Sezary syndrome

Common Name(s)

Sezary syndrome

Sezary syndrome is a type of cutaneous T-cell lymphoma (CTCL), which belongs to a larger group of disorders known as non-HodgkinÕs lymphomas. Sezary syndrome is characterized by a widespread red rash that may cover most of the body, the presence of specific malignant cells (Sezary cells) in the blood, and abnormally enlarged lymph nodes. Other signs and symptoms may include intense itchiness, scaling and peeling of the skin; fever; weight loss; hair loss; outward turning of the eyelids (ectropion); palmoplantar keratoderma; malformation of the nails; and hepatosplenomegaly. The exact cause of cutaneous T-cell lymphomas is currently unknown. Treatment options vary depending on severity and signs and symptoms but may include topical chemotherapy, radiation therapy, photochemotherapy, use of retinoids, and chemotherapy. The prognosis is generally poor with a median survival between 2 and 4 years.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Sezary syndrome" for support, advocacy or research.

Cutaneous Lymphoma Foundation

The Cutaneous Lymphoma Foundation is an independent, nonprofit patient advocacy organization whose mission is supporting every person with cutaneous lymphoma by promoting awareness and education, advancing patient care and facilitating research.

Last Updated: 6 Jan 2013

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Sezary syndrome" for support, advocacy or research.

Cutaneous Lymphoma Foundation

The Cutaneous Lymphoma Foundation is an independent, nonprofit patient advocacy organization whose mission is supporting every person with cutaneous lymphoma by promoting awareness and education, advancing patient care and facilitating research.

http://www.clfoundation.org

Last Updated: 6 Jan 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Sezary syndrome" returned 187 free, full-text research articles on human participants. First 3 results:

MicroRNA-181 contributes to downregulation of SAMHD1 expression in CD4+ T-cells derived from Sèzary syndrome patients.
 

Author(s): Rebecca Kohnken, Karthik M Kodigepalli, Anjali Mishra, Pierluigi Porcu, Li Wu

Journal: Leuk. Res.. 2017 Jan;52():58-66.

 

Sézary syndrome (SS) is a rare subtype of cutaneous T-cell lymphoma (CTCL) that is characterized by aggressive spread of neoplastic CD4+ T-cells from the skin into the bloodstream with metastasis to visceral organs. The deoxynucleoside triphosphohydrolase SAMHD1 is highly expressed ...

Last Updated: 27 Nov 2016

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Alemtuzumab in refractory Sézary syndrome.
 

Author(s): Carmen María Alcántara Reifs, Rafael Salido-Vallejo, Gloria María Garnacho-Saucedo, Sofía De la Corte-Sánchez, Alberto González-Menchen, Antonio Vélez García-Nieto

Journal: An Bras Dermatol. ;91(5):642-644.

 

Sézary syndrome is a primary cutaneous T-cell lymphoma characterized by the triad of erythroderma, lymphadenopathy and circulating atypical cells. The emergence of new molecular targets has enabled the development of drugs such as alemtuzumab, an anti-CD52 monoclonal antibody, which ...

Last Updated: 9 Nov 2016

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[Sézary syndrome treated with extracorporeal photopheresis: Report of one case].
 

Author(s): Montserrat Molgó, Alejandra Jaque, Verónica Vial, Mauricio Ocqueteau, Jaime Pereira, Mayling Chang, Sergio González

Journal: Rev Med Chil. 2015 Nov;143(11):1449-58.

 

Sézary syndrome (SS) is an unusually aggressive T- cell lymphoma characterized by the triad of erythroderma, the presence of more than 1,000 Sézary cells in peripheral blood and lymphadenopathies. It is accompanied by generalized pruritus and poor quality of life. The management ...

Last Updated: 13 Jan 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Sezary syndrome" returned 14 free, full-text review articles on human participants. First 3 results:

Romidepsin for the treatment of relapsed/refractory cutaneous T-cell lymphoma (mycosis fungoides/Sézary syndrome): Use in a community setting.
 

Author(s): Sunil A Reddy

Journal: Crit. Rev. Oncol. Hematol.. 2016 Oct;106():99-107.

 

Cutaneous T-cell lymphoma (CTCL) is a heterogeneous group of rare non-Hodgkin lymphomas that arise in the skin. In advanced stages, CTCL becomes systemic and is associated with poor prognosis. Diagnosis of CTCL and treatment of early-stage disease with topical therapies often occurs ...

Last Updated: 17 Sep 2016

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Sézary Syndrome and Atopic Dermatitis: Comparison of Immunological Aspects and Targets.
 

Author(s): Ieva Saulite, Wolfram Hoetzenecker, Stephan Weidinger, Antonio Cozzio, Emmanuella Guenova, Ulrike Wehkamp

Journal: Biomed Res Int. 2016 ;2016():9717530.

 

Sézary syndrome (SS), an aggressive form of erythrodermic pruritic cutaneous T cell lymphoma (CTCL), from an immunological perspective characterized by increased Th2 cytokine levels, elevated serum IgE and impaired cellular immunity. Not only the clinical appearance but also the ...

Last Updated: 13 Jun 2016

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Hematopoietic Stem Cell Transplant for Mycosis Fungoides and Sézary Syndrome.
 

Author(s): Pooja Virmani, Jasmine Zain, Steven T Rosen, Patricia L Myskowski, Christiane Querfeld

Journal: Dermatol Clin. 2015 Oct;33(4):807-18.

 

Mycosis fungoides (MF) and Sézary syndrome (SS) are common types of primary cutaneous T-cell lymphoma. Early-stage MF has a favorable prognosis and responds well to skin-directed regimens. Patients with advanced-stage MF, transformed MF, and SS are treated with combined systemic ...

Last Updated: 5 Oct 2015

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Clinical Trial Information This information is provided by ClinicalTrials.gov

TSEB and Brentuximab for Treatment of Mycosis Fungoides & Sezary Syndrome
 

Status: Recruiting

Condition Summary: Mycosis Fungoides; Sézary Syndrome

 

Last Updated: 3 May 2017

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Resminostat for Maintenance Treatment of Patients With Advanced Stage Mycosis Fungoides (MF) or Sézary Syndrome (SS)
 

Status: Recruiting

Condition Summary: Mycosis Fungoides; Sezary Syndrome; Lymphoma, T-Cell, Cutaneous

 

Last Updated: 14 Jun 2017

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ID Of Prognostic Factors In Mycosis Fungoides/Sezary Syndrome
 

Status: Recruiting

Condition Summary: Mycosis Fungoides; Non-Hodgkin's Lymphoma

 

Last Updated: 15 Feb 2017

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