Scleroderma

Common Name(s)

Scleroderma

Scleroderma is a rare chronic connective tissue disease. Symptoms associated with the disease involve hardening and tightening of the skin and connective tissues. The connective tissues provide the framework and support for the body. Blood vessels, internal organs, and the digestive tract can also be affected by scleroderma. Although there is no current cure for scleroderma, treatments can lessen symptoms and help prevent further complications. Therapies can also be used to help lessen pain and improve mobility. Scleroderma is more common in women than in men and typically occurs between the ages of 30 to 50. Scleroderma is not contagious, infectious, cancerous or malignant.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Scleroderma" for support, advocacy or research.

Association of Gastrointestinal Motility Disorders, Inc. (AGMD)

AGMD is a nonprofit international organization which serves as an integral educational resource concerning digestive motility diseases and disorders. It also functions as an important information base for members of the medical and scientific communities. In addition, it provides a forum for patients suffering from digestive motility diseases and disorders as well as their families and members of the medical community.

Last Updated: 28 Feb 2013

View Details
HealthyWomen

HealthyWomen (HW) is the nation's leading independent health information source for women. Our core mission is to educate, inform and empower women to make smart health choices for themselves and their families. For more than 20 years, millions of women have been coming to HW for answers to their most pressing and personal health care questions. Through our wide array of online and print publications, HW provides health information that is original, objective, reviewed by medical experts and reflective of the advances in evidence-based health research.

Last Updated: 3 Oct 2013

View Details
International Scleroderma Network

Our mission is to provide stellar worldwide research, support, education and awareness for scleroderma and related illnesses.

Last Updated: 18 Apr 2010

View Details
Logo
Raynaud's & Scleroderma Ireland

• To improve the lives of patients, their families and carers by providing support, advice and information. • To increase the awareness of Raynaud’s and Scleroderma amongst healthcare professionals, Government and Statutory agencies and the general public. • To work in partnership with appropriate healthcare professionals and agencies to promote and co-ordinate the attainment of the objectives of the strategy. • Maintain a working environment that fosters communication, teamwork and diversity among all members of staff- permanent, temporary and voluntary

Last Updated: 6 May 2014

View Details
Logo
Scleroderma Foundation

Our three-fold mission is to help patients and their families cope with scleroderma through mutual support programs, peer counseling, physician referrals, and educational information, to promote public awareness and education through patient and health professional seminars, literature, and publicity campaigns, and to stimulate and support research to improve treatment and ultimately find the cause of and cure for scleroderma and related diseases.

Last Updated: 19 Oct 2012

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Scleroderma" for support, advocacy or research.

Association of Gastrointestinal Motility Disorders, Inc. (AGMD)

AGMD is a nonprofit international organization which serves as an integral educational resource concerning digestive motility diseases and disorders. It also functions as an important information base for members of the medical and scientific communities. In addition, it provides a forum for patients suffering from digestive motility diseases and disorders as well as their families and members of the medical community.

http://www.agmd-gimotility.org

Last Updated: 28 Feb 2013

View Details
HealthyWomen

HealthyWomen (HW) is the nation's leading independent health information source for women. Our core mission is to educate, inform and empower women to make smart health choices for themselves and their families. For more than 20 years, millions of women have been coming to HW for answers to their most pressing and personal health care questions. Through our wide array of online and print publications, HW provides health information that is original, objective, reviewed by medical experts and reflective of the advances in evidence-based health research.

http://www.healthywomen.org

Last Updated: 3 Oct 2013

View Details
International Scleroderma Network

Our mission is to provide stellar worldwide research, support, education and awareness for scleroderma and related illnesses.

http://www.sclero.org/

Last Updated: 18 Apr 2010

View Details
Logo
Raynaud's & Scleroderma Ireland

• To improve the lives of patients, their families and carers by providing support, advice and information. • To increase the awareness of Raynaud’s and Scleroderma amongst healthcare professionals, Government and Statutory agencies and the general public. • To work in partnership with appropriate healthcare professionals and agencies to promote and co-ordinate the attainment of the objectives of the strategy. • Maintain a working environment that fosters communication, teamwork and diversity among all members of staff- permanent, temporary and voluntary

http://www.irishraynauds.com

Last Updated: 6 May 2014

View Details
Logo
Scleroderma Foundation

Our three-fold mission is to help patients and their families cope with scleroderma through mutual support programs, peer counseling, physician referrals, and educational information, to promote public awareness and education through patient and health professional seminars, literature, and publicity campaigns, and to stimulate and support research to improve treatment and ultimately find the cause of and cure for scleroderma and related diseases.

http://www.scleroderma.org

Last Updated: 19 Oct 2012

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Scleroderma" returned 763 free, full-text research articles on human participants. First 3 results:

Oesophageal stenosis dilatation through retrograde trans-gastrostomal approach in a patient with systemic scleroderma.
 

