Sickle Cell Trait

Common Name(s)

Sickle Cell Trait

Sickle cell trait occurs when an individual inherits one copy of the sickle cell hemoglobin gene and one normal, or unchanged, copy of the hemoglobin gene. Hemoglobin is inside red blood cells and helps carry oxygen around to all parts of body. An individual with sickle cell trait does not have sickle cell disease, but is a trait carrier. Sickle cell disease only occurs when an individual inherits two copies of the sickle cell gene. The majority of people with sickle cell trait will be free of symptoms and will live a normal life. Sometimes individuals with sickle cell trait may have some of the health complications seen in sickle cell disease. Certain conditions such as high altitude, low oxygen level, dehydration, increased pressure in the atmosphere, or very intense physical activity can increase the risk that these symptoms occur in some people with sickle cell trait. About 1 in 12 African Americans and 1 in 100 Latinos has sickle cell trait. However, it is possible for anyone of any race or nationality to be a carrier for sickle cell disease.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Sickle Cell Trait" for support, advocacy or research.

North Alabama Sickle Cell Foundation, Inc.

North Alabama Sickle Cell’s mission is to aid and enhance the lives of those affected by Sickle Cell and associated disorders through the provision of supportive services, education and advocacy.

Last Updated: 16 Jan 2014

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Sickle Cell Disease Association of America, Southern Connecticut, Inc.

The Sickle Cell Disease Association of America Southern Connecticut Inc. mission is to provide education,screening, counseling,and support services to persons affected with sickle cell disease and the trait.

Last Updated: 3 May 2014

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William E. Proudford Sickle Cell Fund, Inc.

Our mission is to support sickle cell awareness, education, state-of-the-art treatment and research, and to bring hope to families affected by this devastating disease.

Last Updated: 14 Jan 2014

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The Baton Rouge Sickle Cell Anemia Foundation, Inc.

The Foundation is proud of its ongoing efforts to meet and exceed its established mission by bringing innovative and creative programs (1) to provide financial and advocacy supportive services to persons diagnosed with sickle cell disease; (2) to provide treatment support to enhance the quality of life for those suffering from sickle cell disease; and (3) to educate the general public about sickle cell disease.

Last Updated: 5 Mar 2013

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American Sickle Cell Anemia Association

ASCAA is an organization that provides quality and comprehensive services through diagnostic testing, evaluation, couseling, and supportive services to individuals and families at-risk for sickle cell disease.

Last Updated: 11 Feb 2013

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Sickle Cell Disease Association of Illinois

Our primary mission is to enhance the quality of life for people with sickle cell disease and their families. To effectively achieve this goal, the Sickle Cell Disease Association of Illinois (SCDAI) acts as an advocate for improved health care and services for individuals with sickle cell by educating and informing the community through outreach programs.

Last Updated: 4 Oct 2013

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Sickle Cell Disease Foundation of California

To provide education and life-enhancing programs and services to individuals with sickle cell disease, to broaden public awareness about sickle cell disease and to promote medical research and education to ultimately find a cure.

Last Updated: 27 Mar 2013

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Sickle Cell/Thalassemia Patients Network

SCTPN is dedicated to improving the quality of life for individuals and their families living with sickle cell disease, thalassemia, and other hemoglobin variants by providing services that will help to reduce the negative physical, emotional, educational, social, and economic impact of debilitating hemoglobinopathies.

Last Updated: 17 Oct 2011

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Sickle Cell Trait" for support, advocacy or research.

North Alabama Sickle Cell Foundation, Inc.

North Alabama Sickle Cell’s mission is to aid and enhance the lives of those affected by Sickle Cell and associated disorders through the provision of supportive services, education and advocacy.

http://sicklecellna.org

Last Updated: 16 Jan 2014

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Sickle Cell Disease Association of America, Southern Connecticut, Inc.

The Sickle Cell Disease Association of America Southern Connecticut Inc. mission is to provide education,screening, counseling,and support services to persons affected with sickle cell disease and the trait.

http://www.scdaaofsouthernct.org/

Last Updated: 3 May 2014

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William E. Proudford Sickle Cell Fund, Inc.

Our mission is to support sickle cell awareness, education, state-of-the-art treatment and research, and to bring hope to families affected by this devastating disease.

http://www.wepsicklecell.org

Last Updated: 14 Jan 2014

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The Baton Rouge Sickle Cell Anemia Foundation, Inc.

The Foundation is proud of its ongoing efforts to meet and exceed its established mission by bringing innovative and creative programs (1) to provide financial and advocacy supportive services to persons diagnosed with sickle cell disease; (2) to provide treatment support to enhance the quality of life for those suffering from sickle cell disease; and (3) to educate the general public about sickle cell disease.

http://brscaf.org

Last Updated: 5 Mar 2013

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American Sickle Cell Anemia Association

ASCAA is an organization that provides quality and comprehensive services through diagnostic testing, evaluation, couseling, and supportive services to individuals and families at-risk for sickle cell disease.

http://www.ascaa.org

Last Updated: 11 Feb 2013

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Sickle Cell Disease Association of Illinois

Our primary mission is to enhance the quality of life for people with sickle cell disease and their families. To effectively achieve this goal, the Sickle Cell Disease Association of Illinois (SCDAI) acts as an advocate for improved health care and services for individuals with sickle cell by educating and informing the community through outreach programs.

