Silicosis

Common Name(s)

Silicosis

Silicosis is a respiratory disease caused by breathing in (inhaling) silica dust. There are three types of silicosis:

Simple chronic silicosis, the most common type of silicosis, results from long-term exposure (usually more than 20 years) to low amounts of silica dust. Simple chronic silicosis may cause people to have difficulty breathing.  Accelerated silicosis occurs after 5 to 15 years of exposure of higher levels of silica. Swelling of the lungs and other symptoms occur faster in this type of silicosis than in the simple chronic form.  Acute silicosis results from short-term exposure of large amounts of silica. The lungs become very inflamed and can fill with fluid, causing severe shortness of breath and low blood oxygen levels. Acute silicosis progresses rapidly and can be fatal within months. 

People who work in jobs where they are exposed to silica dust (mining, quarrying, construction, sand blasting, stone cutting) are at risk of developing this condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Silicosis" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Silicosis" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Silicosis" returned 234 free, full-text research articles on human participants. First 3 results:

Surveillance for Silicosis Deaths Among Persons Aged 15-44 Years - United States, 1999-2015.
 

Author(s): Jacek M Mazurek, John M Wood, Patricia L Schleiff, David N Weissman

Journal:

 

Silicosis is usually a disease of long latency affecting mostly older workers; therefore, silicosis deaths in young adults (aged 15-44 years) suggests acute or accelerated disease.* To understand the circumstances surrounding silicosis deaths among young persons, CDC analyzed the ...

Last Updated: 20 Jul 2017

Go To URL
BBC3 in macrophages promoted pulmonary fibrosis development through inducing autophagy during silicosis.
 

Author(s): Haijun Liu, Yusi Cheng, Jian Yang, Wei Wang, Shencun Fang, Wei Zhang, Bing Han, Zewei Zhou, Honghong Yao, Jie Chao, Hong Liao

Journal:

 

Following inhalation into the lungs, silica particles are engulfed by alveolar macrophages, which triggers endogenous or exogenous apoptosis signaling pathways. As an inducer of apoptosis, the role of BBC3/PUMA (BCL2-binding component 3) in macrophages during silicosis remains unknown. ...

Last Updated: 9 Mar 2017

Go To URL
Leveraging Big Data for Exploring Occupational Diseases-Related Interest at the Level of Scientific Community, Media Coverage and Novel Data Streams: The Example of Silicosis as a Pilot Study.
 

Author(s): Nicola Luigi Bragazzi, Guglielmo Dini, Alessandra Toletone, Francesco Brigo, Paolo Durando

Journal:

 

Silicosis is an untreatable but preventable occupational disease, caused by exposure to silica. It can progressively evolve to lung impairment, respiratory failure and death, even after exposure has ceased. However, little is known about occupational diseases-related interest at the ...

Last Updated: 2 Nov 2016

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Silicosis" returned 15 free, full-text review articles on human participants. First 3 results:

Introduction: 'dying for gold': the effects of mineral miningon HIV, tuberculosis, silicosis, and occupational diseases in southern Africa.
 

Author(s): David Stuckler, Sarah Steele, Mark Lurie, Sanjay Basu

Journal: Int J Health Serv. 2013 ;43(4):639-49.

 

Mineral mining is among the world's most hazardous occupations. It is especially dangerous in southern Africa, where mining activity is a leading cause of HIV and tuberculosis epidemics. Inside mines, silica dust exposure causes long-term pulmonary damage. Living conditions are often ...

Last Updated: 8 Jan 2014

Go To URL
A stone miner with both silicosis and constrictive pericarditis: case report and review of the literature.
 

Author(s): Yajian Jiang, Fangchun Shao

Journal:

 

The working environment of stone miners has been believed to cause their susceptibility to respiratory diseases. Silicosis is an occupational disease caused by exposure to crystalline silica dust which is marked by inflammation and scarring in the lung. The immune system boosted after ...

Last Updated: 16 Dec 2013

Go To URL
Tuberculosis and silicosis: epidemiology, diagnosis and chemoprophylaxis.
 

Author(s): Carlos Eduardo Galvão Barboza, Daniel Hugo Winter, Márcia Seiscento, Ubiratan de Paula Santos, Mário Terra Filho

Journal: J Bras Pneumol. 2008 Nov;34(11):959-66.

 

Silicosis, the most prevalent of the pneumoconioses, is caused by inhalation of crystalline silica particles. Silica-exposed workers, with or without silicosis, are at increased risk for tuberculosis and nontuberculous mycobacteria-related diseases. The risk of a patient with silicosis ...

Last Updated: 22 Dec 2008

Go To URL
 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Comprehensive Risk Assessment of People With Silicosis: A Population-based Study
 

Status: Recruiting

Condition Summary: Silicosis

 

Last Updated: 5 Jun 2016

Go to URL
Efficacy of Weekly Rifapentine and Isoniazid for Tuberculosis Prevention
 

Status: Recruiting

Condition Summary: Silicosis; Tuberculosis

 

Last Updated: 25 Apr 2015

Go to URL