Scleromyxedema

Common Name(s)

Scleromyxedema

Scleromyxedema is a rare, severe skin disorder. Signs and symptoms include abnormal accumulation of mucin in the skin (mucinosis), causing papular and sclerodermoid bumps; increased production of fibroblasts (connective tissue cells) in the absence of a thyroid disorder; and monoclonal gammopathy (abnormal proteins in the blood). It often involves internal organs and may affect various body systems. The cause of scleromyxedema is not known. Management may involve the use of intravenous immunoglobulin (IVIG) and/or plasmapheresis, but no standard treatment exists.
 

Advocacy and Support Organizations

 

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Scleromyxedema" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Scleromyxedema" returned 10 free, full-text research articles on human participants. First 3 results:

[Response to thalidomide in scleromyxedema].
 

Author(s): María Florencia Pascualini, Guadalupe Caballero Escuti, Enrique Valente, María Kurpis, Alejandro Ruiz Lascano

Journal: Medicina (B Aires). 2013 ;73(3):252-4.

 

The scleromyxedema is a rare condition characterized by hyperproliferation of fibroblasts with increased dermal deposition of mucin and frequently associated with monoclonal gammopathy of undetermined significance. Various treatments have been reported, with inconsistent results. ...

Last Updated: 4 Jun 2013

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Scleromyxedema: a cutaneous paraneoplastic syndrome associated with thymic carcinoma.
 

Author(s): Johnny Chun-Yin Chan, Nigel Jeremy Trendell-Smith, Chi Keung Yeung

Journal: J. Clin. Oncol.. 2012 Jan;30(3):e27-9.

 

Last Updated: 20 Jan 2012

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Managing scleromyxedema with intravenous immunoglobulin: acute worsening of scleromyxedema with biclonal gammopathy.
 

Author(s): I Manousaridis, C Loeser, S Goerdt, J C Hassel

Journal: Acta Dermatovenerol Alp Pannonica Adriat. 2010 Dec;19(4):15-9.

 

Scleromyxedema is a rare chronic cutaneous mucinosis usually associated with a monoclonal gammopathy and underlying systemic disease. The etiology of the disease is not known. There are no standard treatments and response to various therapeutic modalities varies. We report a case ...

Last Updated: 10 Mar 2011

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Scleromyxedema" returned 1 free, full-text review articles on human participants. First 3 results:

Scleroderma-like acute renal crisis in a patient with scleromyxedema.
 

Author(s): Wilfried Gwinner, Uta Erdbruegger, Michael Mengel, Carsten Hafer, Jens Kittner, Torsten Witte, Bernward Voelker, Hermann Haller

Journal: Nephrol. Dial. Transplant.. 2007 Jul;22(7):2063-7.

 

Last Updated: 2 Jul 2007

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

There are currently no open clinical trials for this condition.