Atrioventricular septal defect

Common Name(s)

Atrioventricular septal defect

Atrioventricular septal defects (AVSD) are a group of heart defects present at birth (congenital). Normally the four heart chambers are separated by walls (septum) to keep oxygen rich and oxygen poor blood separate. The blood flow between the chambers is controlled by valves. AVSDs are caused by a hole being present in the upper chambers (atrium) which allows a mixing of blood. AVSDs may also include defects in the AV valves. These birth defects cause the heart to send too much blood to the lungs. The overworked heart enlarges and causes the blood pressure in the lungs to become too high. Ultimately, an AVSD can lead to heart failure.

Common symptoms include difficulty breathing, abnormal heartbeats (arrhythmia), and poor blood circulation, which can cause bluish lips and skin and swelling in the legs (edema). Children with an AVSD may also have poor appetite and become tired easily. Sometimes symptoms may not appear for weeks or months after birth. The causes of AVSDs are believed to be a combination of genetics and environment. Babies with Down syndrome are at an increased risk for developing the condition. Other risk factors include the mother drinking alcohol during pregnancy or poorly controlled maternal diabetes.

Doctors may hear a swishing sound in the heartbeat (a murmur) when listening with a stethoscope. Tests used to confirm a VSD may include a chest X-ray, electrocardiogram (EKG) (tests the electrical impulses), echocardiogram (used sound waves to create a picture), or cardiac MRI.

Smaller defects may close on their own, but the most common treatment is surgical repair. If your baby or child has been diagnosed with an AVSD, talk to their pediatric cardiologist (a heart doctor for children) about the most current treatment options. Support organizations and genetic counselors are also a good source of information and can help connect you with others affected by AVSDs.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Atrioventricular septal defect" for support, advocacy or research.

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Oklahoma Family Network

To Provide emotional, informational and navigational support to those who have special health care needs or a disability, their families and the professionals who serve them. OFN promotes family/professional partnerships and family-centered care, assuring services are offered as recipients prefer..

Last Updated: 15 Apr 2013

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Atrioventricular septal defect" for support, advocacy or research.

Logo
Oklahoma Family Network

To Provide emotional, informational and navigational support to those who have special health care needs or a disability, their families and the professionals who serve them. OFN promotes family/professional partnerships and family-centered care, assuring services are offered as recipients prefer..

http://www.oklahomafamilynetwork.org

Last Updated: 15 Apr 2013

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Atrioventricular septal defect" returned 78 free, full-text research articles on human participants. First 3 results:

Complete atrioventricular septal defect and pulmonary stenosis diagnosed in a 49-year-old woman after 10 uneventful births.
 

Author(s): Firat H Altin, Okan Yildiz, Mehmet Karacalilar, Oyku Tosun, Ozgen Ilgaz Kocyigit, Ersin Erek

Journal:

 

Atrioventricular septal defects constitute 4% of all congenital cardiac malformations. Patients with complete atrioventricular septal defect rarely survive for decades without surgical treatment. Pulmonary stenosis can provide a delicate balance between the pulmonary and systemic ...

Last Updated: 15 Apr 2015

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Left main coronary artery compression syndrome with an incomplete atrioventricular septal defect presenting as angina induced by hyperthyroidism.
 

Author(s): Kenya Kusunose, Noriko Tomita, Susumu Nishio, Mika Bando, Shuji Hayashi, Junko Hotchi, Takashi Iwase, Hirotsugu Yamada, Masataka Sata

Journal: Intern. Med.. 2014 ;53(18):2083-5.

 

We herein report the case of a 29-year-old woman who was diagnosed with incomplete atrioventricular septal defect and extrinsic compression of the left main coronary artery (LMCA) with chest pain due to postpartum thyroiditis. She exhibited chest pain with ST elevation, and coronary ...

Last Updated: 16 Sep 2014

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Contemporary outcomes of complete atrioventricular septal defect repair: analysis of the Society of Thoracic Surgeons Congenital Heart Surgery Database.
 

Author(s): James D St Louis, Upinder Jodhka, Jeffrey P Jacobs, Xia He, Kevin D Hill, Sara K Pasquali, Marshall L Jacobs

Journal: J. Thorac. Cardiovasc. Surg.. 2014 Dec;148(6):2526-31.

 

Contemporary outcomes data for complete atrioventricular septal defect (CAVSD) repair are limited. We sought to describe early outcomes of CAVSD repair across a large multicenter cohort, and explore potential associations with patient characteristics, including age, weight, and genetic syndromes.

Last Updated: 1 Dec 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Atrioventricular septal defect" returned 4 free, full-text review articles on human participants. First 3 results:

In adult patients undergoing redo surgery for left atrioventricular valve regurgitation after atrioventricular septal defect correction, is replacement superior to repair?
 

Author(s): Giacomo Bianchi, Stefano Bevilacqua, Marco Solinas, Mattia Glauber

Journal: Interact Cardiovasc Thorac Surg. 2011 Jun;12(6):1033-9.

 

A best evidence topic in cardiac surgery was written according to a structured protocol. The question addressed was 'In adult patients undergoing redo surgery for left atrioventricular valve regurgitation after atrioventricular septal defect correction, is replacement superior to ...

Last Updated: 10 Jun 2011

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Emergency redo mitral valve replacement and caesarean section in a patient with previous atrioventricular septal defect repair in childhood.
 

Author(s): Mohan P Devbhandari, Ravish Jeeji, Martin Bewsher, Nicholas Odom

Journal: Interact Cardiovasc Thorac Surg. 2009 Jan;8(1):164-5.

 

A 19-year-old primigravida, with a history of mechanical mitral prosthesis at the age of six years following previous repair of an atrioventricular septal defect, presented at 26 weeks' gestation with cardiogenic shock secondary to obstruction of the mitral prosthesis. She underwent ...

Last Updated: 5 Jan 2009

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Atrioventricular septal defect: from fetus to adult.
 

Author(s): Brian Craig

Journal: Heart. 2006 Dec;92(12):1879-85.

 

Last Updated: 19 Nov 2006

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Aberrations in Carnitine Homeostasis in Congenital Heart Disease With Increased Pulmonary Blood Flow
 

Status: Recruiting

Condition Summary: Heart Septal Defects, Ventricular; Atrioventricular Septal Defect

 

Last Updated: 12 Jan 2015

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Acetaminophen for Oxidative Stress After Cardiopulmonary Bypass
 

Status: Recruiting

Condition Summary: Congenital Heart Disease; Cardiopulmonary Bypass

 

Last Updated: 11 Apr 2012

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