Sjogren's Syndrome

Common Name(s)

Sjogren's Syndrome

Sjogren's syndrome is an autoimmune disease which most commonly causes dry eyes and mouth. Our immune system protects us against infections from viruses and bacteria. Sometimes a person’s immune system attacks the person’s own tissues and organs by mistake. In this case, the immune system attacks the glands which produce moisture, especially those which produce tears and saliva. In addition to dry eyes and mouth, other symptoms may include dry skin, skin rashes, chronic dry cough, thyroid problems, joint and muscle pain, vaginal dryness and numbness and tingling in the arms and legs. The syndrome may also make the person feel very tired. Other complications may include vision and dental problems as well as more serious damage to the liver, kidneys or lungs. A small percentage of people with Sjogren’s develop lymphoma. Overall all symptoms may stay the same or worsen with time and may range from mild to debilitating (unable to do daily tasks). About half the time, a person with Sjogren’s syndrome will also have another autoimmune disease such as arthritis, lupus or scleroderma. Sjogren's syndrome may occur at any age, but is more common in women and people above the age of 40 years old. The cause of Sjorgren’s syndrome is unknown but may be a combination of genetics and bacterial or viral infection. Diagnosis is usually made through a physical exam, special test of the eyes and mouth and blood tests. Treatments for this condition depend on the symptoms present. Dry mouth and eyes may be treated with medications. Medication is also available to help lessen the joint and muscle pain, suppress the immune system and decrease inflammation or swelling. Early diagnosis and treatment may help prevent the more serious complications. Talk with your doctor if you or a family member has been diagnosed with Sjogren’s syndrome to decide on the best treatment. Support groups are also a good source of support and information.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Sjogren's Syndrome" for support, advocacy or research.

HealthyWomen

HealthyWomen (HW) is the nation's leading independent health information source for women. Our core mission is to educate, inform and empower women to make smart health choices for themselves and their families. For more than 20 years, millions of women have been coming to HW for answers to their most pressing and personal health care questions. Through our wide array of online and print publications, HW provides health information that is original, objective, reviewed by medical experts and reflective of the advances in evidence-based health research.

Last Updated: 3 Oct 2013

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International Scleroderma Network

Our mission is to provide stellar worldwide research, support, education and awareness for scleroderma and related illnesses.

Last Updated: 18 Apr 2010

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Sjögren's Syndrome Foundation, Inc.

The Foundation's mission is to: •Educate patients and their families about Sjögren's. •Increase public and professional awareness of Sjögren's. •Encourage research into new treatments and a cure.

Last Updated: 30 Apr 2014

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Sjogren's Syndrome" for support, advocacy or research.

HealthyWomen

HealthyWomen (HW) is the nation's leading independent health information source for women. Our core mission is to educate, inform and empower women to make smart health choices for themselves and their families. For more than 20 years, millions of women have been coming to HW for answers to their most pressing and personal health care questions. Through our wide array of online and print publications, HW provides health information that is original, objective, reviewed by medical experts and reflective of the advances in evidence-based health research.

http://www.healthywomen.org

Last Updated: 3 Oct 2013

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International Scleroderma Network

Our mission is to provide stellar worldwide research, support, education and awareness for scleroderma and related illnesses.

http://www.sclero.org/

Last Updated: 18 Apr 2010

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Sjögren's Syndrome Foundation, Inc.

The Foundation's mission is to: •Educate patients and their families about Sjögren's. •Increase public and professional awareness of Sjögren's. •Encourage research into new treatments and a cure.

http://www.sjogrens.org

Last Updated: 30 Apr 2014

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Sjogren's Syndrome" returned 1073 free, full-text research articles on human participants. First 3 results:

A chimeric human-mouse model of Sjögren's syndrome.
 

Author(s): Nicholas A Young, Lai-Chu Wu, Michael Bruss, Benjamin H Kaffenberger, Jeffrey Hampton, Brad Bolon, Wael N Jarjour

Journal: Clin. Immunol.. 2015 Jan;156(1):1-8.

 

Despite recent advances in the understanding of Sjögren's Syndrome (SjS), the pathogenic mechanisms remain elusive and an ideal model for early drug discovery is not yet available. To establish a humanized mouse model of SjS, peripheral blood mononuclear cells (PBMCs) from healthy ...

