Severe combined immunodeficiency

Common Name(s)

Severe combined immunodeficiency

Severe combined immunodeficiencies (SCID) are inherited immune system disorders characterized by defects in both T cells and B cells. SCID causes a high susceptibility to life-threatening infections and failure to thrive. Without treatment, people with SCID do not tend to live past early childhood. Two common types of SCID include: 

X-linked SCID Adenosine deaminase deficiency (ADA-SCID)
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Severe combined immunodeficiency" for support, advocacy or research.

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SCID, Angels for Life Foundation

Our mission is to increase awareness, benefit research, and provide parent and family education for those affected by SCID.

Last Updated: 20 Feb 2013

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Severe combined immunodeficiency" for support, advocacy or research.

Logo
SCID, Angels for Life Foundation

Our mission is to increase awareness, benefit research, and provide parent and family education for those affected by SCID.

http://www.SCIDAngelsforlife.com

Last Updated: 20 Feb 2013

View Details

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Severe combined immunodeficiency" returned 298 free, full-text research articles on human participants. First 3 results:

Vaccine-associated paralytic poliomyelitis and BCG-osis in an immigrant child with severe combined immunodeficiency syndrome - Texas, 2013.
 

Author(s): Robert Trimble, Jane Atkins, Troy C Quigg, Cara C Burns, Gregory S Wallace, Mary Thomas, Anil T Mangla, Anthony J Infante,

Journal: MMWR Morb. Mortal. Wkly. Rep.. 2014 Aug;63(33):721-4.

 

Poliovirus transmission has been eliminated in most of the world through the use of inactivated poliovirus vaccine (IPV) and live, attenuated oral poliovirus vaccine (OPV). In the United States, use of OPV was discontinued by the year 2000 because of the potential for vaccine-associated ...

Last Updated: 22 Aug 2014

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Successful treatment of systemic cytomegalovirus infection in severe combined immunodeficiency using allogeneic bone marrow transplantation followed by adoptive immunotherapy.
 

Author(s): U Koura, H Sakaki-Nakatsubo, K Otsubo, K Nomura, K Oshima, O Ohara, T Wada, A Yachie, K Imai, T Morio, T Miyawaki, H Kanegane

Journal: J Investig Allergol Clin Immunol. 2014 ;24(3):200-2.

 

Last Updated: 11 Jul 2014

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Severe combined immunodeficiency in Brazil: management, prognosis, and BCG-associated complications.
 

Author(s): J T L Mazzucchelli, C Bonfim, G G Castro, A A Condino-Neto, N M X Costa, L Cunha, E O Dantas, V M Dantas, M I de Moraes-Pinto, J F Fernandes, H C Goes, E Goudouris, A S Grumach, L M B Guirau, G Kuntze, M C Mallozzi, F P Monteiro, L S L Moraes, V Nudelman, J A Pinto, M C V Rizzo, A C Porto-Neto, P Roxo-Junior, M Ruiz, V E V Rullo, A Seber, O A Takano, F S Tavares, E Toledo, M M S Vilela, B T Costa-Carvalho

Journal: J Investig Allergol Clin Immunol. 2014 ;24(3):184-91.

 

Severe combined immunodeficiency (SCID) is one of the most severe forms of primary immunodeficiency. The objectives of this study were to analyze the diagnosis, treatment, and prognosis of SCID in Brazil and to document the impact of BCG vaccine.

Last Updated: 11 Jul 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Severe combined immunodeficiency" returned 14 free, full-text review articles on human participants. First 3 results:

The long quest for neonatal screening for severe combined immunodeficiency.
 

Author(s): Rebecca H Buckley

Journal: J. Allergy Clin. Immunol.. 2012 Mar;129(3):597-604; quiz 605-6.

 

Early recognition of severe combined immunodeficiency (SCID) is a pediatric emergency because a diagnosis before live vaccines or nonirradiated blood products are given and before development of infections permits lifesaving unfractionated HLA-identical or T cell-depleted haploidentical ...

Last Updated: 5 Mar 2012

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Educational paper. The expanding clinical and immunological spectrum of severe combined immunodeficiency.
 

Author(s): Mirjam van der Burg, Andy R Gennery

Journal: Eur. J. Pediatr.. 2011 May;170(5):561-71.

 

Severe combined immunodeficiency (SCID) is one of the most severe forms of primary immunodeficiency characterized by absence of functional T lymphocytes. It is a paediatric emergency, which is life-threatening when recognized too late. The clinical presentation varies from the classical ...

Last Updated: 18 Apr 2011

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Hereditary multiple intestinal atresia (HMIA) with severe combined immunodeficiency (SCID): a case report of two siblings and review of the literature on MIA, HMIA and HMIA with immunodeficiency over the last 50 years.
 

Author(s): Yasser Ali Hussein Ali, Sajjad Rahman, Venkatraman Bhat, Sheikha Al Thani, Adel Ismail, Ibrahim Bassiouny

Journal:

 

Hereditary multiple intestinal atresia (HMIA), a presumed autosomal recessive disorder, is an unusual and rare form of recurrent intestinal atresia which can be associated with severe combined immunodeficiency (SCID). The combination of HMIA and SCID is invariably lethal. The authors ...

Last Updated: 20 Jun 2012

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Generalized Neonatal Screening of Severe Combined Immunodeficiencies
 

Status: Not yet recruiting

Condition Summary: Severe Combined Immunodeficiency, Atypical

 

Last Updated: 18 Sep 2014

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Lentiviral Gene Transfer for Treatment of Children Older Than Two Years of Age With X-Linked Severe Combined Immunodeficiency (XSCID)
 

Status: Recruiting

Condition Summary: X-linked Severe Combined Immunodeficiency; XSCID; SCID-X1; Gamma C-Deficient SCID

 

Last Updated: 11 Apr 2014

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Clinical Characteristics and Genetic Profiles of Severe Combined Immunodeficiency in China
 

Status: Not yet recruiting

Condition Summary: Severe Combined Immunodeficiency

 

Last Updated: 1 Sep 2014

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