Signet ring cell carcinoma

Common Name(s)

Signet ring cell carcinoma, Diffuse gastric cancer

Signet ring cell carcinoma (SRCC) is a rare form of cancer that usually affects the stomach. SRCC is a type of adenocarcinoma, which means that it affects gland cells that are located on the lining of organs (epithelial cells). Cancer is diagnosed by taking a biopsy (or sample) of the tissue and looking at it under a microscope. SRCC is diagnosed when a doctor finds that many of the cells are signet ring cells. Signet ring cells were given their name because they look like old signet rings that were used to place a seal in wax, often used to seal envelopes. These cells have very large spaces used for storage (vacuoles) in the center, which give them their characteristic appearance. SRCC usually starts to grow in the stomach and can spread to other organs such as the lungs, ovaries, or intestines.

Because SRCC usually affects the stomach, common symptoms include abdominal pain, nausea, vomiting, blood in the vomit or stool, loss of appetite, weight loss, and feeling full after eating small meals (early satiety). This cancer has been linked to a mutation in the CDH1 gene, and therefore a family history of this disease may put you at greater risk for developing SRCC. SRCC affects women more than men and can be found in young adults.

If you are experiencing these symptoms, your doctor may ask about your family history and perform diagnostic tests, such as taking a biopsy of the stomach. This type of cancer can be very dangerous if it is not detected early, so it is very important to see your doctor if you are experiencing these symptoms. Chemotherapy has not proved very effective in fighting this type of cancer. Talk to your doctor about the most current treatment options. Speaking with a genetic counselor may also be helpful to discuss how SRCC is passed through families and possible genetic testing options. Support groups can also be a good source of information and comfort.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Signet ring cell carcinoma" for support, advocacy or research.

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Signet ring cell carcinoma" returned 112 free, full-text research articles on human participants. First 3 results:

Signet ring cell carcinoma of early gastric cancer, is endoscopic treatment really risky?
 

Author(s): Sun Hyung Kang, Joo Seok Kim, Hee Seok Moon, Eaum Seok Lee, Seok Hyun Kim, Jae Kyu Sung, Byung Seok Lee, Hyun Yong Jeong

Journal: Medicine (Baltimore). 2017 Aug;96(33):e7532.

 

Signet ring cell carcinoma (SRC) is a poorly differentiated cancer of the stomach. Generally, poorly differentiated cancer is believed to show poor prognosis and aggressive behavior. Recently, however, there is debate on the aggressiveness of SRC in early gastric cancer (EGC). We ...

Last Updated: 17 Aug 2017

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Survival predictors associated with signet ring cell carcinoma of the esophagus (SRCCE): A population-based retrospective cohort study.
 

Author(s): Zihao Wan, Zhihao Huang, Liaobin Chen

Journal:

 

Signet ring cell carcinoma of the esophagus (SRCCE) is an uncommon tumor associated with significant morbidity and mortality. There is still no consensus regarding cut-off values for tumor size, age and optimal treatment for SRCCE. Thus, we elucidated the current survival outcomes ...

Last Updated: 26 Jul 2017

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The clinicopathological features and prognosis of signet ring cell carcinoma of the esophagus: A 10-year retrospective study in China.
 

Author(s): Lei Chen, Xi Liu, Linggen Gao, Rong Wang, Dewei Gao, Dongyu Bai

Journal:

 

The aim of this study was to analyze the clinicopathological features and prognosis of esophageal signet ring cell (SRC) carcinoma in China.

Last Updated: 9 May 2017

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Signet ring cell carcinoma" returned 35 free, full-text review articles on human participants. First 3 results:

Immature enteric ganglion cells were observed in a 13-year-old colon signet ring cell carcinoma patient: A case report and literature review.
 

Author(s): Huili Li, Kun Huang, Hui Wang, Lin Wang, Ming Yang, Lixia Wang, Rong Lin, Hongli Liu, Jinbo Gao, Xiaoming Shuai, Xinghua Liu, Kaixiong Tao, Guobin Wang, Zheng Wang

Journal: Medicine (Baltimore). 2017 Jun;96(25):e7036.

