Severe combined immunodeficiency

Common Name(s)

Severe combined immunodeficiency

Severe combined immunodeficiencies (SCID) are inherited immune system disorders characterized by defects in both T cells and B cells. SCID causes a high susceptibility to life-threatening infections and failure to thrive. Without treatment, people with SCID do not tend to live past early childhood. Two common types of SCID include: 

X-linked SCID Adenosine deaminase deficiency (ADA-SCID)
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Severe combined immunodeficiency" for support, advocacy or research.

Immune Deficiency Foundation

The Immune Deficiency Foundation is the national patient organization dedicated to improving the diagnosis, treatment and quality of life of persons with primary immunodeficiency diseases through advocacy, education and research.

Last Updated: 27 Aug 2015

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SCID, Angels for Life Foundation

Our mission is to increase awareness, benefit research, and provide parent and family education for those affected by SCID.

Last Updated: 20 Feb 2013

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Severe combined immunodeficiency" for support, advocacy or research.

Immune Deficiency Foundation

The Immune Deficiency Foundation is the national patient organization dedicated to improving the diagnosis, treatment and quality of life of persons with primary immunodeficiency diseases through advocacy, education and research.

http://www.primaryimmune.org

Last Updated: 27 Aug 2015

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SCID, Angels for Life Foundation

Our mission is to increase awareness, benefit research, and provide parent and family education for those affected by SCID.

http://www.SCIDAngelsforlife.com

Last Updated: 20 Feb 2013

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Severe combined immunodeficiency" returned 309 free, full-text research articles on human participants. First 3 results:

A modified γ-retrovirus vector for X-linked severe combined immunodeficiency.
 

Author(s): Salima Hacein-Bey-Abina, Sung-Yun Pai, H Bobby Gaspar, Myriam Armant, Charles C Berry, Stephane Blanche, Jack Bleesing, Johanna Blondeau, Helen de Boer, Karen F Buckland, Laure Caccavelli, Guilhem Cros, Satiro De Oliveira, Karen S Fernández, Dongjing Guo, Chad E Harris, Gregory Hopkins, Leslie E Lehmann, Annick Lim, Wendy B London, Johannes C M van der Loo, Nirav Malani, Frances Male, Punam Malik, M Angélica Marinovic, Anne-Marie McNicol, Despina Moshous, Benedicte Neven, Matías Oleastro, Capucine Picard, Jerome Ritz, Christine Rivat, Axel Schambach, Kit L Shaw, Eric A Sherman, Leslie E Silberstein, Emmanuelle Six, Fabien Touzot, Alla Tsytsykova, Jinhua Xu-Bayford, Christopher Baum, Frederic D Bushman, Alain Fischer, Donald B Kohn, Alexandra H Filipovich, Luigi D Notarangelo, Marina Cavazzana, David A Williams, Adrian J Thrasher

Journal: N. Engl. J. Med.. 2014 Oct;371(15):1407-17.

 

In previous clinical trials involving children with X-linked severe combined immunodeficiency (SCID-X1), a Moloney murine leukemia virus-based γ-retrovirus vector expressing interleukin-2 receptor γ-chain (γc) complementary DNA successfully restored immunity in most patients but ...

Last Updated: 9 Oct 2014

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Vaccine-associated paralytic poliomyelitis and BCG-osis in an immigrant child with severe combined immunodeficiency syndrome - Texas, 2013.
 

Author(s): Robert Trimble, Jane Atkins, Troy C Quigg, Cara C Burns, Gregory S Wallace, Mary Thomas, Anil T Mangla, Anthony J Infante,

Journal: MMWR Morb. Mortal. Wkly. Rep.. 2014 Aug;63(33):721-4.

 

Poliovirus transmission has been eliminated in most of the world through the use of inactivated poliovirus vaccine (IPV) and live, attenuated oral poliovirus vaccine (OPV). In the United States, use of OPV was discontinued by the year 2000 because of the potential for vaccine-associated ...

Last Updated: 22 Aug 2014

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Newborn screening for severe combined immunodeficiency in 11 screening programs in the United States.
 

