Atrial Fibrillation Familial

Common Name(s)

Atrial Fibrillation Familial

Atrial fibrillation is the uncontrolled twitching of the upper chambers of the heart (atria). This is a relatively common heart rhythm disorder that can inherited from parents, as in the case of familial atrial fibrillation. Usually, the heart beats at a very purposeful beat, with electrical signals keeping the rhythm of contractions, or pumps, at a regular rhythm. When the electrical signals to the atria conflict with each other, they cause quivering, or fibrillations. Someone with atrial fibrillation may feel dizziness, chest pain, and fast heart rate. The major serious complication of this disorder is that it can cause a blood clot to form in the heart which may then go to the brain causing a stroke. Because of this blood thinners are often prescribed to prevent clots. Medications and the implantation of electrical devices can restore regular heart rate in someone who has atrial fibrillation.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Atrial Fibrillation Familial" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Atrial Fibrillation Familial" returned 32 free, full-text research articles on human participants. First 3 results:

Examining rare and low-frequency genetic variants previously associated with lone or familial forms of atrial fibrillation in an electronic medical record system: a cautionary note.
 

Author(s): Peter Weeke, Joshua C Denny, Lisa Basterache, Christian Shaffer, Erica Bowton, Christie Ingram, Dawood Darbar, Dan M Roden

Journal: Circ Cardiovasc Genet. 2015 Feb;8(1):58-63.

 

Studies in individuals or small kindreds have implicated rare variants in 25 different genes in lone and familial atrial fibrillation (AF) using linkage and segregation analysis, functional characterization, and rarity in public databases. Here, we used a cohort of 20 204 patients ...

Last Updated: 18 Feb 2015

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Whole-exome sequencing in familial atrial fibrillation.
 

Author(s): Peter Weeke, Raafia Muhammad, Jessica T Delaney, Christian Shaffer, Jonathan D Mosley, Marcia Blair, Laura Short, Tanya Stubblefield, Dan M Roden, Dawood Darbar,

Journal: Eur. Heart J.. 2014 Sep;35(36):2477-83.

 

Positional cloning and candidate gene approaches have shown that atrial fibrillation (AF) is a complex disease with familial aggregation. Here, we employed whole-exome sequencing (WES) in AF kindreds to identify variants associated with familial AF.

Last Updated: 22 Sep 2014

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A KCNQ1 mutation causes a high penetrance for familial atrial fibrillation.
 

Author(s): Daniel C Bartos, Jeffrey B Anderson, Rachel Bastiaenen, Jonathan N Johnson, Michael H Gollob, David J Tester, Don E Burgess, Tessa Homfray, Elijah R Behr, Michael J Ackerman, Pascale Guicheney, Brian P Delisle

Journal: J. Cardiovasc. Electrophysiol.. 2013 May;24(5):562-9.

 

Atrial fibrillation (AF) is the most common cardiac arrhythmia, and its incidence is expected to grow. A genetic predisposition for AF has long been recognized, but its manifestation in these patients likely involves a combination of rare and common genetic variants. Identifying genetic ...

Last Updated: 29 Apr 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Atrial Fibrillation Familial" returned 1 free, full-text review articles on human participants. First 3 results:

Genetics of familial atrial fibrillation.
 

Author(s): Oscar Campuzano, Ramon Brugada

Journal: Europace. 2009 Oct;11(10):1267-71.

 

Atrial fibrillation (AF) remains one of the most common and challenging arrhythmias encountered in clinical practice. While familial forms had remained mostly unknown, in this last decade, the identification of genetic defects, which mainly affect ionic currents, has been the key ...

Last Updated: 2 Oct 2009

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

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