Signet ring cell carcinoma

Common Name(s)

Signet ring cell carcinoma, Diffuse gastric cancer

Signet ring cell carcinoma (SRCC) is a rare form of cancer that usually affects the stomach. SRCC is a type of adenocarcinoma, which means that it affects gland cells that are located on the lining of organs (epithelial cells). Cancer is diagnosed by taking a biopsy (or sample) of the tissue and looking at it under a microscope. SRCC is diagnosed when a doctor finds that many of the cells are signet ring cells. Signet ring cells were given their name because they look like old signet rings that were used to place a seal in wax, often used to seal envelopes. These cells have very large spaces used for storage (vacuoles) in the center, which give them their characteristic appearance. SRCC usually starts to grow in the stomach and can spread to other organs such as the lungs, ovaries, or intestines.

Because SRCC usually affects the stomach, common symptoms include abdominal pain, nausea, vomiting, blood in the vomit or stool, loss of appetite, weight loss, and feeling full after eating small meals (early satiety). This cancer has been linked to a mutation in the CDH1 gene, and therefore a family history of this disease may put you at greater risk for developing SRCC. SRCC affects women more than men and can be found in young adults.

If you are experiencing these symptoms, your doctor may ask about your family history and perform diagnostic tests, such as taking a biopsy of the stomach. This type of cancer can be very dangerous if it is not detected early, so it is very important to see your doctor if you are experiencing these symptoms. Chemotherapy has not proved very effective in fighting this type of cancer. Talk to your doctor about the most current treatment options. Speaking with a genetic counselor may also be helpful to discuss how SRCC is passed through families and possible genetic testing options. Support groups can also be a good source of information and comfort.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Signet ring cell carcinoma" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Signet ring cell carcinoma" returned 98 free, full-text research articles on human participants. First 3 results:

Clinicopathological Characteristics and Survival Outcomes of Primary Signet Ring Cell Carcinoma in the Stomach: Retrospective Analysis of Single Center Database.
 

Author(s): Xiaowen Liu, Hong Cai, Weiqi Sheng, Lin Yu, Ziwen Long, Yingqiang Shi, Yanong Wang

Journal:

 

To investigate the clinicopathological features and prognosis of signet ring cell carcinoma of the stomach (SRC).

Last Updated: 8 Dec 2015

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Early stage signet ring cell carcinoma of the colon examined by magnifying endoscopy with narrow-band imaging: a case report.
 

Author(s): Ken Ohnita, Hajime Isomoto, Taro Akashi, Keiichi Hashiguchi, Kayoko Matsushima, Hitomi Minami, Yuko Akazawa, Naoyuki Yamaguchi, Fuminao Takeshima, Kazuo To, Hiroaki Takeshita, Haruna Yasui, Kuniko Abe, Kazuhiko Nakao

Journal:

 

Signet ring cell carcinoma of the colon and rectum is rare, and most cases are detected at an advanced stage. We present a case of primary signet ring cell carcinoma detected at an early stage by magnifying endoscopy with narrow-band imaging (NBI) and crystal violet staining.

Last Updated: 24 Jul 2015

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Differential microRNA expression in signet-ring cell carcinoma compared with tubular adenocarcinoma of human gastric cancer.
 

Author(s): F Q Li, B Xu, Y J Wu, Z L Yang, J J Qian

Journal:

 

Gastric cancer is a disease with a heterogeneous pathology; its pathological mechanisms remain unclear because there is a poor understanding of its etiology. In this study, we identified differentially expressed microRNAs (miRNAs) among various gastric cancer subtypes. miRNA microarray ...

Last Updated: 3 Mar 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Signet ring cell carcinoma" returned 17 free, full-text review articles on human participants. First 3 results:

Breast metastasis of gastric signet-ring cell carcinoma: a case report and literature review.
 

Author(s): Chun-Lan He, Ping Chen, Bing-Lan Xia, Qin Xiao, Feng-Lin Cai

Journal:

 

Cases of primary gastric adenocarcinoma with metastasis to the breast are extremely rare. Till now, only 38 cases have been reported in PubMed since 1908.

Last Updated: 19 Apr 2015

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Outcomes of surgical treatment of primary signet ring cell carcinoma of the colon and rectum: 22 cases reviewed with literature.
 

Author(s): Sedat Belli, Huseyin Ozgur Aytac, Erdal Karagulle, Hakan Yabanoglu, Fazilet Kayaselcuk, Sedat Yildirim

Journal: Int Surg. ;99(6):691-8.

 

Colorectal primary signet ring cell carcinoma (PSRCCR) is a rare entity with a dismal prognosis, mainly because of delayed diagnosis. The objective of this study was to investigate the clinicopathologic features and prognostic factors for PSRCCR. This is a retrospective study including ...

Last Updated: 2 Dec 2014

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Synchronous appendiceal and intramucosal gastric signet ring cell carcinomas in an individual with CDH1-associated hereditary diffuse gastric carcinoma: a case report of a novel association and review of the literature.
 

Author(s): Leslie E Hamilton, Kirsten Jones, Neal Church, Shaun Medlicott

Journal:

 

Hereditary diffuse gastric carcinoma is an autosomal dominant cancer syndrome associated with mutations of the E-cadherin gene (CDH1). E-cadherin is normally involved in cell-cell adhesion, so it not surprising that individuals with this syndrome are predisposed to develop malignancies ...

Last Updated: 19 Jul 2013

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Endodrill vs. Conventional Biopsy. Evaluation of Diagnostic Capacity in Diffuse Gastric Cancer
 

Status: Not yet recruiting

Condition Summary: Stomach Neoplasms

 

Last Updated: 5 Apr 2016

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Hereditary Colorectal and Associated Tumor Registry Study
 

Status: Recruiting

Condition Summary: Lynch Syndrome; FAP; Hereditary Diffuse Gastric Cancer; Juvenile Polyposis Syndrome; Peutz-Jeghers Syndrome

 

Last Updated: 14 Jan 2016

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Evaluation of Surgery Versus Primary Chemotherapy in Resectable Signet Ring Cell Gastric Adenocarcinoma
 

Status: Recruiting

Condition Summary: Signet Ring Cell Gastric Adenocarcinoma

 

Last Updated: 8 Feb 2016

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