Signet ring cell carcinoma

Common Name(s)

Signet ring cell carcinoma, Diffuse gastric cancer

Diffuse gastric cancer is a type of cancer found most often in the glandular cells lining the stomach, but can also develop in the bowel, breast, pancreas, bladder, prostate or lung. The term "signet ring cell" is often used because the cells look like signet rings when viewed under a microscope. The signet cells are a type of epithelial cell. Epithelial tissue is skin tissue, covering and lining the body both inside and out.  
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Signet ring cell carcinoma" for support, advocacy or research.

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Signet ring cell carcinoma" returned 74 free, full-text research articles on human participants. First 3 results:

Signet-ring cell carcinoma of the gallbladder complicated by pulmonary tumor thrombotic microangiopathy.
 

Author(s): Yoshinori Ohno, Teru Kumagi, Taira Kuroda, Mitsuhito Koizumi, Nobuaki Azemoto, Hirofumi Yamanishi, Mayu Oda, Masashi Hirooka, Masanori Abe, Yoshio Ikeda, Bunzo Matsuura, Morikazu Onji, Yoshiko Soga, Yousuke Mizuno, Atsurou Sugita, Yoichi Hiasa

Journal: Intern. Med.. 2014 ;53(11):1125-9.

 

Biliary drainage was performed in a 71-year-old man with obstructive jaundice of unknown origin; however, he died due to acute pulmonary failure. At autopsy, proliferation of adenocarcinoma cells was observed in the gallbladder mucosa transitioning from isolated signet-ring cell carcinoma ...

Last Updated: 2 Jun 2014

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TAZ is highly expressed in gastric signet ring cell carcinoma.
 

Author(s): Guofeng Yue, Xia Sun, Ana Gimenez-Capitan, Jie Shen, Lixia Yu, Cristina Teixido, Wenxian Guan, Rafael Rosell, Baorui Liu, Jia Wei

Journal: Biomed Res Int. 2014 ;2014():393064.

 

Transcriptional coactivator with PDZ-binding motif (TAZ) is known to bind to a variety of transcription factors to control cell differentiation and organ development. We examined TAZ protein levels in 146 stage II-IV gastric cancer using immunohistochemistry (IHC), while TAZ mRNA ...

Last Updated: 7 Apr 2014

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Synchronous diagnosis of signet ring cell colon carcinoma and transitional carcinoma of the left distal ureter.
 

Author(s): Liliana Streba, Corina Gruia, S S Mogoantă, P Mitruţ, Letiţia Adela-Maria Streba, Adriana Bold

Journal: Rom J Morphol Embryol. 2013 ;54(3):629-34.

 

The presence of synchronous multiple primary carcinomas, although recognized, remains very uncommon. Their etiopathogeny is unclear. The wide spread of imaging techniques currently facilitates diagnosis of simultaneous tumors. We present the rare case of a signet ring cell colon carcinoma ...

Last Updated: 26 Sep 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Signet ring cell carcinoma" returned 11 free, full-text review articles on human participants. First 3 results:

Synchronous appendiceal and intramucosal gastric signet ring cell carcinomas in an individual with CDH1-associated hereditary diffuse gastric carcinoma: a case report of a novel association and review of the literature.
 

Author(s): Leslie E Hamilton, Kirsten Jones, Neal Church, Shaun Medlicott

Journal:

 

Hereditary diffuse gastric carcinoma is an autosomal dominant cancer syndrome associated with mutations of the E-cadherin gene (CDH1). E-cadherin is normally involved in cell-cell adhesion, so it not surprising that individuals with this syndrome are predisposed to develop malignancies ...

Last Updated: 19 Jul 2013

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Early-stage primary signet ring cell carcinoma of the colon.
 

Author(s): Jae Hyun Kim, Seun Ja Park, Moo In Park, Won Moon, Sung Eun Kim

Journal: World J. Gastroenterol.. 2013 Jun;19(24):3895-8.

 

Primary signet ring cell carcinoma of the colorectum detected at an early stage is very rare; most cases are detected at an advanced stage. Therefore, its prognosis is poorer than that of ordinary colorectal cancer. A 56-year-old Korean man was seen at this hospital for management ...

Last Updated: 10 Jul 2013

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A new case of primary signet-ring cell carcinoma of the cervix with prominent endometrial and myometrial involvement: Immunohistochemical and molecular studies and review of the literature.
 

Author(s): Giovanna Giordano, Silvia Pizzi, Roberto Berretta, Tiziana D'Adda

Journal:

 

As a rule, endocervical tumours with signet-ring cell are classed as metastatic extra-genital neoplasms. In a patient aged 45 years, we describe primary cervical signet-ring cell carcinoma (PCSRCC) characterized by prominent endometrial and myometrial involvement, simulating primary ...

Last Updated: 6 Apr 2012

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Evaluation of Surgery Versus Primary Chemotherapy in Resectable Signet Ring Cell Gastric Adenocarcinoma
 

Status: Recruiting

Condition Summary: Signet Ring Cell Gastric Adenocarcinoma

 

Last Updated: 13 Aug 2015

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Last Updated: 13 Aug 2015

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Trial Evaluating Surgery With Hyperthermic Intraperitoneal Chemotherapy (HIPEC) in Treating Patients With a High Risk of Developing Colorectal Peritoneal Carcinomatosis
 

Status: Not yet recruiting

Condition Summary: Malignant Neoplasm of Large Intestine TNM Staging Primary Tumor (T) T4; Metastases to Ovary; Peritoneal Carcinomatosis

 

Last Updated: 30 Jun 2014

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