Sjogren's Syndrome

Common Name(s)

Sjogren's Syndrome

Sjogren's syndrome is an autoimmune disease which most commonly causes dry eyes and mouth. Our immune system protects us against infections from viruses and bacteria. Sometimes a person’s immune system attacks the person’s own tissues and organs by mistake. In this case, the immune system attacks the glands which produce moisture, especially those which produce tears and saliva. In addition to dry eyes and mouth, other symptoms may include dry skin, skin rashes, chronic dry cough, thyroid problems, joint and muscle pain, vaginal dryness and numbness and tingling in the arms and legs. The syndrome may also make the person feel very tired. Other complications may include vision and dental problems as well as more serious damage to the liver, kidneys or lungs. A small percentage of people with Sjogren’s develop lymphoma. Overall all symptoms may stay the same or worsen with time and may range from mild to debilitating (unable to do daily tasks). About half the time, a person with Sjogren’s syndrome will also have another autoimmune disease such as arthritis, lupus or scleroderma. Sjogren's syndrome may occur at any age, but is more common in women and people above the age of 40 years old. The cause of Sjorgren’s syndrome is unknown but may be a combination of genetics and bacterial or viral infection. Diagnosis is usually made through a physical exam, special test of the eyes and mouth and blood tests. Treatments for this condition depend on the symptoms present. Dry mouth and eyes may be treated with medications. Medication is also available to help lessen the joint and muscle pain, suppress the immune system and decrease inflammation or swelling. Early diagnosis and treatment may help prevent the more serious complications. Talk with your doctor if you or a family member has been diagnosed with Sjogren’s syndrome to decide on the best treatment. Support groups are also a good source of support and information.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Sjogren's Syndrome" for support, advocacy or research.

HealthyWomen

HealthyWomen (HW) is the nation's leading independent health information source for women. Our core mission is to educate, inform and empower women to make smart health choices for themselves and their families. For more than 20 years, millions of women have been coming to HW for answers to their most pressing and personal health care questions. Through our wide array of online and print publications, HW provides health information that is original, objective, reviewed by medical experts and reflective of the advances in evidence-based health research.

Last Updated: 9 Jul 2015

View Details
International Scleroderma Network

Our mission is to provide stellar worldwide research, support, education and awareness for scleroderma and related illnesses.

Last Updated: 18 Apr 2010

View Details
Sjögren's Syndrome Foundation, Inc.

The Foundation's mission is to: •Educate patients and their families about Sjögren's. •Increase public and professional awareness of Sjögren's. •Encourage research into new treatments and a cure.

Last Updated: 30 Apr 2014

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Sjogren's Syndrome" for support, advocacy or research.

HealthyWomen

HealthyWomen (HW) is the nation's leading independent health information source for women. Our core mission is to educate, inform and empower women to make smart health choices for themselves and their families. For more than 20 years, millions of women have been coming to HW for answers to their most pressing and personal health care questions. Through our wide array of online and print publications, HW provides health information that is original, objective, reviewed by medical experts and reflective of the advances in evidence-based health research.

http://www.healthywomen.org

Last Updated: 9 Jul 2015

View Details
International Scleroderma Network

Our mission is to provide stellar worldwide research, support, education and awareness for scleroderma and related illnesses.

http://www.sclero.org/

Last Updated: 18 Apr 2010

View Details
Sjögren's Syndrome Foundation, Inc.

The Foundation's mission is to: •Educate patients and their families about Sjögren's. •Increase public and professional awareness of Sjögren's. •Encourage research into new treatments and a cure.

http://www.sjogrens.org

Last Updated: 30 Apr 2014

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Sjogren's Syndrome" returned 1094 free, full-text research articles on human participants. First 3 results:

Microscopic polyangiitis associated with primary biliary cirrhosis, Sjogren's syndrome and Hashimoto's thyroiditis.
 

Author(s): I Ben Ghorbel, N Bel Feki, T Ben Salem, A Hamzaoui, M Khanfir, M Lamloum, M Miled, M H Houman

Journal: Saudi J Kidney Dis Transpl. 2015 Mar;26(2):359-62.

