Sickle Cell Trait

Common Name(s)

Sickle Cell Trait

Sickle cell trait occurs when an individual inherits one copy of the sickle cell hemoglobin gene and one normal, or unchanged, copy of the hemoglobin gene. Hemoglobin is inside red blood cells and helps carry oxygen around to all parts of body. An individual with sickle cell trait does not have sickle cell disease, but is a trait carrier. Sickle cell disease only occurs when an individual inherits two copies of the sickle cell gene. The majority of people with sickle cell trait will be free of symptoms and will live a normal life. Sometimes individuals with sickle cell trait may have some of the health complications seen in sickle cell disease. Certain conditions such as high altitude, low oxygen level, dehydration, increased pressure in the atmosphere, or very intense physical activity can increase the risk that these symptoms occur in some people with sickle cell trait. About 1 in 12 African Americans and 1 in 100 Latinos has sickle cell trait. However, it is possible for anyone of any race or nationality to be a carrier for sickle cell disease.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Sickle Cell Trait" for support, advocacy or research.

North Alabama Sickle Cell Foundation, Inc.

North Alabama Sickle Cell’s mission is to aid and enhance the lives of those affected by Sickle Cell and associated disorders through the provision of supportive services, education and advocacy.

Last Updated: 16 Jan 2014

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Sickle Cell Disease Association of America, Southern Connecticut, Inc.

The Sickle Cell Disease Association of America Southern Connecticut Inc. mission is to provide education,screening, counseling,and support services to persons affected with sickle cell disease and the trait.

Last Updated: 3 May 2014

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William E. Proudford Sickle Cell Fund, Inc.

Our mission is to support sickle cell awareness, education, state-of-the-art treatment and research, and to bring hope to families affected by this devastating disease.

Last Updated: 30 May 2015

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The Baton Rouge Sickle Cell Anemia Foundation, Inc.

The Foundation is proud of its ongoing efforts to meet and exceed its established mission by bringing innovative and creative programs (1) to provide financial and advocacy supportive services to persons diagnosed with sickle cell disease; (2) to provide treatment support to enhance the quality of life for those suffering from sickle cell disease; and (3) to educate the general public about sickle cell disease.

Last Updated: 5 Mar 2013

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American Sickle Cell Anemia Association

ASCAA is an organization that provides quality and comprehensive services through diagnostic testing, evaluation, couseling, and supportive services to individuals and families at-risk for sickle cell disease.

Last Updated: 1 Jun 2015

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Sickle Cell Disease Association of Illinois

Our primary mission is to enhance the quality of life for people with sickle cell disease and their families. To effectively achieve this goal, the Sickle Cell Disease Association of Illinois (SCDAI) acts as an advocate for improved health care and services for individuals with sickle cell by educating and informing the community through outreach programs.

Last Updated: 4 Oct 2013

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Sickle Cell Disease Foundation of California

To provide education and life-enhancing programs and services to individuals with sickle cell disease, to broaden public awareness about sickle cell disease and to promote medical research and education to ultimately find a cure.

Last Updated: 27 Mar 2013

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Sickle Cell Society

Our vision is to be the most successful sickle cell organisation nationally with a wide network of well-informed, committed and active supporters working at local, national and international levels. We will be better able to empower and assist people with sickle cell disorders to achieve their full economic and social potential.

Last Updated: 23 Jun 2015

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Sickle Cell/Thalassemia Patients Network

SCTPN is dedicated to improving the quality of life for individuals and their families living with sickle cell disease, thalassemia, and other hemoglobin variants by providing services that will help to reduce the negative physical, emotional, educational, social, and economic impact of debilitating hemoglobinopathies.

Last Updated: 1 Jun 2015

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Sickle Cell Trait" for support, advocacy or research.

North Alabama Sickle Cell Foundation, Inc.

North Alabama Sickle Cell’s mission is to aid and enhance the lives of those affected by Sickle Cell and associated disorders through the provision of supportive services, education and advocacy.

http://sicklecellna.org

Last Updated: 16 Jan 2014

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Sickle Cell Disease Association of America, Southern Connecticut, Inc.

The Sickle Cell Disease Association of America Southern Connecticut Inc. mission is to provide education,screening, counseling,and support services to persons affected with sickle cell disease and the trait.

http://www.scdaaofsouthernct.org/

Last Updated: 3 May 2014

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William E. Proudford Sickle Cell Fund, Inc.

Our mission is to support sickle cell awareness, education, state-of-the-art treatment and research, and to bring hope to families affected by this devastating disease.

http://www.wepsicklecell.org

Last Updated: 30 May 2015

View Details
The Baton Rouge Sickle Cell Anemia Foundation, Inc.

The Foundation is proud of its ongoing efforts to meet and exceed its established mission by bringing innovative and creative programs (1) to provide financial and advocacy supportive services to persons diagnosed with sickle cell disease; (2) to provide treatment support to enhance the quality of life for those suffering from sickle cell disease; and (3) to educate the general public about sickle cell disease.

http://brscaf.org

Last Updated: 5 Mar 2013

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American Sickle Cell Anemia Association

ASCAA is an organization that provides quality and comprehensive services through diagnostic testing, evaluation, couseling, and supportive services to individuals and families at-risk for sickle cell disease.

http://www.ascaa.org

Last Updated: 1 Jun 2015

View Details
Sickle Cell Disease Association of Illinois

Our primary mission is to enhance the quality of life for people with sickle cell disease and their families. To effectively achieve this goal, the Sickle Cell Disease Association of Illinois (SCDAI) acts as an advocate for improved health care and services for individuals with sickle cell by educating and informing the community through outreach programs.

