Sezary syndrome

Common Name(s)

Sezary syndrome

Sezary syndrome is a type of cutaneous T-cell lymphoma (CTCL), which belongs to a larger group of disorders known as non-HodgkinÕs lymphomas. Sezary syndrome is characterized by a widespread red rash that may cover most of the body, the presence of specific malignant cells (Sezary cells) in the blood, and abnormally enlarged lymph nodes. Other signs and symptoms may include intense itchiness, scaling and peeling of the skin; fever; weight loss; hair loss; outward turning of the eyelids (ectropion); palmoplantar keratoderma; malformation of the nails; and hepatosplenomegaly. The exact cause of cutaneous T-cell lymphomas is currently unknown. Treatment options vary depending on severity and signs and symptoms but may include topical chemotherapy, radiation therapy, photochemotherapy, use of retinoids, and chemotherapy. The prognosis is generally poor with a median survival between 2 and 4 years.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Sezary syndrome" for support, advocacy or research.

Cutaneous Lymphoma Foundation

The Cutaneous Lymphoma Foundation is an independent, nonprofit patient advocacy organization whose mission is supporting every person with cutaneous lymphoma by promoting awareness and education, advancing patient care and facilitating research.

Last Updated: 6 Jan 2013

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Sezary syndrome" for support, advocacy or research.

Cutaneous Lymphoma Foundation

The Cutaneous Lymphoma Foundation is an independent, nonprofit patient advocacy organization whose mission is supporting every person with cutaneous lymphoma by promoting awareness and education, advancing patient care and facilitating research.

http://www.clfoundation.org

Last Updated: 6 Jan 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Sezary syndrome" returned 141 free, full-text research articles on human participants. First 3 results:

Disseminated cutaneous leishmaniasis in a patient with Sézary syndrome.
 

Author(s): Priscila Giavedoni, Ignasi Pau-Charles, José M Mascaró, Mercé Alsina-Gibert, Adriana García-Herrera, Teresa Estrach

Journal: J. Am. Acad. Dermatol.. 2014 Nov;71(5):e213-4.

 

Last Updated: 2 Dec 2014

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Medical history, lifestyle, family history, and occupational risk factors for mycosis fungoides and Sézary syndrome: the InterLymph Non-Hodgkin Lymphoma Subtypes Project.
 

Author(s): Briseis Aschebrook-Kilfoy, Pierluigi Cocco, Carlo La Vecchia, Ellen T Chang, Claire M Vajdic, Marshall E Kadin, John J Spinelli, Lindsay M Morton, Eleanor V Kane, Joshua N Sampson, Carol Kasten, Andrew L Feldman, Sophia S Wang, Yawei Zhang

Journal: J. Natl. Cancer Inst. Monographs. 2014 Aug;2014(48):98-105.

 

Mycosis fungoides and Sézary syndrome (MF/SS) are rare cutaneous T-cell lymphomas. Their etiology is poorly understood.

Last Updated: 1 Sep 2014

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Identification of p38β as a therapeutic target for the treatment of Sézary syndrome.
 

Author(s): Meghan Bliss-Moreau, Cristian Coarfa, Preethi H Gunaratne, Joan Guitart, Nancy L Krett, Steven T Rosen

Journal: J. Invest. Dermatol.. 2015 Feb;135(2):599-608.

 

Cutaneous T-cell lymphomas (CTCLs) represent a group of hematopoietic malignancies that home to the skin and have no known molecular basis for disease pathogenesis. Sézary syndrome (SS) is the leukemic variant of CTCL. Currently, CTCL is incurable, highlighting the need for new therapeutic ...

Last Updated: 9 Jan 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Sezary syndrome" returned 10 free, full-text review articles on human participants. First 3 results:

New and established treatment options for mycosis fungoides and Sézary syndrome - an update.
 

Author(s): Susanne Dugas-Breit, Hans-Joachim Schulze, Christian Hallermann

Journal: J Dtsch Dermatol Ges. 2014 Jul;12(7):561-9.

 

At the time of diagnosis primary cutaneous lymphomas are limited to the skin. T-cell lymphomas represent at least two thirds of all primary cutaneous lymphomas with mycosis fungoides and Sézary syndrome being the most frequent entities. A precise staging based on clinical, histological, ...

Last Updated: 1 Jul 2014

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A practical approach to accurate classification and staging of mycosis fungoides and Sézary syndrome.
 

Author(s): Bjorn Rhys Thomas, Sean Whittaker

Journal: Skin Therapy Lett.. 2012 Dec;17(10):5-9.

 

Cutaneous T-cell lymphomas are rare, distinct forms of non-Hodgkin's lymphomas. Of which, mycosis fungoides (MF) and Sézary syndrome (SS) are two of the most common forms. Careful, clear classification and staging of these lymphomas allow dermatologists to commence appropriate therapy ...

Last Updated: 11 Dec 2012

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Mycosis fungoides and Sézary syndrome: clinical, histopathological and immunohistochemical review and update.
 

Author(s): Thamy Yamashita, Luciana Patricia Fernandes Abbade, Mariangela Esther Alencar Marques, Silvio Alencar Marques

Journal: An Bras Dermatol. ;87(6):817-28; quiz 829-30.

 

This paper reviews the diagnostic and classificatory concepts of mycosis fungoides and Sézary syndrome in light of the latest normative publications. It describes the great variability of the clinical expression of mycosis fungoides in its early stages as well as the histopathological ...

Last Updated: 30 Nov 2012

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Pembrolizumab in Treating Patients With Relapsed or Refractory Stage IB-IVB Mycosis Fungoides or Sezary Syndrome
 

Status: Recruiting

Condition Summary: Recurrent Mycosis Fungoides and Sezary Syndrome; Stage IB Mycosis Fungoides and Sezary Syndrome; Stage IIA Mycosis Fungoides and Sezary Syndrome; Stage IIB Mycosis Fungoides and Sezary Syndrome; Stage IIIA Mycosis Fungoides and Sezary Syndrome; Stage IIIB Mycosis Fungoides and Sezary Syndrome; Stage IVA Mycosis Fungoides and Sezary Syndrome; Stage IVB Mycosis Fungoides and Sezary Syndrome

 

Last Updated: 10 Aug 2015

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Effect of Neurokinin-1 Receptor (NK1R) Antagonism on Pruritus in Patients With Sezary Syndrome
 

Status: Recruiting

Condition Summary: Sezary Syndrome; Pruritus

 

Last Updated: 8 Jul 2015

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Stem Cell Transplant Therapy With Campath-1H for Treating Advanced Mycosis Fungoides and Sezary Syndrome
 

Status: Recruiting

Condition Summary: Mycosis Fungoides; Sezary Syndrome

 

Last Updated: 6 May 2015

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