 

The association between microscopic polyangiitis (MPA) and primary biliary cirrhosis (PBC) has seldom been reported. We describe here a patient who presented with sensorimotor neuropathy along with hypothyroidism, renal failure and liver dysfunction. Detection of antinuclear antibodies ...

Last Updated: 12 Mar 2015

Go To URL
Chronic cough due to mucosal dryness in primary Sjögren's syndrome: a case report.
 

Author(s): Ayşe Bilge Öztürk, Erman Öztürk, Esen Kasapoğlu

Journal: Tuberk Toraks. 2014 ;62(3):243-4.

 

Last Updated: 10 Dec 2014

Go To URL
Salivary transforming growth factor alpha in patients with Sjögren's syndrome and reflux laryngitis.
 

Author(s): Marco Antonio dos Anjos Corvo, Claudia Alessandra Eckley, Luis Vicente Rizzo, Luiz Roberto Sardinha, Tomas Navarro Rodriguez, Ivo Bussoloti Filho

Journal: Braz J Otorhinolaryngol. ;80(6):462-9.

 

Saliva plays a key role in the homeostasis of the digestive tract, through its inorganic components and its protein growth factors. Sjögren's syndrome patients have a higher prevalence of gastroesophageal reflux disease and laryngopharyngeal reflux. Decreased salivary transforming ...

Last Updated: 3 Dec 2014

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Sjogren's Syndrome" returned 106 free, full-text review articles on human participants. First 3 results:

[Cell death of salivary gland epithelial cells and involvement of HTLV-I in Sjögren's syndrome].
 

Author(s): Hideki Nakamura

Journal: Nihon Rinsho Meneki Gakkai Kaishi. 2014 ;37(3):117-24.

 

Chronic sialadenitis in Sjögren's syndrome (SS) is associated with cell death induced by Fas or cytotoxic granules. Furthermore, tumor necrosis factor-related apoptosis inducing ligand or toll-like receptor3 are known to induce apoptosis in the salivary gland epithelial cells (SGECs) ...

Last Updated: 30 Jun 2014

Go To URL
Genome-wide association studies in Sjögren's syndrome: What do the genes tell us about disease pathogenesis?
 

Author(s): Peter D Burbelo, Kiran Ambatipudi, Ilias Alevizos

Journal: Autoimmun Rev. 2014 Jul;13(7):756-61.

 

The pathogenesis of Sjögren's syndrome (SS) likely involves complex interactions between genes and the environment. While the candidate gene approach has been previously used to identify several genes associated with SS, two recent large-scale genome-wide association studies (GWAS) ...

Last Updated: 21 Apr 2014

Go To URL
Minor salivary gland biopsy in Sjögren's syndrome: a review and introduction of a new tool to ease the procedure.
 

Author(s): Pablo Varela-Centelles, Juan-Manuel Seoane-Romero, Mariña Sánchez-Sánchez, Antonio González-Mosquera, Pedro Diz-Dios, Juan Seoane

Journal:

 

To review the existing techniques for minor salivary gland biopsy (MSGB) in the lip and to suggest a new approach to ease the procedure and reduce post-operative complications.

Last Updated: 31 Dec 2013

Go To URL
 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Laser Therapy to Treat the Dry Mouth of Sjogren's Syndrome
 

Status: Recruiting

Condition Summary: KERATOCONJUNCTIVITIS SICCA; XEROSTOMIA; SICCA SYNDROME; PRIMARY SJOGREN SYNDROME

 

Last Updated: 19 Feb 2014

Go to URL
Aerobic Exercise in Primary Sjögren's Syndrome
 

Status: Recruiting

Condition Summary: Sjogren's Syndrome

 

Last Updated: 12 Mar 2015

Go to URL
Endoscopic Treatment of Salivary Glands Affected by Sjögren's Syndrome
 

Status: Recruiting

Condition Summary: Sjögren's Syndrome

 

Last Updated: 3 Jun 2014

Go to URL