Author(s): Antonia Kwan, Roshini S Abraham, Robert Currier, Amy Brower, Karen Andruszewski, Jordan K Abbott, Mei Baker, Mark Ballow, Louis E Bartoshesky, Francisco A Bonilla, Charles Brokopp, Edward Brooks, Michele Caggana, Jocelyn Celestin, Joseph A Church, Anne Marie Comeau, James A Connelly, Morton J Cowan, Charlotte Cunningham-Rundles, Trivikram Dasu, Nina Dave, Maria T De La Morena, Ulrich Duffner, Chin-To Fong, Lisa Forbes, Debra Freedenberg, Erwin W Gelfand, Jaime E Hale, I Celine Hanson, Beverly N Hay, Diana Hu, Anthony Infante, Daisy Johnson, Neena Kapoor, Denise M Kay, Donald B Kohn, Rachel Lee, Heather Lehman, Zhili Lin, Fred Lorey, Aly Abdel-Mageed, Adrienne Manning, Sean McGhee, Theodore B Moore, Stanley J Naides, Luigi D Notarangelo, Jordan S Orange, Sung-Yun Pai, Matthew Porteus, Ray Rodriguez, Neil Romberg, John Routes, Mary Ruehle, Arye Rubenstein, Carlos A Saavedra-Matiz, Ginger Scott, Patricia M Scott, Elizabeth Secord, Christine Seroogy, William T Shearer, Subhadra Siegel, Stacy K Silvers, E Richard Stiehm, Robert W Sugerman, John L Sullivan, Susan Tanksley, Millard L Tierce, James Verbsky, Beth Vogel, Rosalyn Walker, Kelly Walkovich, Jolan E Walter, Richard L Wasserman, Michael S Watson, Geoffrey A Weinberg, Leonard B Weiner, Heather Wood, Anne B Yates, Jennifer M Puck, Vincent R Bonagura

Journal: JAMA. 2014 Aug;312(7):729-38.

 

Newborn screening for severe combined immunodeficiency (SCID) using assays to detect T-cell receptor excision circles (TRECs) began in Wisconsin in 2008, and SCID was added to the national recommended uniform panel for newborn screened disorders in 2010. Currently 23 states, the District ...

Last Updated: 20 Aug 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Severe combined immunodeficiency" returned 16 free, full-text review articles on human participants. First 3 results:

Severe combined immunodeficiency mouse-psoriatic human skin xenograft model: a modern tool connecting bench to bedside.
 

Author(s): Smriti Kundu-Raychaudhuri, Ananya Datta-Mitra, Christine J Abria, John Peters, Siba P Raychaudhuri

Journal: Indian J Dermatol Venereol Leprol. ;80(3):204-13.

 

Psoriasis is a multifactorial chronic inflammatory disease. Research into the pathogenesis of this disease is hindered by the lack of a proper animal model. Over the past two decades, many scientists were involved in the development of animal models that nearly mirror the immunopathogenesis ...

Last Updated: 14 May 2014

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The long quest for neonatal screening for severe combined immunodeficiency.
 

Author(s): Rebecca H Buckley

Journal: J. Allergy Clin. Immunol.. 2012 Mar;129(3):597-604; quiz 605-6.

 

Early recognition of severe combined immunodeficiency (SCID) is a pediatric emergency because a diagnosis before live vaccines or nonirradiated blood products are given and before development of infections permits lifesaving unfractionated HLA-identical or T cell-depleted haploidentical ...

Last Updated: 5 Mar 2012

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The case for newborn screening for severe combined immunodeficiency and related disorders.
 

Author(s): Jennifer M Puck

Journal: Ann. N. Y. Acad. Sci.. 2011 Dec;1246():108-17.

 

Early detection of primary immunodeficiency is recognized as important for avoiding infectious complications that compromise outcomes. In particular, severe combined immunodeficiency (SCID) is fatal in infancy unless affected infants can be diagnosed before the onset of devastating ...

Last Updated: 12 Jan 2012

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Lentiviral Gene Transfer for Treatment of Children Older Than Two Years of Age With X-Linked Severe Combined Immunodeficiency (XSCID)
 

Status: Recruiting

Condition Summary: X-linked Severe Combined Immunodeficiency; XSCID; SCID-X1; Gamma C-Deficient SCID

 

Last Updated: 31 Mar 2015

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Generalized Neonatal Screening of Severe Combined Immunodeficiencies
 

Status: Recruiting

Condition Summary: Severe Combined Immunodeficiency, Atypical

 

Last Updated: 20 Jul 2015

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Clinical Characteristics and Genetic Profiles of Severe Combined Immunodeficiency in China
 

Status: Not yet recruiting

Condition Summary: Severe Combined Immunodeficiency

 

Last Updated: 1 Sep 2014

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