Seizures

Common Name(s)

Seizures, Epileptic seizure

Seizures occur when there is abnormal electrical activity in the brain. Chemical changes in our nerve cells trigger the electrical activity in our body. Brain cells either trigger or stop other brain cells from sending messages throughout the body. During a seizure there is either too much or too little activity going on in the brain cells. This causes the sudden electrical activity that leads to seizures. Since there are different types of seizures, the location of the abnormal activity in the brain sets one seizure apart from another.

Non-epileptic seizures are seizures that occur from injuries. In partial seizures, the abnormal activity occurs in only one side of the brain. This results in only one side of the body experiencing the seizure. Generalized seizures affect both sides of the brain. Each seizure has different symptoms. Brief blackout, twitching and jerking movements, sudden falling, shaking of the entire body, sudden eye movements, change in behavior, loss of bladder control, loss of speech control, and teeth clenching are a few symptoms of seizures.

Seizures are often a symptom of other health conditions. They may result from high fever, head injury, infections, trauma, stroke, drug abuse, electric shock, extremely high blood pressure, alcohol withdrawal, and drug withdrawal. Doctors diagnose seizures by running a test called electroencephalogram (EEG). This test checks the brain for unusual electrical activity. There are many types of medications available to treat this condition. If medication does not work, then surgery may be an option. Talk with your doctor to decide which treatment plan is best for you. Support groups are also good resources for support and information.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Seizures" for support, advocacy or research.

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Epilepsy Foundation - Home Office

The mission of the Epilepsy Foundation is to stop seizures and SUDEP, find a cure and overcome the challenges created by epilepsy through efforts including education, advocacy and research to accelerate ideas into therapies.

Last Updated: 28 Apr 2015

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Simons VIP Connect

The Simons Variation in Individuals Project (Simons VIP) is an online community and research initiative. We provide a platform to partner families and researchers to better understand over 40 genetic changes (genomic variants) associated with features related to autism and developmental delay.

Last Updated: 22 Apr 2015

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The Arc of East Central Iowa

The Arc of East Central Iowa empowers people with intellectual and related disabilities to engage in lifelong opportunities to live, learn, work and play with dignity, freedom and full inclusion in their communities.

Last Updated: 11 Apr 2013

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Zellweger Baby Support Network

This organization was started by a small group of parents whose lives have been affected in some way by a rare disorder. Our gift, in honor of our children, was to start this site, so we can help families and to raise awareness of these rare disorders. If your child has been diagnosed with Zellweger syndrome, a peroxisomal disorder or another rare disorder, we are here to help you. You are not alone! Our mission is to promote, advance, and improve awareness of Zellweger syndrome and other peroxisomal disorders, to assist, support, and aid, financially or otherwise, individuals and families affected by Zellweger syndrome. We will help you learn more about these disorders. We will provide emotional support, and we can help you to create a journal site for your child so that family and friends can be kept up to date on your child. We will pray with you and for you as you journey through life with your special angel. We know this is a hard time for you; you want answers, informa

Last Updated: 20 Feb 2013

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Seizures" for support, advocacy or research.

Logo
Epilepsy Foundation - Home Office

The mission of the Epilepsy Foundation is to stop seizures and SUDEP, find a cure and overcome the challenges created by epilepsy through efforts including education, advocacy and research to accelerate ideas into therapies.

http://www.epilepsy.com

Last Updated: 28 Apr 2015

View Details
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Simons VIP Connect

The Simons Variation in Individuals Project (Simons VIP) is an online community and research initiative. We provide a platform to partner families and researchers to better understand over 40 genetic changes (genomic variants) associated with features related to autism and developmental delay.

http://www.simonsvipconnect.org

Last Updated: 22 Apr 2015

View Details
The Arc of East Central Iowa

The Arc of East Central Iowa empowers people with intellectual and related disabilities to engage in lifelong opportunities to live, learn, work and play with dignity, freedom and full inclusion in their communities.

http://www.arceci.org

Last Updated: 11 Apr 2013

View Details
Logo
Zellweger Baby Support Network

This organization was started by a small group of parents whose lives have been affected in some way by a rare disorder. Our gift, in honor of our children, was to start this site, so we can help families and to raise awareness of these rare disorders. If your child has been diagnosed with Zellweger syndrome, a peroxisomal disorder or another rare disorder, we are here to help you. You are not alone! Our mission is to promote, advance, and improve awareness of Zellweger syndrome and other peroxisomal disorders, to assist, support, and aid, financially or otherwise, individuals and families affected by Zellweger syndrome. We will help you learn more about these disorders. We will provide emotional support, and we can help you to create a journal site for your child so that family and friends can be kept up to date on your child. We will pray with you and for you as you journey through life with your special angel. We know this is a hard time for you; you want answers, informa

http://www.zbsn.org

Last Updated: 20 Feb 2013

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Seizures" returned 1258 free, full-text research articles on human participants. First 3 results:

Long-term treatment with responsive brain stimulation in adults with refractory partial seizures.
 

