Shigellosis

Common Name(s)

Shigellosis

Shigellosis is a contagious illness caused by the Shigella bacterium. There are four different types of Shigella which cause diarrhea. The bacteria are present in the fecal matter (bowel movement) of infected individuals. Shigella bacteria are often spread by touching contaminated hands to the mouth, by eating/drinking contaminated food or water, or through person to person contact. Shigella cannot live outside the body for long. Children, childcare workers, and those with weak immune systems are the most likely to be infected. However, not all infected people develop symptoms.

Symptoms of shigellosis begin 1 to 2 days after exposure to the bacteria and may include fever, diarrhea, and stomach cramps. Symptoms generally last 5 to 7 days. Shigellosis may be difficult to diagnose because the symptoms are common to other illnesses. Lab tests of the stool or fecal matter can determine the bacteria type and if antibiotics will help.

Complications include post-infectious arthritis, blood stream infections, seizures, and hemolytic-uremic syndrome. Post-infectious arthritis symptoms include joint pain, eye irritation, and painful urination, which may last only a few months or may be permanent. Blood stream infections usually occur in individuals with weak immune systems by germs entering the blood stream through damaged lining of the intestines. Children with a high fever may experience seizures. Hemolytic-uremic syndrome occurs when bacteria in the digestive system produce toxins to destroy red blood cells, causing bloody diarrhea.

Treatment for shigellosis includes drinking fluids and rest. In most cases, the body will clear the bacterial infection on its own. Antibiotics may be used in severe cases, although some Shigella bacteria are resistant. Common hygiene methods such as washing hands with soap can reduce the spread of shigellosis. If you are suffering from shigellosis, talk to your doctor about the most current treatment options.

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Condition Specific Organizations

Following organizations serve the condition "Shigellosis" for support, advocacy or research.

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Shigellosis" returned 156 free, full-text research articles on human participants. First 3 results:

Intensified shigellosis epidemic associated with sexual transmission in men who have sex with men--Shigella flexneri and S. sonnei in England, 2004 to end of February 2015.
 

Author(s): I Simms, N Field, C Jenkins, T Childs, V L Gilbart, T J Dallman, P Mook, P D Crook, G Hughes

Journal:

 

Surveillance data suggest an intensification of the shigellosis epidemic associated with sexual transmissionin men who have sex with men (MSM) in England with separate introductions into the population. In 2014, sexual transmission between MSM might have accounted for 97%, 89%, and ...

Last Updated: 8 May 2015

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Clinical and microbiological profiles of shigellosis in children.
 

Author(s): A V Sangeetha, Subhash Chandra Parija, Iharna Mandal, Sriram Krishnamurthy

Journal: J Health Popul Nutr. 2014 Dec;32(4):580-6.

 

Shigellosis presents with varied clinical features are dictated by the species involved, virulence factors of the strain, and the host immune status. We studied the species, virulence genes, and antibiotic susceptibility pattern of the Shigella strains isolated from 33 children aged ...

Last Updated: 21 Apr 2015

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A large outbreak of shigellosis commencing in an internally displaced population, Papua New Guinea, 2013.
 

Author(s): Edwin Benny, Kelly Mesere, Boris I Pavlin, Logan Yakam, Rebecca Ford, Mition Yoannes, Debbie Kisa, Mohammad Y Abdad, Lincoln Menda, Andrew R Greenhill, Paul F Horwood

Journal:

 

The objective of this study was to investigate a large outbreak of shigellosis in Papua New Guinea that began in a camp for internally displaced persons before spreading throughout the general community.

Last Updated: 4 Feb 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Shigellosis" returned 8 free, full-text review articles on human participants. First 3 results:

Causative species and serotypes of shigellosis in mainland China: systematic review and meta-analysis.
 

Author(s): Zhili Chang, Shuting Lu, Lihong Chen, Qi Jin, Jian Yang

Journal: PLoS ONE. 2012 ;7(12):e52515.

 

Shigella, the causative agent of shigellosis, is a major global public health concern, particularly in developing countries with poor sanitation. A comprehensive and current understanding of the prevalent species and serotypes of shigellosis is essential for both disease prevention ...

Last Updated: 3 Jan 2013

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Decrease in shigellosis-related deaths without Shigella spp.-specific interventions, Asia.
 

Author(s): Pradip Bardhan, A S G Faruque, Aliya Naheed, David A Sack

Journal: Emerging Infect. Dis.. 2010 Nov;16(11):1718-23.

 

In 1999, a review of the literature for 1966-1997 suggested that ≈1.1 million persons die annually of shigellosis, including ≈880,000 in Asia. Our recent review of the literature for 1990-2009 indicates that ≈125 million shigellosis cases occur annually in Asia, of which ≈14,000 ...

Last Updated: 29 Oct 2010

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Shigellosis: an old disease in new clothes?
 

Author(s): Philippe J Sansonetti

Journal: PLoS Med.. 2006 Sep;3(9):e354.

 

Last Updated: 29 Nov 2006

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Last Updated: 31 Dec 2015

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A Study of the Safety and Immune Response of 2 Doses of a New Shigella Vaccine in Kenyan Adults
 

Status: Not yet recruiting

Condition Summary: Shigella Sonnei Infection

 

Last Updated: 8 Feb 2016

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Phase 2b Challenge Study With the Bioconjugate Vaccine Flexyn2a
 

Status: Recruiting

Condition Summary: Shigellosis

 

Last Updated: 4 Jan 2016

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