Signet ring cell carcinoma

Common Name(s)

Signet ring cell carcinoma, Diffuse gastric cancer

Signet ring cell carcinoma (SRCC) is a rare form of cancer that usually affects the stomach. SRCC is a type of adenocarcinoma, which means that it affects gland cells that are located on the lining of organs (epithelial cells). Cancer is diagnosed by taking a biopsy (or sample) of the tissue and looking at it under a microscope. SRCC is diagnosed when a doctor finds that many of the cells are signet ring cells. Signet ring cells were given their name because they look like old signet rings that were used to place a seal in wax, often used to seal envelopes. These cells have very large spaces used for storage (vacuoles) in the center, which give them their characteristic appearance. SRCC usually starts to grow in the stomach and can spread to other organs such as the lungs, ovaries, or intestines.

Because SRCC usually affects the stomach, common symptoms include abdominal pain, nausea, vomiting, blood in the vomit or stool, loss of appetite, weight loss, and feeling full after eating small meals (early satiety). This cancer has been linked to a mutation in the CDH1 gene, and therefore a family history of this disease may put you at greater risk for developing SRCC. SRCC affects women more than men and can be found in young adults.

If you are experiencing these symptoms, your doctor may ask about your family history and perform diagnostic tests, such as taking a biopsy of the stomach. This type of cancer can be very dangerous if it is not detected early, so it is very important to see your doctor if you are experiencing these symptoms. Chemotherapy has not proved very effective in fighting this type of cancer. Talk to your doctor about the most current treatment options. Speaking with a genetic counselor may also be helpful to discuss how SRCC is passed through families and possible genetic testing options. Support groups can also be a good source of information and comfort.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Signet ring cell carcinoma" for support, advocacy or research.

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Signet ring cell carcinoma" returned 101 free, full-text research articles on human participants. First 3 results:

A Case of Gastric Cancer with Neuroendocrine Carcinoma, Signet Ring Cell Carcinoma Components, and Intramural Metastases.
 

Author(s): Keishiro Aoyagi, Junya Kizaki, Taro Isobe, Yoshito Akagi

Journal:

 

Many neuroendocrine carcinomas exhibit medullary infiltration and expanded proliferation. Differentiated tubular adenocarcinoma is frequently seen in the superficial region in many neuroendocrine carcinoma cases. However, the present case showed non-medullary infiltration and signet ...

Last Updated: 22 Apr 2016

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Cutaneous clear cell/signet-ring cell squamous cell carcinoma arising in the right thigh of a patient with type 2 diabetes: combined morphologic, immunohistochemical, and etiologic analysis.
 

Author(s): Nong-Rong Wang, Meng-Meng Wang, Lv Zhou, Ze-Lin Liu, Nan-Ping Chen, Jin-Ping Hu, Yan-Juan Deng, Xiao-Qing Qi, Xiao-Feng Huang, Yue Su, Si-Yao Zhang, Fei Tong, Yu Zhang, Qi Lu, Zi-Yu Zhu, Huan Deng

Journal:

 

The clear cell/signet-ring cell variant of cutaneous squamous cell carcinoma (cSCC) is extremely rare. Its carcinogenesis has consistently been linked to ultraviolet radiation and HPV in the literature. However, there is little definite information about the contribution of diabetes ...

Last Updated: 12 Apr 2016

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Clinicopathological Characteristics and Survival Outcomes of Primary Signet Ring Cell Carcinoma in the Stomach: Retrospective Analysis of Single Center Database.
 

Author(s): Xiaowen Liu, Hong Cai, Weiqi Sheng, Lin Yu, Ziwen Long, Yingqiang Shi, Yanong Wang

Journal:

 

To investigate the clinicopathological features and prognosis of signet ring cell carcinoma of the stomach (SRC).

Last Updated: 8 Dec 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Signet ring cell carcinoma" returned 18 free, full-text review articles on human participants. First 3 results:

Signet-ring cell carcinoma of the stomach: Impact on prognosis and specific therapeutic challenge.
 

