Signet ring cell carcinoma

Common Name(s)

Signet ring cell carcinoma, Diffuse gastric cancer

Signet ring cell carcinoma (SRCC) is a rare form of cancer that usually affects the stomach. SRCC is a type of adenocarcinoma, which means that it affects gland cells that are located on the lining of organs (epithelial cells). Cancer is diagnosed by taking a biopsy (or sample) of the tissue and looking at it under a microscope. SRCC is diagnosed when a doctor finds that many of the cells are signet ring cells. Signet ring cells were given their name because they look like old signet rings that were used to place a seal in wax, often used to seal envelopes. These cells have very large spaces used for storage (vacuoles) in the center, which give them their characteristic appearance. SRCC usually starts to grow in the stomach and can spread to other organs such as the lungs, ovaries, or intestines.

Because SRCC usually affects the stomach, common symptoms include abdominal pain, nausea, vomiting, blood in the vomit or stool, loss of appetite, weight loss, and feeling full after eating small meals (early satiety). This cancer has been linked to a mutation in the CDH1 gene, and therefore a family history of this disease may put you at greater risk for developing SRCC. SRCC affects women more than men and can be found in young adults.

If you are experiencing these symptoms, your doctor may ask about your family history and perform diagnostic tests, such as taking a biopsy of the stomach. This type of cancer can be very dangerous if it is not detected early, so it is very important to see your doctor if you are experiencing these symptoms. Chemotherapy has not proved very effective in fighting this type of cancer. Talk to your doctor about the most current treatment options. Speaking with a genetic counselor may also be helpful to discuss how SRCC is passed through families and possible genetic testing options. Support groups can also be a good source of information and comfort.

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Advocacy and Support Organizations

 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Signet ring cell carcinoma" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Signet ring cell carcinoma" returned 93 free, full-text research articles on human participants. First 3 results:

Differential microRNA expression in signet-ring cell carcinoma compared with tubular adenocarcinoma of human gastric cancer.
 

Author(s): F Q Li, B Xu, Y J Wu, Z L Yang, J J Qian

Journal:

 

Gastric cancer is a disease with a heterogeneous pathology; its pathological mechanisms remain unclear because there is a poor understanding of its etiology. In this study, we identified differentially expressed microRNAs (miRNAs) among various gastric cancer subtypes. miRNA microarray ...

Last Updated: 3 Mar 2015

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Signet-ring cell carcinoma arising from a fundic gland polyp in the stomach.
 

Author(s): Yong Seol Jeong, Sung Eun Kim, Mi-Jung Kwon, Jae Yong Seo, Hyun Lim, Ji Won Park, Ho Suk Kang, Sung Hoon Moon, Jong Hyuk Kim, Choong Kee Park

Journal: World J. Gastroenterol.. 2014 Dec;20(47):18044-7.

 

Fundic gland polyps (FGPs) are currently the most common type of gastric polyps and are usually benign. However, although rare, gastric adenocarcinoma of FGP has been recently proposed as a new variant of gastric adenocarcinoma. Here we report the first case of a 49-year-old woman ...

Last Updated: 30 Dec 2014

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Signet-ring cell carcinoma of the gallbladder complicated by pulmonary tumor thrombotic microangiopathy.
 

Author(s): Yoshinori Ohno, Teru Kumagi, Taira Kuroda, Mitsuhito Koizumi, Nobuaki Azemoto, Hirofumi Yamanishi, Mayu Oda, Masashi Hirooka, Masanori Abe, Yoshio Ikeda, Bunzo Matsuura, Morikazu Onji, Yoshiko Soga, Yousuke Mizuno, Atsurou Sugita, Yoichi Hiasa

Journal: Intern. Med.. 2014 ;53(11):1125-9.

 

Biliary drainage was performed in a 71-year-old man with obstructive jaundice of unknown origin; however, he died due to acute pulmonary failure. At autopsy, proliferation of adenocarcinoma cells was observed in the gallbladder mucosa transitioning from isolated signet-ring cell carcinoma ...

Last Updated: 2 Jun 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Signet ring cell carcinoma" returned 15 free, full-text review articles on human participants. First 3 results:

Synchronous appendiceal and intramucosal gastric signet ring cell carcinomas in an individual with CDH1-associated hereditary diffuse gastric carcinoma: a case report of a novel association and review of the literature.
 

Author(s): Leslie E Hamilton, Kirsten Jones, Neal Church, Shaun Medlicott

Journal:

 

Hereditary diffuse gastric carcinoma is an autosomal dominant cancer syndrome associated with mutations of the E-cadherin gene (CDH1). E-cadherin is normally involved in cell-cell adhesion, so it not surprising that individuals with this syndrome are predisposed to develop malignancies ...

Last Updated: 19 Jul 2013

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Early-stage primary signet ring cell carcinoma of the colon.
 

Author(s): Jae Hyun Kim, Seun Ja Park, Moo In Park, Won Moon, Sung Eun Kim

Journal: World J. Gastroenterol.. 2013 Jun;19(24):3895-8.

 

Primary signet ring cell carcinoma of the colorectum detected at an early stage is very rare; most cases are detected at an advanced stage. Therefore, its prognosis is poorer than that of ordinary colorectal cancer. A 56-year-old Korean man was seen at this hospital for management ...

Last Updated: 10 Jul 2013

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A new case of primary signet-ring cell carcinoma of the cervix with prominent endometrial and myometrial involvement: Immunohistochemical and molecular studies and review of the literature.
 

Author(s): Giovanna Giordano, Silvia Pizzi, Roberto Berretta, Tiziana D'Adda

Journal:

 

As a rule, endocervical tumours with signet-ring cell are classed as metastatic extra-genital neoplasms. In a patient aged 45 years, we describe primary cervical signet-ring cell carcinoma (PCSRCC) characterized by prominent endometrial and myometrial involvement, simulating primary ...

Last Updated: 6 Apr 2012

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Endodrill vs. Conventional Biopsy. Evaluation of Diagnostic Capacity in Diffuse Gastric Cancer
 

Status: Not yet recruiting

Condition Summary: Stomach Neoplasms

 

Last Updated: 30 Oct 2015

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Hereditary Colorectal and Associated Tumor Registry Study
 

Status: Recruiting

Condition Summary: Lynch Syndrome; FAP; Hereditary Diffuse Gastric Cancer; Juvenile Polyposis Syndrome; Peutz-Jeghers Syndrome

 

Last Updated: 14 Jan 2016

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Evaluation of Surgery Versus Primary Chemotherapy in Resectable Signet Ring Cell Gastric Adenocarcinoma
 

Status: Recruiting

Condition Summary: Signet Ring Cell Gastric Adenocarcinoma

 

Last Updated: 8 Feb 2016

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