Last Updated: 29 Dec 2014

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Osteomalacia complicating renal tubular acidosis in association with Sjogren's syndrome.
 

Author(s): Zohra El Ati, Lilia Ben Fatma, Ghada Boulahya, Lamia Rais, Madiha Krid, Wided Smaoui, Hedi Ben Maiz, Soumaya Beji, Karim Zouaghi, Fatma Ben Moussa

Journal: Saudi J Kidney Dis Transpl. 2014 Sep;25(5):1072-7.

 

Renal involvement in Sjogren's syndrome (SS) is not uncommon and may precede other complaints. Tubulointerstitial nephritis is the most common renal disease in SS and may lead to renal tubular acidosis (RTA), which in turn may cause osteomalacia. Nevertheless, osteomalacia rarely ...

Last Updated: 6 Sep 2014

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Evaluation of diagnostic parameters from parotid and submandibular dynamic salivary glands scintigraphy and unstimulated sialometry in Sjögren's syndrome.
 

Author(s): Sanja Dugonjić, Dušan Stefanović, Branka Ethurović, Vesna Spasić-Jokić, Boris Ajdinović

Journal: Hell J Nucl Med. ;17(2):116-22.

 

Our aim was to validate eight scintigraphic salivary gland (SG) parameters, as diagnostic parameters in patients with Sjögren's syndrome (SS). We used the standardized stimulated dynamic salivary gland scintigraphy (DSGS) protocol and correlated this with the unstimulated whole sialometry ...

Last Updated: 6 Aug 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Sjogren's Syndrome" returned 102 free, full-text review articles on human participants. First 3 results:

Minor salivary gland biopsy in Sjögren's syndrome: a review and introduction of a new tool to ease the procedure.
 

Author(s): Pablo Varela-Centelles, Juan-Manuel Seoane-Romero, Mariña Sánchez-Sánchez, Antonio González-Mosquera, Pedro Diz-Dios, Juan Seoane

Journal:

 

To review the existing techniques for minor salivary gland biopsy (MSGB) in the lip and to suggest a new approach to ease the procedure and reduce post-operative complications.

Last Updated: 31 Dec 2013

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The immune factors involved in the pathogenesis, diagnosis, and treatment of Sjogren's syndrome.
 

Author(s): Yi-fan Huang, Qian Cheng, Chun-miao Jiang, Shu An, Lan Xiao, Yong-chao Gou, Wen-jing Yu, Lei Lei, Qian-ming Chen, Yating Wang, Jun Wang

Journal: Clin. Dev. Immunol.. 2013 ;2013():160491.

 

Sjogren's syndrome (SS) is a systemic, autoimmune disorder characterized by salivary insufficiency and lymphocytic infiltration of the exocrine glands. Even though the mechanism of its pathology and progression has been researched ever since its discovery, the roles of different parts ...

Last Updated: 12 Aug 2013

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T helper subsets in Sjögren's syndrome and IgG4-related dacryoadenitis and sialoadenitis: a critical review.
 

Author(s): Masafumi Moriyama, Akihiko Tanaka, Takashi Maehara, Sachiko Furukawa, Hitoshi Nakashima, Seiji Nakamura

Journal: J. Autoimmun.. 2014 Jun;51():81-8.

 

IgG4-related disease (IgG4-RD) is a systemic disease characterized by the elevation of serum IgG4 and infiltration of IgG4-positive plasma cells in multiple target organs, including the pancreas, kidney, biliary tract and salivary glands. In contrast, Mikulicz's disease (MD) has been ...

Last Updated: 26 May 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Laser Therapy to Treat the Dry Mouth of Sjogren's Syndrome
 

Status: Recruiting

Condition Summary: KERATOCONJUNCTIVITIS SICCA; XEROSTOMIA; SICCA SYNDROME; PRIMARY SJOGREN SYNDROME

 

Last Updated: 19 Feb 2014

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Aerobic Exercise in Primary Sjögren's Syndrome
 

Status: Not yet recruiting

Condition Summary: Sjogren's Syndrome

 

Last Updated: 23 Feb 2015

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Endoscopic Treatment of Salivary Glands Affected by Sjögren's Syndrome
 

Status: Recruiting

Condition Summary: Sjögren's Syndrome

 

Last Updated: 3 Jun 2014

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