Author(s): Gregory K Bergey, Martha J Morrell, Eli M Mizrahi, Alica Goldman, David King-Stephens, Dileep Nair, Shraddha Srinivasan, Barbara Jobst, Robert E Gross, Donald C Shields, Gregory Barkley, Vicenta Salanova, Piotr Olejniczak, Andrew Cole, Sydney S Cash, Katherine Noe, Robert Wharen, Gregory Worrell, Anthony M Murro, Jonathan Edwards, Michael Duchowny, David Spencer, Michael Smith, Eric Geller, Ryder Gwinn, Christopher Skidmore, Stephan Eisenschenk, Michel Berg, Christianne Heck, Paul Van Ness, Nathan Fountain, Paul Rutecki, Andrew Massey, Cormac O'Donovan, Douglas Labar, Robert B Duckrow, Lawrence J Hirsch, Tracy Courtney, Felice T Sun, Cairn G Seale

Journal: Neurology. 2015 Feb;84(8):810-7.

 

The long-term efficacy and safety of responsive direct neurostimulation was assessed in adults with medically refractory partial onset seizures.

Last Updated: 25 Feb 2015

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Last Updated: 7 Nov 2014

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Mapping cortical haemodynamics during neonatal seizures using diffuse optical tomography: a case study.
 

Author(s): Harsimrat Singh, Robert J Cooper, Chuen Wai Lee, Laura Dempsey, Andrea Edwards, Sabrina Brigadoi, Dimitrios Airantzis, Nick Everdell, Andrew Michell, David Holder, Jeremy C Hebden, Topun Austin

Journal:

 

Seizures in the newborn brain represent a major challenge to neonatal medicine. Neonatal seizures are poorly classified, under-diagnosed, difficult to treat and are associated with poor neurodevelopmental outcome. Video-EEG is the current gold-standard approach for seizure detection ...

Last Updated: 27 Aug 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Seizures" returned 158 free, full-text review articles on human participants. First 3 results:

Psychogenic nonepileptic seizures and psychogenic movement disorders: two sides of the same coin?
 

Author(s): Luciano De Paola, Renato L Marchetti, Hélio Afonso Ghizoni Teive, W Curt LaFrance

Journal: Arq Neuropsiquiatr. 2014 Oct;72(10):793-802.

 

Psychogenic nonepileptic seizures (PNES) and psychogenic movement disorders (PMD) are commonly seen in Neurology practice and are categorized in the DSM-5 as functional neurological disorders/conversion disorders. This review encompasses historical and epidemiological data, clinical ...

Last Updated: 23 Oct 2014

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Neuronal ensemble synchrony during human focal seizures.
 

Author(s): Wilson Truccolo, Omar J Ahmed, Matthew T Harrison, Emad N Eskandar, G Rees Cosgrove, Joseph R Madsen, Andrew S Blum, N Stevenson Potter, Leigh R Hochberg, Sydney S Cash

Journal: J. Neurosci.. 2014 Jul;34(30):9927-44.

 

Seizures are classically characterized as the expression of hypersynchronous neural activity, yet the true degree of synchrony in neuronal spiking (action potentials) during human seizures remains a fundamental question. We quantified the temporal precision of spike synchrony in ensembles ...

Last Updated: 24 Jul 2014

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Pharmacotherapeutic targeting of cation-chloride cotransporters in neonatal seizures.
 

Author(s): Martin Puskarjov, Kristopher T Kahle, Eva Ruusuvuori, Kai Kaila

Journal: Epilepsia. 2014 Jun;55(6):806-18.

 

Seizures are a common manifestation of acute neurologic insults in neonates and are often resistant to the standard antiepileptic drugs that are efficacious in children and adults. The paucity of evidence-based treatment guidelines, coupled with a rudimentary understanding of disease ...

Last Updated: 13 Jun 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Remegal Fixed Dose as Adjunctive Therapy in Patients With Partial Seizures
 

Status: Recruiting

Condition Summary: Epilepsy; Simple Partial Seizures; Complex Partial Seizures; Partial Seizures With Secondary Generalization

 

Last Updated: 11 Dec 2012

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Respiratory Physiology in Children With Febrile Seizures.
 

Status: Recruiting

Condition Summary: Febrile Illness in Children; Seizures, Febrile

 

Last Updated: 23 Jul 2013

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