http://www.scdai.org

Last Updated: 4 Oct 2013

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Sickle Cell Disease Foundation of California

To provide education and life-enhancing programs and services to individuals with sickle cell disease, to broaden public awareness about sickle cell disease and to promote medical research and education to ultimately find a cure.

http://www.scdfc.org/

Last Updated: 27 Mar 2013

View Details
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Sickle Cell/Thalassemia Patients Network

SCTPN is dedicated to improving the quality of life for individuals and their families living with sickle cell disease, thalassemia, and other hemoglobin variants by providing services that will help to reduce the negative physical, emotional, educational, social, and economic impact of debilitating hemoglobinopathies.

http://sctpn.org

Last Updated: 17 Oct 2011

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Sickle Cell Trait" returned 132 free, full-text research articles on human participants. First 3 results:

Asymptomatic bacteriuria among pregnant women with sickle cell trait in Enugu, South Eastern Nigeria.
 

Author(s): C C Obiora, C C Dim, H U Ezegwui, E E Nwogu-Ikojo, C Okeudo

Journal: Niger J Clin Pract. ;17(1):95-9.

 

Asymptomatic bacteriuria (ASB) in pregnancy is a major risk factor for developing acute cystitis and pyelonephritis, especially, among women with sickle cell disease. This study compared the prevalence, pattern, and microbiological characteristics of ASB in pregnancy between sickle ...

Last Updated: 11 Dec 2013

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Solid pseudopapillary tumor of pancreas with sickle cell trait: a rare case report.
 

Author(s): Harish S Permi, H L Kishan Prasad, Balakrishna N Shetty, B Preetham Rai, U Raghuraja, Shubha Bhat

Journal: J Cancer Res Ther. ;9(3):537-40.

 

Solid pseudopapillary tumor of pancreas is a rare pancreatic neoplasm affecting young women, has low malignant potential and amenable for surgical excision with good long-term survival. Sickle cell trait is benign condition, which involves one normal beta-globin chain and one HbS ...

Last Updated: 15 Oct 2013

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Reproductive health choices for young adults with sickle cell disease or trait: randomized controlled trial immediate posttest effects.
 

Author(s): Diana J Wilkie, Agatha M Gallo, Yingwei Yao, Robert E Molokie, Christine Stahl, Patricia E Hershberger, Zhongsheng Zhao, Marie L Suarez, Robert J Labotka, Bonnye Johnson, Rigo Angulo, Veronica Angulo, Jesus Carrasco, David Shuey, Stephanie Pelligra, Edward Wang, Dennie T Rogers, Alexis A Thompson

Journal: Nurs Res. ;62(5):352-61.

 

People with sickle cell disease (SCD) or sickle cell trait (SCT) may not have information about genetic inheritance needed for making informed reproductive health decisions. CHOICES is a Web-based, multimedia educational intervention that provides information about reproductive options ...

Last Updated: 2 Sep 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Sickle Cell Trait" returned 7 free, full-text review articles on human participants. First 3 results:

Sickle cell trait testing and athletic participation: a solution in search of a problem?
 

Author(s): Alexis A Thompson

Journal: Hematology Am Soc Hematol Educ Program. 2013 ;2013():632-7.

 

Carriers of a single sickle cell gene mutation generally enjoy normal lifespans without serious health consequences related to their sickle cell status, but under extreme conditions such as severe dehydration and high-intensity physical activity, complications such as exertional rhabdomyolysis, ...

Last Updated: 9 Dec 2013

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Biochemical and immunological mechanisms by which sickle cell trait protects against malaria.
 

Author(s): Lauren Gong, Sunil Parikh, Philip J Rosenthal, Bryan Greenhouse

Journal:

 

Sickle cell trait (HbAS) is the best-characterized genetic polymorphism known to protect against falciparum malaria. Although the protective effect of HbAS against malaria is well known, the mechanism(s) of protection remain unclear. A number of biochemical and immune-mediated mechanisms ...

Last Updated: 15 Nov 2013

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Framing the research agenda for sickle cell trait: building on the current understanding of clinical events and their potential implications.
 

Author(s): Jonathan C Goldsmith, Vence L Bonham, Clinton H Joiner, Gregory J Kato, Allan S Noonan, Martin H Steinberg

Journal: Am. J. Hematol.. 2012 Mar;87(3):340-6.

 

Sickle Cell Trait (HbAS), the heterozygous state for the sickle hemoglobin beta globin gene is carried by as many as 100 million individuals including up to 25% of the population in some regions of the world (World Health Organization, Provisional agenda item 4.8, EB117/34 (22 December ...

Last Updated: 14 Feb 2012

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Sickle Cell Trait in Football Players
 

Status: Recruiting

Condition Summary: Sickle Cell Trait

 

Last Updated: 17 Oct 2014

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Last Updated: 10 Sep 2014

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Natural History of Sickle Cell Disease and Other Hemolytic Disorders
 

Status: Recruiting

Condition Summary: Hemoglobin SC Disease; Hematologic Diseases; Sickle Cell Anemia; Hemolytic Anemia

 

Last Updated: 11 Nov 2014

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