Sertoli-leydig cell tumors

Common Name(s)

Sertoli-leydig cell tumors

Sertoli-Leydig cell tumors are a cancer that starts in the female ovaries. The cancer cells produce and release a male sex hormone which may cause the development of male physical characteristics (virilization), including facial hair and a deep voice.  This type of tumor is sometimes called arrhenoblastoma of the ovary or a stromal tumor.  Sertoli-Leydig cell tumors are rare tumors which account for less than 0.5% of all ovarian tumors. While they can be found in women of all age groups, they are most common in young women. Treatment involves surgery and chemotherapy or radiation if the cancer has spread. Because Sertoli-Leydig cell tumors have a low chance of spreading, if the tumor is found early, chances for survival are good.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Sertoli-leydig cell tumors" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Sertoli-leydig cell tumors" returned 5 free, full-text research articles on human participants. First 3 results:

Treatment of high risk Sertoli-Leydig cell tumors of the ovary using a gonadotropin releasing hormone (GnRH) analog.
 

Author(s): Harsha Prasada Lashkari, Ruth Nash, Assunta Albanese, Bruce Okoye, Robert Millar, Kathy Pritchard-Jones

Journal: Pediatr Blood Cancer. 2013 Jun;60(6):E16-8.

 

Sertoli-Leydig cell tumors are rare ovarian neoplasms. We report two unusual cases with bilateral SLCTs suggesting evidence of genetic predisposition and at high risk of recurrence. To reduce this risk, we exploited the use of GnRH analog to lower gondadotropin and potentially directly ...

Last Updated: 17 Apr 2013

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DICER1 mutations in familial multinodular goiter with and without ovarian Sertoli-Leydig cell tumors.
 

Author(s): Thomas Rio Frio, Amin Bahubeshi, Chryssa Kanellopoulou, Nancy Hamel, Marek Niedziela, Nelly Sabbaghian, Carly Pouchet, Lucy Gilbert, Paul K O'Brien, Kim Serfas, Peter Broderick, Richard S Houlston, Fabienne Lesueur, Elena Bonora, Stefan Muljo, R Neil Schimke, Dorothée Bouron-Dal Soglio, Jocelyne Arseneau, Kris Ann Schultz, John R Priest, Van-Hung Nguyen, H Rubén Harach, David M Livingston, William D Foulkes, Marc Tischkowitz

Journal: JAMA. 2011 Jan;305(1):68-77.

 

Nontoxic multinodular goiter (MNG) is frequently observed in the general population, but little is known about the underlying genetic susceptibility to this disease. Familial cases of MNG have been reported, and published reports describe 5 families that also contain at least 1 individual ...

Last Updated: 5 Jan 2011

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Imaging of gynecological disease (2): clinical and ultrasound characteristics of Sertoli cell tumors, Sertoli-Leydig cell tumors and Leydig cell tumors.
 

Author(s): V N Demidov, J Lipatenkova, O Vikhareva, C Van Holsbeke, D Timmerman, L Valentin

Journal: Ultrasound Obstet Gynecol. 2008 Jan;31(1):85-91.

 

To describe the clinical history and ultrasound findings in women with ovarian Sertoli cell, Sertoli-Leydig cell and Leydig cell tumors.

Last Updated: 27 Dec 2007

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Sertoli-leydig cell tumors" returned 0 free, full-text review articles on human participants.

 
 
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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Elucidating the Genetic Basis of the Pleuropulmonary Blastoma (PPB) Familial Cancer Syndrome
 

Status: Recruiting

Condition Summary: Pleuropulmonary Blastoma; Cystic Nephroma; Sertoli-Leydig Cell Tumor of Ovary; Medulloepithelioma; Embryonal Rhabdomyosarcoma of Cervix

 

Last Updated: 9 Sep 2014

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DICER1-related Pleuropulmonary Blastoma Cancer Predisposition Syndrome: A Natural History Study
 

Status: Recruiting

Condition Summary: Pleuropulmonary Blastoma; Cystic Nephroma; Ovarian Sertoli-Leydig Cell Tumors; Ocular Medulloepithelioma; Nasal Chondromesenchymal Hamartoma

 

Last Updated: 11 Nov 2014

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International Ovarian & Testicular Stromal Tumor Registry
 

Status: Recruiting

Condition Summary: Ovarian Stromal Tumor; Testicular Stromal Tumors; Ovarian Small Cell Carcinoma

 

Last Updated: 25 Jun 2014

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