http://www.scdai.org

Last Updated: 4 Oct 2013

View Details
Sickle Cell Disease Foundation of California

To provide education and life-enhancing programs and services to individuals with sickle cell disease, to broaden public awareness about sickle cell disease and to promote medical research and education to ultimately find a cure.

http://www.scdfc.org/

Last Updated: 27 Mar 2013

View Details
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Sickle Cell Society

Our vision is to be the most successful sickle cell organisation nationally with a wide network of well-informed, committed and active supporters working at local, national and international levels. We will be better able to empower and assist people with sickle cell disorders to achieve their full economic and social potential.

http://www.sicklecellsociety.org/

Last Updated: 23 Jun 2015

View Details
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Sickle Cell/Thalassemia Patients Network

SCTPN is dedicated to improving the quality of life for individuals and their families living with sickle cell disease, thalassemia, and other hemoglobin variants by providing services that will help to reduce the negative physical, emotional, educational, social, and economic impact of debilitating hemoglobinopathies.

http://sctpn.org

Last Updated: 1 Jun 2015

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Sickle Cell Trait" returned 190 free, full-text research articles on human participants. First 3 results:

[Susceptibility of induced sickle in samples of heterozygous hemoglobin S patients (sickle cell trait) suffering diabetes mellitus type 2].
 

Author(s): Pablo Díaz-Piedra, Alberto Rafael Cervantes-Villagrana, Raúl Ramos-Jiménez, José Miguel Presno-Bernal, Rodolfo Daniel Cervantes-Villagrana

Journal: Gac Med Mex. ;151(6):757-63.

 

Hemoglobin S is an abnormal protein that induces morphological changes in erythrocyte in low-oxygen conditions. In Mexico, it is reported that up to 13.7% of the population with mutation in one allele are considered asymptomatic (sickle cell trait). The sickle cell trait and diabetes ...

Last Updated: 20 Nov 2015

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Eligibility and Disqualification Recommendations for Competitive Athletes With Cardiovascular Abnormalities: Task Force 14: Sickle Cell Trait: A Scientific Statement From the American Heart Association and American College of Cardiology.
 

Author(s): Barry J Maron, Kevin M Harris, Paul D Thompson, E Randy Eichner, Martin H Steinberg

Journal: J. Am. Coll. Cardiol.. 2015 Dec;66(21):2444-6.

 

Last Updated: 27 Nov 2015

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Coagulation activation in sickle cell trait: an exploratory study.
 

Author(s): Chirag Amin, Soheir Adam, Micah J Mooberry, Abdullah Kutlar, Ferdane Kutlar, Denise Esserman, Julia E Brittain, Kenneth I Ataga, Jen-Yea Chang, Alisa S Wolberg, Nigel S Key

Journal: Br. J. Haematol.. 2015 Nov;171(4):638-46.

 

Recent epidemiologic data suggest that sickle cell trait (HbAS; AS) is a risk factor for venous thromboembolism. We conducted an exploratory study of healthy subjects with AS under baseline conditions to determine whether a chronic basal hyperactivation of coagulation exists, and ...

Last Updated: 29 Oct 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Sickle Cell Trait" returned 7 free, full-text review articles on human participants. First 3 results:

Negative health implications of sickle cell trait in high income countries: from the football field to the laboratory.
 

Author(s): Nigel S Key, Philippe Connes, Vimal K Derebail

Journal: Br. J. Haematol.. 2015 Jul;170(1):5-14.

 

Worldwide, sickle cell trait is a highly prevalent gene carrier state. While generally a benign condition with a normal life expectancy, it is becoming increasingly clear that the sickle trait is associated with certain adverse outcomes. This article will focus on three of these outcomes, ...

Last Updated: 22 Jun 2015

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Biochemical and immunological mechanisms by which sickle cell trait protects against malaria.
 

Author(s): Lauren Gong, Sunil Parikh, Philip J Rosenthal, Bryan Greenhouse

Journal:

 

Sickle cell trait (HbAS) is the best-characterized genetic polymorphism known to protect against falciparum malaria. Although the protective effect of HbAS against malaria is well known, the mechanism(s) of protection remain unclear. A number of biochemical and immune-mediated mechanisms ...

Last Updated: 15 Nov 2013

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Framing the research agenda for sickle cell trait: building on the current understanding of clinical events and their potential implications.
 

Author(s): Jonathan C Goldsmith, Vence L Bonham, Clinton H Joiner, Gregory J Kato, Allan S Noonan, Martin H Steinberg

Journal: Am. J. Hematol.. 2012 Mar;87(3):340-6.

 

Sickle Cell Trait (HbAS), the heterozygous state for the sickle hemoglobin beta globin gene is carried by as many as 100 million individuals including up to 25% of the population in some regions of the world (World Health Organization, Provisional agenda item 4.8, EB117/34 (22 December ...

Last Updated: 14 Feb 2012

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Sickle Cell Trait in Football Players
 

Status: Recruiting

Condition Summary: Sickle Cell Trait

 

Last Updated: 17 Oct 2014

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Sickle Cell Hemoglobinopathies and Bone Health
 

Status: Recruiting

Condition Summary: Sickle Cell Disease; Sickle Cell Trait

 

Last Updated: 14 Mar 2016

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Collection and Storage of Umbilical Cord Stem Cells for Treatment of Sickle Cell Disease
 

Status: Recruiting

Condition Summary: Sickle Cell Disease; Sickle Cell Trait

 

Last Updated: 11 May 2016

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