Sertoli-leydig cell tumors

Common Name(s)

Sertoli-leydig cell tumors

Sertoli-Leydig cell tumors are a cancer that starts in the female ovaries. The cancer cells produce and release a male sex hormone which may cause the development of male physical characteristics (virilization), including facial hair and a deep voice.  This type of tumor is sometimes called arrhenoblastoma of the ovary or a stromal tumor.  Sertoli-Leydig cell tumors are rare tumors which account for less than 0.5% of all ovarian tumors. While they can be found in women of all age groups, they are most common in young women. Treatment involves surgery and chemotherapy or radiation if the cancer has spread. Because Sertoli-Leydig cell tumors have a low chance of spreading, if the tumor is found early, chances for survival are good.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Sertoli-leydig cell tumors" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Sertoli-leydig cell tumors" returned 13 free, full-text research articles on human participants. First 3 results:

The oncogenic roles of DICER1 RNase IIIb domain mutations in ovarian Sertoli-Leydig cell tumors.
 

Author(s): Yemin Wang, Jiamin Chen, Winnie Yang, Fan Mo, Janine Senz, Damian Yap, Michael S Anglesio, Blake Gilks, Gregg B Morin, David G Huntsman

Journal: Neoplasia. 2015 Aug;17(8):650-60.

 

DICER1, an endoribonuclease required for microRNA (miRNA) biogenesis, is essential for embryogenesis and the development of many organs including ovaries. We have recently identified somatic hotspot mutations in RNase IIIb domain of DICER1 in half of ovarian Sertoli-Leydig cell tumors, ...

Last Updated: 26 Sep 2015

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Clinicopathologic features of ovarian Sertoli-Leydig cell tumors.
 

Author(s): Hai-Yan Zhang, Jia-Er Zhu, Wen Huang, Jin Zhu

Journal:

 

Ovarian Stertoli-Ledig cell tumor (SLCT) is a rare type of sex cord-stromal tumor of the ovary. The present study was to evaluate clinicalopahologic features and prognosis of patients with Sertoli-Leydig cell tumor treated by surgery and adjuvant chemotherapy during short term follow-up.

Last Updated: 17 Nov 2014

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Sertoli-Leydig cell tumors of the ovary: a Taiwanese Gynecologic Oncology Group study.
 

Author(s): Chia-Sui Weng, Min-Yu Chen, Tao-Yeuan Wang, Hsiao-Wen Tsai, Yao-Ching Hung, Ken-Jen Yu, Ying-Cheng Chiang, Hao Lin, Chien-Hsing Lu, Hung-Hsueh Chou

Journal: Taiwan J Obstet Gynecol. 2013 Mar;52(1):66-70.

 

To report the natural history and prognosis of the uncommon Sertoli-Leydig cell tumor (SLCT) of the ovary.

Last Updated: 3 Apr 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Sertoli-leydig cell tumors" returned 0 free, full-text review articles on human participants.

 
 
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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Paclitaxel and Carboplatin or Bleomycin Sulfate, Etoposide Phosphate, and Cisplatin in Treating Patients With Advanced or Recurrent Sex Cord-Ovarian Stromal Tumors
 

Status: Recruiting

Condition Summary: Ovarian Granulosa Cell Tumor; Ovarian Gynandroblastoma; Ovarian Sertoli-Leydig Cell Tumor; Ovarian Sex Cord Tumor With Annular Tubules; Ovarian Sex Cord-Stromal Tumor; Ovarian Sex Cord-Stromal Tumor of Mixed or Unclassified Cell Types; Ovarian Steroid Cell Tumor

 

Last Updated: 16 Mar 2016

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Elucidating the Genetic Basis of the Pleuropulmonary Blastoma (PPB) Familial Cancer Syndrome
 

Status: Recruiting

Condition Summary: Pleuropulmonary Blastoma; Cystic Nephroma; Sertoli-Leydig Cell Tumor of Ovary; Medulloepithelioma; Embryonal Rhabdomyosarcoma of Cervix; Goiter; Sarcoma; Pineoblastoma; Pituitary Tumors; Wilms Tumor

 

Last Updated: 28 Jul 2016

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DICER1-related Pleuropulmonary Blastoma Cancer Predisposition Syndrome: A Natural History Study
 

Status: Recruiting

Condition Summary: Pleuropulmonary Blastoma; Cystic Nephroma; Ovarian Sertoli-Leydig Cell Tumors; Ocular Medulloepithelioma; Nasal Chondromesenchymal Hamartoma

 

Last Updated: 31 Aug 2016

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