Severe combined immunodeficiency

Common Name(s)

Severe combined immunodeficiency

Severe combined immunodeficiencies (SCID) are inherited immune system disorders characterized by defects in both T cells and B cells. SCID causes a high susceptibility to life-threatening infections and failure to thrive. Without treatment, people with SCID do not tend to live past early childhood. Two common types of SCID include: 

X-linked SCID Adenosine deaminase deficiency (ADA-SCID)
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Severe combined immunodeficiency" for support, advocacy or research.

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SCID, Angels for Life Foundation

Our mission is to increase awareness, benefit research, and provide parent and family education for those affected by SCID.

Last Updated: 20 Feb 2013

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Severe combined immunodeficiency" for support, advocacy or research.

Logo
SCID, Angels for Life Foundation

Our mission is to increase awareness, benefit research, and provide parent and family education for those affected by SCID.

http://www.SCIDAngelsforlife.com

Last Updated: 20 Feb 2013

View Details

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Severe combined immunodeficiency" returned 293 free, full-text research articles on human participants. First 3 results:

Engraftment of human iPS cells and allogeneic porcine cells into pigs with inactivated RAG2 and accompanying severe combined immunodeficiency.
 

Author(s): Kiho Lee, Deug-Nam Kwon, Toshihiko Ezashi, Yun-Jung Choi, Chankyu Park, Aaron C Ericsson, Alana N Brown, Melissa S Samuel, Kwang-Wook Park, Eric M Walters, Dae Young Kim, Jae-Hwan Kim, Craig L Franklin, Clifton N Murphy, R Michael Roberts, Randall S Prather, Jin-Hoi Kim

Journal: Proc. Natl. Acad. Sci. U.S.A.. 2014 May;111(20):7260-5.

 

Pigs with severe combined immunodeficiency (SCID) may provide useful models for regenerative medicine, xenotransplantation, and tumor development and will aid in developing therapies for human SCID patients. Using a reporter-guided transcription activator-like effector nuclease (TALEN) ...

Last Updated: 21 May 2014

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Host natural killer immunity is a key indicator of permissiveness for donor cell engraftment in patients with severe combined immunodeficiency.
 

Author(s): Amel Hassan, Pamela Lee, Paraskevi Maggina, Jin Hua Xu, Diana Moreira, Mary Slatter, Zohreh Nademi, Austen Worth, Stuart Adams, Alison Jones, Catherine Cale, Zoe Allwood, Kanchan Rao, Robert Chiesa, Persis Amrolia, Hubert Gaspar, E Graham Davies, Paul Veys, Andrew Gennery, Waseem Qasim

Journal: J. Allergy Clin. Immunol.. 2014 Jun;133(6):1660-6.

 

Severe combined immunodeficiency (SCID) can be cured by using allogeneic hematopoietic stem cell transplantation, and the absence of host immunity often obviates the need for preconditioning. Depending on the underlying genetic defect and when blocks in differentiation occur during ...

Last Updated: 2 Jun 2014

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Gene therapy model of X-linked severe combined immunodeficiency using a modified foamy virus vector.
 

Author(s): Satoshi Horino, Toru Uchiyama, Takanori So, Hiroyuki Nagashima, Shu-Lan Sun, Miki Sato, Atsuko Asao, Yoichi Haji, Yoji Sasahara, Fabio Candotti, Shigeru Tsuchiya, Shigeo Kure, Kazuo Sugamura, Naoto Ishii

Journal:

 

X-linked severe combined immunodeficiency (SCID-X1) is an inherited genetic immunodeficiency associated with mutations in the common cytokine receptor γ chain (γc) gene, and characterized by a complete defect of T and natural killer (NK) cells. Gene therapy for SCID-X1 using conventional ...

Last Updated: 30 Aug 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Severe combined immunodeficiency" returned 14 free, full-text review articles on human participants. First 3 results:

The long quest for neonatal screening for severe combined immunodeficiency.
 

Author(s): Rebecca H Buckley

Journal: J. Allergy Clin. Immunol.. 2012 Mar;129(3):597-604; quiz 605-6.

 

Early recognition of severe combined immunodeficiency (SCID) is a pediatric emergency because a diagnosis before live vaccines or nonirradiated blood products are given and before development of infections permits lifesaving unfractionated HLA-identical or T cell-depleted haploidentical ...

Last Updated: 5 Mar 2012

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Educational paper. The expanding clinical and immunological spectrum of severe combined immunodeficiency.
 

Author(s): Mirjam van der Burg, Andy R Gennery

Journal: Eur. J. Pediatr.. 2011 May;170(5):561-71.

 

Severe combined immunodeficiency (SCID) is one of the most severe forms of primary immunodeficiency characterized by absence of functional T lymphocytes. It is a paediatric emergency, which is life-threatening when recognized too late. The clinical presentation varies from the classical ...

Last Updated: 18 Apr 2011

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Hereditary multiple intestinal atresia (HMIA) with severe combined immunodeficiency (SCID): a case report of two siblings and review of the literature on MIA, HMIA and HMIA with immunodeficiency over the last 50 years.
 

Author(s): Yasser Ali Hussein Ali, Sajjad Rahman, Venkatraman Bhat, Sheikha Al Thani, Adel Ismail, Ibrahim Bassiouny

Journal:

 

Hereditary multiple intestinal atresia (HMIA), a presumed autosomal recessive disorder, is an unusual and rare form of recurrent intestinal atresia which can be associated with severe combined immunodeficiency (SCID). The combination of HMIA and SCID is invariably lethal. The authors ...

Last Updated: 20 Jun 2012

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Generalized Neonatal Screening of Severe Combined Immunodeficiencies
 

Status: Not yet recruiting

Condition Summary: Severe Combined Immunodeficiency, Atypical

 

Last Updated: 18 Sep 2014

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Lentiviral Gene Transfer for Treatment of Children Older Than Two Years of Age With X-Linked Severe Combined Immunodeficiency (XSCID)
 

Status: Recruiting

Condition Summary: X-linked Severe Combined Immunodeficiency; XSCID; SCID-X1; Gamma C-Deficient SCID

 

Last Updated: 11 Apr 2014

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Clinical Characteristics and Genetic Profiles of Severe Combined Immunodeficiency in China
 

Status: Not yet recruiting

Condition Summary: Severe Combined Immunodeficiency

 

Last Updated: 1 Sep 2014

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