Syndrome Foundation, Inc.

The Foundation's mission is to: •Educate patients and their families about Sjögren's. •Increase public and professional awareness of Sjögren's. •Encourage research into new treatments and a cure.

Last Updated: 30 Apr 2014

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Sjogren's Syndrome" for support, advocacy or research.

HealthyWomen

HealthyWomen (HW) is the nation's leading independent health information source for women. Our core mission is to educate, inform and empower women to make smart health choices for themselves and their families. For more than 20 years, millions of women have been coming to HW for answers to their most pressing and personal health care questions. Through our wide array of online and print publications, HW provides health information that is original, objective, reviewed by medical experts and reflective of the advances in evidence-based health research.

http://www.healthywomen.org

Last Updated: 9 Jul 2015

View Details
International Scleroderma Network

Our mission is to provide stellar worldwide research, support, education and awareness for scleroderma and related illnesses.

http://www.sclero.org/

Last Updated: 18 Apr 2010

View Details
Sjögren's Syndrome Foundation, Inc.

The Foundation's mission is to: •Educate patients and their families about Sjögren's. •Increase public and professional awareness of Sjögren's. •Encourage research into new treatments and a cure.

http://www.sjogrens.org

Last Updated: 30 Apr 2014

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Sjogren's Syndrome" returned 1281 free, full-text research articles on human participants. First 3 results:

The Clinical Relevance of IL-17-Producing CD4+CD161+ Cell and Its Subpopulations in Primary Sjögren's Syndrome.
 

Author(s): Linbo Li, Jing He, Lei Zhu, Yuqin Yang, Yuebo Jin, Rulin Jia, Xu Liu, Yanying Liu, Xiaolin Sun, Zhanguo Li

Journal: J Immunol Res. 2015 ;2015():307453.

 

Th17 cells have been demonstrated to play an important role in the onset and development of primary Sjögren's syndrome (pSS). In this study, we evaluated the expansion and clinical significance of circulating CD4+CD161+ T cell and its "effector" (CD4+CD25-CD161+ T cell) and "regulatory" ...

Last Updated: 5 Oct 2015

Go To URL
Local and Systemic IKKε and NF-κB Signaling Associated with Sjögren's Syndrome Immunopathogenesis.
 

Author(s): Weiqian Chen, Jin Lin, Heng Cao, Danyi Xu, Bei Xu, Liqin Xu, Lihuan Yue, Chuanyin Sun, Guolin Wu, Wenbin Qian

Journal: J Immunol Res. 2015 ;2015():534648.

 

The activated NF-κB signaling pathway plays an important role in pathogenesis of primary Sjögren's syndrome (pSS). The inhibitor of κB (IκB) kinase (IKK) family such as IKKα, IKKβ, IKKγ, and IKKε, is required for this signaling. Our aim was to investigate the role of IKKα/β/γ/ε ...

Last Updated: 18 Sep 2015

Go To URL
[Sjogren's syndrome revealed by respiratory failure].
 

Author(s): Lilia Baili, Zohra Aydi, Mane Dridi, Besma Ben Dhaou, Fatma Daoued, Sami Kochbati, Ezzedine Boussema, Fatma Boussema

Journal: Tunis Med. 2015 Mar;93(3):196-7.

 

Last Updated: 15 Sep 2015

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Sjogren's Syndrome" returned 121 free, full-text review articles on human participants. First 3 results:

Biomarkers for Primary Sjögren's Syndrome.
 

Author(s): Weiqian Chen, Heng Cao, Jin Lin, Nancy Olsen, Song Guo Zheng

Journal: Genomics Proteomics Bioinformatics. 2015 Aug;13(4):219-23.

 

Primary Sjögren's syndrome (pSS) is a systemic autoimmune disease with exocrine gland dysfunction and multi-organ involvement. Recent progress in understanding the pathogenesis of pSS offers an opportunity to find new biomarkers for the diagnosis and assessment of disease activity. ...

Last Updated: 20 Oct 2015

Go To URL
The clinical relevance of animal models in Sjögren's syndrome: the interferon signature from mouse to man.
 

Author(s): Naomi I Maria, Petra Vogelsang, Marjan A Versnel

Journal:

 

Mouse models have been widely used to elucidate the pathogenic mechanisms of human diseases. The advantages of using these models include the ability to study different stages of the disease with particular respect to specific target organs, to focus on the role of specific pathogenic ...

Last Updated: 3 Jul 2015

Go To URL
A systematic review of non-pharmacological interventions for primary Sjögren's syndrome.
 

Author(s): Katie L Hackett, Katherine H O Deane, Victoria Strassheim, Vincent Deary, Tim Rapley, Julia L Newton, Wan-Fai Ng

Journal: Rheumatology (Oxford). 2015 Nov;54(11):2025-32.

 

To evaluate the effects of non-pharmacological interventions for primary SS (pSS) on outcomes falling within the World Health Organization International Classification of Functioning Disability and Health domains.

Last Updated: 14 Oct 2015

Go To URL
 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Implantology and Sjögren's Syndrome
 

Status: Recruiting

Condition Summary: Sjogren's Syndrome

 

Last Updated: 18 Jan 2016

Go to URL
Laser Therapy to Treat the Dry Mouth of Sjogren's Syndrome
 

Status: Recruiting

Condition Summary: KERATOCONJUNCTIVITIS SICCA; XEROSTOMIA; SICCA SYNDROME; PRIMARY SJOGREN SYNDROME

 

Last Updated: 1 Feb 2016

Go to URL
Endoscopic Treatment of Salivary Glands Affected by Sjögren's Syndrome
 

Status: Recruiting

Condition Summary: Sjögren's Syndrome

 

Last Updated: 18 Jan 2016

Go to URL