Author(s): D Serban, C Brănescu, M Comandaşu, A M Dascălu, D Dumitrescu, H Bumbea, B Braticievici, C Savlovschi

Journal: Chirurgia (Bucur). ;109(3):396-401.

 

The paper presents the surgical solving of an oesophageal stenosis, using a device of pneumatic dilatation with trans-gastrostomal approach, in a patient with multiple disabling handicaps, secondary severe malnutrition and previously diagnosed with scleroderma.

Last Updated: 24 Jun 2014

Go To URL
Comparison of a new, modified lung ultrasonography technique with high-resolution CT in the diagnosis of the alveolo-interstitial syndrome of systemic scleroderma.
 

Author(s): Afshin Mohammadi, Sima Oshnoei, Mohammad Ghasemi-rad

Journal: Med Ultrason. 2014 Mar;16(1):27-31.

 

Pulmonary fibrosis is the main cause of mortality in patients with Systemic Scleroderma (SSc). This study was performed to investigate the utility of modified trans-thoracic ultrasound (TTUS) scoring system according to the comet tail sign (B-line artifacts) and to compare it with ...

Last Updated: 25 Feb 2014

Go To URL
Interferon-gamma inducible protein-10 as a potential biomarker in localized scleroderma.
 

Author(s): Kelsey E Magee, Christina E Kelsey, Katherine L Kurzinski, Jonhan Ho, Logan R Mlakar, Carol A Feghali-Bostwick, Kathryn S Torok

Journal: Arthritis Res. Ther.. 2013 ;15(6):R188.

 

The purpose of this study was to evaluate the presence and levels of interferon-gamma inducible protein-10 (IP-10) in the plasma and skin of pediatric localized scleroderma (LS) patients compared to those of healthy pediatric controls and to determine if IP-10 levels correlate to ...

Last Updated: 6 Mar 2014

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Scleroderma" returned 77 free, full-text review articles on human participants. First 3 results:

Scleroderma renal crisis in a case of mixed connective tissue disease.
 

Author(s): Mukul Vij, Vinita Agrawal, Manoj Jain

Journal: Saudi J Kidney Dis Transpl. 2014 Jul;25(4):844-8.

 

Mixed connective tissue disease (MCTD) is an overlap syndrome first defined in 1972 by Sharp et al. In this original study, the portrait emerged of a connective tissue disorder sharing features of systemic lupus erythematosus, systemic sclerosis (scleroderma) and polymyositis. Scleroderma ...

Last Updated: 27 Jun 2014

Go To URL
Screening patients with scleroderma for pulmonary arterial hypertension and implications for other at-risk populations.
 

Author(s): Johannes P Schwaiger, Dinesh Khanna, J Gerry Coghlan

Journal: Eur Respir Rev. 2013 Dec;22(130):515-25.

 

Pulmonary arterial hypertension (PAH) is a progressive vasculopathy that is advanced by the time symptoms develop. As symptoms are nonspecific and the condition uncommon, continued progression toward end-stage disease occurs for an average of 2 years between symptom onset and diagnosis. ...

Last Updated: 2 Dec 2013

Go To URL
MicroRNAs: their involvement in fibrosis pathogenesis and use as diagnostic biomarkers in scleroderma.
 

Author(s): Honglin Zhu, Hui Luo, Xiaoxia Zuo

Journal:

 

miRNAs are important post-transcriptional regulators. The aberrant expression of miRNAs is strongly associated with the initiation and progression of pathophysiologic processes in a wide range of human diseases. Scleroderma (systemic sclerosis; SSc) is a highly heterogeneous autoimmune ...

Last Updated: 20 Sep 2013

Go To URL
 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Multi-center, Web Based Observational Study of Pulmonary Hypertension in Scleroderma Patients
 

Status: Recruiting

Condition Summary: Systemic Sclerosis; Scleroderma; Pulmonary Hypertension; Pulmonary Arterial Hypertension

 

Last Updated: 18 Aug 2014

Go to URL
Gastroesophageal Reflux Treatment in Scleroderma
 

Status: Recruiting

Condition Summary: Gastroesophageal Reflux Disease; Systemic Sclerosis; Scleroderma

 

Last Updated: 24 Sep 2013

Go to URL
Scleroderma Registry
 

Status: Recruiting

Condition Summary: Systemic Sclerosis; Scleroderma

 

Last Updated: 8 Apr 2014

Go to URL