 

All the enteric ganglion cells are fully mature by 2 to 5 years of age in human. No one had reported the presentation of immature enteric ganglion cells in elder ones. Colorectal carcinoma is also rare in the adolescent population. The coincidence of these 2 rare events in a 13-year-old ...

Last Updated: 22 Jun 2017

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Intracranial hypertension as the primary symptom of gastric signet-ring cell carcinoma: A case report and literature review.
 

Author(s): Jiali Pu, Lingjia Xu, Xinzhen Yin, Baorong Zhang

Journal: Medicine (Baltimore). 2016 Aug;95(35):e4687.

 

Intracranial hypertension (IH) is a neurological disorder characterized by increased intracranial pressure. It is a poorly understood syndrome that most commonly manifests nonspecific symptoms such as stroke-like headache, vision changes, nausea, vomiting, and papilledema. IH has ...

Last Updated: 2 Sep 2016

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Signet-ring cell carcinoma of the stomach: Impact on prognosis and specific therapeutic challenge.
 

Author(s): Simon Pernot, Thibault Voron, Geraldine Perkins, Christine Lagorce-Pages, Anne Berger, Julien Taieb

Journal: World J. Gastroenterol.. 2015 Oct;21(40):11428-38.

 

While the incidence of gastric cancer has decreased worldwide in recent decades, the incidence of signet-ring cell carcinoma (SRCC) is rising. SRCC has a specific epidemiology and oncogenesis and has two forms: early gastric cancer, which can be resected endoscopically in some cases ...

Last Updated: 2 Nov 2015

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Endodrill vs. Conventional Biopsy. Evaluation of Diagnostic Capacity in Diffuse Gastric Cancer
 

Status: Not yet recruiting

Condition Summary: Stomach Neoplasms

 

Last Updated: 4 Sep 2017

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Talimogene Laherparepvec and Nivolumab in Treating Patients With Refractory Lymphomas or Advanced or Refractory Non-melanoma Skin Cancers
 

Status: Recruiting

Condition Summary: Adenoid Cystic Carcinoma; Adnexal Carcinoma; Apocrine Carcinoma; Eccrine Porocarcinoma; Extraocular Cutaneous Sebaceous Carcinoma; Hidradenocarcinoma; Keratoacanthoma; Malignant Sweat Gland Neoplasm; Merkel Cell Carcinoma; Microcystic Adnexal Carcinoma; NK-Cell Lymphoma, Unclassifiable; Non-Melanomatous Lesion; Paget Disease; Papillary Adenocarcinoma; Primary Cutaneous Mucinous Carcinoma; Refractory Anaplastic Large Cell Lymphoma; Refractory Mature T-Cell and NK-Cell Non-Hodgkin Lymphoma; Refractory Mycosis Fungoides; Refractory Primary Cutaneous T-Cell Non-Hodgkin Lymphoma; Refractory T-Cell Non-Hodgkin Lymphoma; Sezary Syndrome; Signet Ring Cell Carcinoma; Skin Basal Cell Carcinoma; Skin Basosquamous Cell Carcinoma; Skin Squamous Cell Carcinoma; Spiradenocarcinoma; Squamous Cell Carcinoma of Unknown Primary Origin; Stage III Skin Cancer; Stage IV Skin Cancer; Sweat Gland Carcinoma; Trichilemmocarcinoma; Vulvar Squamous Cell Carcinoma

 

Last Updated: 9 Oct 2017

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Hereditary Colorectal and Associated Tumor Registry Study
 

Status: Recruiting

Condition Summary: Lynch Syndrome; FAP; Hereditary Diffuse Gastric Cancer; Juvenile Polyposis Syndrome; Peutz-Jeghers Syndrome

 

Last Updated: 21 Jul 2017

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