Author(s): Simon Pernot, Thibault Voron, Geraldine Perkins, Christine Lagorce-Pages, Anne Berger, Julien Taieb

Journal: World J. Gastroenterol.. 2015 Oct;21(40):11428-38.

 

While the incidence of gastric cancer has decreased worldwide in recent decades, the incidence of signet-ring cell carcinoma (SRCC) is rising. SRCC has a specific epidemiology and oncogenesis and has two forms: early gastric cancer, which can be resected endoscopically in some cases ...

Last Updated: 2 Nov 2015

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Breast metastasis of gastric signet-ring cell carcinoma: a case report and literature review.
 

Author(s): Chun-Lan He, Ping Chen, Bing-Lan Xia, Qin Xiao, Feng-Lin Cai

Journal:

 

Cases of primary gastric adenocarcinoma with metastasis to the breast are extremely rare. Till now, only 38 cases have been reported in PubMed since 1908.

Last Updated: 19 Apr 2015

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Outcomes of surgical treatment of primary signet ring cell carcinoma of the colon and rectum: 22 cases reviewed with literature.
 

Author(s): Sedat Belli, Huseyin Ozgur Aytac, Erdal Karagulle, Hakan Yabanoglu, Fazilet Kayaselcuk, Sedat Yildirim

Journal: Int Surg. ;99(6):691-8.

 

Colorectal primary signet ring cell carcinoma (PSRCCR) is a rare entity with a dismal prognosis, mainly because of delayed diagnosis. The objective of this study was to investigate the clinicopathologic features and prognostic factors for PSRCCR. This is a retrospective study including ...

Last Updated: 2 Dec 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Endodrill vs. Conventional Biopsy. Evaluation of Diagnostic Capacity in Diffuse Gastric Cancer
 

Status: Not yet recruiting

Condition Summary: Stomach Neoplasms

 

Last Updated: 5 Apr 2016

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Talimogene Laherparepvec and Nivolumab in Treating Patients With Refractory Lymphomas or Advanced or Refractory Non-melanoma Skin Cancers
 

Status: Not yet recruiting

Condition Summary: Adenoid Cystic Carcinoma; Adnexal Carcinoma; Apocrine Carcinoma; Eccrine Porocarcinoma; Extraocular Cutaneous Sebaceous Carcinoma; Hidradenocarcinoma; Keratoacanthoma; Malignant Sweat Gland Neoplasm; Merkel Cell Carcinoma; Microcystic Adnexal Carcinoma; NK-Cell Lymphoma, Unclassifiable; Non-Melanomatous Lesion; Paget Disease; Papillary Adenocarcinoma; Primary Cutaneous Mucinous Carcinoma; Refractory Anaplastic Large Cell Lymphoma; Refractory Cutaneous T-Cell Non-Hodgkin Lymphoma; Refractory Mature T-Cell and NK-Cell Non-Hodgkin Lymphoma; Refractory Mycosis Fungoides; Refractory T-Cell Non-Hodgkin Lymphoma; Sezary Syndrome; Signet Ring Cell Carcinoma; Skin Basal Cell Carcinoma; Skin Basosquamous Cell Carcinoma; Skin Squamous Cell Carcinoma; Spiradenocarcinoma; Squamous Cell Carcinoma of Unknown Primary Origin; Stage III Skin Cancer; Stage IV Skin Cancer; Sweat Gland Carcinoma; Trichilemmocarcinoma; Vulvar Squamous Cell Carcinoma

 

Last Updated: 8 Dec 2016

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Hereditary Colorectal and Associated Tumor Registry Study
 

Status: Recruiting

Condition Summary: Lynch Syndrome; FAP; Hereditary Diffuse Gastric Cancer; Juvenile Polyposis Syndrome; Peutz-Jeghers Syndrome

 

Last Updated: 14 Jan 2016

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