Selective IgA deficiency

Common Name(s)

Selective IgA deficiency

Selective IgA deficiency refers to the complete or severe deficiency of IgA. This deficiency makes one more prone to infections, allergies, diarrhea, and autoimmune diseases. It is the most common type of primary immunodeficiency and is caused by a lack of mature B-lymphocytes. Why the B-lymphocytes fail to mature and produce IgA is not clear. Familial occurrence has been reported in the medical literature, some cases were suggestive of autosomal dominant inheritance, others of autosomal recessive inheritance.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Selective IgA deficiency" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Selective IgA deficiency" returned 56 free, full-text research articles on human participants. First 3 results:

Prediction of the evolution of common variable immunodeficiency: HLA typing for patients with selective IgA deficiency.
 

Author(s): T Cheraghi, A Aghamohammadi, B Mirminachi, T Keihanian, E Hedayat, H Abolhassani, B Torabi Sagvand, N Rezaei

Journal: J Investig Allergol Clin Immunol. 2014 ;24(3):198-200.

 

Last Updated: 11 Jul 2014

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Asthma and risk of selective IgA deficiency or common variable immunodeficiency: a population-based case-control study.
 

Author(s): Sang-Hwa Urm, Hyun Don Yun, Yilma A Fenta, Kwang Ha Yoo, Roshini S Abraham, John Hagan, Young J Juhn

Journal: Mayo Clin. Proc.. 2013 Aug;88(8):813-21.

 

To determine the association between a history of asthma and a diagnosis of selective IgA deficiency (sIgAD)/common variable immunodeficiency (CVID).

Last Updated: 5 Aug 2013

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B-cell subsets in patients with transient hypogammaglobulinemia of infancy, partial IgA deficiency, and selective IgM deficiency.
 

Author(s): F E Cipe, F Doğu, D Güloğlu, C Aytekin, M Polat, Z Biyikli, A Ikincioğullari

Journal: J Investig Allergol Clin Immunol. 2013 ;23(2):94-100.

 

The pathogenesis of some primary humoral immunodeficiencies, such as transient hypogammaglobulinemia of infancy (THI) and immunoglobulin (Ig) A deficiency, remains unknown and can render diagnosis problematic.

Last Updated: 9 May 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Selective IgA deficiency" returned 3 free, full-text review articles on human participants. First 3 results:

Selective IgA deficiency in autoimmune diseases.
 

Author(s): Ning Wang, Nan Shen, Timothy J Vyse, Vidya Anand, Iva Gunnarson, Gunnar Sturfelt, Solbritt Rantapää-Dahlqvist, Kerstin Elvin, Lennart Truedsson, Bengt A Andersson, Charlotte Dahle, Eva Ortqvist, Peter K Gregersen, Timothy W Behrens, Lennart Hammarström

Journal: Mol. Med.. 2011 ;17(11-12):1383-96.

 

Selective immunoglobulin A deficiency (IgAD) is the most common primary immunodeficiency in Caucasians. It has previously been suggested to be associated with a variety of concomitant autoimmune diseases. In this review, we present data on the prevalence of IgAD in patients with Graves ...

Last Updated: 9 Apr 2012

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Selective IgA deficiency.
 

Author(s): Leman Yel

Journal: J. Clin. Immunol.. 2010 Jan;30(1):10-6.

 

Immunoglobulin A (IgA) deficiency is the most common primary immunodeficiency defined as decreased serum level of IgA in the presence of normal levels of other immunoglobulin isotypes. Most individuals with IgA deficiency are asymptomatic and identified coincidentally. However, some ...

Last Updated: 15 Feb 2010

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Selective IgA deficiency (SIgAD) and common variable immunodeficiency (CVID).
 

Author(s): L Hammarström, I Vorechovsky, D Webster

Journal: Clin. Exp. Immunol.. 2000 May;120(2):225-31.

 

Last Updated: 27 Jun 2000

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

There are currently no open clinical trials for this condition.