Shy-Drager syndrome

Common Name(s)

Shy-Drager syndrome, Multiple system atrophy (MSA) with orthostatic hypotension

Multiple system atrophy with orthostatic hypotension is the current classification for a neurological disorder that was once called Shy-Drager syndrome. A progressive disorder of the central and autonomic nervous systems, it is characterized by orthostatic hypotension (an excessive drop in blood pressure when standing up) which causes dizziness or fainting. Multiple system atrophy can occur without orthostatic hypotension, but it is rare. Doctors classify the disorder into 3 types: the Parkinsonian-type includes symptoms of Parkinson's disease such as slow movement, stiff muscles, and tremor; the cerebellar-type, which causes problems with coordination and speech; and the combined-type, which includes symptoms of both parkinsonism and cerebellar failure. The cause of multiple system atrophy is unknown, although environmental toxins, trauma, and genetic factors have been suggested.  There is no cure for this condition, and there is no known way to prevent the disease from getting worse. The goal of treatment is to control symptoms.  
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Shy-Drager syndrome" for support, advocacy or research.

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National MSA Support Group

The MSA Support Group has a four pillar mission statement: 1) To support patients and caregivers 2) To educate patients, caregivers, healthcare providers, and others affected by MSA 3) To raise money for MSA research 4) to advocate and create awareness for MSA

Last Updated: 16 Nov 2012

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Shy-Drager syndrome" for support, advocacy or research.

Logo
National MSA Support Group

The MSA Support Group has a four pillar mission statement: 1) To support patients and caregivers 2) To educate patients, caregivers, healthcare providers, and others affected by MSA 3) To raise money for MSA research 4) to advocate and create awareness for MSA

http://www.shy-drager.org

Last Updated: 16 Nov 2012

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General Support Organizations

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General Resources

The MSA Research Fund

The MSA Research Fund is the National MSA Support Group's fund dedicated to supporting meaningful MSA research. The Support Group is a 501(c)3 so donations are tax deductible.

Updated 16 Nov 2012

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The MSA Forum

The MSA Forum is hosted by the National MSA Support Group. The forum offers an opportunity for patients and caregivers to communicate and share with others affected by MSA.

Updated 16 Nov 2012

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Blogs

The MSA Blog

The multiple system atrophy MSA) blog is dedicated to providing relevant information about support, education, research and advocacy to those affected by MSA

Updated 16 Nov 2012

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Shy-Drager syndrome" returned 25 free, full-text research articles on human participants. First 3 results:

From orthostatic hypotension to Shy-Drager syndrome.
 

Author(s): J M S Pearce

Journal: J. Neurol. Neurosurg. Psychiatr.. 2004 Dec;75(12):1666.

 

Last Updated: 19 Nov 2004

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Correlative studies of MR findings with neuropathology in Shy-Drager syndrome and striatonigral degeneration.
 

Author(s): X Lu, J Chen, L Wang, Y Liang, Q Gui

Journal: Chin. Med. J.. 1997 Aug;110(8):628-31.

 

To determine the pathologic bases of the abnormal signal intensities detected on magnetic resonance imaging (MRI) in Shy-Drager syndrome (SDS) and striatonigral degeneration (SND).

Last Updated: 2 Jun 1998

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Differences in cardiovascular responses to supine exercise and to standing after exercise in two clinical subgroups of Shy-Drager syndrome (multiple system atrophy).
 

Author(s): G D Smith, C J Mathias

Journal: J. Neurol. Neurosurg. Psychiatr.. 1996 Sep;61(3):297-303.

 

In chronic autonomic failure of varying aetiologies, there are differences in the cardiovascular responses to supine leg exercise and to standing after exercise. Whether this occurs between the different subgroups with Shy-Drager syndrome (SDS) is unknown.

Last Updated: 17 Oct 1996

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Shy-Drager syndrome" returned 0 free, full-text review articles on human participants.

 
 
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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

PET Imaging Study of Neurochemical and Autonomic Disorders in Multiple System Atrophy (MSA)
 

Status: Recruiting

Condition Summary: Multiple System Atrophy - Parkinsonian Subtype (MSA-P); Multiple System Atrophy - Cerebellar Subtype (MSA-C)

 

Last Updated: 23 May 2014

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Cognitive and Behavioral Dysexecutive Syndrome in Multiple System Atrophy
 

Status: Recruiting

Condition Summary: Multiple System Atrophy

 

Last Updated: 3 Jul 2014

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Oligomeric Alpha-synuclein in Multiple System Atrophy
 

Status: Recruiting

Condition Summary: Multiple System Atrophy (MSA)

 

Last Updated: 12 Nov 2014

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